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hdbuzzfeed.bsky.social
HDBuzz
@hdbuzzfeed.bsky.social
260 followers 48 following 1.6K posts
Huntington’s disease research news. In plain language. Written by scientists. hdbuzz.net
Editors - @sjh508 @rjharding
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hdbuzzfeed.bsky.social
Unique research highlights an overlooked mental health disparity among Indigenous North American people with Huntington’s disease (HD) - and the need for care grounded in trust, community partnership, and cultural understanding.

Read more here: en.hdbuzz.net/highlighting...
September 21, 2026 at 1:10 PM
hdbuzzfeed.bsky.social
Skyhawk Therapeutics shared data for SKY-0515, an experimental once-daily pill that targets both huntingtin and somatic instability, making it a possible “two-for-one” drug to treat HD.

Read more about this exciting news on HDBuzz → en.hdbuzz.net/encouraging-...
Graphic of a megaphone with the words, "Encouraging news from Skyhawk Therapeutics!" above. Picture of pills from a pill bottle with words on text boxes: "A potential 2-for-1 approach to treat HD is safe and shows potential! SKY-0515 is an experimental once-daily pill that aims to lower huntingtin AND target somatic instability." Close up photo of a doctor checking lab results. Words in text boxes read, "In the Phase 1/2 study, SKY0515 did just that, and showed positive changes in tests of movement & thinking." But will that add up to a treatment that slows HD?" Text box: "Skyhawk's Phase 2/3 study, FALCON-HD, will tell us whether the Phase 1/2 study's promising signs hold up in a larger, placebo-controlled trial."
September 16, 2026 at 1:00 PM
hdbuzzfeed.bsky.social
What if nutrition is one of the warning lights we should be checking earlier in Huntington’s disease? New research suggests simple nutrition measures may help identify when people with HD need extra support.

en.hdbuzz.net/food-for-tho...
Photo of puzzle pieces on a dinner plate. Title reads, "Food for Thought: The Importance of Nutrition in Huntington's Disease". Graphic of a wind cloud blowing at a woman holding onto an umbrella. Text reads, "Living with HD can be like walking into a strong headwind..." Text continues, "... you're still moving forward, but it takes more energy. So a new study on nutrition in people with HD set out to discover if..." Text continues, "1. malnutrition is more common in HD, 2. malnutrition is linked with symptoms such as movement and thinking changes, and 3. simple nutrition checks might help care teams spot when extra support is needed."
September 14, 2026 at 1:01 PM
hdbuzzfeed.bsky.social
A review of 23 studies suggests that EEG could offer a non-invasive way to track brain changes across the course of Huntington’s disease (HD). #hdresearch

Read all about it → en.hdbuzz.net/could-brain-...
September 10, 2026 at 1:01 PM
hdbuzzfeed.bsky.social
Five Huntington’s disease (HD) researchers discuss the cutting-edge techniques driving their work, accelerating discovery and guiding development of treatments. #hdresearch

Read all about it → en.hdbuzz.net/hot-techniqu...
Five research scientists compare notes. Title reads "Hot Techniques in HD Research: Five HD researches discuss the cutting-edge techniques driving their work." Scientist looks in a microscope. "From reading DNA molecule by molecule..." "... to visualizing proteins and neurons in remarkable detail," Man with a camera over the words, "these technologies are giving scientists an increasingly complete picture of how HD begins and progresses."
September 7, 2026 at 1:08 PM
hdbuzzfeed.bsky.social
What if Huntington’s disease (HD) changes how we “see” the world before we even notice symptoms? New research suggests visual thinking skills may help track HD progression.

en.hdbuzz.net/keeping-an-e...
September 3, 2026 at 1:05 PM
hdbuzzfeed.bsky.social
NEWS! uniQure has submitted AMT-130 for regulatory approval in the US and UK. This drug is NOT yet approved; regulators must now review the evidence. Read more about this milestone here -> uniqure.gcs-web.com/node/12991/pdf and on HDBuzz here -> en.hdbuzz.net/the-other-sh...
Graphics of a megaphone and arrow pointing to words: "Press Release: uniQure has submitted AMT-130 for regulatory approval in the US & UK"
September 2, 2026 at 10:40 PM
hdbuzzfeed.bsky.social
August was a busy month for Huntington’s disease (HD) research! Setbacks, new trials, a conference, and the HDBuzz Prize for Young Science Writers!

