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levayerr.bsky.social
Levayer Lab
@levayerr.bsky.social
3.5K followers 500 following 240 posts
Epithelial cell death, cell extrusion, self-organisation, mechanotransduction and many other things
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Reposted by Levayer Lab
jpsastro.bsky.social
Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky
I am writing to let you know that, unfortunately, your application was not successful. Review process As part of the initial triage of the 179 proposals submitted to this call, each was assessed using an AI-based review. Every proposal was read independently by several different AI models against the same seven criteria used to shape this call (including cyber security relevance, research quality and novelty, importance of the problem addressed, feasibility of the project plan, likely outputs and impact, value for money, and responsible research practice), with each model asked to give a score and a written justification with supporting quotations from the text. To guard against any one model's idiosyncrasies, we also ran a second, independent process in which different AI models debated the merits and weaknesses of each proposal before reaching a judgement, again against the same criteria. Scores from both processes were combined to produce an overall ranking. This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review. Projects selected for funding were drawn from those that progressed to the full human review stage. We recognise that AI-assisted assessment is a new and evolving part of the review process, and we are continuing to evaluate how well it aligns with the judgements of human reviewers on this call. We will soon produce a document detailing our method, so that others can build upon it and improve it. Feedback on your application Your application was not selected to progress beyond the AI triage stage. To provide transparency on the outcome of this assessment, we are sharing below the scores (out of 5) from each of the two AI review processes described above, together with the mean score across the two processes.
September 24, 2026 at 9:13 AM
Reposted by Levayer Lab
marionbaraban.bsky.social
A funded postdoctoral position is available at the IBPS, Sorbonne
University/CNRS/INSERM in Paris, to investigate the
formation of the olfactory organ in zebrafish.
We are looking for an postdoctoral researcher with expertise in transcriptomics
and bioinformatics, (scRNAseq analysis).
September 24, 2026 at 9:15 AM
levayerr.bsky.social
Only one week left to apply ! Check below for more details but the course will be great. Please spread the word 🙏
levayerr.bsky.social Levayer Lab @levayerr.bsky.social · 22d
📢master or PhD student interested in cell biology ? There are spots left for the Molecular Biology of the Cell course @pasteur.fr. Check the amazing list of lecturers + 1 week practical pocking choano cytokeleton with @thibautbrunet.bsky.social team. Registration 👇
www.pasteur.fr/fr/nous-conn...
September 24, 2026 at 8:15 PM
levayerr.bsky.social
Not every cell react the same way to caspase activation. In our recent study (led by @tomcumming.bsky.social and initiated by @avillars.bsky.social ), we tried to better understand what explains this difference and outlined a role of past caspase exposure 👇
www.nature.com/articles/s41...
September 23, 2026 at 9:02 PM
Reposted by Levayer Lab
milanlab.bsky.social
Milan Lab is recruiting a new PhD student. Deadline: October 30th. Please, spread the news. www.irbbarcelona.org/en/careers/y...
IRB Barcelona International PhD Fellowships - Extraordinary call 2026
The following will be offered in this call:Up to 8 FPI positions associated with the “Proyectos de Generación de Conocimiento 2025” Call (funded by the Agencia Estatal de Investigación AEI- MICINN).Ch...
www.irbbarcelona.org
September 16, 2026 at 7:50 AM
Reposted by Levayer Lab
teorth.bsky.social
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
Declaration — Math and AI
Read the declaration and add your name.
mathandai.org
September 11, 2026 at 5:40 PM
Reposted by Levayer Lab
priscaliberali.bsky.social
What if we stop asking only how cells build tissues and ask how tissues shape cells? That’s what we’ll explore at Modelling Life from Tissues to Cells 🇨🇭 lakeconferences.org/conf/8334d9b...
Conference - Modelling Life from Tissues to Cells: Coordination and Robustness - Lake Conferences
lakeconferences.org
September 8, 2026 at 12:24 PM
levayerr.bsky.social
Institut Curie, Paris, symposium: Where Form Takes Shape October 27-28th 2026 (after the yearly International Developmental Biology course)

