Chloé Roffay
@chloeroffay.bsky.social
From physics to cells to gastruloids • Postdoc @dianapinheiro.bsky.social 🇦🇹• PhD @rouxlab.bsky.social 🇨🇭 • alum cpes @psl-univ.bsky.social 🇨🇵 • she/her • Views my own
Reposted by Chloé Roffay
From MBoC: How do cells coordinate their movements as a group?
New research shows how vimentin helps connect individual cell movement with coordinated collective migration and efficient wound closure.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-01-0052
New research shows how vimentin helps connect individual cell movement with coordinated collective migration and efficient wound closure.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-01-0052
October 7, 2026 at 4:05 PM
From MBoC: How do cells coordinate their movements as a group?
New research shows how vimentin helps connect individual cell movement with coordinated collective migration and efficient wound closure.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-01-0052
New research shows how vimentin helps connect individual cell movement with coordinated collective migration and efficient wound closure.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-01-0052
Reposted by Chloé Roffay
📣Our department is hiring a new group leader!📣
Want to start your team in a vibrant scientific environment in the center of Paris? I was very lucky to do that 10 years ago, reach out if you have any question.
Apply by December 18th:
jpi-recruitment-curie-umr3215-u934.curie.fr
Want to start your team in a vibrant scientific environment in the center of Paris? I was very lucky to do that 10 years ago, reach out if you have any question.
Apply by December 18th:
jpi-recruitment-curie-umr3215-u934.curie.fr
October 6, 2026 at 10:43 AM
📣Our department is hiring a new group leader!📣
Want to start your team in a vibrant scientific environment in the center of Paris? I was very lucky to do that 10 years ago, reach out if you have any question.
Apply by December 18th:
jpi-recruitment-curie-umr3215-u934.curie.fr
Want to start your team in a vibrant scientific environment in the center of Paris? I was very lucky to do that 10 years ago, reach out if you have any question.
Apply by December 18th:
jpi-recruitment-curie-umr3215-u934.curie.fr
Reposted by Chloé Roffay
BREAKING NEWS
The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
October 5, 2026 at 9:40 AM
BREAKING NEWS
The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
Reposted by Chloé Roffay
📣 #NewCall: SNSF Starting Grants 2027
For researchers wanting to lead their own independent project and research team in Switzerland. SNSF Starting Grants are open to all disciplines and topics.
🗓️ Call opening: 1 February 2027
Submission deadline: 4 May 2027
Read more: sohub.io/hj2m
For researchers wanting to lead their own independent project and research team in Switzerland. SNSF Starting Grants are open to all disciplines and topics.
🗓️ Call opening: 1 February 2027
Submission deadline: 4 May 2027
Read more: sohub.io/hj2m
October 1, 2026 at 7:30 AM
📣 #NewCall: SNSF Starting Grants 2027
For researchers wanting to lead their own independent project and research team in Switzerland. SNSF Starting Grants are open to all disciplines and topics.
🗓️ Call opening: 1 February 2027
Submission deadline: 4 May 2027
Read more: sohub.io/hj2m
For researchers wanting to lead their own independent project and research team in Switzerland. SNSF Starting Grants are open to all disciplines and topics.
🗓️ Call opening: 1 February 2027
Submission deadline: 4 May 2027
Read more: sohub.io/hj2m
Reposted by Chloé Roffay
📢 Institut Jacques Monod Seminar
📅 October, 2
📍Institut Jacques Monod
Invited by the @spinalorga.bsky.social Lab, @chloeroffay.bsky.social will present an Institut Jacques Monod seminar on the theme "Uncovering the forces driving fate and form of amnion in human gastrula models"
➡️ buff.ly/XdWQi6B
📅 October, 2
📍Institut Jacques Monod
Invited by the @spinalorga.bsky.social Lab, @chloeroffay.bsky.social will present an Institut Jacques Monod seminar on the theme "Uncovering the forces driving fate and form of amnion in human gastrula models"
➡️ buff.ly/XdWQi6B
September 24, 2026 at 1:55 PM
📢 Institut Jacques Monod Seminar
📅 October, 2
📍Institut Jacques Monod
Invited by the @spinalorga.bsky.social Lab, @chloeroffay.bsky.social will present an Institut Jacques Monod seminar on the theme "Uncovering the forces driving fate and form of amnion in human gastrula models"
➡️ buff.ly/XdWQi6B
📅 October, 2
📍Institut Jacques Monod
Invited by the @spinalorga.bsky.social Lab, @chloeroffay.bsky.social will present an Institut Jacques Monod seminar on the theme "Uncovering the forces driving fate and form of amnion in human gastrula models"
➡️ buff.ly/XdWQi6B
Reposted by Chloé Roffay
Not every cell react the same way to caspase activation. In our recent study (led by @tomcumming.bsky.social and initiated by @avillars.bsky.social ), we tried to better understand what explains this difference and outlined a role of past caspase exposure 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 23, 2026 at 9:02 PM
Not every cell react the same way to caspase activation. In our recent study (led by @tomcumming.bsky.social and initiated by @avillars.bsky.social ), we tried to better understand what explains this difference and outlined a role of past caspase exposure 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chloé Roffay
📢Call for Group Leader in our unit within the Institut de Biologie Paris Seine in Paris @ibps.bsky.social
www.ibps.sorbonne-universite.fr/fr/Recherche...
