John Ebos
@ebos.bsky.social
Associate Prof. in Cancer Genetics at Roswell Park Comprehensive Cancer Center studying drug resistance, metastasis, the tumor microenvironment, immunecheckpoints, and angiogenesis.
https://www.roswellpark.org/research/labs/ebos-lab
https://www.roswellpark.org/research/labs/ebos-lab
Reposted by John Ebos
Thrilled to share that our paper jitc.bmj.com/content/14/9... ) has just been accepted in the Journal for ImmunoTherapy of Cancer (JITC)!
Our key finding: For prostate cancer Immunotherapy, timing may be a game changer!!
Our key finding: For prostate cancer Immunotherapy, timing may be a game changer!!
September 28, 2026 at 8:27 PM
Thrilled to share that our paper jitc.bmj.com/content/14/9... ) has just been accepted in the Journal for ImmunoTherapy of Cancer (JITC)!
Our key finding: For prostate cancer Immunotherapy, timing may be a game changer!!
Our key finding: For prostate cancer Immunotherapy, timing may be a game changer!!
Tumor immune microenvironment remodeling predicts response to checkpoi... www.sciencedirect.com/science/arti...
www.sciencedirect.com
September 17, 2026 at 2:15 PM
Tumor immune microenvironment remodeling predicts response to checkpoi... www.sciencedirect.com/science/arti...
Reposted by John Ebos
I made a presentation to other faculty about recent progress in general AI, to facilitate the discussion around the impact for research and teaching in biology. It could be that the slides are useful for others trying to do that same. Feel free to re-use.
docs.google.com/presentation...
docs.google.com/presentation...
generalAI_for research_intro.pptx
Recent AI developments and what they mean for us Quick primer on general AI models* State-of-the-art in AI agent capabilities AI agents in biology (examples) Discussion - what does this mean for our r...
docs.google.com
September 9, 2026 at 10:53 AM
I made a presentation to other faculty about recent progress in general AI, to facilitate the discussion around the impact for research and teaching in biology. It could be that the slides are useful for others trying to do that same. Feel free to re-use.
docs.google.com/presentation...
docs.google.com/presentation...
Reposted by John Ebos
A Perspective in Nature Reviews Drug Discovery highlights issues in #AI development for drug discovery, such as inadequate clinical translation focus and challenges with applying AI to life science data, while offering recommendations for improvement. go.nature.com/45Bjpia 🧪
August 28, 2026 at 4:30 PM
A Perspective in Nature Reviews Drug Discovery highlights issues in #AI development for drug discovery, such as inadequate clinical translation focus and challenges with applying AI to life science data, while offering recommendations for improvement. go.nature.com/45Bjpia 🧪
Reposted by John Ebos
As part of the JCI’s series on The cGAS-STING pathway: DNA sensing in health and disease: Mahajan et al. present: Therapeutic targeting of the cGAS–STING pathway in human disease: doi.org/10.1172/JCI2...
July 2, 2026 at 12:03 PM
As part of the JCI’s series on The cGAS-STING pathway: DNA sensing in health and disease: Mahajan et al. present: Therapeutic targeting of the cGAS–STING pathway in human disease: doi.org/10.1172/JCI2...
Reposted by John Ebos
Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues.
www.nature.com/articles/s41...
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www.nature.com/articles/s41...
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June 24, 2026 at 3:57 PM
Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues.
www.nature.com/articles/s41...
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www.nature.com/articles/s41...
1/
Thank you to all the organizers at the American Cancer Society Relay for Life event this weekend in Niagara Falls for all of their hard work on behalf of patients to help fund critical cancer research! @americancancersoc.bsky.social @roswellpark.bsky.social
secure.acsevents.org/site/STR?pg=...
secure.acsevents.org/site/STR?pg=...
June 1, 2026 at 12:27 PM
Thank you to all the organizers at the American Cancer Society Relay for Life event this weekend in Niagara Falls for all of their hard work on behalf of patients to help fund critical cancer research! @americancancersoc.bsky.social @roswellpark.bsky.social
secure.acsevents.org/site/STR?pg=...
secure.acsevents.org/site/STR?pg=...
Reposted by John Ebos
Scientific figures can strongly influence how research findings are interpreted. This ‘How to’ Comment article in Nature Human Behaviour outlines a practical strategy for creating figures that communicate clearly across audiences and scientific contexts. go.nature.com/3R00b1t #Academicsky 🧪
May 11, 2026 at 1:01 PM
Scientific figures can strongly influence how research findings are interpreted. This ‘How to’ Comment article in Nature Human Behaviour outlines a practical strategy for creating figures that communicate clearly across audiences and scientific contexts. go.nature.com/3R00b1t #Academicsky 🧪
Reposted by John Ebos
The May issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by @jeremynigri.bsky.social, Dave Tuveson, & colleagues showing myofibroblasts induce neuroplasticity to promote pancreatic inflammation & cancer progression. That & more: aacrjournals.org/cancerdiscov...
May 4, 2026 at 7:13 PM
The May issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by @jeremynigri.bsky.social, Dave Tuveson, & colleagues showing myofibroblasts induce neuroplasticity to promote pancreatic inflammation & cancer progression. That & more: aacrjournals.org/cancerdiscov...
Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response
Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response
AbstractMultiplexed imaging of tissues is an approach that holds promise for improving early detection, diagnosis, and treatment of cancer. In this study, we investigated multiplexed histologic images...
aacrjournals.org
May 4, 2026 at 12:11 PM
Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response
Reposted by John Ebos
Nature research paper: The integrated stress response promotes immune evasion through lipocalin 2
go.nature.com/3MR7cQv
go.nature.com/3MR7cQv
The integrated stress response promotes immune evasion through lipocalin 2 - Nature
The transcription factor ATF4 and its effector lipocalin 2 (LCN2) have a key role in immune evasion and tumour progression, and targeting the ATF4–LCN2 axis might provide a way to treat several types of solid tumour by increasing anti-cancer immunity.
go.nature.com
February 19, 2026 at 5:37 PM
Nature research paper: The integrated stress response promotes immune evasion through lipocalin 2
go.nature.com/3MR7cQv
go.nature.com/3MR7cQv
Reposted by John Ebos
New FeiginLab paper is OUT! A commonly prescribed anti-anxiety drug reduces inflammatory signaling in pancreatic cancer through regulation of cancer-associated fibroblast activity!
aacrjournals.org/cancerrescom...
aacrjournals.org/cancerrescom...
Alprazolam reduces inflammatory cytokine production in pancreatic cancer-associated fibroblasts
Abstract. Pancreatic ductal adenocarcinoma (PDAC) diagnoses are often accompanied by a number of physical and psychological symptoms, including anxiety and depression. As a result, many patients are p...
aacrjournals.org
April 17, 2026 at 7:46 PM
New FeiginLab paper is OUT! A commonly prescribed anti-anxiety drug reduces inflammatory signaling in pancreatic cancer through regulation of cancer-associated fibroblast activity!
aacrjournals.org/cancerrescom...
aacrjournals.org/cancerrescom...
Reposted by John Ebos
Don’t miss our featured posters for Monday, April 20—highlighting even more critical discoveries from Roswell Park. See you at AACR!
#AACR26
#AACR26
April 15, 2026 at 5:50 PM
Don’t miss our featured posters for Monday, April 20—highlighting even more critical discoveries from Roswell Park. See you at AACR!
#AACR26
#AACR26
Reposted by John Ebos
Repeated cloning cannot be sustained indefinitely in mammals, according to a 20-year study in mice published in Nature Communications. The results suggest that sexual reproduction is necessary to eliminate large-scale genetic mutations that can accumulate in mammalian clones. 🧬 🧪
Limitations of serial cloning in mammals - Nature Communications
Here they show that extended serial somatic cell cloning imposes a threefold increase in de novo mutations compared to natural reproduction, progressively reducing birth rates and ultimately limiting clonal propagation to 58 generations.
go.nature.com
March 25, 2026 at 4:15 PM
Repeated cloning cannot be sustained indefinitely in mammals, according to a 20-year study in mice published in Nature Communications. The results suggest that sexual reproduction is necessary to eliminate large-scale genetic mutations that can accumulate in mammalian clones. 🧬 🧪
Reposted by John Ebos
WATCH: Emese Zsiros, MD, PhD, FACOG, of @roswellpark.bsky.social, discusses the @fda.gov approval of pembrolizumab plus paclitaxel with or without pembrolizumab for PD-L1–positive ovarian cancer. #gyncsm #oncology
www.onclive.com/view/dr-zsir...
www.onclive.com/view/dr-zsir...
Dr Zsiros on the Use of Pembrolizumab/Paclitaxel/Bevacizumab for Ovarian Cancer | OncLive
Emese Zsiros, MD, PhD, FACOG, discusses the FDA approval of pembrolizumab plus paclitaxel with or without pembrolizumab for PD-L1–positive ovarian cancer.
www.onclive.com
March 19, 2026 at 5:15 PM
WATCH: Emese Zsiros, MD, PhD, FACOG, of @roswellpark.bsky.social, discusses the @fda.gov approval of pembrolizumab plus paclitaxel with or without pembrolizumab for PD-L1–positive ovarian cancer. #gyncsm #oncology
www.onclive.com/view/dr-zsir...
www.onclive.com/view/dr-zsir...
Reposted by John Ebos
AI for cancer treatment information: Can academia stay in the game?
AI for cancer treatment information: Can academia stay in the game?
In this issue of Cancer Cell, Jun et al. developed a retrieval-augmented large language model linked to an academia-led molecular knowledge database, demonstrating how AI may deliver cancer treatment information without hallucination. It must compete for adoption amid a fast-paced, industry-led transformation in the flow of clinical information to patients.
dlvr.it
March 16, 2026 at 2:18 PM
AI for cancer treatment information: Can academia stay in the game?
Reposted by John Ebos
For readers interested in drug repurposing, this review summarizes the approaches, evaluates available in silico resources and presents case studies
www.nature.com/articles/s41...
rdcu.be/e60em
www.nature.com/articles/s41...
rdcu.be/e60em
March 5, 2026 at 2:59 PM
For readers interested in drug repurposing, this review summarizes the approaches, evaluates available in silico resources and presents case studies
www.nature.com/articles/s41...
rdcu.be/e60em
www.nature.com/articles/s41...
rdcu.be/e60em
Thank you to the Sinclair Cancer Research Institute at Queens University for hosting my visit this week. It was fantastic to share our science from Roswell Park and to meet with so many investigators and trainees. @sinclaircri.bsky.social @queensuresearch.bsky.social @roswellpark.bsky.social
Coming soon! Dr. Ebos @ebos.bsky.social will be presenting in our @sinclaircri.bsky.social seminar series on Feb 26 at 4 PM. Questions? Send us an email: [email protected] #ResearchTalk #SeminarAlert #CancerResearch #CancerDrugResistance @queensuhealth.bsky.social @queensuresearch.bsky.social
February 28, 2026 at 4:21 PM
Thank you to the Sinclair Cancer Research Institute at Queens University for hosting my visit this week. It was fantastic to share our science from Roswell Park and to meet with so many investigators and trainees. @sinclaircri.bsky.social @queensuresearch.bsky.social @roswellpark.bsky.social