Dave Barefield
@barefieldlab.bsky.social
Assistant Professor at Loyola University Chicago studying cardiomyopathy and atrial contractility.
#HCM #DCM #Arrhythmia #AFib
Views are my own.
https://www.barefieldlab.org/
#HCM #DCM #Arrhythmia #AFib
Views are my own.
https://www.barefieldlab.org/
Pinned
Dave Barefield
@barefieldlab.bsky.social
· Sep 20
Intro post! My lab at Loyola University Chicago studies genetic causes of #cardiomyopathy (#HCM, #DCM) and #AFib with a focus on #myofilament and #sarcomere function.
This looks like a massive fraud across the industry. I've wasted so many resources on failed antibodies. These companies and executives need to be held accountable. I can't believe the conclusion of "probably nothing will happen". We need an investigation and a class action lawsuit, at minimum.
‘I don’t know how they’ll rebuild trust. I hope there will be some lawsuit, I’m not a fan of suing people in general but this is a big scandal,’ says Elisabeth Bik.
#ChemSky @elisabethbik.bsky.social @reeserichardson.bsky.social @sholtodavid.bsky.social
www.chemistryworld.com/news/antibod...
#ChemSky @elisabethbik.bsky.social @reeserichardson.bsky.social @sholtodavid.bsky.social
www.chemistryworld.com/news/antibod...
Antibody data manipulation extends to thousands of images across 15 suppliers
Sleuths discover widespread, systematic alteration of Western blots and other antibody data
www.chemistryworld.com
September 17, 2026 at 1:02 PM
This looks like a massive fraud across the industry. I've wasted so many resources on failed antibodies. These companies and executives need to be held accountable. I can't believe the conclusion of "probably nothing will happen". We need an investigation and a class action lawsuit, at minimum.
Apparently we could be going so much harder for our #AHA conference designs. @ahascience.bsky.social
Somehow it's taken until now for me to become aware of the concept of #Smaugust but it gives me an excuse to make you look at old dragon things
August 21, 2026 at 2:59 PM
Apparently we could be going so much harder for our #AHA conference designs. @ahascience.bsky.social
Reposted by Dave Barefield
Scary stories about teens sell. The data tells a different story.
After decades studying adolescent mental health, here's what I found: This isn't an anxious generation. It's a resilient one. Let's start treating them that way. go.ted.com/candiceodgers
After decades studying adolescent mental health, here's what I found: This isn't an anxious generation. It's a resilient one. Let's start treating them that way. go.ted.com/candiceodgers
What we're getting wrong about teens and tech
For years, the warning has been: smartphones are destroying a generation. But developmental psychologist Candice Odgers says that decades of data on teens tells a different story — violence, alcohol u...
go.ted.com
June 23, 2026 at 4:21 PM
Scary stories about teens sell. The data tells a different story.
After decades studying adolescent mental health, here's what I found: This isn't an anxious generation. It's a resilient one. Let's start treating them that way. go.ted.com/candiceodgers
After decades studying adolescent mental health, here's what I found: This isn't an anxious generation. It's a resilient one. Let's start treating them that way. go.ted.com/candiceodgers
Reposted by Dave Barefield
Happy gender-ambiguous cavalry hero day to all who celebrate.
March 2, 2026 at 1:27 PM
Happy gender-ambiguous cavalry hero day to all who celebrate.
New work in JGP from the Barefield Lab!
Myosin binding protein H-like (terrible name) and its big brother, myosin binding protein-C have similar C'-terminal regions. Nonsense mutations in C protein are well known to prevent sarcomere incorporation. But what about this relatively unstudied paralog?
Myosin binding protein H-like (terrible name) and its big brother, myosin binding protein-C have similar C'-terminal regions. Nonsense mutations in C protein are well known to prevent sarcomere incorporation. But what about this relatively unstudied paralog?
New study from Alvarez-Arce et al. @barefieldlab.bsky.social shows that premature stop variants in myosin-binding protein H-like prevent sarcomere incorporation of the translated protein regardless of the location of the premature stop along the protein. rupress.org/jgp/article/...
#Myofilaments
#Myofilaments
November 19, 2025 at 5:29 PM
New work in JGP from the Barefield Lab!
Myosin binding protein H-like (terrible name) and its big brother, myosin binding protein-C have similar C'-terminal regions. Nonsense mutations in C protein are well known to prevent sarcomere incorporation. But what about this relatively unstudied paralog?