www.ibps.sorbonne-universite.fr/fr/Recherche...
September 22, 2026 at 9:09 AM
📢Call for Group Leader in our unit within the Institut de Biologie Paris Seine in Paris @ibps.bsky.social
www.ibps.sorbonne-universite.fr/fr/Recherche...
www.ibps.sorbonne-universite.fr/fr/Recherche...
Reposted by Chloé Roffay
🐟 New preprint ! 🐟 For Hippo pathway aficionados.
We generated a CRISPR/Cas9 mediated single-copy endogenous Yap1-mGreenLantern fusion protein in medaka to follow Yap1 dynamics in vivo, through embryogenesis and beyond. And it is such a beautiful line ! 🧵
We generated a CRISPR/Cas9 mediated single-copy endogenous Yap1-mGreenLantern fusion protein in medaka to follow Yap1 dynamics in vivo, through embryogenesis and beyond. And it is such a beautiful line ! 🧵
Spatio-temporal visualisation and manipulation of endogenous Yap1 in medaka
A key requirement to address fundamental questions in developmental biology is the ability to visualise and manipulate endogenous signalling proteins in vivo. Here we generate such an enabling experim...
www.biorxiv.org
September 22, 2026 at 9:59 AM
🐟 New preprint ! 🐟 For Hippo pathway aficionados.
We generated a CRISPR/Cas9 mediated single-copy endogenous Yap1-mGreenLantern fusion protein in medaka to follow Yap1 dynamics in vivo, through embryogenesis and beyond. And it is such a beautiful line ! 🧵
We generated a CRISPR/Cas9 mediated single-copy endogenous Yap1-mGreenLantern fusion protein in medaka to follow Yap1 dynamics in vivo, through embryogenesis and beyond. And it is such a beautiful line ! 🧵
Reposted by Chloé Roffay
In preprints – the embryo, the placenta and lessons from developmental metabolism
@bernasozen.bsky.social explores how recent #preprints by Aguilera-Castrejon et al. & Xu et al. reveal metabolic roles for embryonic and extra-embryonic tissues during mid-gestation.
doi.org/10.1242/dev....
@bernasozen.bsky.social explores how recent #preprints by Aguilera-Castrejon et al. & Xu et al. reveal metabolic roles for embryonic and extra-embryonic tissues during mid-gestation.
doi.org/10.1242/dev....
In preprints – the embryo, the placenta and lessons from developmental metabolism
This article discusses the preprinted work of Lokshtanov and colleagues (Lokshtanov et al., 2026 preprint) as well as that of Xu and team (Xu et al., 2026 preprint). As preprints, these works have…
doi.org
September 15, 2026 at 12:55 PM
In preprints – the embryo, the placenta and lessons from developmental metabolism
@bernasozen.bsky.social explores how recent #preprints by Aguilera-Castrejon et al. & Xu et al. reveal metabolic roles for embryonic and extra-embryonic tissues during mid-gestation.
doi.org/10.1242/dev....
@bernasozen.bsky.social explores how recent #preprints by Aguilera-Castrejon et al. & Xu et al. reveal metabolic roles for embryonic and extra-embryonic tissues during mid-gestation.
doi.org/10.1242/dev....
Reposted by Chloé Roffay
Join us for the symposium
Morphogenesis: Where Form Takes Shape
Oct. 27-28 Institute Curie Paris
Free attendance, but registration is required.
