Bas van Steensel lab (NKI)
@basvansteensellab.bsky.social
We are a research lab at the Netherlands Cancer Institute. We develop and apply new genomics tools to study genome biology and gene regulation.
Inferring transcription factor activity: use ATAC-seq, reporter assays, or both? link.springer.com/article/10.1...
Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays - Molecular Systems Biology
Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to under...
link.springer.com
August 18, 2026 at 9:39 AM
Inferring transcription factor activity: use ATAC-seq, reporter assays, or both? link.springer.com/article/10.1...
Reposted by Bas van Steensel lab (NKI)
We;re hiring Junior Group Leaders! 🔬✨
We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment.
www.nki.nl/news-events/...
We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment.
www.nki.nl/news-events/...
February 20, 2026 at 1:32 PM
We;re hiring Junior Group Leaders! 🔬✨
We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment.
www.nki.nl/news-events/...
We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment.
www.nki.nl/news-events/...
New preprint from our lab... We applied our hopping technology to relocate CTCF binding sites to thousands of alternative positions in the Sox2 locus: www.biorxiv.org/content/10.6...
www.biorxiv.org
March 19, 2026 at 6:29 AM
New preprint from our lab... We applied our hopping technology to relocate CTCF binding sites to thousands of alternative positions in the Sox2 locus: www.biorxiv.org/content/10.6...
Our reporter hopping scaled up to thousands of integrations in a single locus, to produce high-resolution functional maps, with plenty of interesting insights: www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 24, 2025 at 8:56 AM
Our reporter hopping scaled up to thousands of integrations in a single locus, to produce high-resolution functional maps, with plenty of interesting insights: www.science.org/doi/10.1126/...
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
September 2, 2025 at 5:26 PM
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
Together with the De Ridder lab www.deridderlab.nl we just published a review on deep learning as a tool for gene expression analysis/ prediction: rdcu.be/elQCc.
Predicting gene expression from DNA sequence using deep learning models
Nature Reviews Genetics - Barbadilla-Martínez et al. review recent progress in deep-learning-based sequence-to-expression models, which predict gene expression levels solely from DNA sequence....
rdcu.be
May 17, 2025 at 7:30 AM
Together with the De Ridder lab www.deridderlab.nl we just published a review on deep learning as a tool for gene expression analysis/ prediction: rdcu.be/elQCc.
In @elife.bsky.social: Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function doi.org/10.7554/eLif...
Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function
doi.org
March 31, 2025 at 9:37 AM
In @elife.bsky.social: Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function doi.org/10.7554/eLif...
Welcome to our lab! We are no longer active on Twitter/X. New results/preprints/papers will be posted here.
January 13, 2025 at 10:17 PM
Welcome to our lab! We are no longer active on Twitter/X. New results/preprints/papers will be posted here.