Registration before October 10th (for free !): docs.google.com/forms/d/e/1F...
There will be short talks and posters selected from abstracts.
September 8, 2026 at 12:10 PM
levayerr.bsky.social
📢master or PhD student interested in cell biology ? There are spots left for the Molecular Biology of the Cell course @pasteur.fr. Check the amazing list of lecturers + 1 week practical pocking choano cytokeleton with @thibautbrunet.bsky.social team. Registration 👇
www.pasteur.fr/fr/nous-conn...
September 4, 2026 at 2:14 PM
Reposted by Levayer Lab
dev-journal.bsky.social
The role of geometry in morphogenesis

Read this Review from our special issue #DevSIextracellular by Ryan Harrison, Olivier Hamant and @timesaunders.bsky.social.

journals.biologists.com/dev/article/...
Role of geometry in shaping tissues. Multiple factors, including cell shape (top left), boundary constraints (top right), topological inputs (bottom left) including from different cell alignment defects (±1/2) and biophysical factors (bottom right) impact how the final tissue form emerges (centre). Centre shows images of a 48 h neuruloid (left; magenta, DAPI; green, actin) and a young Arabidopsis flower (right) treated with oryzalin (depolymerised microtubules) thus showing isotropic growth, but no defect in patterning (organs are still initiated in the right position).
September 4, 2026 at 6:00 AM
levayerr.bsky.social
The last version of our EpiCure tool is now out in @dev-journal.bsky.social, a user friendly Napari plugin for epithelial segmentation curation. A bit thanks to @gaellel.bsky.social for carrying all along this joint department effort (check the details below). Feel free to use it and expand it !
gaellel.bsky.social Gaëlle Letort @gaellel.bsky.social · 23d
The final version of the paper presenting our tool EpiCure is now online: journals.biologists.com/dev/article/... !! Thanks again to all collaborators in this project
September 3, 2026 at 2:56 PM
Reposted by Levayer Lab
thibautbrunet.bsky.social
🚨 New preprint alert! 🚨

Choanoflagellates reorganize their global cytoskeletal architecture within seconds to explore confined microspaces. This is the main PhD work of the amazing @maitefreired.bsky.social www.biorxiv.org/content/10.6...

A tread 🧵⬇️
Rapid repurposing of microvillar content drives a flagellate-to-amoeboid switch in the closest relative of animals
Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...
www.biorxiv.org
September 2, 2026 at 9:19 PM
Reposted by Levayer Lab
cellsdev.bsky.social
A very intriguing story by Joao F. Botelho et al shows that in bird, the digit formation (their ✋) is not only governed by apoptosis but also due to changes in the rate of growth extension and cell division between the interdigital zone and the digital zone. So cool! #devbio
doi.org/10.1016/j.cd...
August 28, 2026 at 4:05 PM
Reposted by Levayer Lab
crezaval.bsky.social
We’re recruiting postdocs to join our @wellcometrust.bsky.social , Decoding Competition in the Brain.

How does the brain resolve competing needs and prioritise behaviour?

📅 New deadline: 15 September

🔗 Apply: rezavallab.org

Please share!
August 26, 2026 at 4:37 PM
Reposted by Levayer Lab
katecavanaugh.bsky.social
🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical?

Thrilled to share our new paper in
@NatureCellBio
:

Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇

www.nature.com/articles/s41...

