Manuel Irimia
@mirimiam.bsky.social
ICREA Evolutionary Biologist working on transcriptomics of development and evolution at @upf.edu and @crg.eu. Coordinator of the @evomg-bcn.bsky.social Joint Program.
Lab website: http://transdevolab.com
Lab website: http://transdevolab.com
Reposted by Manuel Irimia
🚨🚨🚨
As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu
Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇
www.findaphd.com/phds/project...
As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu
Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇
www.findaphd.com/phds/project...
DECODES at University of Santiago de Compostela on FindAPhD.com
PhD Project - DECODES at University of Santiago de Compostela, listed on FindAPhD.com
www.findaphd.com
September 3, 2026 at 7:30 AM
🚨🚨🚨
As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu
Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇
www.findaphd.com/phds/project...
As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu
Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇
www.findaphd.com/phds/project...
🚨🚨🚨
As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu
Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇
www.findaphd.com/phds/project...
As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu
Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇
www.findaphd.com/phds/project...
DECODES at University of Santiago de Compostela on FindAPhD.com
PhD Project - DECODES at University of Santiago de Compostela, listed on FindAPhD.com
www.findaphd.com
September 3, 2026 at 7:30 AM
🚨🚨🚨
As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu
Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇
www.findaphd.com/phds/project...
As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu
Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇
www.findaphd.com/phds/project...
Reposted by Manuel Irimia
Transcription stops. RNA splicing takes over 🧬
✨ Our new preprint uncovers the post-transcriptional RNA splicing landscape powering mammalian oocyte development.
Read it here 👇
www.biorxiv.org/content/10.6...
✨ Our new preprint uncovers the post-transcriptional RNA splicing landscape powering mammalian oocyte development.
Read it here 👇
www.biorxiv.org/content/10.6...
August 21, 2026 at 7:33 AM
Transcription stops. RNA splicing takes over 🧬
✨ Our new preprint uncovers the post-transcriptional RNA splicing landscape powering mammalian oocyte development.
Read it here 👇
www.biorxiv.org/content/10.6...
✨ Our new preprint uncovers the post-transcriptional RNA splicing landscape powering mammalian oocyte development.
Read it here 👇
www.biorxiv.org/content/10.6...
Reposted by Manuel Irimia
What happens when evolution adds an extra pair of eyes?
Male mayflies evolve an extra pair of dorsal compound eyes, the Turbanate eyes, thought to help males detect females during mating swarms.
we have investigate how this remarkable evolutionary novelty develops.
www.biorxiv.org/content/10.6...
Male mayflies evolve an extra pair of dorsal compound eyes, the Turbanate eyes, thought to help males detect females during mating swarms.
we have investigate how this remarkable evolutionary novelty develops.
www.biorxiv.org/content/10.6...
August 7, 2026 at 9:19 AM
What happens when evolution adds an extra pair of eyes?
Male mayflies evolve an extra pair of dorsal compound eyes, the Turbanate eyes, thought to help males detect females during mating swarms.
we have investigate how this remarkable evolutionary novelty develops.
www.biorxiv.org/content/10.6...
Male mayflies evolve an extra pair of dorsal compound eyes, the Turbanate eyes, thought to help males detect females during mating swarms.
we have investigate how this remarkable evolutionary novelty develops.
www.biorxiv.org/content/10.6...
Reposted by Manuel Irimia
Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵
August 3, 2026 at 9:33 AM
Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵
Reposted by Manuel Irimia
Wow! A fourth class of transmissible cancers. CONTAGIOUS FISH MELANOMA, discovered in Lake Memphremagog (Vermont / Quebec) 🎣 🧬 😷
www.nature.com/articles/s41...
@uvmvermont.bsky.social
www.nature.com/articles/s41...
@uvmvermont.bsky.social
Brown bullhead catfish melanoma represents a novel transmissible cancer - Nature
Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.
www.nature.com
July 22, 2026 at 7:51 PM
Wow! A fourth class of transmissible cancers. CONTAGIOUS FISH MELANOMA, discovered in Lake Memphremagog (Vermont / Quebec) 🎣 🧬 😷
www.nature.com/articles/s41...
@uvmvermont.bsky.social
www.nature.com/articles/s41...
@uvmvermont.bsky.social
Reposted by Manuel Irimia
What happens if you delete large intronic regions? In human tissue culture cells, we found many deletions that decrease growth and some that increase it. In most cases, deletion affected expression or splicing of the gene.
www.cell.com/cell-reports...
1/3
www.cell.com/cell-reports...
1/3
A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns
Farhangmehr et al. investigate functions of highly conserved intronic sequences in
cell fitness using a CRISPR-based deletion screen. Deletions in FNBP4 intron lead
to changes in p53 pathway genes. De...
www.cell.com
July 20, 2026 at 9:08 PM
What happens if you delete large intronic regions? In human tissue culture cells, we found many deletions that decrease growth and some that increase it. In most cases, deletion affected expression or splicing of the gene.
www.cell.com/cell-reports...
1/3
www.cell.com/cell-reports...
