Cannabis and Cannabinoid Research
@cannabisjrnl.bsky.social
Cannabis and Cannabinoid Research is the premier peer-reviewed journal dedicated to the scientific, medical, and psychosocial exploration of clinical cannabis, cannabinoids, and the endocannabinoid system.
🐭 Low-THC, CBD-rich hemp oil boosted sociability in mice — no sedation, no side effects. An early lead for conditions like autism.
doi.org/10.1089/can....
doi.org/10.1089/can....
October 5, 2026 at 12:02 PM
🐭 Low-THC, CBD-rich hemp oil boosted sociability in mice — no sedation, no side effects. An early lead for conditions like autism.
doi.org/10.1089/can....
doi.org/10.1089/can....
⚖️ Could cannabis compounds help treat obesity?
This review makes the mechanistic case: obesity involves chronic inflammation, and THCV, THC, and CBD have anti-inflammatory and metabolic effects. Cannabis users also tend to have lower BMI.
doi.org/10.1089/can....
This review makes the mechanistic case: obesity involves chronic inflammation, and THCV, THC, and CBD have anti-inflammatory and metabolic effects. Cannabis users also tend to have lower BMI.
doi.org/10.1089/can....
September 30, 2026 at 12:03 PM
⚖️ Could cannabis compounds help treat obesity?
This review makes the mechanistic case: obesity involves chronic inflammation, and THCV, THC, and CBD have anti-inflammatory and metabolic effects. Cannabis users also tend to have lower BMI.
doi.org/10.1089/can....
This review makes the mechanistic case: obesity involves chronic inflammation, and THCV, THC, and CBD have anti-inflammatory and metabolic effects. Cannabis users also tend to have lower BMI.
doi.org/10.1089/can....
🐀 CBD cut alcohol intake by ~50% in alcohol-preferring rats — without affecting chocolate seeking, so it's not sedation. May work by easing the anxiety that drives drinking.
A preclinical lead for anxiety + AUD.
doi.org/10.1089/can....
A preclinical lead for anxiety + AUD.
doi.org/10.1089/can....
September 30, 2026 at 12:01 PM
🐀 CBD cut alcohol intake by ~50% in alcohol-preferring rats — without affecting chocolate seeking, so it's not sedation. May work by easing the anxiety that drives drinking.
A preclinical lead for anxiety + AUD.
doi.org/10.1089/can....
A preclinical lead for anxiety + AUD.
doi.org/10.1089/can....
🌍 In 2020, Lebanon became the first Arab country to legalize medical cannabis — driven by economics ($1B/year in projected exports), not public health. The law is export-only, excludes traditional farmers, and psychiatrists warned it skipped proper consultation.
doi.org/10.1089/can....
doi.org/10.1089/can....
September 28, 2026 at 12:02 PM
🌍 In 2020, Lebanon became the first Arab country to legalize medical cannabis — driven by economics ($1B/year in projected exports), not public health. The law is export-only, excludes traditional farmers, and psychiatrists warned it skipped proper consultation.
doi.org/10.1089/can....
doi.org/10.1089/can....
📉 Who needs high-dose cannabis for chronic low back pain? A new 4-factor score predicts it with solid accuracy (AUC 0.80) — and high-dose users saw the most pain relief. Bonus: 93% of baseline opioid users quit by year 5. 🌿
doi.org/10.1177/2578...
doi.org/10.1177/2578...
September 23, 2026 at 12:01 PM
📉 Who needs high-dose cannabis for chronic low back pain? A new 4-factor score predicts it with solid accuracy (AUC 0.80) — and high-dose users saw the most pain relief. Bonus: 93% of baseline opioid users quit by year 5. 🌿
doi.org/10.1177/2578...
doi.org/10.1177/2578...
📣 Marc (hah) your calendars! The MACRC 2026 Annual Conference is headed to Philadelphia, November 6–8, 2026!
This year's theme = "New Frontiers in Cannabinoid Science"
🔗 Learn more & register: www.m-acrc.org
This year's theme = "New Frontiers in Cannabinoid Science"
🔗 Learn more & register: www.m-acrc.org
September 21, 2026 at 12:01 PM
📣 Marc (hah) your calendars! The MACRC 2026 Annual Conference is headed to Philadelphia, November 6–8, 2026!
