Jerome Epsztein
@jeromeepsztein.bsky.social
Neurobiologist interested in spatial cognition and navigation
Research director at INSERM
Team leader "Neuronal mechanisms of spatial cognition" at INMED in Marseille
Research director at INSERM
Team leader "Neuronal mechanisms of spatial cognition" at INMED in Marseille
Pinned
Happy to share our new paper with Mathilde Nordlund and Julie Koenig out @currentbiology.bsky.social. We used virtual reality in mice to study hippocampal distance coding. Our results suggest a primary contribution of grid cells to distance over cue-dependent place cell coding.
shorturl.at/63yFo
shorturl.at/63yFo
Reposted by Jerome Epsztein
Hi friends & colleagues! I’m on the hunt for a tenure-track home! I’m a BRAIN Initiative K99/R00 scholar studying learning & memory at the intersection of experimental neuroscience, theory, & machine learning/AI. I’d love to connect & would appreciate help spreading the word! web.mit.edu/hsw/www/
September 15, 2026 at 8:11 PM
Hi friends & colleagues! I’m on the hunt for a tenure-track home! I’m a BRAIN Initiative K99/R00 scholar studying learning & memory at the intersection of experimental neuroscience, theory, & machine learning/AI. I’d love to connect & would appreciate help spreading the word! web.mit.edu/hsw/www/
Reposted by Jerome Epsztein
doi.org/10.1038/s415...
doi.org/10.1016/j.ce...
Correlated Neural Activity across the Brains of Socially Interacting Bats
doi.org/10.1016/j.ce...
Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals
doi.org/10.1016/j.ce...
Correlated Neural Activity across the Brains of Socially Interacting Bats
doi.org/10.1016/j.ce...
Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals
https://doi.org/10.1038/s42003…
September 13, 2026 at 5:26 PM
doi.org/10.1038/s415...
doi.org/10.1016/j.ce...
Correlated Neural Activity across the Brains of Socially Interacting Bats
doi.org/10.1016/j.ce...
Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals
doi.org/10.1016/j.ce...
Correlated Neural Activity across the Brains of Socially Interacting Bats
doi.org/10.1016/j.ce...
Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals
Reposted by Jerome Epsztein
@sppin-cnrs.bsky.social @cnrs.fr is organizing #NeuralNet2026 in Paris on Nov. 25–27 !
Join the 15th annual meeting of GDR NeuralNet @upcite.bsky.social , bringing together researchers working across systems neuroscience, neural data, computational modeling, NeuroAI & data science.
Join the 15th annual meeting of GDR NeuralNet @upcite.bsky.social , bringing together researchers working across systems neuroscience, neural data, computational modeling, NeuroAI & data science.
September 11, 2026 at 10:52 AM
@sppin-cnrs.bsky.social @cnrs.fr is organizing #NeuralNet2026 in Paris on Nov. 25–27 !
Join the 15th annual meeting of GDR NeuralNet @upcite.bsky.social , bringing together researchers working across systems neuroscience, neural data, computational modeling, NeuroAI & data science.
Join the 15th annual meeting of GDR NeuralNet @upcite.bsky.social , bringing together researchers working across systems neuroscience, neural data, computational modeling, NeuroAI & data science.
Reposted by Jerome Epsztein
Reposted by Jerome Epsztein
Hearing hippocampal ripples: Event-faithful, reproducible sonification of multineuronal spiking with hierarchy-guided orchestration https://www.biorxiv.org/content/10.64898/2026.09.05.749637v1
September 9, 2026 at 8:16 PM
Hearing hippocampal ripples: Event-faithful, reproducible sonification of multineuronal spiking with hierarchy-guided orchestration https://www.biorxiv.org/content/10.64898/2026.09.05.749637v1
Reposted by Jerome Epsztein
Prestigious, fully funded, 3 yearlong postdoctoral fellowship ($90,000/year salary plus benefits) in neural computation and NeuroAI is available starting October 2027. The Candidate must have a very strong CV, including empirical publications. See our lab's page for our research directions.
September 8, 2026 at 5:40 PM
Prestigious, fully funded, 3 yearlong postdoctoral fellowship ($90,000/year salary plus benefits) in neural computation and NeuroAI is available starting October 2027. The Candidate must have a very strong CV, including empirical publications. See our lab's page for our research directions.
Reposted by Jerome Epsztein
Ma contribution aux assises pour l'Université et pour la Recherche (3-4/9/2026), concernant le financement de la recherche.
romainbrette.fr/pour-un-fina...
romainbrette.fr/pour-un-fina...
