Nature Reviews Immunology
@natrevimmunol.nature.com
Bluesky account for the journal Nature Reviews Immunology https://www.nature.com/nri/ Skyquakes from the editors.
ICYMI: Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization
Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization
Nature Reviews Immunology, Published online: 16 September 2026; doi:10.1038/s41577-026-01356-5The formation of tertiary lymphoid structures (TLSs) has been associated with better outcomes in patients with certain tumours. Here the authors discuss how immunogenic cell death can lead to the formation of TLSs and explain why this knowledge could help us design better cancer therapies.
dlvr.it
September 17, 2026 at 10:10 AM
ICYMI: Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization
Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization
Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization
Nature Reviews Immunology, Published online: 16 September 2026; doi:10.1038/s41577-026-01356-5The formation of tertiary lymphoid structures (TLSs) has been associated with better outcomes in patients with certain tumours. Here the authors discuss how immunogenic cell death can lead to the formation of TLSs and explain why this knowledge could help us design better cancer therapies.
dlvr.it
September 16, 2026 at 10:09 AM
Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization
ICYMI: Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential
Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential
Nature Reviews Immunology, Published online: 02 September 2026; doi:10.1038/s41577-026-01345-8This Review summarizes our current understanding of the immunological roles of IL-33 and the IL-33 receptor, also known as ST2. The authors focus on the effects of IL-33 in different disease settings, including infections, cancer, autoimmunity, chronic inflammation and allergy. They further discuss emerging clinical data from studies targeting IL-33 receptor signalling in disease.
dlvr.it
September 3, 2026 at 3:38 PM
ICYMI: Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential
Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential
Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential
Nature Reviews Immunology, Published online: 02 September 2026; doi:10.1038/s41577-026-01345-8This Review summarizes our current understanding of the immunological roles of IL-33 and the IL-33 receptor, also known as ST2. The authors focus on the effects of IL-33 in different disease settings, including infections, cancer, autoimmunity, chronic inflammation and allergy. They further discuss emerging clinical data from studies targeting IL-33 receptor signalling in disease.
dlvr.it
September 2, 2026 at 3:37 PM
Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential
Reposted by Nature Reviews Immunology
In our latest review, out now in @natrevimmunol.nature.com, we extend the concept of excitotoxicity beyond glutamate receptor overactivation to include innate and adaptive immune pathways, introducing the framework of immune-mediated excitotoxicity.
August 28, 2026 at 3:21 PM
In our latest review, out now in @natrevimmunol.nature.com, we extend the concept of excitotoxicity beyond glutamate receptor overactivation to include innate and adaptive immune pathways, introducing the framework of immune-mediated excitotoxicity.
ICYMI: Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease
Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease
Nature Reviews Immunology, Published online: 27 August 2026; doi:10.1038/s41577-026-01344-9Epigenetic programmes collectively orchestrate B cell development, activation, germinal centre responses and the maintenance of self-tolerance. This Review examines how layered epigenetic mechanisms govern normal B cell function and enforce self-tolerance, and how their dysregulation breaches successive tolerance checkpoints to drive autoreactive B cell emergence and autoantibody production in systemic autoimmune disease.
dlvr.it
August 28, 2026 at 3:10 PM
ICYMI: Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease
ICYMI: Immune-mediated excitotoxicity in brain disorders
Immune-mediated excitotoxicity in brain disorders
Nature Reviews Immunology, Published online: 27 August 2026; doi:10.1038/s41577-026-01348-5Excessive glutamate receptor signalling contributes to central nervous system pathology in different neurological settings, including in epilepsy, Parkinson disease and multiple sclerosis. Here, the authors discuss the need to integrate the immune system along with glutamate-centric mechanisms as a core driver of excitotoxic pathology. They suggest that this concept of ‘immune-mediated excitotoxicity’ can help us develop better therapeutic interventions for various neurological conditions.
dlvr.it
August 28, 2026 at 11:38 AM
ICYMI: Immune-mediated excitotoxicity in brain disorders
Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease
Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease
Nature Reviews Immunology, Published online: 27 August 2026; doi:10.1038/s41577-026-01344-9Epigenetic programmes collectively orchestrate B cell development, activation, germinal centre responses and the maintenance of self-tolerance. This Review examines how layered epigenetic mechanisms govern normal B cell function and enforce self-tolerance, and how their dysregulation breaches successive tolerance checkpoints to drive autoreactive B cell emergence and autoantibody production in systemic autoimmune disease.
dlvr.it
August 27, 2026 at 3:09 PM
Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease
Immune-mediated excitotoxicity in brain disorders
Immune-mediated excitotoxicity in brain disorders
Nature Reviews Immunology, Published online: 27 August 2026; doi:10.1038/s41577-026-01348-5Excessive glutamate receptor signalling contributes to central nervous system pathology in different neurological settings, including in epilepsy, Parkinson disease and multiple sclerosis. Here, the authors discuss the need to integrate the immune system along with glutamate-centric mechanisms as a core driver of excitotoxic pathology. They suggest that this concept of ‘immune-mediated excitotoxicity’ can help us develop better therapeutic interventions for various neurological conditions.
dlvr.it
August 27, 2026 at 11:36 AM
Immune-mediated excitotoxicity in brain disorders
Dolly Parton dies aged 80 – researchers celebrate her contributions to science www.nature.com/articles/d41... “I’m old enough to get it, and I’m smart enough to get it”, quipped Parton, before reworking her hit song ‘Jolene’ to include the words, “vaccine, vaccine, vaccine, vaccine..."