This year's theme = "New Frontiers in Cannabinoid Science"
🔗 Learn more & register: www.m-acrc.org
This year's theme = "New Frontiers in Cannabinoid Science"
🔗 Learn more & register: www.m-acrc.org
📣 MACRC 2026 Annual Conference: "New Frontiers in Cannabinoid Science." Philadelphia, Nov 6-8, 2026.
Cannabinoids in women's health, GI, metabolic disease, infection, and cancer, plus policy and public health. Registration and abstract submission now open. 🌿
www.m-acrc.org
Cannabinoids in women's health, GI, metabolic disease, infection, and cancer, plus policy and public health. Registration and abstract submission now open. 🌿
www.m-acrc.org
September 16, 2026 at 12:02 PM
📣 MACRC 2026 Annual Conference: "New Frontiers in Cannabinoid Science." Philadelphia, Nov 6-8, 2026.
Cannabinoids in women's health, GI, metabolic disease, infection, and cancer, plus policy and public health. Registration and abstract submission now open. 🌿
www.m-acrc.org
Cannabinoids in women's health, GI, metabolic disease, infection, and cancer, plus policy and public health. Registration and abstract submission now open. 🌿
www.m-acrc.org
📢 Call for papers: Cannabis & Cannabinoid Research special issue on minor cannabinoids (CBG, CBN, THCV, CBDV, acidic + semisynthetic).
Mechanisms, PK, chemistry, safety, policy.
Deadline April 30, 2027. Select the special issue in ScholarOne. 🧪
journals.sagepub.com/page/ccb/cal...
Mechanisms, PK, chemistry, safety, policy.
Deadline April 30, 2027. Select the special issue in ScholarOne. 🧪
journals.sagepub.com/page/ccb/cal...
September 14, 2026 at 12:02 PM
📢 Call for papers: Cannabis & Cannabinoid Research special issue on minor cannabinoids (CBG, CBN, THCV, CBDV, acidic + semisynthetic).
Mechanisms, PK, chemistry, safety, policy.
Deadline April 30, 2027. Select the special issue in ScholarOne. 🧪
journals.sagepub.com/page/ccb/cal...
Mechanisms, PK, chemistry, safety, policy.
Deadline April 30, 2027. Select the special issue in ScholarOne. 🧪
journals.sagepub.com/page/ccb/cal...
🧪 How to store cannabinoids so they don't degrade:
Room temperature turns THC into CBN. CBD-only products hold up fine on the shelf, but THC-rich ones need the cold. Most stable option for THC: an ethanol solution kept at −20°C.
Storage should match the product.
doi.org/10.1177/2578...
Room temperature turns THC into CBN. CBD-only products hold up fine on the shelf, but THC-rich ones need the cold. Most stable option for THC: an ethanol solution kept at −20°C.
Storage should match the product.
doi.org/10.1177/2578...
September 7, 2026 at 12:01 PM
🧪 How to store cannabinoids so they don't degrade:
Room temperature turns THC into CBN. CBD-only products hold up fine on the shelf, but THC-rich ones need the cold. Most stable option for THC: an ethanol solution kept at −20°C.
Storage should match the product.
doi.org/10.1177/2578...
Room temperature turns THC into CBN. CBD-only products hold up fine on the shelf, but THC-rich ones need the cold. Most stable option for THC: an ethanol solution kept at −20°C.
Storage should match the product.
doi.org/10.1177/2578...
🔬 Do cannabis "cured my cancer" stories hold up?
Researchers tried to verify them against medical records. Of 97 patients who reported a benefit, only 15 had reviewable data, and just 1 case met the bar for strong evidence.
doi.org/10.1177/2578...
Researchers tried to verify them against medical records. Of 97 patients who reported a benefit, only 15 had reviewable data, and just 1 case met the bar for strong evidence.
doi.org/10.1177/2578...
September 7, 2026 at 12:01 PM
🔬 Do cannabis "cured my cancer" stories hold up?
Researchers tried to verify them against medical records. Of 97 patients who reported a benefit, only 15 had reviewable data, and just 1 case met the bar for strong evidence.
doi.org/10.1177/2578...
Researchers tried to verify them against medical records. Of 97 patients who reported a benefit, only 15 had reviewable data, and just 1 case met the bar for strong evidence.
doi.org/10.1177/2578...
👵 12.1% of US adults 50–80 used cannabis in the past year, and 34.2% of them used 4+ days/week.
Use skewed toward unpartnered, unemployed, and drinking respondents. That's frequent use in an age group with polypharmacy, fall risk, and thin evidence.
journals.sagepub.com/doi/abs/10.1...