1/3
Reposted by Manuel Irimia
🚨 Early Bird registration and abstract submission deadline for #SEBD2026 extended!!
📅 Early registration and abstract submission deadline: 10th July
📅 Scholarship application deadline: 29th June
www.sebd2026.com
#SEBD #DevBio
@sebioldev.bsky.social
👇👇👇
📅 Early registration and abstract submission deadline: 10th July
📅 Scholarship application deadline: 29th June
www.sebd2026.com
#SEBD #DevBio
@sebioldev.bsky.social
👇👇👇
June 24, 2026 at 5:11 PM
🚨 Early Bird registration and abstract submission deadline for #SEBD2026 extended!!
📅 Early registration and abstract submission deadline: 10th July
📅 Scholarship application deadline: 29th June
www.sebd2026.com
#SEBD #DevBio
@sebioldev.bsky.social
👇👇👇
📅 Early registration and abstract submission deadline: 10th July
📅 Scholarship application deadline: 29th June
www.sebd2026.com
#SEBD #DevBio
@sebioldev.bsky.social
👇👇👇
Reposted by Manuel Irimia
Paying peer reviewers
Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review
Spoiler: it works - fast, high quality reviews
www.nature.com/articles/d41...
Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review
Spoiler: it works - fast, high quality reviews
www.nature.com/articles/d41...
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
www.nature.com
July 2, 2026 at 5:36 AM
Paying peer reviewers
Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review
Spoiler: it works - fast, high quality reviews
www.nature.com/articles/d41...
Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review
Spoiler: it works - fast, high quality reviews
www.nature.com/articles/d41...
Reposted by Manuel Irimia
Very excited to finally share my PhD! 🎉
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish
Loss of the conserved splicing factor for neuronal microexons disrupts neuromodulatory signaling and drives hyperarousal.
www.science.org
June 28, 2026 at 4:37 PM
Very excited to finally share my PhD! 🎉
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Reposted by Manuel Irimia
🦟 Why don’t viruses kill the mosquitoes that transmit them?
🔬 A study reveals how these insects coexist with viruses such as dengue and Zika, and what this can teach us about their spread and control.
Learn more:
https://tuit.cat/uu8EJ
@melisupf.bsky.social
🔬 A study reveals how these insects coexist with viruses such as dengue and Zika, and what this can teach us about their spread and control.
Learn more:
https://tuit.cat/uu8EJ
@melisupf.bsky.social
June 19, 2026 at 11:55 AM
🦟 Why don’t viruses kill the mosquitoes that transmit them?
🔬 A study reveals how these insects coexist with viruses such as dengue and Zika, and what this can teach us about their spread and control.
Learn more:
https://tuit.cat/uu8EJ
@melisupf.bsky.social
🔬 A study reveals how these insects coexist with viruses such as dengue and Zika, and what this can teach us about their spread and control.
Learn more:
https://tuit.cat/uu8EJ
@melisupf.bsky.social
Reposted by Manuel Irimia
Thank you to organisers to James Hombría and Antónia Monteiro @monteirolab.bsky.social and everyone who joined us at this week's Workshop on 'Novelty, Co-option and Divergence During Gene Network Evolution'
biologists.com/workshops
#BiologistsWorkshops
biologists.com/workshops
#BiologistsWorkshops
June 18, 2026 at 11:22 AM
Thank you to organisers to James Hombría and Antónia Monteiro @monteirolab.bsky.social and everyone who joined us at this week's Workshop on 'Novelty, Co-option and Divergence During Gene Network Evolution'
biologists.com/workshops
#BiologistsWorkshops
biologists.com/workshops
#BiologistsWorkshops
Reposted by Manuel Irimia
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature.
Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
June 10, 2026 at 3:00 PM
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature.
Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
Reposted by Manuel Irimia
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome. 🧬
Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology
#preLight: prelights.biologists.com/highlights/e...
Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology
#preLight: prelights.biologists.com/highlights/e...
Evolutionary landscapes of zygotic genome activation across animals - preLights
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome.
prelights.biologists.com
June 2, 2026 at 2:38 PM
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome. 🧬
Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology
#preLight: prelights.biologists.com/highlights/e...
Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology
#preLight: prelights.biologists.com/highlights/e...
Reposted by Manuel Irimia
Fin-catching prelight on @mirimiam.bsky.social et al.'s preprint on the animal zoo 🐟🧬
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome. 🧬
Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology
#preLight: prelights.biologists.com/highlights/e...
Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology
#preLight: prelights.biologists.com/highlights/e...
Evolutionary landscapes of zygotic genome activation across animals - preLights
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome.
prelights.biologists.com
June 2, 2026 at 4:20 PM
Fin-catching prelight on @mirimiam.bsky.social et al.'s preprint on the animal zoo 🐟🧬
Reposted by Manuel Irimia
We had a great seminar by Duncan Odom @odomlab.bsky.social today about mutagenesis and cancer evolution!
June 1, 2026 at 10:48 AM
We had a great seminar by Duncan Odom @odomlab.bsky.social today about mutagenesis and cancer evolution!
