Daniel R. Weilandt Ph.D.
@danielweilandt.bsky.social
PostDoc @Princeton University with Joshua Rabinowitz | Ph.D. in #ChemEng trained @EPFL with Vassily Hatzimanikatis | Working on quantitative analysis and modeling of #Metabolism | Interested in Biotech and Systems Biology | he/him | 🇩🇪~🇺🇸
Reposted by Daniel R. Weilandt Ph.D.
Online now: Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity
Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity
The mechanisms coordinating the homeostasis of glucose, lactate, fatty acids, and ketones remain unknown. Through quantitative modeling and experiments, Weilandt et al. reveal that these nutrients compete to be oxidized to meet systemic energy demands. Competitive catabolism normally produces homeostasis but, in obesity, converts increased lipolytic propensity into hyperglycemia and hyperinsulinemia.
dlvr.it
July 21, 2026 at 6:50 PM
Online now: Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity
1/11 New paper out today in Cell Metabolism 🧵
We set out to understand how the body keeps its fuels in balance, and discovered competitive catabolism, which provides a physiological explanation for why obesity causes hyperglycemia and hyperinsulinemia.
doi.org/10.1016/j.cm...
We set out to understand how the body keeps its fuels in balance, and discovered competitive catabolism, which provides a physiological explanation for why obesity causes hyperglycemia and hyperinsulinemia.
doi.org/10.1016/j.cm...
July 21, 2026 at 10:13 PM
1/11 New paper out today in Cell Metabolism 🧵
We set out to understand how the body keeps its fuels in balance, and discovered competitive catabolism, which provides a physiological explanation for why obesity causes hyperglycemia and hyperinsulinemia.
doi.org/10.1016/j.cm...
We set out to understand how the body keeps its fuels in balance, and discovered competitive catabolism, which provides a physiological explanation for why obesity causes hyperglycemia and hyperinsulinemia.
doi.org/10.1016/j.cm...
Reposted by Daniel R. Weilandt Ph.D.
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
All meeting details can be found here:
www.sablesys.com/metphys-the-...
January 13, 2026 at 4:12 PM
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
All meeting details can be found here:
www.sablesys.com/metphys-the-...
Reposted by Daniel R. Weilandt Ph.D.
Ever wondered how fever helps fight flu? Our research shows that fever-like temperature tip the scales in the battle between the influenza virus and the immune system by enhancing antiviral responses and altering viral RNA dynamics. Check out the full article here:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis
Fever promotes aberrant influenza A virus RNA synthesis and innate immune activation.
www.science.org
January 5, 2026 at 3:00 PM
Ever wondered how fever helps fight flu? Our research shows that fever-like temperature tip the scales in the battle between the influenza virus and the immune system by enhancing antiviral responses and altering viral RNA dynamics. Check out the full article here:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Excited to share my latest postdoc work on systemic metabolic homeostasis! We show that nutrient consumption fluxes compete, and this competitive catabolism helps explain why obesity drives diabetes. Explore the model with our interactive web app: compcat.princeton.edu
doi.org/10.1101/2025...
doi.org/10.1101/2025...
October 31, 2025 at 1:19 PM
Excited to share my latest postdoc work on systemic metabolic homeostasis! We show that nutrient consumption fluxes compete, and this competitive catabolism helps explain why obesity drives diabetes. Explore the model with our interactive web app: compcat.princeton.edu
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Daniel R. Weilandt Ph.D.
Super excited to share my final postdoc paper from Rabinowitz lab- on how whole-body and tissue metabolism changes in viral infection!
pubmed.ncbi.nlm.nih.gov/40581045/
pubmed.ncbi.nlm.nih.gov/40581045/
pubmed.ncbi.nlm.nih.gov
July 7, 2025 at 8:51 PM
Super excited to share my final postdoc paper from Rabinowitz lab- on how whole-body and tissue metabolism changes in viral infection!
pubmed.ncbi.nlm.nih.gov/40581045/
pubmed.ncbi.nlm.nih.gov/40581045/
Reposted by Daniel R. Weilandt Ph.D.