Use skewed toward unpartnered, unemployed, and drinking respondents. That's frequent use in an age group with polypharmacy, fall risk, and thin evidence.
journals.sagepub.com/doi/abs/10.1...
September 2, 2026 at 12:02 PM
👵 12.1% of US adults 50–80 used cannabis in the past year, and 34.2% of them used 4+ days/week.
Use skewed toward unpartnered, unemployed, and drinking respondents. That's frequent use in an age group with polypharmacy, fall risk, and thin evidence.
journals.sagepub.com/doi/abs/10.1...
Use skewed toward unpartnered, unemployed, and drinking respondents. That's frequent use in an age group with polypharmacy, fall risk, and thin evidence.
journals.sagepub.com/doi/abs/10.1...
🐟 CB1 agonist cut aggression and brain oxidative stress in zebrafish.
After 24h isolation, ACEA-treated fish struck and bit less than controls or AM-251 fish, with lower malondialdehyde and higher sulfhydryl in dominants and subordinates alike.
journals.sagepub.com/doi/abs/10.1...
After 24h isolation, ACEA-treated fish struck and bit less than controls or AM-251 fish, with lower malondialdehyde and higher sulfhydryl in dominants and subordinates alike.
journals.sagepub.com/doi/abs/10.1...
August 31, 2026 at 12:01 PM
🐟 CB1 agonist cut aggression and brain oxidative stress in zebrafish.
After 24h isolation, ACEA-treated fish struck and bit less than controls or AM-251 fish, with lower malondialdehyde and higher sulfhydryl in dominants and subordinates alike.
journals.sagepub.com/doi/abs/10.1...
After 24h isolation, ACEA-treated fish struck and bit less than controls or AM-251 fish, with lower malondialdehyde and higher sulfhydryl in dominants and subordinates alike.
journals.sagepub.com/doi/abs/10.1...
🧪 Cannabis self-report doesn't hold up in psychosis.
38% with a positive urine or hair test denied use in the past 90 days (CATIE); 70% denied it in a forensic sample. The authors argue for creatinine-corrected urine THC-COOH as an objective standard.
journals.sagepub.com/doi/full/10....
38% with a positive urine or hair test denied use in the past 90 days (CATIE); 70% denied it in a forensic sample. The authors argue for creatinine-corrected urine THC-COOH as an objective standard.
journals.sagepub.com/doi/full/10....
August 26, 2026 at 12:02 PM
🧪 Cannabis self-report doesn't hold up in psychosis.
38% with a positive urine or hair test denied use in the past 90 days (CATIE); 70% denied it in a forensic sample. The authors argue for creatinine-corrected urine THC-COOH as an objective standard.
journals.sagepub.com/doi/full/10....
38% with a positive urine or hair test denied use in the past 90 days (CATIE); 70% denied it in a forensic sample. The authors argue for creatinine-corrected urine THC-COOH as an objective standard.
journals.sagepub.com/doi/full/10....
🧠 Medical cannabis for non-motor symptoms in Parkinson's: 3-month open-label cohort, 50 completers.
Improvements in overall NMS burden, sleep, pain, and quality of life. Nighttime urinary frequency also dropped, while daytime measures held steady.
journals.sagepub.com/doi/10.1177/...
Improvements in overall NMS burden, sleep, pain, and quality of life. Nighttime urinary frequency also dropped, while daytime measures held steady.
journals.sagepub.com/doi/10.1177/...
August 24, 2026 at 12:01 PM
🧠 Medical cannabis for non-motor symptoms in Parkinson's: 3-month open-label cohort, 50 completers.
Improvements in overall NMS burden, sleep, pain, and quality of life. Nighttime urinary frequency also dropped, while daytime measures held steady.
journals.sagepub.com/doi/10.1177/...
Improvements in overall NMS burden, sleep, pain, and quality of life. Nighttime urinary frequency also dropped, while daytime measures held steady.
journals.sagepub.com/doi/10.1177/...
📊 Cannabis research mapped: 10,577 articles across 7 databases.
Most from the US, UK, and Canada; peak in 2021. Top journals lean addiction and toxicology, but neuroscience was just 1.6% of the literature. The mechanistic work is the gap.
journals.sagepub.com/doi/abs/10.1...
Most from the US, UK, and Canada; peak in 2021. Top journals lean addiction and toxicology, but neuroscience was just 1.6% of the literature. The mechanistic work is the gap.
journals.sagepub.com/doi/abs/10.1...
