PXD058490 🚨

Quantitative chemical cross-linking of live cells, organelles, or tissues together with mass spectrometry provides a new insight on protein conformational plasticity within organisms, cells, and tissues.

🚨 New dataset alert! 🚨

Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...

Glad to see our antibody design paper finally out in
@nature.com
(and congrats to lead authors and everyone involved )!
At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs.
Paper:
www.nature.com/articles/s41...

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc

‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...

‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT
www.verwaltung.uni-halle.de/dezern3/Auss...

#Academicsky
#Chemsky
#teammassspec

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.

nationalmaglab.org/careers/meet...

Large-Scale Quantitative Cross-Linking and Mass Spectrometry Provide New Insight into Protein Conformational Plasticity within Organelles, Cells, and Tissues pubs.acs.org/doi/10....

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#proteomics #prot-paper

We had built something conceptually similar using the front lens on an ICR (or adjacent quad segments) in a segmented PCB quad to trap ions between the LIT and ICR cell on our development instrument to improve trapping for short ICR array cells. Nightmarish to optimize timings, very impressive work

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...

Job alert 🧪 ‼️ Hi #teammassspec: In our #RTG2467 @unihalle.bsky.social we have a job opening for a PhD student in my group! 🎉 If you want to do cool stuff in cross-linking mass spectrometry of the tumor suppressor p53, please take a look:
personal.verwaltung.uni-halle.de/jobs/wissmi/
Please RT!

Hi #TeamMassSpec! #FeMS+ has joined BlueSky! Please share and get the word out so we can build up a base here.

Last bit of my PhD work, a four-armed cross-linker (Bisby) prepared by SPPS and a real-time ms3 targeting method written in ITCL based on Chad's original ReACT implementation running on our Velos-FTICR with mito samples from long-time collaborator Arianne.

Multidimensional Cross-Linking and Real-Time Informatics for Multiprotein Interaction Studies pubs.acs.org/doi/10....

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#proteomics #prot-paper