Catch up on everything in our monthly roundup: en.hdbuzz.net/august-2026-...
August 31, 2026 at 1:03 PM
hdbuzzfeed.bsky.social
A new Huntington's disease (HD) clinical trial has officially begun! It will test whether the drug pridopidine can slow the progression of HD.

For more details, read our article: en.hdbuzz.net/first-partic...
An "OPEN" sign on a door handle. Over it is the title "PRECISE-HD trial of pridopidine begins!" and the logo HDBuzz. Over a photo of medication pills is the text: "Analysis of a previous trial’s data suggested that people who were not taking antidopaminergic medications (ADMs) appeared to have greater benefit from pridopidine than those who were." Over a photo of medication pills is the text "PRECISE-HD is a new confirmatory trial specifically designed to test that hypothesis."
August 27, 2026 at 1:00 PM
Reposted by HDBuzz
hdfcures.bsky.social
Rachel Harding & Leora Fox from @hdbuzzfeed.bsky.social will join us on 9/9 to share the buzz from HDF’s recent HD2026 Symposium. They'll recap some of the exciting science from the meeting and hold a live Q&A.
Register Now: us06web.zoom.us/.../501.../W...
#curehd #HD2026 #researchspotlightwebinars
August 25, 2026 at 2:26 PM
Reposted by HDBuzz
andygates.bsky.social
If you've got stage 2 HD and want to do a science, here's a new Phase 1 study for a potential injectable therapy. They've got a cunning plan for getting treatments across the blood-brain barrier.
hdbuzzfeed.bsky.social HDBuzz @hdbuzzfeed.bsky.social · Aug 20
New Huntington’s disease (HD) trial begins! A Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development quiver.

More details here -> en.hdbuzz.net/a-shot-in-th...
HDBuzz logo plus the title "A shot in the arm for HTT lowering: INSIGHT trial begins!" Photo is of gloved hands administering a needle into a person's arm.
August 20, 2026 at 1:25 PM
hdbuzzfeed.bsky.social
New research points to HTT1a, a toxic shortened form of huntingtin (HTT), as a key driver of disease and a promising therapeutic target in Huntington’s disease (HD).

Read the full article here: en.hdbuzz.net/taking-a-sho...
Aerial photo of a car driving along a windy, gravel road through the forest. Title above the photo reads "Taking a Short Cut: New Routes to Huntingtin-Lowering Therapies" and below is the logo for HDBuzz.
August 24, 2026 at 1:11 PM
hdbuzzfeed.bsky.social
New Huntington’s disease (HD) trial begins! A Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development quiver.

More details here -> en.hdbuzz.net/a-shot-in-th...
HDBuzz logo plus the title "A shot in the arm for HTT lowering: INSIGHT trial begins!" Photo is of gloved hands administering a needle into a person's arm.
August 20, 2026 at 1:00 PM
Reposted by HDBuzz
jjlucaslab.bsky.social
Thanks, Leora Fox & Rachel Harding @hdbuzzfeed.bsky.social, for the excellent summary of my presentation at @hdfcures.bsky.social Meeting on the #HUNTIAM clinical trial (Thiamine+Biotin) for HD, including the evidence that originated it.
👇👇👇
en.hdbuzz.net/hd2026-milto...
@cbm-csic-uam.bsky.social
Thank you – HDBuzz
en.hdbuzz.net
August 20, 2026 at 12:02 PM
hdbuzzfeed.bsky.social
Announcing the 2026 HDBuzz Prize for Young Science Writers – sponsored by the Hereditary Disease Foundation! Submission details here:

en.hdbuzz.net/the-2026-hdb...
August 17, 2026 at 2:47 PM
hdbuzzfeed.bsky.social
Day 3 of #HD2026 put the huntingtin protein (HTT) under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT might help. Read our roundup here:

