Julie Charlton
@juliecharlton.bsky.social
Postdoc in the Brody lab at Princeton. Trying to understand how multiple brain regions coordinate to make decisions
I never lose, I either win or I learn. Washington Square Park
September 21, 2026 at 1:34 PM
I never lose, I either win or I learn. Washington Square Park
Apparently having a PhD doesn't mean you're allowed to call your doctors by their first names :/
August 1, 2026 at 2:20 PM
Apparently having a PhD doesn't mean you're allowed to call your doctors by their first names :/
Reposted by Julie Charlton
How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)
Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience
Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...
www.nature.com
July 30, 2026 at 4:09 PM
How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)
Reposted by Julie Charlton
New preprint from @nienborglab.bsky.social. Led by the extremely talented postbacc, Sriram Thothathri.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Decoupling Choice from Motor Response Reduces Choice-History Effects
Perception and action form a loop as an organism interacts with its environment. Here, we probe the interdependence between the two in the context of choice-history effects, the tendency of past choic...
www.biorxiv.org
July 11, 2026 at 9:07 PM
New preprint from @nienborglab.bsky.social. Led by the extremely talented postbacc, Sriram Thothathri.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Julie Charlton
LC influences OFC probablistic learning www.pnas.org/doi/10.1073/...
Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning | PNAS
Adaptive decision-making in dynamic environments requires flexible adjustment of learning
speed to balance stability and flexibility. When outcomes...
www.pnas.org
July 16, 2026 at 6:16 AM
LC influences OFC probablistic learning www.pnas.org/doi/10.1073/...
Reposted by Julie Charlton
One of the things that perplexes me most about human memory is how we can recall distant events with sustained effort. Sometimes it can take minutes, hours or several days of dwelling on episodes in the past before a vivid memory appears that was manifestly there all along. We don't seem to have
June 12, 2026 at 9:44 PM
One of the things that perplexes me most about human memory is how we can recall distant events with sustained effort. Sometimes it can take minutes, hours or several days of dwelling on episodes in the past before a vivid memory appears that was manifestly there all along. We don't seem to have
After living in Philadelphia for almost 3 years, it make SO much sense to me that David Lynch said it was his biggest influence. In 1987 he said "there was so much fear and crime that just for a moment there was an opening to another world"
May 13, 2026 at 3:01 PM
After living in Philadelphia for almost 3 years, it make SO much sense to me that David Lynch said it was his biggest influence. In 1987 he said "there was so much fear and crime that just for a moment there was an opening to another world"
Reposted by Julie Charlton
Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...
Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey - Scientific Data
Scientific Data - Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey
www.nature.com
April 4, 2026 at 3:57 PM
Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...
Reposted by Julie Charlton
Super, super interesting work by @kathaschmack.bsky.social on a neuroimmune model of psychosis! 👏
🥁🎉The Psychosis Collective proudly presents our first preprint
𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞
𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴
starring Le He & Harriet Feldman
www.biorxiv.org/content/10.6...
We wanted to understand how antipsychotics work. Thread🧵
𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞
𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴
starring Le He & Harriet Feldman
www.biorxiv.org/content/10.6...
We wanted to understand how antipsychotics work. Thread🧵
April 1, 2026 at 12:23 AM
Super, super interesting work by @kathaschmack.bsky.social on a neuroimmune model of psychosis! 👏
Reposted by Julie Charlton
I’m excited to share my newest work with @benhayden.bsky.social, and the work I’m most proud of to date, on characterizing semantic coding in single-neuron hippocampal activity in patients with autism during natural language comprehension!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
March 20, 2026 at 6:58 PM
I’m excited to share my newest work with @benhayden.bsky.social, and the work I’m most proud of to date, on characterizing semantic coding in single-neuron hippocampal activity in patients with autism during natural language comprehension!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Julie Charlton
New preprint: our lab’s first Alzheimer’s paper! “Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease”
www.biorxiv.org/content/10.6... 🧪🧵1/
www.biorxiv.org/content/10.6... 🧪🧵1/
March 20, 2026 at 5:05 PM
New preprint: our lab’s first Alzheimer’s paper! “Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease”
www.biorxiv.org/content/10.6... 🧪🧵1/
www.biorxiv.org/content/10.6... 🧪🧵1/
Reposted by Julie Charlton
The basal ganglia output is often framed as a motor gate: corticostriatal circuits select an action, then GPi/SNr-thalamus helps release it. In humans, we find this same pathway carries cognitive variables embedded in movement signals—and even produces learning-relevant signals after feedback. 1/10
biorxiv.org
February 12, 2026 at 5:43 PM
The basal ganglia output is often framed as a motor gate: corticostriatal circuits select an action, then GPi/SNr-thalamus helps release it. In humans, we find this same pathway carries cognitive variables embedded in movement signals—and even produces learning-relevant signals after feedback. 1/10
Reposted by Julie Charlton
Wow are they fortunate to have Daphna Shohamy at the helm - selecting her was a wise move (and I do hope they appreciate her for it).
