Sabina (née Dylan) N. (They/Them)
@kpmanstheorem.bsky.social
Postdoc in Filizola Lab @ ISMMS | Voelz lab + Folding@home alum | Muay Thai
Studying GPCRs is fun because I get to get into the lab and Google LSD as my first order of business.
Also people should be more embarrassed of how boring they reveal themselves to be by listening to their AI tiktokified slop videos in public.
Morning musings
Also people should be more embarrassed of how boring they reveal themselves to be by listening to their AI tiktokified slop videos in public.
Morning musings
September 22, 2026 at 1:58 PM
Studying GPCRs is fun because I get to get into the lab and Google LSD as my first order of business.
Also people should be more embarrassed of how boring they reveal themselves to be by listening to their AI tiktokified slop videos in public.
Morning musings
Also people should be more embarrassed of how boring they reveal themselves to be by listening to their AI tiktokified slop videos in public.
Morning musings
Reposted by Sabina (née Dylan) N. (They/Them)
I don't think people really understand the psychic impact of knowing that multiple times a day every day your friends, family, coworkers, neighbors, and everyone who could ever have any power over you is being flooded with agitprop designed to make them hate you
September 15, 2026 at 10:48 PM
I don't think people really understand the psychic impact of knowing that multiple times a day every day your friends, family, coworkers, neighbors, and everyone who could ever have any power over you is being flooded with agitprop designed to make them hate you
Proud of this one, it's been quite the journey [and continues to be :)]
A fantastic collaboration with the Skiniotis lab! Using a massive ~1 ms aggregate MD dataset, we uncover how ligand efficacy is encoded not simply by static active/inactive states, but by the transition intermediates connecting them. www.biorxiv.org/content/10.6...
Transition Intermediates Encode Ligand Efficacy at the μ-Opioid Receptor-Gi Protein Complex
How ligands with different efficacies regulate G protein-coupled receptor signaling remains incompletely understood. Here, we combine Markov state modeling of nearly one millisecond of aggregate all-a...
www.biorxiv.org
September 9, 2026 at 3:11 PM
Proud of this one, it's been quite the journey [and continues to be :)]
Reposted by Sabina (née Dylan) N. (They/Them)
Congrats to Guangfeng Zhou, Ph.D., who joins the Wistar Institute in Philly as an assistant professor!
Guangfeng was one of the first grad students to join my lab at Temple in 2011 when *I* was an assistant prof; he went on to trailblaze AI-based drug discovery at the IPD at Univ. of Washington
Guangfeng was one of the first grad students to join my lab at Temple in 2011 when *I* was an assistant prof; he went on to trailblaze AI-based drug discovery at the IPD at Univ. of Washington
The Wistar Institute Strengthens AI-Driven Drug Discovery with Recruitment of Computational Biophysicist Guangfeng Zhou
The Wistar Institute Strengthens AI-Driven Drug Discovery with Recruitment of Computational Biophysicist Guangfeng Zhou Press Releases
www.wistar.org
August 7, 2026 at 1:37 AM
Congrats to Guangfeng Zhou, Ph.D., who joins the Wistar Institute in Philly as an assistant professor!
Guangfeng was one of the first grad students to join my lab at Temple in 2011 when *I* was an assistant prof; he went on to trailblaze AI-based drug discovery at the IPD at Univ. of Washington
Guangfeng was one of the first grad students to join my lab at Temple in 2011 when *I* was an assistant prof; he went on to trailblaze AI-based drug discovery at the IPD at Univ. of Washington
Reposted by Sabina (née Dylan) N. (They/Them)
Do not make a craphical abstract
How to use AI for your grapgical abstracts:
- do not
- dont even think about it
- congrats now everyone thinks your paper is made up data and you plagiarised the results
- lost all scientific credibility
- do not
- dont even think about it
- congrats now everyone thinks your paper is made up data and you plagiarised the results
- lost all scientific credibility
July 22, 2026 at 7:24 PM
Do not make a craphical abstract
Reposted by Sabina (née Dylan) N. (They/Them)
New preprint! Do all kinase domains have similar activation mechanisms?
We steer AlphaFold2 using "transfer seeding" of known kinases to sample 8.3 ms of MD simulations via Folding@home. We find unique pathways that are kinase-specific and depend on different elements!
Link: doi.org/10.64898/202...