en.hdbuzz.net/hd2026-milto...
The final day of HD2026 put the huntingtin protein (HTT) under the microscope. Researchers shared: - new insights into HTT1a - next-generation HTT-lowering approaches - why boosting healthy HTT might help  And lots more!
August 14, 2026 at 3:14 PM
hdbuzzfeed.bsky.social
Day 2 #HD2026 - insights into the mechanics of somatic instability, new ways we can track Huntington’s disease (HD) in people over time, how AI can help us drive research forward, and new developments in our understanding of the HTT protein. Catch up on everything we learned on HDBuzz.net
August 13, 2026 at 4:44 PM
hdbuzzfeed.bsky.social
Welcome to Day 3 of the #HD2026 Milton Wexler Biennial Symposium, where HDBuzz is reporting live for this final day of talks. Morning sessions will focus on huntingtin (HTT), including a fragment of the expanded HTT protein that seems to be extra harmful.
August 13, 2026 at 1:06 PM
hdbuzzfeed.bsky.social
Day 1 of #HD2026 - From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, today’s talks spanned the spectrum from fundamental biology to potential treatments. Catch up on everything we learned right here.

en.hdbuzz.net/hd-2026-milt...
August 12, 2026 at 2:53 PM
hdbuzzfeed.bsky.social
We are back for Day 2 at #HD2026! This morning kicks off with talks focussed on HD genetics and how DNA repair machines might influence how symptoms start and then progress in people with HD.
August 12, 2026 at 1:05 PM
hdbuzzfeed.bsky.social
Good morning from Boston! We’re looking forward to bringing you live updates from Day 1 of #HD2026, a biannual conference hosted by the Huntington’s Disease Foundation (HDF) that brings together HD scientists and clinicians from around the world.
August 11, 2026 at 12:46 PM
hdbuzzfeed.bsky.social
Welcome to #HD2026! Held every other year in Boston, MA and organized by the Huntington’s Disease Foundation (HDF), this conference brings together almost 300 of the world-leading experts in Huntington’s disease (HD) and other CAG repeat diseases.
August 10, 2026 at 9:58 PM
hdbuzzfeed.bsky.social
Prilenia Therapeutics has donated data from two of its Huntington’s Disease (HD) clinical trials to CHDI Foundation, creating a valuable resource that researchers can use to better understand placebo effects, disease progression and future trial design.

en.hdbuzz.net/prilenia-sha...
Hands holding a box of files (presumably) to be shared. Title reads: "Prilenia shares HD trial data with CHDI to help future research." Underneath is the HDBuzz logo. Text reads: Although data sharing has become increasingly common across biomedical research, it has not always been routine, so this is an important step forward for the field. Text reads: Researchers will use the data to better understand placebo effects, disease progression and how to improve the design and interpretation of future clinical trials. Text reads: In a disease where every participant and every dataset is precious, this an important investment in the future of HD research.
August 6, 2026 at 1:11 PM
hdbuzzfeed.bsky.social
Roche's decision to stop development of two huntingtin-lowering programmes is disappointing, but the story doesn't end there. Years of research have answered some key questions, raised many new ones, and will inform the next generation of HD trials. Read about it here: en.hdbuzz.net/looking-back...
A road with arrows, one pointing forward and one back. Title words on screen: "Looking Back & Moving Forward - Four weeks after Roche announced two Huntington's disease programs were closing, questions remain..."
August 3, 2026 at 1:01 PM
hdbuzzfeed.bsky.social
July was a hard month for Huntington’s disease research, with Roche ending two HD programs. But the month also brought promising new tools to visualize and track huntingtin, and important studies on eating and self-awareness in HD.

Read the full recap: en.hdbuzz.net/july-2026-th...
July 2026 was a month of hard news and continuing progress. Image - arrows pointing up and down. Logo - HDBuzz Sketch of someone reading a newspaper that's on fire. On the firey side is "HARD NEWS" and the fire's out smoking side is "CONTINUING PROGRESS".
July 30, 2026 at 1:02 PM