1/11
Elevated contractility drives implantation failure in mouse embryos from aged females - Nature Cell Biology
Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...
www.nature.com
August 25, 2026 at 6:37 PM
Reposted by Levayer Lab
delarueresearch.bsky.social
Please save the date: The Microphysio Conference is back and will be held in Cargèse from April 25th to April 30th!
With a great lineup of speakers, it’s an excellent opportunity to exchange ideas in fields related to organ-on-chip, organoids, bioprinting, mechanobiology, and much more!
Stay tuned.
August 25, 2026 at 1:44 PM
Reposted by Levayer Lab
ditalialab.bsky.social
Happy to see Ashley's paper out @natphys.nature.com

www.nature.com/articles/s41...
Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration
Nature Physics - Zebrafish can regenerate amputated fins back to their original size. It is now shown that gradients in extracellular signal-regulated kinase activity act as rulers during fin bone...
www.nature.com
August 24, 2026 at 11:44 AM
Reposted by Levayer Lab
flybase.bsky.social
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...
Treat biological databases as infrastructure, not projects
Letter to the Editor
www.nature.com
August 20, 2026 at 12:46 PM
levayerr.bsky.social
So cells do count eventually (still need to check the details but the abstract sounds very appealing)
www.nature.com/articles/s41...
Intestinal stem cells count self-renewal divisions to switch multipotency - Nature
In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...
www.nature.com
August 20, 2026 at 11:30 AM
levayerr.bsky.social
This 👇, and Europe should also have more scheme to finance those essential "infrastructures" (rathen than implementing 10 millions single person grant...)
www.nature.com/articles/d41...
Treat biological databases as infrastructure, not projects
Letter to the Editor
www.nature.com
August 20, 2026 at 11:02 AM
Reposted by Levayer Lab
tinekelenstra.bsky.social
Sign up now for the EMBO meeting 'quantitative biology to molecular mechanisms'. Fantastic speaker lineup and plenty of speakers slots selected from abstracts. Submit your abstract before Sept 11!
events.embl.org EMBL Events @events.embl.org · Aug 11
You only have until 11 Sep to submit your abstract for #EMBOomics!
➡️ s.embl.org/omx26-01-bl

Join us to discuss the latest developments in the field with leaders in genomics, dynamic proteomics, quantitative imaging, and synthetic biology.
August 17, 2026 at 2:03 PM
Reposted by Levayer Lab
What does an ovary actually look like as it ages—one oocyte at a time?
We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan.
And the ovary turned out to be much more organized than we expected. 🧵 1/5
www.nature.com/articles/s43...
Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature Aging
The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...
www.nature.com
August 12, 2026 at 11:41 AM
Reposted by Levayer Lab
jcellsci.bsky.social
The CellExIt#1 symposium gathered investigators working on cell extrusion. This report offers a panoramic view of the research teams and ongoing projects of the field.
@levayerr.bsky.social
@magalisuzanne.bsky.social

journals.biologists.com/jcs/article/...
The CellExIt#1 participants. From left to right: Marija Matekcic, Sabrina Vinzens, Xavier Trepat, Saranne J. Mitchell, Yusuke Toyama, Romain Levayer, Lucy Erin O'Brien, Jakub Sedzinski, Jody Rosenblatt, Alpha Yap, Simon de Beco, Cécile Daubech, Benoit Ladoux, Léa Roquin, Naoka Shiratsuchi, Magali Suzanne, Angela K. O. Lwin, Lieke Stockmann, Aline Grata, Jean-François Rupprecht, Yasuyuki Fujita, Sara A. Wickström, Rashmi Priya and Emile Magny.
August 14, 2026 at 11:01 AM
Reposted by Levayer Lab
greenbaron.bsky.social
Really excited to finally show off our work on the specification of neuroblasts. While it has been a long-standing model for lateral inhibition, we show that Notch does not select the NB, but instead reinforces fate decisions.

www.cell.com/current-biol...

@currentbiology.bsky.social
Positional cues, not Notch, direct neuroblast selection during early neurogenesis in the Drosophila embryo
Using quantitative live imaging, Green et al. show that proneural gene expression is biased by positional cues and that Notch is activated only after neuroblast selection in the Drosophila embryo. Thi...
www.cell.com
August 13, 2026 at 10:33 AM
levayerr.bsky.social
A lot of food for thought here. Down the line, many aspects here are based on the hypothesis that we need to have machine readable scientfic results (completly repurposing article from : we write for a "human" community - to - we write for LLM using our results). That opens a lot of questions...
August 12, 2026 at 2:35 PM