Eduardo Bruera
@brueraeduardo.bsky.social
Chair, Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center
Only one in three patients with advanced cancer had an accurate understanding of their curability, with limited improvement over time. Systematic screening may provide opportunities to improve illness understanding and coping support.
pubmed.ncbi.nlm.nih.gov/40992638/
pubmed.ncbi.nlm.nih.gov/40992638/
Systematic Screening of Advanced Cancer Patients' Curability Perception: A Longitudinal Analysis - PubMed
Only one in three patients with advanced cancer had an accurate understanding of their curability, with limited improvement over time. Systematic screening may provide opportunities to improve illness...
pubmed.ncbi.nlm.nih.gov
September 16, 2026 at 11:51 AM
Only one in three patients with advanced cancer had an accurate understanding of their curability, with limited improvement over time. Systematic screening may provide opportunities to improve illness understanding and coping support.
pubmed.ncbi.nlm.nih.gov/40992638/
pubmed.ncbi.nlm.nih.gov/40992638/
This case series highlights the potential use of this combination to reduce suffering and distress secondary to hemoptysis in the palliative setting.
pubmed.ncbi.nlm.nih.gov/41207344/
pubmed.ncbi.nlm.nih.gov/41207344/
Use of Nebulized Tranexamic Acid (TA) in Combination With Nebulized Recombinant Coagulation Factor VIIa to Treat Hemoptysis in Pediatric Patients With Cancer At End-Of-Life (EOL) - PubMed
Hemoptysis is a distressing symptom for both patients and families at end of life (EOL). In the acute care setting, this can be managed surgically or medically. However, research regarding interventions, such as nebulized tranexamic acid (TA) and nebulized factor VIIa, for palliative management of h …
pubmed.ncbi.nlm.nih.gov
September 16, 2026 at 11:48 AM
This case series highlights the potential use of this combination to reduce suffering and distress secondary to hemoptysis in the palliative setting.
pubmed.ncbi.nlm.nih.gov/41207344/
pubmed.ncbi.nlm.nih.gov/41207344/
Relative to other analgesics, tramadol is neither superior nor inferior. There may exist a different safety profile and therefore an opportunity to provide individualized patient-centered treatment strategies focused on safety and quality of life
pubmed.ncbi.nlm.nih.gov/41324745/
pubmed.ncbi.nlm.nih.gov/41324745/
The use of tramadol for cancer-associated pain-a systematic review - PubMed
Relative to other analgesics, tramadol is neither superior nor inferior. There may exist a different safety profile and therefore an opportunity to provide individualized patient-centered treatment strategies focused on safety and quality of life.
pubmed.ncbi.nlm.nih.gov
September 16, 2026 at 11:46 AM
Relative to other analgesics, tramadol is neither superior nor inferior. There may exist a different safety profile and therefore an opportunity to provide individualized patient-centered treatment strategies focused on safety and quality of life
pubmed.ncbi.nlm.nih.gov/41324745/
pubmed.ncbi.nlm.nih.gov/41324745/
: Slow iv hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, suggest that the slow infusion may be considered as a first-line modality for iv opioid administration
pubmed.ncbi.nlm.nih.gov/39865340/
pubmed.ncbi.nlm.nih.gov/39865340/
Abuse potential and analgesic efficacy of intravenous hydromorphone bolus administration among hospitalized patients with cancer pain: A double-blind, double dummy, randomized crossover trial - PubMed
Slow iv hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, taken together, suggest that the slow infusion may be considered as a first-line modality for iv opioid administration in hospitalized patients req …
pubmed.ncbi.nlm.nih.gov
September 14, 2026 at 8:54 PM
: Slow iv hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, suggest that the slow infusion may be considered as a first-line modality for iv opioid administration
pubmed.ncbi.nlm.nih.gov/39865340/
pubmed.ncbi.nlm.nih.gov/39865340/
During the study period, we observed a five-fold decline in opioid dose prescribed by oncologists for cancer pain. This raises concerns for undertreatment of pain in patients with cancer.
pubmed.ncbi.nlm.nih.gov/40138614/
pubmed.ncbi.nlm.nih.gov/40138614/
Trends in Outpatient Opioid Prescriptions for Cancer Pain Between 2016 and 2021 - PubMed
During the study period, we observed a five-fold decline in opioid dose prescribed by oncologists for cancer pain. This raises concerns for undertreatment of pain in patients with cancer.
pubmed.ncbi.nlm.nih.gov
September 14, 2026 at 8:50 PM
During the study period, we observed a five-fold decline in opioid dose prescribed by oncologists for cancer pain. This raises concerns for undertreatment of pain in patients with cancer.
