Alessio Ugolini
@alessiougolini.bsky.social
M.D., Ph.D. with a focus on Cancer Immunology Translational Research.
Our new paper is out in Neuro-Oncology! Targeting hypoxia-driven histone lactylation in myeloid cells synergizes with CD137 agonism to expand effector-like exhausted CD8+ T cells in glioblastoma academic.oup.com/neuro-oncolo...
Targeting hypoxia-driven histone lactylation in myeloid cells synergizes with CD137 agonism to expand effector-like exhausted CD8+ T cells in glioblastoma
AbstractBackground. Overwhelming presence of immunoregulatory myeloid cells and dysfunctional T cells is a major barrier to effective immunotherapies in gl
academic.oup.com
October 8, 2026 at 11:29 AM
Our new paper is out in Neuro-Oncology! Targeting hypoxia-driven histone lactylation in myeloid cells synergizes with CD137 agonism to expand effector-like exhausted CD8+ T cells in glioblastoma academic.oup.com/neuro-oncolo...
I am thrilled to share that our latest work has been published on Cancer Discovery.
In this manuscript, we provided a potential therapeutic strategy to counteract neutrophils-induced immunosuppression in cancer.
doi.org/10.1158/2159...
In this manuscript, we provided a potential therapeutic strategy to counteract neutrophils-induced immunosuppression in cancer.
doi.org/10.1158/2159...
Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation
Abstract. Despite functional heterogeneity, high frequency of intratumoral neutrophils predicts poor clinical outcomes. The tumor microenvironment reprograms neutrophils into immunosuppressive subsets...
doi.org
March 3, 2025 at 8:51 PM
I am thrilled to share that our latest work has been published on Cancer Discovery.
In this manuscript, we provided a potential therapeutic strategy to counteract neutrophils-induced immunosuppression in cancer.
doi.org/10.1158/2159...
In this manuscript, we provided a potential therapeutic strategy to counteract neutrophils-induced immunosuppression in cancer.
doi.org/10.1158/2159...