Pour un financement collégial, non bureaucratique de la recherche
Ce texte est ma courte contribution aux assises pour l’Université et pour la Recherche (3-4/9/2026), concernant le financement de la recherche. La recherche repose sur deux principes indissoc…
romainbrette.fr
September 2, 2026 at 3:13 PM
Ma contribution aux assises pour l'Université et pour la Recherche (3-4/9/2026), concernant le financement de la recherche.
romainbrette.fr/pour-un-fina...
romainbrette.fr/pour-un-fina...
Reposted by Jerome Epsztein
I’m very excited to share our new paper, led by the very talented Jack Bowler, a postdoc in the lab!
www.nature.com/articles/s41...
We all know that the way we learn something matters. But how does a training curriculum actually shape how the brain learns to solve a problem? a 🧵 1/N
www.nature.com/articles/s41...
We all know that the way we learn something matters. But how does a training curriculum actually shape how the brain learns to solve a problem? a 🧵 1/N
Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex - Nature Neuroscience
The authors use recurrent neural networks to predict how structured prior experience shapes neural dynamics as mice learn flexible timing strategies during complex context-dependent behavior.
www.nature.com
September 3, 2026 at 3:08 PM
I’m very excited to share our new paper, led by the very talented Jack Bowler, a postdoc in the lab!
www.nature.com/articles/s41...
We all know that the way we learn something matters. But how does a training curriculum actually shape how the brain learns to solve a problem? a 🧵 1/N
www.nature.com/articles/s41...
We all know that the way we learn something matters. But how does a training curriculum actually shape how the brain learns to solve a problem? a 🧵 1/N
Reposted by Jerome Epsztein
Very excited to see this out — real teamwork, led by @laurenb29.bsky.social & Will de Cothi with @lgiocomo.bsky.social, @colinlever.bsky.social, Laurenz Muessig, Fábio Rodrigues, Francesca Cacucci, Tom Wills, Yanjun Sun & Steven Poulter. In Nature Comms:
www.nature.com/articles/s41467-026-76686-y
www.nature.com/articles/s41467-026-76686-y
September 1, 2026 at 8:35 AM
Very excited to see this out — real teamwork, led by @laurenb29.bsky.social & Will de Cothi with @lgiocomo.bsky.social, @colinlever.bsky.social, Laurenz Muessig, Fábio Rodrigues, Francesca Cacucci, Tom Wills, Yanjun Sun & Steven Poulter. In Nature Comms:
www.nature.com/articles/s41467-026-76686-y
www.nature.com/articles/s41467-026-76686-y
Reposted by Jerome Epsztein
New paper from the lab! In this project we identified different ripple types and link them to behavior and other sleep oscillations doi.org/10.1093/slee...
September 1, 2026 at 10:51 AM
New paper from the lab! In this project we identified different ripple types and link them to behavior and other sleep oscillations doi.org/10.1093/slee...
Reposted by Jerome Epsztein
September 1, 2026 at 7:47 PM
Reposted by Jerome Epsztein
With profound sadness we announce the passing of our colleague and friend Antoine de Chevigny, an expert in cortical development respected for his creativity and curiosity and cherished for his kindness and joie de vivre. He leaves an immense void.
Support for his partner: tinyurl.com/2yrh7huc
Support for his partner: tinyurl.com/2yrh7huc
August 27, 2026 at 9:24 AM
With profound sadness we announce the passing of our colleague and friend Antoine de Chevigny, an expert in cortical development respected for his creativity and curiosity and cherished for his kindness and joie de vivre. He leaves an immense void.
Support for his partner: tinyurl.com/2yrh7huc
Support for his partner: tinyurl.com/2yrh7huc
Reposted by Jerome Epsztein
preprint🚨 ✨A Stickiness Response System in Rats
tinyurl.com/4wnu88v9
What underlies that sticky, icky feeling? Sticky sensing is surprisingly underexplored. we investigated its neural and behavioural basis
Congrats to Sandra, @simonerencken.bsky.social @jasmine-stone.bsky.social Adam, Tom & Pam! 👏
tinyurl.com/4wnu88v9
What underlies that sticky, icky feeling? Sticky sensing is surprisingly underexplored. we investigated its neural and behavioural basis
Congrats to Sandra, @simonerencken.bsky.social @jasmine-stone.bsky.social Adam, Tom & Pam! 👏
August 12, 2026 at 4:31 PM
preprint🚨 ✨A Stickiness Response System in Rats
tinyurl.com/4wnu88v9
What underlies that sticky, icky feeling? Sticky sensing is surprisingly underexplored. we investigated its neural and behavioural basis
Congrats to Sandra, @simonerencken.bsky.social @jasmine-stone.bsky.social Adam, Tom & Pam! 👏
tinyurl.com/4wnu88v9
What underlies that sticky, icky feeling? Sticky sensing is surprisingly underexplored. we investigated its neural and behavioural basis
Congrats to Sandra, @simonerencken.bsky.social @jasmine-stone.bsky.social Adam, Tom & Pam! 👏
Reposted by Jerome Epsztein
New preprint from the lab!
