Biohub
@biohub.org
Combining frontier AI & frontier biology to help scientists cure or prevent disease
Reposted by Biohub
AI has become such a powerful tool, enabling entire areas of science and biology. I got to talk about this as part of a new PBS special on how AI and biotech are transforming medicine.
Overall, the documentary is quite interesting!
It's worth a watch!
www.pbs.org/video/data-c...
Overall, the documentary is quite interesting!
It's worth a watch!
www.pbs.org/video/data-c...
Data Cure: Stories of Healing and Hope | Episode 1
A race to stop superbugs before medicine enters an era where antibiotics no longer work.
www.pbs.org
September 14, 2026 at 9:37 PM
AI has become such a powerful tool, enabling entire areas of science and biology. I got to talk about this as part of a new PBS special on how AI and biotech are transforming medicine.
Overall, the documentary is quite interesting!
It's worth a watch!
www.pbs.org/video/data-c...
Overall, the documentary is quite interesting!
It's worth a watch!
www.pbs.org/video/data-c...
Biohub scientist Dr. Angela Oliveira Pisco worked with a team of genomics and software experts to more than double the number of cells in the Tabula Sapiens dataset, and increase the number of cell types represented, to 700.
Now online! Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types
Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types
An expanded atlas of human cells maps the expression of nearly all human transcription factors across 701 cell-type/tissue combinations and uncovers the heterogeneous nature of senescence across tissues and cell types.
dlvr.it
September 8, 2026 at 5:41 PM
Biohub scientist Dr. Angela Oliveira Pisco worked with a team of genomics and software experts to more than double the number of cells in the Tabula Sapiens dataset, and increase the number of cell types represented, to 700.
🔬New in @cellpress.bsky.social from Biohub Investigator Bo Huang: AI-designed proteins built from scratch (dubbed "Rhobins") work in living cells and now match or even surpass fluorescent tags refined over decades of natural protein engineering.
Read the paper: www.cell.com/cell/fulltex...
Read the paper: www.cell.com/cell/fulltex...
September 2, 2026 at 5:42 PM
🔬New in @cellpress.bsky.social from Biohub Investigator Bo Huang: AI-designed proteins built from scratch (dubbed "Rhobins") work in living cells and now match or even surpass fluorescent tags refined over decades of natural protein engineering.
Read the paper: www.cell.com/cell/fulltex...
Read the paper: www.cell.com/cell/fulltex...
Organoids can mimic human organs, but we study them mostly with static, endpoint assays. A new perspective argues for instrumented tissues, which are engineered human tissue woven with electrical, chemical, mechanical, and optical sensor arrays, to move faster from disease mechanism to therapy.
September 1, 2026 at 9:45 PM
Organoids can mimic human organs, but we study them mostly with static, endpoint assays. A new perspective argues for instrumented tissues, which are engineered human tissue woven with electrical, chemical, mechanical, and optical sensor arrays, to move faster from disease mechanism to therapy.
This is the largest dataset contributed to the Billion Cells Project to date. It is an important step toward the scale and coordination needed to build the Virtual Biology Initiative.
An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies.
@ucsanfrancisco.bsky.social
@marsonlab.bsky.social
@stanford.edu
@biohub.org
@cp-cell.bsky.social
@10xgenomics.bsky.social
@ucsanfrancisco.bsky.social
@marsonlab.bsky.social
@stanford.edu
@biohub.org
@cp-cell.bsky.social
@10xgenomics.bsky.social
Scientists Decode Gene Circuits of Human Immunity, Fueling New Era of Disease Research
An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies.
gladstone.org
August 28, 2026 at 7:49 PM
This is the largest dataset contributed to the Billion Cells Project to date. It is an important step toward the scale and coordination needed to build the Virtual Biology Initiative.
Tumors aren't one disease—they're patchworks of coexisting cancer cell states. Two new Nature Genetics papers show these are AI-mappable (ARACNe+VIPER) and nearly identical across patients. We found drug combos hitting multiple states at once, doubling survival in a rare brain tumor. bit.ly/45TNIkb
Why one drug isn't enough: AI reveals cancer's secret weapon
Tumors are patchworks of distinct malignant cell states, each with its own survival strategy. With AI, Biohub scientists are discovering drug combinations that defeat them all at once.
bit.ly
August 26, 2026 at 4:38 PM
Tumors aren't one disease—they're patchworks of coexisting cancer cell states. Two new Nature Genetics papers show these are AI-mappable (ARACNe+VIPER) and nearly identical across patients. We found drug combos hitting multiple states at once, doubling survival in a rare brain tumor. bit.ly/45TNIkb
Proteins are the machinery of life. Scientists have cataloged billions of protein sequences—but their biology is still mostly unknown.
