How serotonin neurons wire the forebrain after birth: 4D whole-brain maps of mouse serotonin axons show region-specific growth plus a brain-wide, synchronized wave of innervation, lined up with a surge in wiring-molecule expression at postnatal day 4.

Adams, Ren et al., PNAS #neuroskyence

New on Frontier: all 44 peer-reviewed papers that joined the index from 21 to 30 September, each scored on evidence, impact and novelty. Leading the issue: an AI framework that turns coarse climate projections into local weather, and four Mount Sinai studies of the human prefrontal cortex.

#SciSky

Earlier network theory suggested that differences between nodes destabilize a network. Montanari, Zanin and Motter show that came from simplified models: when each node has richer dynamics, disorder can stabilize networks, from neural circuits to power grids.

Science #physics #ComplexSystems

Some Pseudomonas phages infect via the type IV pilus, whose subunits vary widely between strains. Phages with sequence-diverse tail fiber C-terminal domains infected strains with highly divergent pilins; conserved ones were more sensitive to change.

@dr-lori-burrows.bsky.social et al. #MicroSky

The human prefrontal cortex across a lifetime, cell type by cell type: remodeling in development, relative stability in midlife, selective reactivation late in life, including glial programs tied to immune activation, stress and circadian change.

@panosroussos.bsky.social et al. #neuroskyence

Eating less protein as a larva makes fruit flies live longer. The carrier of that memory is Lsp2, a storage protein that stays low into early adulthood; silencing it cut ribosomal proteins and translation and extended lifespan.

@kosakamotohina.bsky.social @obataf-lab.bsky.social #Drosophila

Phage genomes teem with genes of unknown function. HIDEN-SEQ, transposon sequencing for phages, recovered T4's decades-old essentiality map and found conditionally essential genes in non-model phages, including new antidefense factors.

@humollidorentina.bsky.social @aharms485.bsky.social #MicroSky

3.2 g whiskers let tiny drones navigate by touch in darkness. A lab demonstration, not yet a rescue-ready system.

Our source-linked breakdown of the TU Delft work, primary paper in the thread. #robotics #drones