We steer AlphaFold2 using "transfer seeding" of known kinases to sample 8.3 ms of MD simulations via Folding@home. We find unique pathways that are kinase-specific and depend on different elements!
Link: doi.org/10.64898/202...
July 7, 2026 at 8:30 PM
New preprint! Do all kinase domains have similar activation mechanisms?
We steer AlphaFold2 using "transfer seeding" of known kinases to sample 8.3 ms of MD simulations via Folding@home. We find unique pathways that are kinase-specific and depend on different elements!
Link: doi.org/10.64898/202...
We steer AlphaFold2 using "transfer seeding" of known kinases to sample 8.3 ms of MD simulations via Folding@home. We find unique pathways that are kinase-specific and depend on different elements!
Link: doi.org/10.64898/202...
Why do AIP journals require me to do dark magick to download a pdf...
June 25, 2026 at 3:15 PM
Why do AIP journals require me to do dark magick to download a pdf...
Excellent interview and analysis on why and how martial arts training and culture is important in combating the growing trend between fight culture and fascism, both on the street and state level!
my good friend and comrade interviewed me about UFC 250 and radical martial arts.
blackagendareport.com/you-gotta-do...
blackagendareport.com/you-gotta-do...
"You Gotta Do the Road Work": Ben Passmore on the UFC, White Nationalism, and Radical Fight Culture | Black Agenda Report
Joshua Reaves-Charmelus spoke with Ben Passmore to discuss the “Freedom 250” UFC event, its meaning, and the broader problem of right-wing fighting culture.
blackagendareport.com
June 24, 2026 at 2:55 PM
Excellent interview and analysis on why and how martial arts training and culture is important in combating the growing trend between fight culture and fascism, both on the street and state level!
Reposted by Sabina (née Dylan) N. (They/Them)
Now out in the Special Issue on "New Concepts in Drug Discovery: Drug residence time!"
Edited by Markus Seeliger & Ruth Nussinov, the reviews cover new computational and experimental methodologies for predicting ligand affinity & kinetics.
Link:
www.sciencedirect.com/special-issu...
Edited by Markus Seeliger & Ruth Nussinov, the reviews cover new computational and experimental methodologies for predicting ligand affinity & kinetics.
Link:
www.sciencedirect.com/special-issu...
More protein-ligand data are needed for AlphaFold-like models (& AI/ML) to enable prospective design!
Check out our piece in "Current Opinion in Structural Biology" – Equal parts a thank-you-letter to the PDB & summarizes how datasets will enable task-focused models!
Link: doi.org/10.1016/j.sb...
Check out our piece in "Current Opinion in Structural Biology" – Equal parts a thank-you-letter to the PDB & summarizes how datasets will enable task-focused models!
Link: doi.org/10.1016/j.sb...
June 23, 2026 at 5:57 PM
Now out in the Special Issue on "New Concepts in Drug Discovery: Drug residence time!"
Edited by Markus Seeliger & Ruth Nussinov, the reviews cover new computational and experimental methodologies for predicting ligand affinity & kinetics.
Link:
www.sciencedirect.com/special-issu...
Edited by Markus Seeliger & Ruth Nussinov, the reviews cover new computational and experimental methodologies for predicting ligand affinity & kinetics.
Link:
www.sciencedirect.com/special-issu...
Kinda like The Order funneled money from their bank robberies into early internet infrastructure as a long game propaganda tool, forming the contemporary global fascist movement and that technocracy has uncritically trained the machines they wish to extract "free" labor from on it.
You’re not going to believe this, but the thieving prejudice machines are also racist.
AI generates covertly racist decisions about people based on their dialect - Nature
Despite efforts to remove overt racial prejudice, language models using artificial intelligence still show covert racism against speakers of African American English that is triggered by features...
www.nature.com
June 17, 2026 at 12:17 PM
Kinda like The Order funneled money from their bank robberies into early internet infrastructure as a long game propaganda tool, forming the contemporary global fascist movement and that technocracy has uncritically trained the machines they wish to extract "free" labor from on it.
Reposted by Sabina (née Dylan) N. (They/Them)
RFK Jr: Kids with autism will never hold a job. They'll never play baseball. They'll never write a poem. They'll never go out on a date.
