Mit Joshi
@mitjoshi256.bsky.social
Ph.D.
Cancer cachexia and adipose tissue research.
#Cancercachexia #cachexia #Sarcopenia #adiposetissue
Cancer cachexia and adipose tissue research.
#Cancercachexia #cachexia #Sarcopenia #adiposetissue
Cancer Cachexia Awareness Day
#CancerCachexiaAwarenessDay
#CancerCachexiaAwarenessDay
September 1, 2026 at 5:20 PM
Cancer Cachexia Awareness Day
#CancerCachexiaAwarenessDay
#CancerCachexiaAwarenessDay
What a comeback by Argentina 🇦🇷
It’s Spain 🇪🇸 v/s Argentina 🇦🇷
FIFA FINAL 2026 ⚽️ 🥅
It’s Spain 🇪🇸 v/s Argentina 🇦🇷
FIFA FINAL 2026 ⚽️ 🥅
July 15, 2026 at 9:09 PM
What a comeback by Argentina 🇦🇷
It’s Spain 🇪🇸 v/s Argentina 🇦🇷
FIFA FINAL 2026 ⚽️ 🥅
It’s Spain 🇪🇸 v/s Argentina 🇦🇷
FIFA FINAL 2026 ⚽️ 🥅
🚨 Potential breakthrough in pancreatic cancer at #ASCO2026.
The Phase III RASolute-302 trial showed that the pan-RAS inhibitor daraxonrasib (RMC-6236) nearly doubled median overall survival in previously treated metastatic pancreatic cancer (13.2 vs 6.7 months).
www.asco.org/abstracts-pr...
The Phase III RASolute-302 trial showed that the pan-RAS inhibitor daraxonrasib (RMC-6236) nearly doubled median overall survival in previously treated metastatic pancreatic cancer (13.2 vs 6.7 months).
www.asco.org/abstracts-pr...
Daraxonrasib, a RAS(ON) multi-selective inhibitor vs chemotherapy in previously treated metastatic pancreatic adenocarcinoma (mPDAC): Primary and final analysis from the phase 3 RASolute 302 study. - ...
www.asco.org
June 1, 2026 at 11:13 AM
🚨 Potential breakthrough in pancreatic cancer at #ASCO2026.
The Phase III RASolute-302 trial showed that the pan-RAS inhibitor daraxonrasib (RMC-6236) nearly doubled median overall survival in previously treated metastatic pancreatic cancer (13.2 vs 6.7 months).
www.asco.org/abstracts-pr...
The Phase III RASolute-302 trial showed that the pan-RAS inhibitor daraxonrasib (RMC-6236) nearly doubled median overall survival in previously treated metastatic pancreatic cancer (13.2 vs 6.7 months).
www.asco.org/abstracts-pr...
Happy to share that part of my PhD dissertation is now published in the Journal of Biomedical and Toxicology.
Our study shows that pindolol can reduce sympathetic overactivation and improve cancer cachexia outcomes in a mouse model.
onlinelibrary.wiley.com/doi/10.1002/...
Our study shows that pindolol can reduce sympathetic overactivation and improve cancer cachexia outcomes in a mouse model.
onlinelibrary.wiley.com/doi/10.1002/...
Pindolol Mitigates Cancer Cachexia by Modulating Inflammation, Lipolysis, and Muscle Atrophy
Pindolol attenuates prolonged sympathetic overactivation in cancer cachexia, thereby exerting beneficial effects in a mouse model of cancer-associated cachexia.
onlinelibrary.wiley.com
March 24, 2026 at 2:52 AM
Happy to share that part of my PhD dissertation is now published in the Journal of Biomedical and Toxicology.
Our study shows that pindolol can reduce sympathetic overactivation and improve cancer cachexia outcomes in a mouse model.
onlinelibrary.wiley.com/doi/10.1002/...
Our study shows that pindolol can reduce sympathetic overactivation and improve cancer cachexia outcomes in a mouse model.
onlinelibrary.wiley.com/doi/10.1002/...
Interesting study and findings ✅
Fat breakdown in skin cells restarts hair growth
"Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling"
www.cell.com/cell-metabol...
"Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling"
www.cell.com/cell-metabol...
Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling
Tai et al. employed mouse models of skin injury to demonstrate that injury-induced
panniculitis stimulates hair regeneration by promoting adipocyte lipolysis via macrophage-adipocyte
interactions. Thi...
www.cell.com
November 17, 2025 at 1:44 PM
Interesting study and findings ✅
Thank you Jane Goodall.
October 2, 2025 at 9:31 AM
Thank you Jane Goodall.
A seemingly small but significant milestone.
#100citations
#100citations
September 12, 2025 at 5:46 AM
A seemingly small but significant milestone.
#100citations
#100citations
Dasgupta Lab is hiring! 🚀 Great opportunity, amazing mentor. Don’t miss it! @aneedasgupta.bsky.social @cancercachexia.bsky.social
Dasgupta Lab at UNC Charlotte is hiring!
This space needs to be filled with laughter, breakthroughs, failures, high fives and everything in between! (Of course equipment!😛)
We will be studying cancer-induced muscle wasting!
DM or email for more info!
@cancercachexia.bsky.social
#myoblue
This space needs to be filled with laughter, breakthroughs, failures, high fives and everything in between! (Of course equipment!😛)
We will be studying cancer-induced muscle wasting!
DM or email for more info!
@cancercachexia.bsky.social
#myoblue
August 24, 2025 at 1:21 PM
Dasgupta Lab is hiring! 🚀 Great opportunity, amazing mentor. Don’t miss it! @aneedasgupta.bsky.social @cancercachexia.bsky.social
Researchers found brain lithium levels drop early in Alzheimer’s. In mice, Li loss worsened amyloid, tau, inflammation & memory loss. Lithium orotate restored function. Maintaining Li balance could be a new path for prevention & treatment of Alzheimer’s.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lithium deficiency and the onset of Alzheimer’s disease - Nature
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level...
www.nature.com
August 14, 2025 at 2:14 PM
Researchers found brain lithium levels drop early in Alzheimer’s. In mice, Li loss worsened amyloid, tau, inflammation & memory loss. Lithium orotate restored function. Maintaining Li balance could be a new path for prevention & treatment of Alzheimer’s.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The hidden secrets of adipose tissue:
Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults.
#adiposetissue
#adiposeresearch
www.sciencedirect.com/science/arti...
Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults.
#adiposetissue
#adiposeresearch
www.sciencedirect.com/science/arti...
Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults
Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), …
www.sciencedirect.com
August 13, 2025 at 12:50 PM
The hidden secrets of adipose tissue:
Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults.
#adiposetissue
#adiposeresearch
www.sciencedirect.com/science/arti...
Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults.
#adiposetissue
#adiposeresearch
www.sciencedirect.com/science/arti...
Cancer cachexia drives ~1/3 of cancer deaths. In mice, cancer-induced inflammation disrupts vagal tone, impairing the brain–liver axis via HNF4α loss. Restoring vagal function slowed cachexia, eased symptoms & boosted chemo efficacy.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Vagal blockade of the brain-liver axis deters cancer-associated cachexia
Vagal dysfunction mediates the impact of tumor on liver metabolism, leading to cachexia.
Blocking the right cervical vagus nerve with various invasive or non-invasive approaches
alleviates cachexia, d...
www.cell.com
August 10, 2025 at 6:51 PM
Cancer cachexia drives ~1/3 of cancer deaths. In mice, cancer-induced inflammation disrupts vagal tone, impairing the brain–liver axis via HNF4α loss. Restoring vagal function slowed cachexia, eased symptoms & boosted chemo efficacy.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Histamine signaling, driven by increased histamine decarboxylase activity, contributes to muscle wasting in cancer cachexia, and inhibition of this pathway using α-fluoromethylhistidine protects against muscle atrophy in aged, tumor-bearing mice. From @jdoles.bsky.social & @aneedasgupta.bsky.social
Cachexia is a devastating cancer comorbidity that impacts numerous cancer outcomes. In @jem.org, @aneedasgupta.bsky.social, @jdoles.bsky.social et al describe a novel metabolic pathway/target w/ clinical implications for the treatment of cachectic #PancreaticCancer rupress.org/jem/article/...