Myosin binding protein H-like (terrible name) and its big brother, myosin binding protein-C have similar C'-terminal regions. Nonsense mutations in C protein are well known to prevent sarcomere incorporation. But what about this relatively unstudied paralog?
I had very little time to enjoy having gotten this particular boulder to the top of the hill this morning.
November 3, 2025 at 4:36 PM
I had very little time to enjoy having gotten this particular boulder to the top of the hill this morning.
Reposted by Dave Barefield
Oak Park resident Scott Sakiyama reports feds pointed weapons at him across from an elementary school today. They then arrested him and took him to Broadview. While in custody, he saw agents texting in a group chat called "Chiraq Team 2."
Full testimony: www.facebook.com/share/p/1GqB...
Full testimony: www.facebook.com/share/p/1GqB...
October 20, 2025 at 11:48 PM
Oak Park resident Scott Sakiyama reports feds pointed weapons at him across from an elementary school today. They then arrested him and took him to Broadview. While in custody, he saw agents texting in a group chat called "Chiraq Team 2."
Full testimony: www.facebook.com/share/p/1GqB...
Full testimony: www.facebook.com/share/p/1GqB...
The Cardiovascular Research Institute team from @loyolachicago.bsky.social had a blast at the AHA #heartwalk25 walking 3 miles and raising money to fight heart disease!
September 20, 2025 at 4:06 PM
The Cardiovascular Research Institute team from @loyolachicago.bsky.social had a blast at the AHA #heartwalk25 walking 3 miles and raising money to fight heart disease!
Supporting research is more important than ever. Please consider supporting the American Heart Association by supporting the Heart Walk team for Loyola University Chicago's Cardiovascular Research Institute.
Any donation is greatly appreciated!
Click here to donate now: bndfr.com/3s59Z
Any donation is greatly appreciated!
Click here to donate now: bndfr.com/3s59Z
American Heart Association Heart Walk
The Heart Walk is the American Heart Association's premiere event for raising funds to save lives from USA's #1 and #5 killers - heart disease and stroke.
bndfr.com
September 15, 2025 at 5:36 PM
Supporting research is more important than ever. Please consider supporting the American Heart Association by supporting the Heart Walk team for Loyola University Chicago's Cardiovascular Research Institute.
Any donation is greatly appreciated!
Click here to donate now: bndfr.com/3s59Z
Any donation is greatly appreciated!
Click here to donate now: bndfr.com/3s59Z
Reposted by Dave Barefield
A friendly reminder that the NIH Public Access Policy IS NOT “you must publish open access” but rather “you must ensure your copy of your paper is deposited into PubMed Central.”
Yes, it is very confusing. Yes, you should be able to do that deposit yourself without paying anything to a journal.
Yes, it is very confusing. Yes, you should be able to do that deposit yourself without paying anything to a journal.
August 20, 2025 at 4:33 PM
A friendly reminder that the NIH Public Access Policy IS NOT “you must publish open access” but rather “you must ensure your copy of your paper is deposited into PubMed Central.”
Yes, it is very confusing. Yes, you should be able to do that deposit yourself without paying anything to a journal.
Yes, it is very confusing. Yes, you should be able to do that deposit yourself without paying anything to a journal.
Reposted by Dave Barefield
NIH progress on new R01s in FY 2025 drugmonkey.wordpress.com/2025/08/18/n...
NIH progress on new R01s in FY 2025
I know Doctor Editor Director Professor Berg has more sophisticated analyses going but this simple data set made sense to me once I realized how few new R01 NIAAA has issued so far (5). Since we ar…
drugmonkey.wordpress.com
August 19, 2025 at 1:56 AM
NIH progress on new R01s in FY 2025 drugmonkey.wordpress.com/2025/08/18/n...
Great sunset shot for the end of Pride month.
July 1, 2025 at 1:34 AM
Great sunset shot for the end of Pride month.
Reposted by Dave Barefield
New online! Tailored therapeutics for cardiomyopathies #CardioSky
Tailored therapeutics for cardiomyopathies
Nature Reviews Cardiology, Published online: 27 June 2025; doi:10.1038/s41569-025-01183-6Treatment of cardiomyopathies has historically focused on symptom management. In this Review, Elliott and colleagues discuss how elucidation of the complex cellular and molecular pathways has led to the development of novel therapeutic agents that modify or mitigate the effects of causative genetic variants, enabling tailored treatment for cardiomyopathies.
bit.ly
June 27, 2025 at 11:58 AM
New online! Tailored therapeutics for cardiomyopathies #CardioSky
Reposted by Dave Barefield
🚨 Editor's Choice! 🚨 Research from University of Arizona shows L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation & is embryonic lethal in homozygous CRISPR gene-edited mice
Read: doi.org/10.1016/j.yj...