Short talks and posters will be selected from submitted abstracts.
Abstract submission deadline: Oct. 10, 2026.
Morphogenesis: Where Form Takes Shape
Oct. 27-28 Institute Curie Paris
Free attendance, but registration is required.
Short talks and posters will be selected from submitted abstracts.
Abstract submission deadline: Oct. 10, 2026.
September 11, 2026 at 12:40 PM
Join us for the symposium
Morphogenesis: Where Form Takes Shape
Oct. 27-28 Institute Curie Paris
Free attendance, but registration is required.
Short talks and posters will be selected from submitted abstracts.
Abstract submission deadline: Oct. 10, 2026.
Morphogenesis: Where Form Takes Shape
Oct. 27-28 Institute Curie Paris
Free attendance, but registration is required.
Short talks and posters will be selected from submitted abstracts.
Abstract submission deadline: Oct. 10, 2026.
Reposted by Chloé Roffay
The growth of #plant leaves is highly dynamic and should be coordinated, but how is #leaf flatness preserved? @roederlab.bsky.social &co show that global coordination of growth across the leaf blade is required to maintain flatness in #Arabidopsis @plosbiology.org 🧪 buff.ly/QUMxOcF
September 10, 2026 at 1:02 PM
The growth of #plant leaves is highly dynamic and should be coordinated, but how is #leaf flatness preserved? @roederlab.bsky.social &co show that global coordination of growth across the leaf blade is required to maintain flatness in #Arabidopsis @plosbiology.org 🧪 buff.ly/QUMxOcF
Reposted by Chloé Roffay
What if we stop asking only how cells build tissues and ask how tissues shape cells? That’s what we’ll explore at Modelling Life from Tissues to Cells 🇨🇭 lakeconferences.org/conf/8334d9b...
Conference - Modelling Life from Tissues to Cells: Coordination and Robustness - Lake Conferences
lakeconferences.org
September 8, 2026 at 12:24 PM
What if we stop asking only how cells build tissues and ask how tissues shape cells? That’s what we’ll explore at Modelling Life from Tissues to Cells 🇨🇭 lakeconferences.org/conf/8334d9b...
Reposted by Chloé Roffay
Dynamic control of cell state transitions during tissue morphogenesis
Elias Barriga et al @eliasbarrigalab.bsky.social review how gene expression, chromatin modifications & microenvironmental biophysical factors contribute to robust coordination of morphogenesis
link.springer.com/article/10.1...
Elias Barriga et al @eliasbarrigalab.bsky.social review how gene expression, chromatin modifications & microenvironmental biophysical factors contribute to robust coordination of morphogenesis
link.springer.com/article/10.1...
September 7, 2026 at 10:49 AM
Dynamic control of cell state transitions during tissue morphogenesis
Elias Barriga et al @eliasbarrigalab.bsky.social review how gene expression, chromatin modifications & microenvironmental biophysical factors contribute to robust coordination of morphogenesis
link.springer.com/article/10.1...
Elias Barriga et al @eliasbarrigalab.bsky.social review how gene expression, chromatin modifications & microenvironmental biophysical factors contribute to robust coordination of morphogenesis
link.springer.com/article/10.1...
Reposted by Chloé Roffay
A developmental biologist's guide to mechanics
Read this Primer from our special issue #DevSIextracellular by Jialing Cao, @raphclement.bsky.social, @pflenne.bsky.social and colleagues.
journals.biologists.com/dev/article/...
Read this Primer from our special issue #DevSIextracellular by Jialing Cao, @raphclement.bsky.social, @pflenne.bsky.social and colleagues.
journals.biologists.com/dev/article/...
September 4, 2026 at 11:01 AM
A developmental biologist's guide to mechanics
Read this Primer from our special issue #DevSIextracellular by Jialing Cao, @raphclement.bsky.social, @pflenne.bsky.social and colleagues.
journals.biologists.com/dev/article/...
Read this Primer from our special issue #DevSIextracellular by Jialing Cao, @raphclement.bsky.social, @pflenne.bsky.social and colleagues.
journals.biologists.com/dev/article/...
Reposted by Chloé Roffay
Fundamental limits on symmetry breaking by Turing-like activator-inhibitor mechanisms
Read this Research Article from our special issue #DevSIextracellular by Daniel Muzatko, Bijoy Daga and @hiscocklab.bsky.social from @uniofaberdeen.bsky.social.
journals.biologists.com/dev/article/...