August 6, 2025 at 1:51 PM
Histamine signaling, driven by increased histamine decarboxylase activity, contributes to muscle wasting in cancer cachexia, and inhibition of this pathway using α-fluoromethylhistidine protects against muscle atrophy in aged, tumor-bearing mice. From @jdoles.bsky.social & @aneedasgupta.bsky.social
And the biggest question is whether these drugs are truly effective in older patients and in conditions of wasting or not. Thanks to @katsufunai.bsky.social for highlighting such questions.
Published today in @cp-cellmetabolism.bsky.social, we report the unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Work by co-first authors Drs. Takuya Karasawa and Ran-Hee Choi. 1/
Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice
Loss of lean mass is a potential concern for semaglutide-induced weight loss. This
study indicates that semaglutide has unexpected effects on skeletal muscle mass and
strength in mice, demonstrating a...
www.cell.com
August 6, 2025 at 1:39 PM
And the biggest question is whether these drugs are truly effective in older patients and in conditions of wasting or not. Thanks to @katsufunai.bsky.social for highlighting such questions.
In cancer cachexia, liver dysfunction drives body wasting. Researchers identified REV-ERBα as a key regulator in hepatic reprogramming. Restoring it reduced wasting by lowering harmful hepatokines—offering a new therapeutic target. #CancerCachexia #Liver #REVERBα
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia
Cancer-induced liver changes promote body wasting through secreted factors, with circadian
regulators and hepatokines being important contributors to cancer cachexia.
www.cell.com
July 23, 2025 at 7:45 AM
In cancer cachexia, liver dysfunction drives body wasting. Researchers identified REV-ERBα as a key regulator in hepatic reprogramming. Restoring it reduced wasting by lowering harmful hepatokines—offering a new therapeutic target. #CancerCachexia #Liver #REVERBα
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Mit Joshi
Homemade Espresso and Red-bull combo summer drink 🧋🧋🧋
June 15, 2025 at 6:07 AM
Homemade Espresso and Red-bull combo summer drink 🧋🧋🧋
🌍 Historic first: A child with CPS1 deficiency has been successfully treated using personalized CRISPR gene editing by @ChildrensPhila & @PennMedicine.
The age of gene editing + personalized medicine has officially begun. 💊🧬
#CRISPR #Genomics #MedTwitter
www.nejm.org/doi/full/10....
The age of gene editing + personalized medicine has officially begun. 💊🧬
#CRISPR #Genomics #MedTwitter
www.nejm.org/doi/full/10....
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
Base editors can correct disease-causing genetic variants. After a neonate had received
a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with
an estimated 50% mortality ...
www.nejm.org
May 16, 2025 at 5:03 PM
🌍 Historic first: A child with CPS1 deficiency has been successfully treated using personalized CRISPR gene editing by @ChildrensPhila & @PennMedicine.
The age of gene editing + personalized medicine has officially begun. 💊🧬
#CRISPR #Genomics #MedTwitter
www.nejm.org/doi/full/10....
The age of gene editing + personalized medicine has officially begun. 💊🧬
#CRISPR #Genomics #MedTwitter
www.nejm.org/doi/full/10....
This is a commendable initiative. It is our collective responsibility to spread awareness and educate others about cachectic syndrome.
CANCER CACHEXIA AWARENESS DAY = 4TH FRIDAY OF EVERY SEPTEMBER.
CANCER CACHEXIA AWARENESS DAY = 4TH FRIDAY OF EVERY SEPTEMBER.
📣 Big News! The Cancer Cachexia Society is launching the first-ever Cancer Cachexia Awareness Day! 🗓️ Starting this year, the 4th Friday of every September = Cancer Cachexia Awareness Day! #CancerCachexiaAwarenessDay2025
May 16, 2025 at 4:53 PM
This is a commendable initiative. It is our collective responsibility to spread awareness and educate others about cachectic syndrome.
CANCER CACHEXIA AWARENESS DAY = 4TH FRIDAY OF EVERY SEPTEMBER.
