Marson Lab
@marsonlab.bsky.social
News from Dr. Alex Marson's lab UCSF & Gladstone Institutes, focusing on advances in immunology, CRISPR & genomics.
Reposted by Marson Lab
A new screening platform uncovers gene edits that enhance CAR-T cells’ ability to infiltrate and eliminate solid tumors.
@marsonlab.bsky.social
@nature.com
@ucsanfrancisco.bsky.social
@marsonlab.bsky.social
@nature.com
@ucsanfrancisco.bsky.social
New CRISPR Screening Platform Boosts Power of Immunotherapy Against Solid Tumors
A new screening platform uncovers gene edits that enhance CAR-T cells' ability to infiltrate and eliminate solid tumors.
gladstone.org
August 13, 2026 at 4:53 PM
A new screening platform uncovers gene edits that enhance CAR-T cells’ ability to infiltrate and eliminate solid tumors.
@marsonlab.bsky.social
@nature.com
@ucsanfrancisco.bsky.social
@marsonlab.bsky.social
@nature.com
@ucsanfrancisco.bsky.social
A truly incredible first paper from Julia's lab finally out in @nature.com! Just one of many big things to come from her group. @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @parkerici.bsky.social
Very excited to share my lab's first major paper, led by postdoc Qi Liu @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social executing the first ever genome-wide in vivo screens for genetic modifications to enhance human T cell therapies for solid tumors. www.nature.com/articles/s41...
In vivo genome-wide CRISPR screens of human T cells in solid tumours - Nature
An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.
www.nature.com
August 13, 2026 at 5:26 PM
A truly incredible first paper from Julia's lab finally out in @nature.com! Just one of many big things to come from her group. @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @parkerici.bsky.social
My lab has been studying human genes that control infection HIV infection of CD4+ T cells for over a decade. Today we report a major milestone in Cell: www.cell.com/cell/fulltex...
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
April 21, 2026 at 12:41 PM
My lab has been studying human genes that control infection HIV infection of CD4+ T cells for over a decade. Today we report a major milestone in Cell: www.cell.com/cell/fulltex...
Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social
December 15, 2025 at 2:02 PM
Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social
Reposted by Marson Lab
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
www.nature.com
December 11, 2025 at 5:54 PM
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...
December 10, 2025 at 10:57 PM
Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...
Happy to share our latest paper in Nature Biotech, led by graduate student Laine Goudy, joint with Luke Gilbert at Arc, developing CRISPRon/off technology for epigenetic programming of human T cells.
Integrated epigenetic and genetic programming of primary human T cells
Nature Biotechnology - Multiplexed editing in primary human T cells generates enhanced immune cell therapies.
rdcu.be
October 22, 2025 at 4:07 PM
Happy to share our latest paper in Nature Biotech, led by graduate student Laine Goudy, joint with Luke Gilbert at Arc, developing CRISPRon/off technology for epigenetic programming of human T cells.