Read this Research Article from our special issue #DevSIextracellular by Daniel Muzatko, Bijoy Daga and @hiscocklab.bsky.social from @uniofaberdeen.bsky.social.
journals.biologists.com/dev/article/...
September 2, 2026 at 6:00 AM
Fundamental limits on symmetry breaking by Turing-like activator-inhibitor mechanisms
Read this Research Article from our special issue #DevSIextracellular by Daniel Muzatko, Bijoy Daga and @hiscocklab.bsky.social from @uniofaberdeen.bsky.social.
journals.biologists.com/dev/article/...
Read this Research Article from our special issue #DevSIextracellular by Daniel Muzatko, Bijoy Daga and @hiscocklab.bsky.social from @uniofaberdeen.bsky.social.
journals.biologists.com/dev/article/...
Reposted by Chloé Roffay
📣Paris Cytoskeleton Day - Registrations are open!
📅 November, 24th
📍Institut Jacques Monod
Abstract submission closes on 2 November
Registration closes on 16 November
🔗 pcd2026.sciencesconf.org
📅 November, 24th
📍Institut Jacques Monod
Abstract submission closes on 2 November
Registration closes on 16 November
🔗 pcd2026.sciencesconf.org
September 1, 2026 at 12:53 PM
📣Paris Cytoskeleton Day - Registrations are open!
📅 November, 24th
📍Institut Jacques Monod
Abstract submission closes on 2 November
Registration closes on 16 November
🔗 pcd2026.sciencesconf.org
📅 November, 24th
📍Institut Jacques Monod
Abstract submission closes on 2 November
Registration closes on 16 November
🔗 pcd2026.sciencesconf.org
Reposted by Chloé Roffay
Registration is still open for the EPFL Latsis Symposium 2026, "Decoding the Cell: Modeling, Predicting, and Engineering Cellular States."
29–30 Oct, Olympic Museum, Lausanne.
Quake, Haniffa, Engelhardt, Liberali, Paluch, Kundaje and more.
Abstracts close 15 Sept.
latsis2026.epfl.ch/event/1/
29–30 Oct, Olympic Museum, Lausanne.
Quake, Haniffa, Engelhardt, Liberali, Paluch, Kundaje and more.
Abstracts close 15 Sept.
latsis2026.epfl.ch/event/1/
EPFL Latsis Symposium 2026
Join us in Lausanne to connect with the global community shaping the future of cell understanding and engineering.
latsis2026.epfl.ch
August 28, 2026 at 9:43 AM
Registration is still open for the EPFL Latsis Symposium 2026, "Decoding the Cell: Modeling, Predicting, and Engineering Cellular States."
29–30 Oct, Olympic Museum, Lausanne.
Quake, Haniffa, Engelhardt, Liberali, Paluch, Kundaje and more.
Abstracts close 15 Sept.
latsis2026.epfl.ch/event/1/
29–30 Oct, Olympic Museum, Lausanne.
Quake, Haniffa, Engelhardt, Liberali, Paluch, Kundaje and more.
Abstracts close 15 Sept.
latsis2026.epfl.ch/event/1/
Reposted by Chloé Roffay
A developmental biologist's guide to mechanics, just out in Development! In which we learn about the three pillars of any mechanical model: forces, mechanical properties, and boundary conditions.
@pflenne.bsky.social @alessandrochppr.bsky.social @caojialing1002.bsky.social @dev-journal.bsky.social
@pflenne.bsky.social @alessandrochppr.bsky.social @caojialing1002.bsky.social @dev-journal.bsky.social
A developmental biologist's guide to mechanics
Summary: A guide to mechanics in development: unlock how forces, material properties and geometry shape the forms of life.
journals.biologists.com
August 27, 2026 at 7:46 AM
A developmental biologist's guide to mechanics, just out in Development! In which we learn about the three pillars of any mechanical model: forces, mechanical properties, and boundary conditions.
@pflenne.bsky.social @alessandrochppr.bsky.social @caojialing1002.bsky.social @dev-journal.bsky.social
@pflenne.bsky.social @alessandrochppr.bsky.social @caojialing1002.bsky.social @dev-journal.bsky.social
Reposted by Chloé Roffay
More than 3 weeks already passed by at @kitp-ucsb.bsky.social QBio Summer Course. So much people to learn from. Wanting to keep my eyes, ears and mind open for what’s coming. What a beautiful job!