Excited to share our latest preprint in which we integrate mathematical modeling with experimental approaches to investigate how ⬆️ temperature influences aberrant RNA synthesis and innate immunity in flu infection 🦠
Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...
www.biorxiv.org
May 20, 2025 at 3:58 PM
Excited to share our latest preprint in which we integrate mathematical modeling with experimental approaches to investigate how ⬆️ temperature influences aberrant RNA synthesis and innate immunity in flu infection 🦠
Reposted by Daniel R. Weilandt Ph.D.
Last talk of morning 1 at METPHYS2025 Daniel Weilandt is working to convince us that hyperinsulinemia and hyperglycemia sustain lipid homeostasis in obesity
April 29, 2025 at 4:45 PM
Last talk of morning 1 at METPHYS2025 Daniel Weilandt is working to convince us that hyperinsulinemia and hyperglycemia sustain lipid homeostasis in obesity
Exited to present my latest PostDoc work at METPHYS2025. Looking forward to connecting with everyone there.
Here's the final program, for METPHYS2025
Really looking forward to the third edition of the Metabolic Physiology Meeting in 3 weeks !
If you haven't already registered, the link will stay open until April 15.
Hope to see you there!
www.sablesys.com/metphys2025-...
Really looking forward to the third edition of the Metabolic Physiology Meeting in 3 weeks !
If you haven't already registered, the link will stay open until April 15.
Hope to see you there!
www.sablesys.com/metphys2025-...
April 11, 2025 at 12:44 AM
Exited to present my latest PostDoc work at METPHYS2025. Looking forward to connecting with everyone there.
Reposted by Daniel R. Weilandt Ph.D.
An update with latest data available for graph of life expectancy vs health care expenditures per capita for 20 countries and one outlier.
February 3, 2025 at 3:19 PM
An update with latest data available for graph of life expectancy vs health care expenditures per capita for 20 countries and one outlier.
Elevated lactate is a hallmark of human disease. In our latest work in the Rabinowitz lab, Won Dong Lee and I uncover how multiple mechanisms work in concert to robustly maintain lactate levels.
Checkout our work @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
Checkout our work @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
Lactate elevations are a hallmark of human disease, but the mechanisms regulating
lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms
of lactate homeostasis. These invol...
www.cell.com
February 1, 2025 at 3:27 PM
Elevated lactate is a hallmark of human disease. In our latest work in the Rabinowitz lab, Won Dong Lee and I uncover how multiple mechanisms work in concert to robustly maintain lactate levels.
Checkout our work @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
Checkout our work @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
Reposted by Daniel R. Weilandt Ph.D.
lysosome experts! if you are trying to show that a stimulus increases lysosome mass/activity, how would you demonstrate that? (pls reskee)
January 27, 2025 at 1:51 PM
lysosome experts! if you are trying to show that a stimulus increases lysosome mass/activity, how would you demonstrate that? (pls reskee)
This made my day, we need more of this ❤️:
“Phase behavior of Cacio and Pepe sauce”
arxiv.org/pdf/2501.00536
“Phase behavior of Cacio and Pepe sauce”
arxiv.org/pdf/2501.00536
arxiv.org
January 25, 2025 at 3:39 PM
This made my day, we need more of this ❤️:
“Phase behavior of Cacio and Pepe sauce”
arxiv.org/pdf/2501.00536
“Phase behavior of Cacio and Pepe sauce”
arxiv.org/pdf/2501.00536
Reposted by Daniel R. Weilandt Ph.D.
Study explores link between people's professions and their genetic predisposition to neuropsychiatric traits
medicalxpress.com/news/2025-01...
medicalxpress.com/news/2025-01...
January 19, 2025 at 8:56 AM
Study explores link between people's professions and their genetic predisposition to neuropsychiatric traits
medicalxpress.com/news/2025-01...
medicalxpress.com/news/2025-01...