CANCER CACHEXIA AWARENESS DAY = 4TH FRIDAY OF EVERY SEPTEMBER.
What emoji is Reviewer #2 going to choose? 🧐🧐
May 2, 2025 at 6:32 PM
What emoji is Reviewer #2 going to choose? 🧐🧐
A new era for GLP-1 therapy?
Eli Lilly's oral drug orforglipron shows promise for weight loss & type 2 diabetes. If approved, it could be the first oral GLP-1 agonist, offering a convenient alternative to injectables like Ozempic & Mounjaro.
#obesity #GLP1
time.com/7278429/weig...
Eli Lilly's oral drug orforglipron shows promise for weight loss & type 2 diabetes. If approved, it could be the first oral GLP-1 agonist, offering a convenient alternative to injectables like Ozempic & Mounjaro.
#obesity #GLP1
time.com/7278429/weig...
How a New Weight-Loss Pill Could Transform Health
The first truly revolutionary oral drug for obesity, made by Eli Lilly, may soon be on the way.
time.com
April 19, 2025 at 4:15 PM
A new era for GLP-1 therapy?
Eli Lilly's oral drug orforglipron shows promise for weight loss & type 2 diabetes. If approved, it could be the first oral GLP-1 agonist, offering a convenient alternative to injectables like Ozempic & Mounjaro.
#obesity #GLP1
time.com/7278429/weig...
Eli Lilly's oral drug orforglipron shows promise for weight loss & type 2 diabetes. If approved, it could be the first oral GLP-1 agonist, offering a convenient alternative to injectables like Ozempic & Mounjaro.
#obesity #GLP1
time.com/7278429/weig...
Looks like many more awards are on the horizon for GLP-1 related basic and applied research.
Congratulations to everyone involved!
Congratulations to everyone involved!
April 7, 2025 at 9:45 AM
Looks like many more awards are on the horizon for GLP-1 related basic and applied research.
Congratulations to everyone involved!
Congratulations to everyone involved!
Fueling up with coffee because it’s time to wrestle with my thesis. Wish me luck—I’ll need caffeine and divine intervention 😅😅
February 22, 2025 at 5:20 PM
Fueling up with coffee because it’s time to wrestle with my thesis. Wish me luck—I’ll need caffeine and divine intervention 😅😅
Over the past five years, I’ve read many articles on the struggles of PhD researchers worldwide, yet little has changed to encourage young minds in science. I hope that one day, society will see science as a long-term investment and give it the support it deserves.
www.firstpost.com/explainers/i...
www.firstpost.com/explainers/i...
Is the PhD dream dying? Why fewer students are enrolling in doctoral programmes
PhD enrolments are declining globally as financial hardships, limited job prospects, and shifting perceptions of academia deter students. Australia, Japan, Brazil, the UK, and India are witnessing a d...
www.firstpost.com
February 17, 2025 at 8:58 AM
Over the past five years, I’ve read many articles on the struggles of PhD researchers worldwide, yet little has changed to encourage young minds in science. I hope that one day, society will see science as a long-term investment and give it the support it deserves.
www.firstpost.com/explainers/i...
www.firstpost.com/explainers/i...
DO-HEALTH trial (777 participants) found that omega-3 (1 g/day) slowed biological aging based on DNAm clocks, with additive benefits from vitamin D (2,000 IU/day) and exercise. Over 3 yrs, aging slowed by 2.9–3.8 months, suggesting a small but good protective effect.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial - Nature Aging
Applying epigenetic clocks to samples from the DO-HEALTH trial, Bischoff-Ferrari et al. report a small protective effect of omega-3 supplementation over 3 years on several clocks and an additive prote...
www.nature.com
February 4, 2025 at 10:36 AM
DO-HEALTH trial (777 participants) found that omega-3 (1 g/day) slowed biological aging based on DNAm clocks, with additive benefits from vitamin D (2,000 IU/day) and exercise. Over 3 yrs, aging slowed by 2.9–3.8 months, suggesting a small but good protective effect.
www.nature.com/articles/s43...
www.nature.com/articles/s43...