James Nathan
@jamesnathanlab.bsky.social
Professor of Respiratory Medicine, University of Cambridge.
Cellular mechanisms of oxygen sensing and metabolism.
https://jamesnathanlab.co.uk/
Cellular mechanisms of oxygen sensing and metabolism.
https://jamesnathanlab.co.uk/
Secure your place at Redox – The Good, The Bad and The Unexpected by the super earlybird deadline of 16 August to save £100! Featuring an international lineup of redox experts, a publishing panel, networking opportunities and more, browse the exciting programme so far 🧪 bit.ly/Redox-26
Redox – The Good, The Bad and The Unexpected
bit.ly
August 14, 2026 at 10:26 AM
Secure your place at Redox – The Good, The Bad and The Unexpected by the super earlybird deadline of 16 August to save £100! Featuring an international lineup of redox experts, a publishing panel, networking opportunities and more, browse the exciting programme so far 🧪 bit.ly/Redox-26
Reposted by James Nathan
Secure your place at Redox – The Good, The Bad and The Unexpected by the super earlybird deadline of 16 August to save £100! Featuring an international lineup of redox experts, a publishing panel, networking opportunities and more, browse the exciting programme so far 🧪 bit.ly/Redox-26
August 12, 2026 at 8:12 AM
Secure your place at Redox – The Good, The Bad and The Unexpected by the super earlybird deadline of 16 August to save £100! Featuring an international lineup of redox experts, a publishing panel, networking opportunities and more, browse the exciting programme so far 🧪 bit.ly/Redox-26
Reposted by James Nathan
🔬 Respiratory Mechanisms of Disease (RC49887)
Join @jamesnathanlab.bsky.social at #CITIID & @mitogene.bsky.social @mrc-mbu.bsky.social to investigate how mitochondrial dysfunction and mtDNA damage drive innate immune activation and contribute to COPD.
📅 Closing date: 5 July 2026
🔗 buff.ly/ujQDD8l
Join @jamesnathanlab.bsky.social at #CITIID & @mitogene.bsky.social @mrc-mbu.bsky.social to investigate how mitochondrial dysfunction and mtDNA damage drive innate immune activation and contribute to COPD.
📅 Closing date: 5 July 2026
🔗 buff.ly/ujQDD8l
CG-TIC Postdoctoral Research Associate (Fixed Term)
We are seeking an experienced and motivated researcher to work on a Cambridge-GSK Translational Immunology Collaboration (CG-TIC) project. CG-TIC is a new translational initiative between Cambridge…
buff.ly
June 10, 2026 at 10:00 AM
🔬 Respiratory Mechanisms of Disease (RC49887)
Join @jamesnathanlab.bsky.social at #CITIID & @mitogene.bsky.social @mrc-mbu.bsky.social to investigate how mitochondrial dysfunction and mtDNA damage drive innate immune activation and contribute to COPD.
📅 Closing date: 5 July 2026
🔗 buff.ly/ujQDD8l
Join @jamesnathanlab.bsky.social at #CITIID & @mitogene.bsky.social @mrc-mbu.bsky.social to investigate how mitochondrial dysfunction and mtDNA damage drive innate immune activation and contribute to COPD.
📅 Closing date: 5 July 2026
🔗 buff.ly/ujQDD8l
Reposted by James Nathan
Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
www.nature.com
May 21, 2026 at 12:14 AM
Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
Reposted by James Nathan
📍 Registration is now open for this #Redox #BiochemicalSociety Meeting! Excellent invited speakers, plus many slots for elevated talks from abstracts, including #ECRs 🫵
🌍 Cambridge, UK
🗓️ 16-18 Nov 2026
⏳ Super early bird deadline: 16 Aug 2026
🌐 bit.ly/Redox-26
#BiochemEvent
@biochemsoc.bsky.social
🌍 Cambridge, UK
🗓️ 16-18 Nov 2026
⏳ Super early bird deadline: 16 Aug 2026
🌐 bit.ly/Redox-26
#BiochemEvent
@biochemsoc.bsky.social
May 14, 2026 at 11:37 PM
📍 Registration is now open for this #Redox #BiochemicalSociety Meeting! Excellent invited speakers, plus many slots for elevated talks from abstracts, including #ECRs 🫵
🌍 Cambridge, UK
🗓️ 16-18 Nov 2026
⏳ Super early bird deadline: 16 Aug 2026
🌐 bit.ly/Redox-26
#BiochemEvent
@biochemsoc.bsky.social
🌍 Cambridge, UK
🗓️ 16-18 Nov 2026
⏳ Super early bird deadline: 16 Aug 2026
🌐 bit.ly/Redox-26
#BiochemEvent
@biochemsoc.bsky.social
Congratulations Qing and Team on this exciting work www.jci.org/articles/vie...
JCI -
Genome-wide CRISPR screen identifies a cytokine–enhancer circuit driving HIF-2α activation in renal cancer
www.jci.org
March 25, 2026 at 1:05 PM
Congratulations Qing and Team on this exciting work www.jci.org/articles/vie...
Delighted to share the 'early access' version of our work examining genetic dependencies with VHL loss in ccRCC. Led by James Bertlin. Thanks to our wonderful collaborators Qing Zhang, Annie Speak, Tom Mitchell. Presenting the work today at #AACRkidney26 www.nature.com/articles/s41...
VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING - Nature Communications
Biallelic inactivation of the VHL tumour suppressor gene is a hallmark of Clear cell renal cell carcinoma (ccRCC). Here the authors perform genome-wide CRISPR/Cas9 screening to identify that loss of C...
www.nature.com
March 15, 2026 at 11:12 AM
Delighted to share the 'early access' version of our work examining genetic dependencies with VHL loss in ccRCC. Led by James Bertlin. Thanks to our wonderful collaborators Qing Zhang, Annie Speak, Tom Mitchell. Presenting the work today at #AACRkidney26 www.nature.com/articles/s41...