ESM Atlas is a new way in. https://bit.ly/4dJcF6G
ESM Atlas is a new way in. https://bit.ly/4dJcF6G
August 6, 2026 at 6:24 PM
Proteins are the machinery of life. Scientists have cataloged billions of protein sequences—but their biology is still mostly unknown.
ESM Atlas is a new way in. https://bit.ly/4dJcF6G
ESM Atlas is a new way in. https://bit.ly/4dJcF6G
Reposted by Biohub
SeqHub protein searches now show which regions of a predicted structure are tied to specific biological functions or evolutionary patterns, powered by @biohub.org's SAE features. 🧵
August 6, 2026 at 2:19 PM
SeqHub protein searches now show which regions of a predicted structure are tied to specific biological functions or evolutionary patterns, powered by @biohub.org's SAE features. 🧵
🎉 Congrats to Scott Fraser, Biohub’s President of Dynamic Imaging, on receiving the Microscopy Society of America’s Distinguished Scientist Award - Biological Sciences, in recognition of his transformative contributions in bioimaging and molecular analysis!
August 3, 2026 at 6:08 PM
🎉 Congrats to Scott Fraser, Biohub’s President of Dynamic Imaging, on receiving the Microscopy Society of America’s Distinguished Scientist Award - Biological Sciences, in recognition of his transformative contributions in bioimaging and molecular analysis!
Reposted by Biohub
Preprint: biorxiv.org/content/10.6...
This is the product of many years of effort, and particularly amazing summer teamwork by Qi Yu, Haedong Kim, @seidels.bsky.social @cxqiu.bsky.social and many others from Shendure Lab & SeaHub (a @alleninstitute.org @biohub.org @uwmedicine.bsky.social colab) 2/n
This is the product of many years of effort, and particularly amazing summer teamwork by Qi Yu, Haedong Kim, @seidels.bsky.social @cxqiu.bsky.social and many others from Shendure Lab & SeaHub (a @alleninstitute.org @biohub.org @uwmedicine.bsky.social colab) 2/n
In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis
The complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant. Most animals are none of these, having orders of m...
biorxiv.org
July 31, 2026 at 8:11 PM
Preprint: biorxiv.org/content/10.6...
This is the product of many years of effort, and particularly amazing summer teamwork by Qi Yu, Haedong Kim, @seidels.bsky.social @cxqiu.bsky.social and many others from Shendure Lab & SeaHub (a @alleninstitute.org @biohub.org @uwmedicine.bsky.social colab) 2/n
This is the product of many years of effort, and particularly amazing summer teamwork by Qi Yu, Haedong Kim, @seidels.bsky.social @cxqiu.bsky.social and many others from Shendure Lab & SeaHub (a @alleninstitute.org @biohub.org @uwmedicine.bsky.social colab) 2/n
How hard was it to get the laser phase plate to work? Like “trying to hit a bullet with a bullet” hard, says Biohub scientist David Agard. Check out the latest episode of the Uncovered podcast from @cenmag.bsky.social.
Learn about a device that boosts the contrast in electron microscopy using the most intense laser beam yet made, and the story of its path from an idea to an invention that could open new lines of inquiry in structural biology and biochemistry.
#chemsky 🧪
#chemsky 🧪
Uncovered: Record-setting laser boosts cryo-electron microscopy
Phase-contrast device could allow in-cell proteomics
cen.acs.org
July 24, 2026 at 4:37 PM
How hard was it to get the laser phase plate to work? Like “trying to hit a bullet with a bullet” hard, says Biohub scientist David Agard. Check out the latest episode of the Uncovered podcast from @cenmag.bsky.social.
Can science give you superpowers? Don’t miss Biohub Investigators @profhernandez.bsky.social and KC Huang at San Diego Comic-Con tonight! #SDCC
I’m excited about my upcoming talk at San Diego Comic Con in a panel entitled “How science may give you superpowers” with KC Huang and Tom Galloway. #SDCC #Makeitcannon #Originstory www.comic-con.org/cc/things-to...
