Alessandro De Simone
@desimonelab.bsky.social
Physical principles of regeneration in zebrafish. Assist. Prof. @Genevunige. Passionate of zebrafish scales, bone morphogenesis and signalling dynamics. #SciComm and Improv theatre. https://tinyurl.com/23str3yn
How is proliferation modulated in regeneration for tissues to reach their right size? We found that, in zebrafish scales, proliferation is shut down by a moving front of osteoblast maturation. The front's dynamics scale with tissue size, ensuring proper osteoblast amplification. tinyurl.com/5e45twx3
A moving front of osteoblast maturation scales regenerating zebrafish bone
Successful regeneration recovers lost tissues to their original form. Here, we investigate how proliferation of bone-forming osteoblasts is timely regulated to control tissue size during zebrafish sca...
tinyurl.com
September 17, 2026 at 5:33 PM
How is proliferation modulated in regeneration for tissues to reach their right size? We found that, in zebrafish scales, proliferation is shut down by a moving front of osteoblast maturation. The front's dynamics scale with tissue size, ensuring proper osteoblast amplification. tinyurl.com/5e45twx3
Reposted by Alessandro De Simone
Charles Darwin comes back to life to wish Sir David Attenborough a happy 100th birthday.
Our 3.5-min film from the LANE (University of Geneva) celebrates "the man who helped the world fall in love with nature".
Happy #AttenboroughDay ! #bbc @biology-unige.bsky.social
Our 3.5-min film from the LANE (University of Geneva) celebrates "the man who helped the world fall in love with nature".
Happy #AttenboroughDay ! #bbc @biology-unige.bsky.social
An extraordinary guest to celebrate Sir David Attenborough
YouTube video by The LANE channel
youtu.be
May 8, 2026 at 5:30 AM
Charles Darwin comes back to life to wish Sir David Attenborough a happy 100th birthday.
Our 3.5-min film from the LANE (University of Geneva) celebrates "the man who helped the world fall in love with nature".
Happy #AttenboroughDay ! #bbc @biology-unige.bsky.social
Our 3.5-min film from the LANE (University of Geneva) celebrates "the man who helped the world fall in love with nature".
Happy #AttenboroughDay ! #bbc @biology-unige.bsky.social
Tristan Guyomar and I wrote a review on physical mechanisms coordinating regeneration - Featured: signalling/mechanical gradients, travelling waves and nematic fields - Dramatis personae: axolotls, hydra, planaria, spiny mice and zebrafish (ofc) with a jellyfish cameo
tinyurl.com/3upzrdbs
tinyurl.com/3upzrdbs
Gradients, waves and nematics: quantitative perspectives on regeneration
Regeneration restores a damaged body part to its original size, shape and structure. Research over the last decades identified signaling pathways, cel…
tinyurl.com
December 16, 2025 at 10:33 AM
Tristan Guyomar and I wrote a review on physical mechanisms coordinating regeneration - Featured: signalling/mechanical gradients, travelling waves and nematic fields - Dramatis personae: axolotls, hydra, planaria, spiny mice and zebrafish (ofc) with a jellyfish cameo
tinyurl.com/3upzrdbs
tinyurl.com/3upzrdbs
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
November 20, 2025 at 6:11 PM
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
Reposted by Alessandro De Simone
New work from @desimonelab.bsky.social lab 🌊🐟
Transcriptional feedback of Erk signaling waves in zebrafish scale regeneration https://www.biorxiv.org/content/10.1101/2025.11.19.689292v1
November 20, 2025 at 9:13 AM
New work from @desimonelab.bsky.social lab 🌊🐟
Reposted by Alessandro De Simone
We have moved to this new location as we prepare to launch a new edition of the Practical Course on Developmental Biology, Quintya-2025. This course began more than 25 years ago, and we are excited to bring together an excellent lineup of faculty and students for this latest edition
December 11, 2024 at 4:47 PM
We have moved to this new location as we prepare to launch a new edition of the Practical Course on Developmental Biology, Quintya-2025. This course began more than 25 years ago, and we are excited to bring together an excellent lineup of faculty and students for this latest edition
Reposted by Alessandro De Simone
Dive into our latest findings on this powerful structure here: “The claustrum is critical for maintaining working memory” biorxiv.org/cgi/content/...
The claustrum is critical for maintaining working memory information
Working memory (WM) enables the mammalian brain to temporarily store and manipulate information, supporting cognitive tasks and communication processes. Rather than depending on a single specialized a...
biorxiv.org
November 22, 2024 at 7:50 AM
Dive into our latest findings on this powerful structure here: “The claustrum is critical for maintaining working memory” biorxiv.org/cgi/content/...