Read: doi.org/10.1016/j.yj...
June 10, 2025 at 9:23 PM
🚨 Editor's Choice! 🚨 Research from University of Arizona shows L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation & is embryonic lethal in homozygous CRISPR gene-edited mice
Read: doi.org/10.1016/j.yj...
Read: doi.org/10.1016/j.yj...
Reposted by Dave Barefield
David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...
The Missing 11th of the Month - David R Hagen
Personal website of David R Hagen, scientific software engineer
drhagen.com
June 19, 2025 at 11:40 AM
David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...
Reposted by Dave Barefield
The shift in cardiovascular disease. From reduction of heart attacks, coronary artery disease, and strokes to more atrial fibrillation ("the most common cardiovascular problem")
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
The changing spectrum of cardiovascular diseases
Advances in cardiovascular disease prevention are often hailed as one of the major
public health accomplishments of the past 50 years. The progress achieved is rooted
in efforts challenging the inevit...
www.thelancet.com
June 11, 2025 at 12:05 AM
The shift in cardiovascular disease. From reduction of heart attacks, coronary artery disease, and strokes to more atrial fibrillation ("the most common cardiovascular problem")
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Today's XKCD is a great excuse to plug Loyola's @loyolachicago.bsky.social Master of Science in Clinical and Applied Proteomics:
www.luc.edu/stritch/cell...
#massspec @jonathankirk.bsky.social
www.luc.edu/stritch/cell...
#massspec @jonathankirk.bsky.social
May 27, 2025 at 4:34 PM
Today's XKCD is a great excuse to plug Loyola's @loyolachicago.bsky.social Master of Science in Clinical and Applied Proteomics:
www.luc.edu/stritch/cell...
#massspec @jonathankirk.bsky.social
www.luc.edu/stritch/cell...
#massspec @jonathankirk.bsky.social
When you revise a rejected grant and it gets funded as a new A0.
a lego batman and a lego beaky are standing next to each other
ALT: a lego batman and a lego beaky are standing next to each other
media.tenor.com
April 4, 2025 at 4:40 PM
When you revise a rejected grant and it gets funded as a new A0.
Reposted by Dave Barefield
From reddit: a letter from a postdoc who survived the Bolsonaro years. This is helpful framing for how to science in this administration. 🧪
www.reddit.com/r/labrats/s/...
www.reddit.com/r/labrats/s/...
From the labrats community on Reddit
Explore this post and more from the labrats community
www.reddit.com
February 12, 2025 at 8:01 PM
From reddit: a letter from a postdoc who survived the Bolsonaro years. This is helpful framing for how to science in this administration. 🧪
www.reddit.com/r/labrats/s/...
www.reddit.com/r/labrats/s/...
Reposted by Dave Barefield
Wondering if it could be any colder outside? Yes! Come to Chicago! Accepting applications now for summer 2025 research experience in cardiovascular physiology for undergrads! Email applications to [email protected].
January 20, 2025 at 8:37 PM
Wondering if it could be any colder outside? Yes! Come to Chicago! Accepting applications now for summer 2025 research experience in cardiovascular physiology for undergrads! Email applications to [email protected].
When you're trying to keep yourself motivated but then you remember survivorship bias.
January 2, 2025 at 3:53 PM
When you're trying to keep yourself motivated but then you remember survivorship bias.
Seasonal contribution to #FluorescenceFriday.
Neonatal rat cardiomyocytes with their sarcomeres stained green. Red staining is under peer review.
Neonatal rat cardiomyocytes with their sarcomeres stained green. Red staining is under peer review.
December 6, 2024 at 4:33 PM
Seasonal contribution to #FluorescenceFriday.
Neonatal rat cardiomyocytes with their sarcomeres stained green. Red staining is under peer review.
Neonatal rat cardiomyocytes with their sarcomeres stained green. Red staining is under peer review.
Me every time I sit at my desk after a few weeks of grant rejections.
December 5, 2024 at 4:01 PM
Me every time I sit at my desk after a few weeks of grant rejections.
I've never shown a badge without channeling this scene.
November 17, 2024 at 9:32 PM
I've never shown a badge without channeling this scene.