August 19, 2026 at 12:01 PM
📊 Cannabis research mapped: 10,577 articles across 7 databases.
Most from the US, UK, and Canada; peak in 2021. Top journals lean addiction and toxicology, but neuroscience was just 1.6% of the literature. The mechanistic work is the gap.
journals.sagepub.com/doi/abs/10.1...
Most from the US, UK, and Canada; peak in 2021. Top journals lean addiction and toxicology, but neuroscience was just 1.6% of the literature. The mechanistic work is the gap.
journals.sagepub.com/doi/abs/10.1...
🌱 Cannabis roots: the discarded part of the plant, reviewed.
Roots carry triterpenes, sterols, alkaloids, and phenolic amides, with preclinical anti-inflammatory and analgesic signals. Cannabinoid content is minimal.
journals.sagepub.com/doi/abs/10.1...
Roots carry triterpenes, sterols, alkaloids, and phenolic amides, with preclinical anti-inflammatory and analgesic signals. Cannabinoid content is minimal.
journals.sagepub.com/doi/abs/10.1...
August 17, 2026 at 12:00 PM
🌱 Cannabis roots: the discarded part of the plant, reviewed.
Roots carry triterpenes, sterols, alkaloids, and phenolic amides, with preclinical anti-inflammatory and analgesic signals. Cannabinoid content is minimal.
journals.sagepub.com/doi/abs/10.1...
Roots carry triterpenes, sterols, alkaloids, and phenolic amides, with preclinical anti-inflammatory and analgesic signals. Cannabinoid content is minimal.
journals.sagepub.com/doi/abs/10.1...
🧴 Topical CBD for fibromyalgia: 12-week single-arm pilot, 30 women.
Localized pain down by week 4 and held at week 12 (60% hit MCID). Function improved. Full adherence, no adverse events. No change in fatigue, anxiety, or depression. No control arm; RCT needed. journals.sagepub.com/doi/10.1177/...
Localized pain down by week 4 and held at week 12 (60% hit MCID). Function improved. Full adherence, no adverse events. No change in fatigue, anxiety, or depression. No control arm; RCT needed. journals.sagepub.com/doi/10.1177/...
August 12, 2026 at 12:01 PM
🧴 Topical CBD for fibromyalgia: 12-week single-arm pilot, 30 women.
Localized pain down by week 4 and held at week 12 (60% hit MCID). Function improved. Full adherence, no adverse events. No change in fatigue, anxiety, or depression. No control arm; RCT needed. journals.sagepub.com/doi/10.1177/...
Localized pain down by week 4 and held at week 12 (60% hit MCID). Function improved. Full adherence, no adverse events. No change in fatigue, anxiety, or depression. No control arm; RCT needed. journals.sagepub.com/doi/10.1177/...
🎧 Cannabis + music: survey of 122 users.
Most rated the combo positively: more relaxation, better mood, more connection. Many also used cannabis to substitute for meds for pain, anxiety, and sleep, with music amplifying the effect.
journals.sagepub.com/doi/10.1177/...
Most rated the combo positively: more relaxation, better mood, more connection. Many also used cannabis to substitute for meds for pain, anxiety, and sleep, with music amplifying the effect.
journals.sagepub.com/doi/10.1177/...
August 10, 2026 at 12:01 PM
🎧 Cannabis + music: survey of 122 users.
Most rated the combo positively: more relaxation, better mood, more connection. Many also used cannabis to substitute for meds for pain, anxiety, and sleep, with music amplifying the effect.
journals.sagepub.com/doi/10.1177/...
Most rated the combo positively: more relaxation, better mood, more connection. Many also used cannabis to substitute for meds for pain, anxiety, and sleep, with music amplifying the effect.
journals.sagepub.com/doi/10.1177/...
🧭 Oldie but goodie: 2024 review on the endocannabinoid system & axon guidance. Across animal models, disrupting CB1, CB2, GPR55, or eCB metabolism causes axon pathfinding errors. Developing axons are sensitive to cannabinoids: a frame for prenatal exposure work. journals.sagepub.com/doi/abs/10.1...
August 5, 2026 at 12:02 PM
🧭 Oldie but goodie: 2024 review on the endocannabinoid system & axon guidance. Across animal models, disrupting CB1, CB2, GPR55, or eCB metabolism causes axon pathfinding errors. Developing axons are sensitive to cannabinoids: a frame for prenatal exposure work. journals.sagepub.com/doi/abs/10.1...