Looking for your next Director of a Fancy Thing? Pick a Daphna.
www.columbiaspectator.com/news/2023/04...
Looking for your next Director of a Fancy Thing? Pick a Daphna.
www.columbiaspectator.com/news/2023/04...
February 25, 2026 at 8:13 AM
Wow are they fortunate to have Daphna Shohamy at the helm - selecting her was a wise move (and I do hope they appreciate her for it).
Looking for your next Director of a Fancy Thing? Pick a Daphna.
www.columbiaspectator.com/news/2023/04...
Looking for your next Director of a Fancy Thing? Pick a Daphna.
www.columbiaspectator.com/news/2023/04...
Reposted by Julie Charlton
With this one in print, I think I finally earned that PhD... 😅
Presented for the first time at the cosyne when the world ended (March 2020). I'll bring over a summary thread from twitter when it was still twitter...
www.sciencedirect.com/science/arti...
Presented for the first time at the cosyne when the world ended (March 2020). I'll bring over a summary thread from twitter when it was still twitter...
www.sciencedirect.com/science/arti...
Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state
Neuronal firing patterns have significant spatiotemporal variability with no agreed-upon theoretical framework. Using a combined experimental and mode…
www.sciencedirect.com
February 18, 2026 at 7:00 PM
With this one in print, I think I finally earned that PhD... 😅
Presented for the first time at the cosyne when the world ended (March 2020). I'll bring over a summary thread from twitter when it was still twitter...
www.sciencedirect.com/science/arti...
Presented for the first time at the cosyne when the world ended (March 2020). I'll bring over a summary thread from twitter when it was still twitter...
www.sciencedirect.com/science/arti...
Reposted by Julie Charlton
seems like they are both very busy these days. Huh !
February 12, 2026 at 8:12 PM
seems like they are both very busy these days. Huh !
Hey @eboyden3.bsky.social care to explain?
February 7, 2026 at 1:28 PM
Hey @eboyden3.bsky.social care to explain?
Reposted by Julie Charlton
for fuck's sake
www.justice.gov/epstein/file...
www.justice.gov/epstein/file...
January 31, 2026 at 7:52 AM
for fuck's sake
www.justice.gov/epstein/file...
www.justice.gov/epstein/file...
Reposted by Julie Charlton
the Epstein files are really devastating because they remind me of how many girls and women miss out on professional opportunities, mentorship and careers because of how many powerful, rich and influential men only view girls and women — and interactions with them — through the lens of sex
February 5, 2026 at 5:05 PM
the Epstein files are really devastating because they remind me of how many girls and women miss out on professional opportunities, mentorship and careers because of how many powerful, rich and influential men only view girls and women — and interactions with them — through the lens of sex
Reposted by Julie Charlton
One of the heartbreaking files to me was EFTA00258604 because the girl obviously has talent & you can tell she spent a lot of time making this beautiful medieval style letter bc she thinks this is the man helping her reach her dreams with her art, but we know he's preying on her & will devour her. 😞
February 5, 2026 at 6:38 PM
One of the heartbreaking files to me was EFTA00258604 because the girl obviously has talent & you can tell she spent a lot of time making this beautiful medieval style letter bc she thinks this is the man helping her reach her dreams with her art, but we know he's preying on her & will devour her. 😞
It would be great if neuroscientists could stop frothing at the mouth over the data they hope to someday get from non-medically-necessary neuralink recordings in humans. Get the data from your own brain if the risk is so low
January 30, 2026 at 3:44 AM
It would be great if neuroscientists could stop frothing at the mouth over the data they hope to someday get from non-medically-necessary neuralink recordings in humans. Get the data from your own brain if the risk is so low
Reposted by Julie Charlton
We are very excited to announce that our new preprint with Saleh Esteki, @stefanofusi.bsky.social, and @roozbehkiani.bsky.social is now available on biorxiv! www.biorxiv.org/content/10.6.... We investigated how reward context is learned, represented, and updated to bias decisions. Thread 🧵👇! 1/13
www.biorxiv.org
January 16, 2026 at 10:16 PM
We are very excited to announce that our new preprint with Saleh Esteki, @stefanofusi.bsky.social, and @roozbehkiani.bsky.social is now available on biorxiv! www.biorxiv.org/content/10.6.... We investigated how reward context is learned, represented, and updated to bias decisions. Thread 🧵👇! 1/13