pubmed.ncbi.nlm.nih.gov/40138614/
pubmed.ncbi.nlm.nih.gov/40138614/
September 3, 2026 at 1:17 AM
This paper examines the implications of AI for patients, physicians, and health care and provides guidance for its ethical use. pubmed.ncbi.nlm.nih.gov/42673596/
Ethics and Professionalism in Artificial Intelligence and Medical Practice: A Position Paper From the American College of Physicians - PubMed
Artificial intelligence (AI) in health care is being rapidly adopted in perhaps one of the most rapid implementations of technology in medicine to date. Better thought of as augmented intelligence, as a tool that provides assistance to physicians and patients, many guidelines for its use have been i …
pubmed.ncbi.nlm.nih.gov
September 1, 2026 at 3:48 PM
This paper examines the implications of AI for patients, physicians, and health care and provides guidance for its ethical use. pubmed.ncbi.nlm.nih.gov/42673596/
The delivery of optimal supportive care involves a family-focused perspective such as screening for parenting status and referrals to social work services to address the need of tangible resources and manage parenting-related distress.
pubmed.ncbi.nlm.nih.gov/37148983/
pubmed.ncbi.nlm.nih.gov/37148983/
Living With an Advanced Cancer While Parenting Minor Children: A Needs Assessment Study - PubMed
The delivery of optimal supportive care involves a family-focused perspective such as screening for parenting status and referrals to social work services to address the need of tangible resources and manage parenting-related distress.
pubmed.ncbi.nlm.nih.gov
August 31, 2026 at 10:42 AM
The delivery of optimal supportive care involves a family-focused perspective such as screening for parenting status and referrals to social work services to address the need of tangible resources and manage parenting-related distress.
pubmed.ncbi.nlm.nih.gov/37148983/
pubmed.ncbi.nlm.nih.gov/37148983/
Ciprofloxacin can inhibit CYP3A4 enzymes, reducing fentanyl metabolism. Combining them can elevate fentanyl levels, significantly increasing the risk of severe toxicity and respiratory depression.
pubmed.ncbi.nlm.nih.gov/37150364/
pubmed.ncbi.nlm.nih.gov/37150364/
Fentanyl Toxicity Related to Concomitant Use of Ciprofloxacin and its Effects as a CYP3A4 Inhibitor - PubMed
Fentanyl Toxicity Related to Concomitant Use of Ciprofloxacin and its Effects as a CYP3A4 Inhibitor
pubmed.ncbi.nlm.nih.gov
August 31, 2026 at 10:40 AM
Ciprofloxacin can inhibit CYP3A4 enzymes, reducing fentanyl metabolism. Combining them can elevate fentanyl levels, significantly increasing the risk of severe toxicity and respiratory depression.
pubmed.ncbi.nlm.nih.gov/37150364/
pubmed.ncbi.nlm.nih.gov/37150364/
PubMed is not updated due apparently to massive federal government layoffs and it is now unreliable . We need a European/ Canadian non corporate COI alternative source of quality peer reviewed medical information.
August 29, 2026 at 12:15 PM
PubMed is not updated due apparently to massive federal government layoffs and it is now unreliable . We need a European/ Canadian non corporate COI alternative source of quality peer reviewed medical information.
Oral breakthrough opioid 10% of daily dose works quite well. Rapid fentanyl unnecessary and dangerous
pubmed.ncbi.nlm.nih.gov/30254187/
pubmed.ncbi.nlm.nih.gov/30254187/
Response to Oral Immediate-Release Opioids for Breakthrough Pain in Patients with Advanced Cancer with Adequately Controlled Background Pain - PubMed
Oral immediate-release opioids are standard treatment for cancer breakthrough pain. However, information regarding treatment response to these commonly used opioids is limited. This study provides information that the vast majority of patients with advanced cancer, with adequately controlled backgro …
pubmed.ncbi.nlm.nih.gov
August 21, 2026 at 12:18 PM
Oral breakthrough opioid 10% of daily dose works quite well. Rapid fentanyl unnecessary and dangerous
pubmed.ncbi.nlm.nih.gov/30254187/
pubmed.ncbi.nlm.nih.gov/30254187/
Most advanced cancer pts have low vitamin D
.ncbi.nlm.nih.gov/42104875/
pubmed.ncbi.nlm.nih.gov/21964001/
.ncbi.nlm.nih.gov/42104875/
pubmed.ncbi.nlm.nih.gov/21964001/
Hypovitaminosis D in acute inpatient cancer rehabilitation: Prevalence, predictors, and practical implications - PubMed
Hypovitaminosis D was highly prevalent among adult patients with cancer undergoing inpatient rehabilitation. Identified predictors, including relatively younger age and neurogenic bladder or bowel, may help guide targeted screening.
pubmed.ncbi.nlm.nih.gov
August 14, 2026 at 8:33 PM
Most advanced cancer pts have low vitamin D
.ncbi.nlm.nih.gov/42104875/
pubmed.ncbi.nlm.nih.gov/21964001/
.ncbi.nlm.nih.gov/42104875/
pubmed.ncbi.nlm.nih.gov/21964001/