Jake June-Koo Lee
@jakeleemd.bsky.social
Physician Scientist and Thoracic Oncologist at MSKCC | Historian of Cancer Genomes | Chromosome Biology | Therapy Resistance
1/n Have you ever wondered whether an amplified oncogene in a patient’s tumor (HER2/EGFR/CCND1/…) is carried on extrachromosomal DNA (ecDNA) vs embedded within a chromosome? Bulk WGS + genome graph can hint, but in practice it’s often hard to resolve. Here is our new preprint.
February 16, 2026 at 6:49 PM
1/n Have you ever wondered whether an amplified oncogene in a patient’s tumor (HER2/EGFR/CCND1/…) is carried on extrachromosomal DNA (ecDNA) vs embedded within a chromosome? Bulk WGS + genome graph can hint, but in practice it’s often hard to resolve. Here is our new preprint.
Today marks a meaningful milestone -- I am starting as a lab investigator and thoracic oncologist at MSKCC, focused on improving treatment through a deep understanding of cancer evolution. I will soon be looking for fellow travelers on this mission. Stay tuned!
July 1, 2025 at 9:09 PM
Today marks a meaningful milestone -- I am starting as a lab investigator and thoracic oncologist at MSKCC, focused on improving treatment through a deep understanding of cancer evolution. I will soon be looking for fellow travelers on this mission. Stay tuned!
Reposted by Jake June-Koo Lee
Harold Varmus on science policy today www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 14, 2025 at 10:43 PM
Harold Varmus on science policy today www.nytimes.com/2025/02/14/o...
An amazing work utilizing Cre-LoxP system creating oncogene amplification by ecDNA. Fascinating parallels with human liposarcomagenesis. Huge congratulations to the Ventura lab and the whole team!
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 6:33 PM
An amazing work utilizing Cre-LoxP system creating oncogene amplification by ecDNA. Fascinating parallels with human liposarcomagenesis. Huge congratulations to the Ventura lab and the whole team!