June 16, 2026 at 11:39 PM
Reposted by Sabina (née Dylan) N. (They/Them)
Cyclic peptides, such as this one conceived by Yu-Shan Lin’s group at Tufts University, are increasingly being explored for their therapeutic potential.
#chemsky 🧪
#chemsky 🧪
Cyclic peptides are having a moment
In this Eye on Patents column, we explore the pharmaceutical industry’s embrace of these circular molecules
cen.acs.org
June 8, 2026 at 9:56 PM
Cyclic peptides, such as this one conceived by Yu-Shan Lin’s group at Tufts University, are increasingly being explored for their therapeutic potential.
#chemsky 🧪
#chemsky 🧪
Reposted by Sabina (née Dylan) N. (They/Them)
happy pride from estrogen receptor alpha
June 1, 2026 at 6:03 PM
happy pride from estrogen receptor alpha
Reposted by Sabina (née Dylan) N. (They/Them)
gwen does fantastic work as usual on some of the 401,000 trans people who’ve had to flee hostile territory in their own country in the past 18 months.
May 14, 2026 at 2:16 PM
gwen does fantastic work as usual on some of the 401,000 trans people who’ve had to flee hostile territory in their own country in the past 18 months.
Reposted by Sabina (née Dylan) N. (They/Them)
If you missed the preprint, now is a good time to read the journal version of @grocklin.bsky.social et al’s fantastic paper on multiplexed HDX measurements
Large-scale discovery, analysis and design of protein energy landscapes
doi.org/10.1038/s415...
Large-scale discovery, analysis and design of protein energy landscapes
doi.org/10.1038/s415...
May 13, 2026 at 6:04 PM
If you missed the preprint, now is a good time to read the journal version of @grocklin.bsky.social et al’s fantastic paper on multiplexed HDX measurements
Large-scale discovery, analysis and design of protein energy landscapes
doi.org/10.1038/s415...
Large-scale discovery, analysis and design of protein energy landscapes
doi.org/10.1038/s415...
Reposted by Sabina (née Dylan) N. (They/Them)
Reposted by Sabina (née Dylan) N. (They/Them)
We just preprinted one of my favorite studies @FlatironInst
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
April 24, 2026 at 10:12 PM
We just preprinted one of my favorite studies @FlatironInst
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
Big week!
Interested in AI applications for GPCR drug discovery? @kpmanstheorem.bsky.social, a talented trainee from the Filizola Lab has something to say. "Computer-aided structural modeling and drug discovery for G-protein-coupled receptors in the age of AI" www.sciencedirect.com/science/arti...
Computer-aided structural modeling and drug discovery for G-protein-coupled receptors in the age of artificial intelligence
G-protein-coupled receptors (GPCRs) are a large family of membrane proteins that mediate cellular responses to diverse stimuli and serve as targets fo…
www.sciencedirect.com
March 13, 2026 at 11:44 AM
Big week!
Pleasantly surprised this morning to wake up to both the first preprint of my postdoc and first preprint using my new name :)
We used a combination of experiment and simulation to tease out the mechanistic basis of specific recognition of FcγRIIa.
www.biorxiv.org/content/10.6...
We used a combination of experiment and simulation to tease out the mechanistic basis of specific recognition of FcγRIIa.
www.biorxiv.org/content/10.6...
www.biorxiv.org
March 9, 2026 at 10:47 AM
Pleasantly surprised this morning to wake up to both the first preprint of my postdoc and first preprint using my new name :)
We used a combination of experiment and simulation to tease out the mechanistic basis of specific recognition of FcγRIIa.
www.biorxiv.org/content/10.6...
We used a combination of experiment and simulation to tease out the mechanistic basis of specific recognition of FcγRIIa.
www.biorxiv.org/content/10.6...
Reposted by Sabina (née Dylan) N. (They/Them)
I'd like to propose that we stop inventing new ways to log in
March 7, 2026 at 7:34 PM
I'd like to propose that we stop inventing new ways to log in
Reposted by Sabina (née Dylan) N. (They/Them)
@filizolalab1 kicking off at #bps2026 with a poster presentation by Kirill, on a collaborative work with the Skiniotis and Robertson labs. Go listen to Kirill!
February 22, 2026 at 4:25 PM
@filizolalab1 kicking off at #bps2026 with a poster presentation by Kirill, on a collaborative work with the Skiniotis and Robertson labs. Go listen to Kirill!