Behavioral and neural mechanisms for stochastic choices in mixed-strategy games:
doi.org/10.64898/202...
We use game theoretic tasks, cross species comparisons, modelling strategies, and mesoscale imaging to reveal a cortical mechanism for unpredictable choices.
Behavioral and neural mechanisms for stochastic choices in mixed-strategy games:
doi.org/10.64898/202...
We use game theoretic tasks, cross species comparisons, modelling strategies, and mesoscale imaging to reveal a cortical mechanism for unpredictable choices.
doi.org
August 6, 2026 at 7:15 PM
New preprint from the lab!
Behavioral and neural mechanisms for stochastic choices in mixed-strategy games:
doi.org/10.64898/202...
We use game theoretic tasks, cross species comparisons, modelling strategies, and mesoscale imaging to reveal a cortical mechanism for unpredictable choices.
Behavioral and neural mechanisms for stochastic choices in mixed-strategy games:
doi.org/10.64898/202...
We use game theoretic tasks, cross species comparisons, modelling strategies, and mesoscale imaging to reveal a cortical mechanism for unpredictable choices.
Reposted by Jerome Epsztein
🎉 this paper is now out - we show how subicular plateaus are linked to reward locations. Congratulations to the whole team! www.cell.com/cell-reports...
August 5, 2026 at 10:51 PM
🎉 this paper is now out - we show how subicular plateaus are linked to reward locations. Congratulations to the whole team! www.cell.com/cell-reports...
Reposted by Jerome Epsztein
This was a super team project with Rebecca Morse-Mora, the Peter Jonas lab and scientific services at @istaresearch.bsky.social, enabled by our fantastic collaboration with Prof. Karl Rössler at the @meduniwien.ac.at. We still have a lot to learn about hippocampal function and #humancircuits!! 🔎
Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans
Associational memory is critically dependent on the CA3 recurrent circuit, at the centre of the hippocampal system. While diversity amongst CA3 pyramidal neurons (PNs) has been long reported, the prin...
doi.org
July 11, 2026 at 12:41 PM
This was a super team project with Rebecca Morse-Mora, the Peter Jonas lab and scientific services at @istaresearch.bsky.social, enabled by our fantastic collaboration with Prof. Karl Rössler at the @meduniwien.ac.at. We still have a lot to learn about hippocampal function and #humancircuits!! 🔎
Reposted by Jerome Epsztein
Very happy to share our new review on visual computation in the cephalopod brain, with @vangeliqueallen.bsky.social, out now! We discuss exciting recent advances in understanding how the radically different brain of cephalopods processes the visual scene. 🐙🔬👀
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
August 3, 2026 at 3:35 PM
Very happy to share our new review on visual computation in the cephalopod brain, with @vangeliqueallen.bsky.social, out now! We discuss exciting recent advances in understanding how the radically different brain of cephalopods processes the visual scene. 🐙🔬👀
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jerome Epsztein
***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social
Generative replay across hippocampal-neocortical circuits
To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...
www.biorxiv.org
July 28, 2026 at 2:10 PM
***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social
Prior experience dynamically determines differential cue weighting in the medial entorhinal cortex
July 23, 2026 at 10:11 AM
Prior experience dynamically determines differential cue weighting in the medial entorhinal cortex
Reposted by Jerome Epsztein
We wrote a French digest for médecine/sciences about our recent work in Nat. Neuro with @nicolasguyon.bsky.social
Original work: www.nature.com/articles/s41...
French piece:
www.medecinesciences.org/fr/articles/...
Original work: www.nature.com/articles/s41...
French piece:
www.medecinesciences.org/fr/articles/...
Comment redessiner la carte du cerveau en écoutant les neurones un par un ? | médecine/sciences
médecine/sciences (M/S), revue internationale dans le domaine de la recherche biologique, médicale et en santé
www.medecinesciences.org
July 20, 2026 at 7:29 PM
We wrote a French digest for médecine/sciences about our recent work in Nat. Neuro with @nicolasguyon.bsky.social
Original work: www.nature.com/articles/s41...
French piece:
www.medecinesciences.org/fr/articles/...
Original work: www.nature.com/articles/s41...
French piece:
www.medecinesciences.org/fr/articles/...
Reposted by Jerome Epsztein
Help needed!