Programming Schedule - Comic-Con
Check out the programming schedule for Comic-Con in San Diego!
www.comic-con.org
July 23, 2026 at 4:42 PM
Can science give you superpowers? Don’t miss Biohub Investigators @profhernandez.bsky.social and KC Huang at San Diego Comic-Con tonight! #SDCC
🚨 New preprint: We reprocessed 77k zebrafish RNA-seq datasets from across the global research community and found hidden viruses in 10% of them—including a fish virus whose proteins are 91% identical to human Influenza B—then built a generalizable pipeline.
bit.ly/4vxFF72
bit.ly/4vxFF72
July 16, 2026 at 7:54 PM
🚨 New preprint: We reprocessed 77k zebrafish RNA-seq datasets from across the global research community and found hidden viruses in 10% of them—including a fish virus whose proteins are 91% identical to human Influenza B—then built a generalizable pipeline.
bit.ly/4vxFF72
bit.ly/4vxFF72
7.5M people in the U.S. live with psoriasis. Many still struggle despite treatment.
Our team combined AI + CRISPR to find overlooked biological pathways — then tested an existing asthma drug. It worked.
This is frontier AI and frontier biology working together. 🧬
Learn more: bit.ly/44QSiyW
Our team combined AI + CRISPR to find overlooked biological pathways — then tested an existing asthma drug. It worked.
This is frontier AI and frontier biology working together. 🧬
Learn more: bit.ly/44QSiyW
A Genome-Wide CRISPR Screen Reveals New Psoriasis Targets
Biohub researchers combined a genome-wide CRISPR screen with AI to uncover an unexpected psoriasis drug target: the receptor for oxytocin.
bit.ly
July 8, 2026 at 3:59 PM
7.5M people in the U.S. live with psoriasis. Many still struggle despite treatment.
Our team combined AI + CRISPR to find overlooked biological pathways — then tested an existing asthma drug. It worked.
This is frontier AI and frontier biology working together. 🧬
Learn more: bit.ly/44QSiyW
Our team combined AI + CRISPR to find overlooked biological pathways — then tested an existing asthma drug. It worked.
This is frontier AI and frontier biology working together. 🧬
Learn more: bit.ly/44QSiyW
Excited to be at #ICML 2026! We’ll share three papers on virtual cell modeling, single-cell data generation, and immune recognition.
→ Virtual Cells Need Context, Not Just Scale icml.cc/virtual/2026...
→ scLDM icml.cc/virtual/2026...
→ DecoderTCR icml.cc/virtual/2026...
→ Virtual Cells Need Context, Not Just Scale icml.cc/virtual/2026...
→ scLDM icml.cc/virtual/2026...
→ DecoderTCR icml.cc/virtual/2026...
July 7, 2026 at 4:21 PM
Excited to be at #ICML 2026! We’ll share three papers on virtual cell modeling, single-cell data generation, and immune recognition.
→ Virtual Cells Need Context, Not Just Scale icml.cc/virtual/2026...
→ scLDM icml.cc/virtual/2026...
→ DecoderTCR icml.cc/virtual/2026...
→ Virtual Cells Need Context, Not Just Scale icml.cc/virtual/2026...
→ scLDM icml.cc/virtual/2026...
→ DecoderTCR icml.cc/virtual/2026...
🎉Congrats to the Remoscope team, 1st place winner of the Medical Device category of the Nebius AI Discovery Awards! Developed at Biohub, Remoscope is an AI-powered diagnostic platform that can rapidly image and analyze blood and other biological fluids to diagnose disease.
July 2, 2026 at 6:48 PM
🎉Congrats to the Remoscope team, 1st place winner of the Medical Device category of the Nebius AI Discovery Awards! Developed at Biohub, Remoscope is an AI-powered diagnostic platform that can rapidly image and analyze blood and other biological fluids to diagnose disease.
The deadline for this funding opportunity is fast approaching: applications are due July 16!
Better vitrification = better cryo-ET.
We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science.
Apply here: bit.ly/4uip6eJ
We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science.
Apply here: bit.ly/4uip6eJ
July 1, 2026 at 6:11 PM
The deadline for this funding opportunity is fast approaching: applications are due July 16!
How do you track thousands of cells in complex systems, in 3D & over time? We are launching a Kaggle challenge to push the frontier of AI-powered cell tracking, building on advances like Ultrack & the DaXi lightsheet microscope from the @loicaroyer.bsky.social lab.
bit.ly/4bfdzWE
bit.ly/4bfdzWE
June 29, 2026 at 10:16 PM
How do you track thousands of cells in complex systems, in 3D & over time? We are launching a Kaggle challenge to push the frontier of AI-powered cell tracking, building on advances like Ultrack & the DaXi lightsheet microscope from the @loicaroyer.bsky.social lab.
bit.ly/4bfdzWE
bit.ly/4bfdzWE
Reposted by Biohub
1/ 🧬🔬
How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇
www.kaggle.com/competitions...
