Ishani Banerji
@ishanibanerji.bsky.social
🧑🔬Postdoc @University Hospital Heidelberg & @embl.org
🧑💻 Researcher fascinated with RNA
🧑🎓 Ph.D. @CSIR-IICB
✍️ Passionate about Science Comm
RNA | 3'UTRs | EVs | RBPs | Inherited metabolic disorders | Neuropediatrics | Zebrafish models
🧑💻 Researcher fascinated with RNA
🧑🎓 Ph.D. @CSIR-IICB
✍️ Passionate about Science Comm
RNA | 3'UTRs | EVs | RBPs | Inherited metabolic disorders | Neuropediatrics | Zebrafish models
Pinned
Ishani Banerji
@ishanibanerji.bsky.social
· Jan 28
Happy to receive my final Ph.D. degree certificate at the AcSIR Convocation, New Delhi.
#AcSIR #PhD #CSIR-IICB #Convocation #Biological #Science #RNA #Biology
#AcSIR #PhD #CSIR-IICB #Convocation #Biological #Science #RNA #Biology
July 10, 2026 at 12:15 PM
Reposted by Ishani Banerji
Excited to share the first pre-print from our lab!!
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
June 8, 2026 at 8:49 PM
Excited to share the first pre-print from our lab!!
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Highly interesting study. mRNA 3'UTRs are indeed the dark horses regulating gene expression.
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
www.cell.com
June 8, 2026 at 8:52 PM
Highly interesting study. mRNA 3'UTRs are indeed the dark horses regulating gene expression.
Reposted by Ishani Banerji
Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...
www.science.org
March 12, 2026 at 9:24 PM
Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
Reposted by Ishani Banerji
RNA-specific local translation is patterned by condensates for multinucleate cell growth
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology
Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...
www.nature.com
March 2, 2026 at 4:51 PM
RNA-specific local translation is patterned by condensates for multinucleate cell growth
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ishani Banerji
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
Redirecting
doi.org
February 25, 2026 at 4:02 PM
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
Reposted by Ishani Banerji
Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...
www.science.org
February 20, 2026 at 11:06 AM
Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Reposted by Ishani Banerji
I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration, #ALS #FTD #Ribosomes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes
GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation...
www.science.org
February 6, 2026 at 10:07 AM
I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration, #ALS #FTD #Ribosomes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Great work!
Delighted to share my PhD work with @schuhlab.bsky.social @mpi-nat.bsky.social on #humaneggrejuvenation, now available as a preprint on @biorxivpreprint.bsky.social 🎉
Grateful to my collaborators for the teamwork and support 🙌
More details here 👇
www.biorxiv.org/content/10.6...
#Aging #Aneuploidy
Grateful to my collaborators for the teamwork and support 🙌
More details here 👇
www.biorxiv.org/content/10.6...
#Aging #Aneuploidy
January 13, 2026 at 1:04 PM
Great work!
Reposted by Ishani Banerji
Honored that our work on rescuing age-dependent chromosome errors in human eggs was highlighted by @theguardian.com. 👇
Our work on improving human egg quality was featured in @theguardian.com.
We hope this will help to make #IVF more successful and allow more couples to conceive. 💜
We hope this will help to make #IVF more successful and allow more couples to conceive. 💜
Human eggs ‘rejuvenated’ in an advance that could boost IVF success rates
Exclusive: Research suggests supplementing eggs with a key protein reduces age-related defects, raising hopes of improved IVF for older women
www.theguardian.com
January 13, 2026 at 8:46 AM
Honored that our work on rescuing age-dependent chromosome errors in human eggs was highlighted by @theguardian.com. 👇
Reposted by Ishani Banerji
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature
Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...
www.nature.com
July 16, 2025 at 3:23 PM
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
Reposted by Ishani Banerji
Check out the latest study from our lab, led by @mhall98.bsky.social :
www.biorxiv.org/content/10.1... (1/2)
www.biorxiv.org/content/10.1... (1/2)
March 15, 2025 at 12:36 AM
Check out the latest study from our lab, led by @mhall98.bsky.social :
www.biorxiv.org/content/10.1... (1/2)
www.biorxiv.org/content/10.1... (1/2)
Reposted by Ishani Banerji
Excited to share our lab’s first review, focusing on RNA localization! #RNA #RNAlocalization genomebiology.biomedcentral.com/articles/10....
Decoding subcellular RNA localization one molecule at a time - Genome Biology
Eukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various bi...
genomebiology.biomedcentral.com
March 6, 2025 at 1:10 PM
Excited to share our lab’s first review, focusing on RNA localization! #RNA #RNAlocalization genomebiology.biomedcentral.com/articles/10....
Reposted by Ishani Banerji
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
go.nature.com
February 20, 2025 at 11:17 AM
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Single-molecule live-cell RNA imaging with CRISPR–Csm - @doudna-lab.bsky.social @qb3-berkeley.bsky.social @innovativegenomics.bsky.social go.nature.com/3EJPKsM
Single-molecule live-cell RNA imaging with CRISPR–Csm - Nature Biotechnology
Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs.
go.nature.com
February 19, 2025 at 7:12 AM
An interesting title capturing two intriguing studies. Biomolecular condensates: it was RNA all along!
#RNAsky #RNPcondensates
#RNAsky #RNPcondensates
Not sure if anyone posted this on BSky, but here is a 'condensate' (pun intended) of the latest #RNA granules papers 'en vogue':
www.cell.com/molecular-ce...
#RNAsky #RNAbiology #MolCondensates
www.cell.com/molecular-ce...
#RNAsky #RNAbiology #MolCondensates
Biomolecular condensates: It was RNA all along!
In this issue of Molecular Cell, Trussina et al. and Parker et al. present complementary
lines of evidence that suggest that stress granules regulate trans RNA-RNA interactions
through the action of h...
www.cell.com
February 14, 2025 at 9:31 AM
An interesting title capturing two intriguing studies. Biomolecular condensates: it was RNA all along!
#RNAsky #RNPcondensates
#RNAsky #RNPcondensates
Reposted by Ishani Banerji
Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic.
globalnews.ca/news/9793403...
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 5:38 PM
Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic.
globalnews.ca/news/9793403...
globalnews.ca/news/9793403...
Reposted by Ishani Banerji
Small RNAs - history. Now its small proteins, dark matter all around us!
www.nature.com/articles/d41...
www.nature.com/articles/d41...
‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases
The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.
www.nature.com
January 29, 2025 at 10:04 PM
Small RNAs - history. Now its small proteins, dark matter all around us!
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Happy to receive my final Ph.D. degree certificate at the AcSIR Convocation, New Delhi.
#AcSIR #PhD #CSIR-IICB #Convocation #Biological #Science #RNA #Biology
#AcSIR #PhD #CSIR-IICB #Convocation #Biological #Science #RNA #Biology
January 28, 2025 at 7:42 AM
Happy to receive my final Ph.D. degree certificate at the AcSIR Convocation, New Delhi.
#AcSIR #PhD #CSIR-IICB #Convocation #Biological #Science #RNA #Biology
#AcSIR #PhD #CSIR-IICB #Convocation #Biological #Science #RNA #Biology