@mvstaller.bsky.social
Our new paper went live today! We build biophysical neural networks to predict transcriptional activation domains from protein sequence. We interpret these neural networks to show how acidic and hydrophobic residues control abundance and activation strength. www.sciencedirect.com/science/arti...
www.sciencedirect.com
August 17, 2026 at 6:14 PM
Our new paper went live today! We build biophysical neural networks to predict transcriptional activation domains from protein sequence. We interpret these neural networks to show how acidic and hydrophobic residues control abundance and activation strength. www.sciencedirect.com/science/arti...
I am thrilled to announce publication of our new paper! We show transcription factor evolution in fungi is driven evolutionary turnover at two length scales. 1) Turnover of entire activation domains and 2) turnover of key residues within an activation domain. journals.plos.org/plosgenetics...
Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains
Author summary When and where genes are turned on determine what an organism looks like and how it responds to its environment. The turning on and off of genes is controlled by proteins known as trans...
journals.plos.org
March 17, 2026 at 5:52 PM
I am thrilled to announce publication of our new paper! We show transcription factor evolution in fungi is driven evolutionary turnover at two length scales. 1) Turnover of entire activation domains and 2) turnover of key residues within an activation domain. journals.plos.org/plosgenetics...
I'm super excited that our paper was published last month! We find that very short activation domains can control the fraction of transcription factor molecules bound to chromatin. Vinson added some very nice extra experiments in the revised version! elifesciences.org/articles/105...
Short activation domains control chromatin association of transcription factors
Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to c...
elifesciences.org
February 26, 2026 at 4:43 PM
I'm super excited that our paper was published last month! We find that very short activation domains can control the fraction of transcription factor molecules bound to chromatin. Vinson added some very nice extra experiments in the revised version! elifesciences.org/articles/105...
Happy new year! Our new preprint is live! We use single molecule imaging in live cells to show that activation domains can control how transcription factors bind to chromatin. SMT 1 TF Dogma 0 www.biorxiv.org/content/10.1...
Short activation domains control chromatin association of transcription factors
Transcription factors regulate gene expression with DNA-binding domains (DBDs) and activation domains. It is generally assumed that DBDs are solely responsible for interacting with DNA and chromatin. ...
www.biorxiv.org
January 10, 2025 at 5:07 PM
Happy new year! Our new preprint is live! We use single molecule imaging in live cells to show that activation domains can control how transcription factors bind to chromatin. SMT 1 TF Dogma 0 www.biorxiv.org/content/10.1...
Our new preprint went live on biorxiv. We show: 1) conservation of function without conservation of sequence for a transcription factor over 600 million years of evolution. 2) The key phenylalanine residues turnover, moving around. www.biorxiv.org/content/10.1...
www.biorxiv.org
December 10, 2024 at 8:51 PM
Our new preprint went live on biorxiv. We show: 1) conservation of function without conservation of sequence for a transcription factor over 600 million years of evolution. 2) The key phenylalanine residues turnover, moving around. www.biorxiv.org/content/10.1...