I'm part of a team tasked with creating a 2nd year undergraduate module/course "Computational Skills for Psychologists"
Its remit is the fundamentals of coding and good practice.
Any advice from others who've done similar courses?
(Assume no programming knowledge. Assume Python)
I'm part of a team tasked with creating a 2nd year undergraduate module/course "Computational Skills for Psychologists"
Its remit is the fundamentals of coding and good practice.
Any advice from others who've done similar courses?
(Assume no programming knowledge. Assume Python)
July 17, 2026 at 10:48 AM
Help needed!
I'm part of a team tasked with creating a 2nd year undergraduate module/course "Computational Skills for Psychologists"
Its remit is the fundamentals of coding and good practice.
Any advice from others who've done similar courses?
(Assume no programming knowledge. Assume Python)
I'm part of a team tasked with creating a 2nd year undergraduate module/course "Computational Skills for Psychologists"
Its remit is the fundamentals of coding and good practice.
Any advice from others who've done similar courses?
(Assume no programming knowledge. Assume Python)
Reposted by Jerome Epsztein
A neat description of @agnesland.bsky.social 's discovery. (I wish I could write as clearly as @ericaklarreich.bsky.social)
Neuroscientists have long wondered exactly how brain activity relates to blood flow. A new paper from the Simons Collaboration on the Global Brain suggests the answer lies in a hidden balance between two opposing groups of neurons.
Read more: https://bit.ly/3QX90to
#science #neuroscience
Read more: https://bit.ly/3QX90to
#science #neuroscience
July 20, 2026 at 7:46 AM
A neat description of @agnesland.bsky.social 's discovery. (I wish I could write as clearly as @ericaklarreich.bsky.social)
Reposted by Jerome Epsztein
Is space & time coding in entorhinal cortex interchangeable?
Cells switching between space & time as needed by task?
For some cells yes, and other no:
Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex
www.biorxiv.org/content/10.6...
Cells switching between space & time as needed by task?
For some cells yes, and other no:
Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex
www.biorxiv.org/content/10.6...
www.biorxiv.org
July 16, 2026 at 8:26 PM
Is space & time coding in entorhinal cortex interchangeable?
Cells switching between space & time as needed by task?
For some cells yes, and other no:
Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex
www.biorxiv.org/content/10.6...
Cells switching between space & time as needed by task?
For some cells yes, and other no:
Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex
www.biorxiv.org/content/10.6...
Reposted by Jerome Epsztein
The latest result from a fun ongoing collaboration!
@mbeyeler.bsky.social @michaelgoard.bsky.social @spencerlaveresmith.bsky.social
@mbeyeler.bsky.social @michaelgoard.bsky.social @spencerlaveresmith.bsky.social
Ecological Visual Processing
in the Mouse - with @michaelgoard.bsky.social @crisniell.bsky.social @mbeyeler.bsky.social Visual computations that are engaged in ecological contexts: active sensing, motion processing, scene analysis, distance estimation, and spatial perception. doi.org/10.1146/annu...
in the Mouse - with @michaelgoard.bsky.social @crisniell.bsky.social @mbeyeler.bsky.social Visual computations that are engaged in ecological contexts: active sensing, motion processing, scene analysis, distance estimation, and spatial perception. doi.org/10.1146/annu...
July 13, 2026 at 4:00 PM
The latest result from a fun ongoing collaboration!
@mbeyeler.bsky.social @michaelgoard.bsky.social @spencerlaveresmith.bsky.social
@mbeyeler.bsky.social @michaelgoard.bsky.social @spencerlaveresmith.bsky.social
Reposted by Jerome Epsztein
Thank you Natalia Mesa at the @thetransmitter.bsky.social for highlighting our labs preprint on synaptic mechanisms of head direction learning!! 🪰🧭
Work from @markplitt.bsky.social in my lab in collaboration with the Jayaraman lab!
www.thetransmitter.org/learning-and...
Work from @markplitt.bsky.social in my lab in collaboration with the Jayaraman lab!
www.thetransmitter.org/learning-and...
Unique learning mechanism drives navigation in fruit flies
The neuromodulator octopamine, the insect counterpart to norepinephrine, helps flies get their bearings in an unfamiliar environment.
www.thetransmitter.org
July 7, 2026 at 2:56 PM
Thank you Natalia Mesa at the @thetransmitter.bsky.social for highlighting our labs preprint on synaptic mechanisms of head direction learning!! 🪰🧭
Work from @markplitt.bsky.social in my lab in collaboration with the Jayaraman lab!
www.thetransmitter.org/learning-and...
Work from @markplitt.bsky.social in my lab in collaboration with the Jayaraman lab!
www.thetransmitter.org/learning-and...