These last days I’ll be working with Honeypot ants, Myrmecocystus navajo. They ara amazing👇🏼
These last days I’ll be working with Honeypot ants, Myrmecocystus navajo. They ara amazing👇🏼
August 12, 2026 at 6:42 AM
More than 3 weeks already passed by at @kitp-ucsb.bsky.social QBio Summer Course. So much people to learn from. Wanting to keep my eyes, ears and mind open for what’s coming. What a beautiful job!
These last days I’ll be working with Honeypot ants, Myrmecocystus navajo. They ara amazing👇🏼
These last days I’ll be working with Honeypot ants, Myrmecocystus navajo. They ara amazing👇🏼
Reposted by Chloé Roffay
🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical?
Thrilled to share our new paper in
@NatureCellBio
:
Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇
www.nature.com/articles/s41...
1/11
Thrilled to share our new paper in
@NatureCellBio
:
Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇
www.nature.com/articles/s41...
1/11
Elevated contractility drives implantation failure in mouse embryos from aged females - Nature Cell Biology
Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...
www.nature.com
August 25, 2026 at 6:37 PM
🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical?
Thrilled to share our new paper in
@NatureCellBio
:
Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇
www.nature.com/articles/s41...
1/11
Thrilled to share our new paper in
@NatureCellBio
:
Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇
www.nature.com/articles/s41...
1/11
Reposted by Chloé Roffay
Neuromesodermal progenitor cells generate multiple tissues. This study by @abinagui.bsky.social @edinuni-irr.bsky.social @osvaldo-chara.bsky.social @cellysally.bsky.social &co maps their functional heterogeneity and links TF expression thresholds to #cellFate.
🧪 #AcademicSky
plos.io/4xWA8Ze
🧪 #AcademicSky
plos.io/4xWA8Ze
August 26, 2026 at 8:05 AM
Neuromesodermal progenitor cells generate multiple tissues. This study by @abinagui.bsky.social @edinuni-irr.bsky.social @osvaldo-chara.bsky.social @cellysally.bsky.social &co maps their functional heterogeneity and links TF expression thresholds to #cellFate.
🧪 #AcademicSky
plos.io/4xWA8Ze
🧪 #AcademicSky
plos.io/4xWA8Ze
Reposted by Chloé Roffay
The structural origin of irreversible transitions in biological networks
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
The structural origin of irreversible transitions in biological networks | PNAS
Cellular processes often exhibit irreversible state transitions even after external signals responsible for a transition are withdrawn. Long-standi...
doi.org
August 22, 2026 at 11:00 AM
The structural origin of irreversible transitions in biological networks
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
Reposted by Chloé Roffay
A new pharynx for #FluorescenceFriday. ✨ Hofstenia miamia are able to completely regenerate their pharynx after amputation, building new muscle (🟠, transgenic line) that surrounds an internal ciliated tube (🔵, b-tubulin).
August 21, 2026 at 5:38 PM
A new pharynx for #FluorescenceFriday. ✨ Hofstenia miamia are able to completely regenerate their pharynx after amputation, building new muscle (🟠, transgenic line) that surrounds an internal ciliated tube (🔵, b-tubulin).
Reposted by Chloé Roffay
📣 #OpenCall: Project Funding
Researchers can determine the nature and topic of their research projects independently. Open to all disciplines.
📆 Submission deadline: 1 October 2026
➡️ Read more: sohub.io/b6cm
Researchers can determine the nature and topic of their research projects independently. Open to all disciplines.
📆 Submission deadline: 1 October 2026
➡️ Read more: sohub.io/b6cm
July 10, 2026 at 7:30 AM
📣 #OpenCall: Project Funding
Researchers can determine the nature and topic of their research projects independently. Open to all disciplines.
📆 Submission deadline: 1 October 2026
➡️ Read more: sohub.io/b6cm
Researchers can determine the nature and topic of their research projects independently. Open to all disciplines.
📆 Submission deadline: 1 October 2026
➡️ Read more: sohub.io/b6cm
Reposted by Chloé Roffay
Tissue mechanics sets developmental scaling of collective cell migration https://www.biorxiv.org/content/10.64898/2026.08.19.745692v1
August 20, 2026 at 2:36 PM
Tissue mechanics sets developmental scaling of collective cell migration https://www.biorxiv.org/content/10.64898/2026.08.19.745692v1