@biohub.org
How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇
www.kaggle.com/competitions...
@biohub.org
June 29, 2026 at 8:00 PM
1/ 🧬🔬
How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇
www.kaggle.com/competitions...
@biohub.org
How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇
www.kaggle.com/competitions...
@biohub.org
What happens when physicists turn their tools on living systems?
That's the question at the heart of the Physics of Life Symposium—and this year marks its fifth edition.
Submit an abstract or register to attend by Aug. 14:
bit.ly/4xJIPH7
That's the question at the heart of the Physics of Life Symposium—and this year marks its fifth edition.
Submit an abstract or register to attend by Aug. 14:
bit.ly/4xJIPH7
June 29, 2026 at 3:32 PM
What happens when physicists turn their tools on living systems?
That's the question at the heart of the Physics of Life Symposium—and this year marks its fifth edition.
Submit an abstract or register to attend by Aug. 14:
bit.ly/4xJIPH7
That's the question at the heart of the Physics of Life Symposium—and this year marks its fifth edition.
Submit an abstract or register to attend by Aug. 14:
bit.ly/4xJIPH7
The 2nd Chicago BioEngineering Conference (CBEC) is back — Sept. 17–18 in downtown Chicago! 🧬
Omics. Bioelectronics. AI × bio. A stellar speaker lineup. Two days of science that matters.
Space is limited → register now: bit.ly/4vqlXLj
Omics. Bioelectronics. AI × bio. A stellar speaker lineup. Two days of science that matters.
Space is limited → register now: bit.ly/4vqlXLj
June 22, 2026 at 7:01 PM
The 2nd Chicago BioEngineering Conference (CBEC) is back — Sept. 17–18 in downtown Chicago! 🧬
Omics. Bioelectronics. AI × bio. A stellar speaker lineup. Two days of science that matters.
Space is limited → register now: bit.ly/4vqlXLj
Omics. Bioelectronics. AI × bio. A stellar speaker lineup. Two days of science that matters.
Space is limited → register now: bit.ly/4vqlXLj
Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures.
Read the preprint ⤵️
www.biorxiv.org/content/10.6...
Read the preprint ⤵️
www.biorxiv.org/content/10.6...
June 16, 2026 at 4:14 PM
Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures.
Read the preprint ⤵️
www.biorxiv.org/content/10.6...
Read the preprint ⤵️
www.biorxiv.org/content/10.6...
Reposted by Biohub
Phase contrast enables structures of smaller proteins, could drive in-cell proteomics: cen.acs.org/analytical-c...
#chemsky 🧪
#chemsky 🧪
June 13, 2026 at 9:51 AM
Phase contrast enables structures of smaller proteins, could drive in-cell proteomics: cen.acs.org/analytical-c...
#chemsky 🧪
#chemsky 🧪
“The laser phase plate has the highest continuous light intensity in the solar system, outside of the inner regions of the Sun,” says physicist Holger Müller.
Learn more about this landmark achievement in microscopy in @cenmag.bsky.social: cen.acs.org/analytical-c...
Learn more about this landmark achievement in microscopy in @cenmag.bsky.social: cen.acs.org/analytical-c...
15 years, flawless mirrors, and the brightest laser in the world: How physicists brought phase contrast to cryo-EM
Phase contrast enables structures of smaller proteins, could drive in-cell proteomics
cen.acs.org
June 12, 2026 at 8:08 PM
“The laser phase plate has the highest continuous light intensity in the solar system, outside of the inner regions of the Sun,” says physicist Holger Müller.
Learn more about this landmark achievement in microscopy in @cenmag.bsky.social: cen.acs.org/analytical-c...
Learn more about this landmark achievement in microscopy in @cenmag.bsky.social: cen.acs.org/analytical-c...
Check out Alex Rives on Latent Space discussing the science behind ESMFold2, ESMC, and ESM Atlas, and what a world model of protein biology actually makes possible. 🎙️ https://bit.ly/4vwqLy3
June 12, 2026 at 7:24 PM
Check out Alex Rives on Latent Space discussing the science behind ESMFold2, ESMC, and ESM Atlas, and what a world model of protein biology actually makes possible. 🎙️ https://bit.ly/4vwqLy3