Abstract. The model plant Arabidopsis thaliana hosts diverse microbial communities collectively known as the microbiota. The plant microbiota is generally

Pearl millet and finger millet are important food crops but are notoriously recalcitrant to genetic transformation and gene editing, limiting their improve

Optimized long-read sequencing constructs megabase-scale genome assemblies from complex soil samples.

The model plant Arabidopsis thaliana has been a workhorse of plant biology since the 1950s, when the Columbia-0 (Col-0) accession was widely adopted by the research community as a reference genotype. ...

Light leaf spot (LLS), caused by subcuticular hemibiotrophic ascomycete fungus Pyrenopeziza brassicae , is a major constraint on oilseed rape ( Brassica napus ) production, yet the genetic and biochem...

Asst Professor - Plant or Fungal Genomics Join Our Campus Community! Thank you for your interest in joining the University of Wyoming. Our...

Genes involved in the biosynthesis of microbial natural products (NPs) are typically arranged in biosynthetic gene clusters (BGCs). Different congeners of an NP family typically possess distinct chemical features introduced by additional tailoring enzymes encoded in the corresponding BGC variants. However, tools to rapidly visualize the core gene set and distinguish it from variant-specific tailoring genes (VSTGs) in these BGCs are lacking. Here, the software tool BisCEET (Biosynthetic Cluster Environment Examination Tool) was developed, allowing comparison and visualization of the gene composition of related BGCs, thereby streamlining the identification of VSTGs in uncharacterized BGC variants and strains likely to produce novel NP congeners. The use of BisCEET is exemplified by analyzing bacterial BGCs of staurosporine-like indolocarbazoles and xantholipin-like polyketides, which enabled the identification of numerous apparent BGC variants. We anticipate that BisCEET will become a valuable bioinformatic asset, streamlining the prioritization of BGCs and the cultivation of microbial strains for the discovery of distinct NP variants and novel tailoring enzymes.

*Applications are reviewed on a rolling-basis. ARS Office/Lab and Location: A research opportunity is currently available with the U.S. Department of Agric

Nature Plants - The plant general non-self response system is triggered by leaf microbiota members and, in turn, impacts their colonization.

Genome-wide loss-of-function burden tests in Arabidopsis reveal functional insights into dispensable genes and demonstrate how collapsing variants by funct

OmicsCanvas integrates diverse epigenomic and transcriptomic data into a unified framework, enabling users to visualize complex multi-omics patterns, generate publication-ready figures, and uncover r...

Leveraging decades of technological development, dozens of reference genomes and thousands of resequenced sorghum varieties, a resource for breeders and researchers to harness the traits that let this...