Reposted by Manuel Irimia
Huge congrats to the CRG's Mafalda Dias for being one of eight finalists for the 2026 Premio Vanguardia de la Ciencia, one of Spain's most visible science prizes. Voting is open now and closes on Sunday 28 June at 23:59 (peninsular time).
La IA mejora el estudio de las enfermedades raras
Vota a las finalistas del premio Vanguardia de la Ciencia
www.lavanguardia.com
May 31, 2026 at 12:20 PM
Huge congrats to the CRG's Mafalda Dias for being one of eight finalists for the 2026 Premio Vanguardia de la Ciencia, one of Spain's most visible science prizes. Voting is open now and closes on Sunday 28 June at 23:59 (peninsular time).
Reposted by Manuel Irimia
1\ Excited to finally share some of my PhD work: OpenSplice!
We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.
We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.
OpenSplice: the impact of half a million mutations on the alternative splicing of 600 human exons https://www.biorxiv.org/content/10.64898/2026.05.22.727141v1
May 26, 2026 at 3:08 PM
1\ Excited to finally share some of my PhD work: OpenSplice!
We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.
We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.
Reposted by Manuel Irimia
New preprint! In an fun collaboration with @imaeso.bsky.social and @mirimiam.bsky.social led by Manu F-M, we set to explore the potential adaptation of transposable elements 👾 to host adenine DNA methylation by recruiting prokaryotic DAM methyltransferases: www.biorxiv.org/content/10.6.... 1/6
www.biorxiv.org
May 26, 2026 at 9:58 AM
New preprint! In an fun collaboration with @imaeso.bsky.social and @mirimiam.bsky.social led by Manu F-M, we set to explore the potential adaptation of transposable elements 👾 to host adenine DNA methylation by recruiting prokaryotic DAM methyltransferases: www.biorxiv.org/content/10.6.... 1/6
Reposted by Manuel Irimia
🧬 New research from the Burga lab! We took a closer look at a rogue selfish protein and caught evolution in the act of turning something old into something radically new 💡 (a.k.a. neofunctionalization) @imbavienna.bsky.social
www.biorxiv.org/content/10.6...
Curious? Here’s a breakdown:
www.biorxiv.org/content/10.6...
Curious? Here’s a breakdown:
May 18, 2026 at 1:49 PM
🧬 New research from the Burga lab! We took a closer look at a rogue selfish protein and caught evolution in the act of turning something old into something radically new 💡 (a.k.a. neofunctionalization) @imbavienna.bsky.social
www.biorxiv.org/content/10.6...
Curious? Here’s a breakdown:
www.biorxiv.org/content/10.6...
Curious? Here’s a breakdown:
Reposted by Manuel Irimia
Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6...
1/9
1/9
www.biorxiv.org
May 7, 2026 at 8:24 AM
Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6...
1/9
1/9
Reposted by Manuel Irimia
Exhausted but extremely happy for the two past days of very exciting Science! The EvoDevOmics Spanish Network gathered together in BCN to discuss about evodevo & omics, lots of great talks, discussions and future collaborations. 🤩
#evodevo
#evodevo
April 29, 2026 at 2:11 PM
Exhausted but extremely happy for the two past days of very exciting Science! The EvoDevOmics Spanish Network gathered together in BCN to discuss about evodevo & omics, lots of great talks, discussions and future collaborations. 🤩
#evodevo
#evodevo
Reposted by Manuel Irimia
@fany-real.bsky.social, @multicellgenome.bsky.social, @obog.bsky.social, @arnausebe.bsky.social, @bpernaute.bsky.social, @malmuedocas.bsky.social & Nuria Flames
April 29, 2026 at 7:22 PM
Reposted by Manuel Irimia
Amazing couple of days enjoying & discussing science in the best possible company during the Barcelona meeting of the 'EvoDevOmics Network', funded by @ageinves.bsky.social. Really happy to see how the EvoDevo community in Spain is thriving & fostering a fantastic new generation of PhDs & Postdocs.
April 29, 2026 at 6:55 PM
Amazing couple of days enjoying & discussing science in the best possible company during the Barcelona meeting of the 'EvoDevOmics Network', funded by @ageinves.bsky.social. Really happy to see how the EvoDevo community in Spain is thriving & fostering a fantastic new generation of PhDs & Postdocs.
Reposted by Manuel Irimia
What should Europe do when demand for #ERC funding keeps rising?
Restrict access or invest in excellence?
Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness
Consider to share & sign - see below 🧪
Restrict access or invest in excellence?
Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness
Consider to share & sign - see below 🧪
#erc | Johanna Joyce
What should Europe do when demand for its most successful frontier research programme keeps rising?
Restrict access, or invest in the excellence it has created?
A new open letter, spearheaded by Sara...
www.linkedin.com
April 22, 2026 at 9:24 AM
What should Europe do when demand for #ERC funding keeps rising?
Restrict access or invest in excellence?
Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness
Consider to share & sign - see below 🧪
Restrict access or invest in excellence?
Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness
Consider to share & sign - see below 🧪