🧬 New RCT (n=24): oral THC:CBD eased fibromyalgia symptoms but left plasma NAEs (PEA, OEA, SEA) flat over 16 weeks, with near-zero effect sizes.
Takeaway: blood NAEs may not track cannabis response here. The mechanism looks central, not peripheral. 📄
journals.sagepub.com/doi/10.1177/...
Takeaway: blood NAEs may not track cannabis response here. The mechanism looks central, not peripheral. 📄
journals.sagepub.com/doi/10.1177/...
August 3, 2026 at 12:01 PM
🧬 New RCT (n=24): oral THC:CBD eased fibromyalgia symptoms but left plasma NAEs (PEA, OEA, SEA) flat over 16 weeks, with near-zero effect sizes.
Takeaway: blood NAEs may not track cannabis response here. The mechanism looks central, not peripheral. 📄
journals.sagepub.com/doi/10.1177/...
Takeaway: blood NAEs may not track cannabis response here. The mechanism looks central, not peripheral. 📄
journals.sagepub.com/doi/10.1177/...
Medical cannabis is legal in 47 states, but contaminant testing standards vary widely. A new review covers testing for heavy metals, pesticides, mycotoxins, and residual solvents. The science is there. The harmonization isn't. 🌿⚗️
Link: journals.sagepub.com/doi/abs/10.1...
Link: journals.sagepub.com/doi/abs/10.1...
July 29, 2026 at 12:02 PM
Medical cannabis is legal in 47 states, but contaminant testing standards vary widely. A new review covers testing for heavy metals, pesticides, mycotoxins, and residual solvents. The science is there. The harmonization isn't. 🌿⚗️
Link: journals.sagepub.com/doi/abs/10.1...
Link: journals.sagepub.com/doi/abs/10.1...
Topical/transdermal CBD is everywhere, but the clinical evidence is thin and poorly designed. A systematic review in Cannabis & Cannabinoid Research found just 8 qualifying studies out of 544, all with high risk of bias. The market is way ahead of the science. 🌿⚗️
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
July 27, 2026 at 12:02 PM
Topical/transdermal CBD is everywhere, but the clinical evidence is thin and poorly designed. A systematic review in Cannabis & Cannabinoid Research found just 8 qualifying studies out of 544, all with high risk of bias. The market is way ahead of the science. 🌿⚗️
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
"Fast-acting" cannabis edibles actually live up to the name — new PK data show THC peaks ~30 min earlier than standard edibles. Same Cmax and AUC though, so the total exposure is identical. Useful for dose timing; doesn't solve overconsumption. 🌿📊
Link: journals.sagepub.com/doi/abs/10.1...
Link: journals.sagepub.com/doi/abs/10.1...
July 22, 2026 at 12:02 PM
"Fast-acting" cannabis edibles actually live up to the name — new PK data show THC peaks ~30 min earlier than standard edibles. Same Cmax and AUC though, so the total exposure is identical. Useful for dose timing; doesn't solve overconsumption. 🌿📊
Link: journals.sagepub.com/doi/abs/10.1...
Link: journals.sagepub.com/doi/abs/10.1...
THC suppressed BDNF gene expression in the adolescent mouse hippocampus — but co-administration with CBD prevented it. A reminder that what's in the product matters as much as whether cannabis is used at all. Sex differences observed too. 🧠🌿
Link: journals.sagepub.com/doi/abs/10.1...
Link: journals.sagepub.com/doi/abs/10.1...
July 20, 2026 at 12:01 PM
THC suppressed BDNF gene expression in the adolescent mouse hippocampus — but co-administration with CBD prevented it. A reminder that what's in the product matters as much as whether cannabis is used at all. Sex differences observed too. 🧠🌿
Link: journals.sagepub.com/doi/abs/10.1...
Link: journals.sagepub.com/doi/abs/10.1...
HPLC is the gold standard for cannabinoid quantification — but slow and costly. A new study tests A-TEEM spectroscopy + machine learning as a faster alternative, hitting R² = 0.994 across 14 cannabinoids. One to watch for high-throughput work. 🌿🔬
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
July 15, 2026 at 12:02 PM
HPLC is the gold standard for cannabinoid quantification — but slow and costly. A new study tests A-TEEM spectroscopy + machine learning as a faster alternative, hitting R² = 0.994 across 14 cannabinoids. One to watch for high-throughput work. 🌿🔬
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...