Reposted by James Nathan
VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 13, 2026 at 2:38 AM
VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congratulations Manu, Sarah and Team! Enjoyed contributing to this work www.nature.com/articles/s41...
October 29, 2025 at 2:09 PM
Congratulations Manu, Sarah and Team! Enjoyed contributing to this work www.nature.com/articles/s41...
Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab @jellevda.bsky.social , we developed DamMapper damid-seq.readthedocs.io/en/latest/, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy. rdcu.be/eK2TS
Mapping SET1B chromatin interactions with DamID using DamMapper, a comprehensive Snakemake workflow
rdcu.be
October 15, 2025 at 10:10 AM
Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab @jellevda.bsky.social , we developed DamMapper damid-seq.readthedocs.io/en/latest/, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy. rdcu.be/eK2TS
Reposted by James Nathan
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
October 11, 2025 at 8:22 AM
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
Reposted by James Nathan
Congrats to #ListerFellow @jamesnathanlab.bsky.social and team on this tremendous paper in Science Advances exploring iron flux and metabolism. "Potentially explaining how some tumors evade antitumoral immunity."
Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.
Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux
Genetic screens using endogenous reporters map key modulators of cellular iron, including the transcriptional regulator SETD2.
www.science.org
September 22, 2025 at 1:02 PM
Congrats to #ListerFellow @jamesnathanlab.bsky.social and team on this tremendous paper in Science Advances exploring iron flux and metabolism. "Potentially explaining how some tumors evade antitumoral immunity."
Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.
Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux
Genetic screens using endogenous reporters map key modulators of cellular iron, including the transcriptional regulator SETD2.
www.science.org
September 18, 2025 at 7:02 PM
Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.
Reposted by James Nathan
"The Lister... spans an incredible breadth of science, giving access to world-leading experts in fields far from my own." @jamesnathanlab.bsky.social
James and other #ListerFellows reflect on surprise discoveries and following their curiosity. #ListerPrize
👉 lister-institute.org.uk/curiosity-at...
James and other #ListerFellows reflect on surprise discoveries and following their curiosity. #ListerPrize
👉 lister-institute.org.uk/curiosity-at...
August 21, 2025 at 10:35 AM
"The Lister... spans an incredible breadth of science, giving access to world-leading experts in fields far from my own." @jamesnathanlab.bsky.social
James and other #ListerFellows reflect on surprise discoveries and following their curiosity. #ListerPrize
👉 lister-institute.org.uk/curiosity-at...
James and other #ListerFellows reflect on surprise discoveries and following their curiosity. #ListerPrize
👉 lister-institute.org.uk/curiosity-at...
Reposted by James Nathan
🧬 New in @natchembio.nature.com :
Researchers at #CITIID @cam.ac.uk & @ki.se identified #ABHD11 – a key enzyme that controls cellular energy production & immune response. Learn more: buff.ly/ZdOAdLe
@hudsonwilco.bsky.social @jamesnathanlab.bsky.social
Researchers at #CITIID @cam.ac.uk & @ki.se identified #ABHD11 – a key enzyme that controls cellular energy production & immune response. Learn more: buff.ly/ZdOAdLe
@hudsonwilco.bsky.social @jamesnathanlab.bsky.social
New study reveals key enzyme to control cellular energy production and immune function | Cambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID)
Uncovering ABHD11 as a key metabolic regulator could lead to new treatments for cancer, autoimmune diseases, and metabolic disorders.
buff.ly
July 15, 2025 at 10:12 AM
🧬 New in @natchembio.nature.com :
Researchers at #CITIID @cam.ac.uk & @ki.se identified #ABHD11 – a key enzyme that controls cellular energy production & immune response. Learn more: buff.ly/ZdOAdLe
@hudsonwilco.bsky.social @jamesnathanlab.bsky.social
Researchers at #CITIID @cam.ac.uk & @ki.se identified #ABHD11 – a key enzyme that controls cellular energy production & immune response. Learn more: buff.ly/ZdOAdLe
@hudsonwilco.bsky.social @jamesnathanlab.bsky.social
Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism
Nature Chemical Biology - Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a...
rdcu.be
July 15, 2025 at 4:12 PM
Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.
Reposted by James Nathan
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis - Nature
Nature - Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
www.nature.com
April 16, 2025 at 5:44 PM
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by James Nathan
🚨 New paper alert! 🚨
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social
Redirecting
doi.org
February 17, 2025 at 11:53 PM
🚨 New paper alert! 🚨
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social
Having just joined bsky, thought it would be good to share our latest review and a couple of recent preprints from the group. First our review on the roles of deubiquitinating enzymes in hypoxia responses. portlandpress.com/biochemsoctr...
A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway
Hypoxia Inducible transcription Factors (HIFs) are central to the metazoan oxygen-sensing response. Under low oxygen conditions (hypoxia), HIFs are stabilised and govern an adaptive transcriptional pr...
portlandpress.com
November 27, 2024 at 2:23 PM
Having just joined bsky, thought it would be good to share our latest review and a couple of recent preprints from the group. First our review on the roles of deubiquitinating enzymes in hypoxia responses. portlandpress.com/biochemsoctr...
Reposted by James Nathan
People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.
a bald man in a blue suit is making a funny face and pointing at something .
ALT: a bald man in a blue suit is making a funny face and pointing at something .
media.tenor.com
November 13, 2024 at 7:24 PM
People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.