Dolly Parton dies aged 80 – researchers celebrate her contributions to science
The country singer was an advocate for vaccines, public health, literacy and marginalized communities.
www.nature.com
August 26, 2026 at 5:07 PM
Dolly Parton dies aged 80 – researchers celebrate her contributions to science www.nature.com/articles/d41... “I’m old enough to get it, and I’m smart enough to get it”, quipped Parton, before reworking her hit song ‘Jolene’ to include the words, “vaccine, vaccine, vaccine, vaccine..."
ICYMI: Beyond the quick win: rebuilding the foundations of cancer immunotherapy
Beyond the quick win: rebuilding the foundations of cancer immunotherapy
Nature Reviews Immunology, Published online: 25 August 2026; doi:10.1038/s41577-026-01352-9Checkpoint inhibitors, CAR T cells and bispecific T cell engagers have demonstrated the transformative potential of cancer immunotherapy. However, progress has slowed as efforts have focused on replicating PD-(L)1 blockade successes, highlighting the need for deeper understanding of human cancer immunity.
dlvr.it
August 26, 2026 at 11:39 AM
ICYMI: Beyond the quick win: rebuilding the foundations of cancer immunotherapy
ICYMI: Can immunology still surprise itself?
Can immunology still surprise itself?
Nature Reviews Immunology, Published online: 24 August 2026; doi:10.1038/s41577-026-01351-wThe discoveries that have transformed immunology often seem obvious in retrospect. Yet none began as an inevitable destination. They began with observations that did not fit, assumptions that somebody challenged, or questions that nobody yet realized were important. Discovery was the outcome. Surprise was the process.
dlvr.it
August 25, 2026 at 3:36 PM
ICYMI: Can immunology still surprise itself?
Beyond the quick win: rebuilding the foundations of cancer immunotherapy
Beyond the quick win: rebuilding the foundations of cancer immunotherapy
Nature Reviews Immunology, Published online: 25 August 2026; doi:10.1038/s41577-026-01352-9Checkpoint inhibitors, CAR T cells and bispecific T cell engagers have demonstrated the transformative potential of cancer immunotherapy. However, progress has slowed as efforts have focused on replicating PD-(L)1 blockade successes, highlighting the need for deeper understanding of human cancer immunity.
dlvr.it
August 25, 2026 at 11:38 AM
Beyond the quick win: rebuilding the foundations of cancer immunotherapy
Can immunology still surprise itself?
Can immunology still surprise itself?
Nature Reviews Immunology, Published online: 24 August 2026; doi:10.1038/s41577-026-01351-wThe discoveries that have transformed immunology often seem obvious in retrospect. Yet none began as an inevitable destination. They began with observations that did not fit, assumptions that somebody challenged, or questions that nobody yet realized were important. Discovery was the outcome. Surprise was the process.
dlvr.it
August 24, 2026 at 3:36 PM
Can immunology still surprise itself?
In this World View, Adrian Hayday discusses the importance of protecting the deep immersion within a subject that reveals unexpected opportunities.
"History repeatedly shows that transformative discoveries usually arise from the margins, unstifled by prevailing assumptions and expectations. "
"History repeatedly shows that transformative discoveries usually arise from the margins, unstifled by prevailing assumptions and expectations. "
Building clinical translation on squares of discovery
Nature Reviews Immunology - Why do so many promising immunotherapies fail to reach their potential? Adrian Hayday argues that transformative clinical advances depend on protecting specialized...
rdcu.be
August 21, 2026 at 8:31 AM
In this World View, Adrian Hayday discusses the importance of protecting the deep immersion within a subject that reveals unexpected opportunities.
"History repeatedly shows that transformative discoveries usually arise from the margins, unstifled by prevailing assumptions and expectations. "
"History repeatedly shows that transformative discoveries usually arise from the margins, unstifled by prevailing assumptions and expectations. "
ICYMI: Living in the age of inflammation: the reverse hygiene hypothesis
Living in the age of inflammation: the reverse hygiene hypothesis
Nature Reviews Immunology, Published online: 19 August 2026; doi:10.1038/s41577-026-01349-4Inflammation seems to permeate many aspects of our lives, with the incidence of inflammatory diseases on the rise and ageing being blamed on it. Will the next 25 years see better ways to treat or prevent inflammation and allow us to live longer and healthier lives?
dlvr.it
August 20, 2026 at 5:39 PM
ICYMI: Living in the age of inflammation: the reverse hygiene hypothesis
ICYMI: Building clinical translation on squares of discovery
Building clinical translation on squares of discovery
Nature Reviews Immunology, Published online: 19 August 2026; doi:10.1038/s41577-026-01347-6Why do so many promising immunotherapies fail to reach their potential? Adrian Hayday argues that transformative clinical advances depend on protecting specialized ‘squares of discovery’ in which deep understanding and unexpected insights emerge, while building stronger pathways to biotechnology, pharmaceutical development and patient care.
dlvr.it
August 20, 2026 at 5:39 PM
ICYMI: Building clinical translation on squares of discovery
Living in the age of inflammation: the reverse hygiene hypothesis
Living in the age of inflammation: the reverse hygiene hypothesis
Nature Reviews Immunology, Published online: 19 August 2026; doi:10.1038/s41577-026-01349-4Inflammation seems to permeate many aspects of our lives, with the incidence of inflammatory diseases on the rise and ageing being blamed on it. Will the next 25 years see better ways to treat or prevent inflammation and allow us to live longer and healthier lives?
dlvr.it
August 19, 2026 at 5:38 PM
Living in the age of inflammation: the reverse hygiene hypothesis
Building clinical translation on squares of discovery
Building clinical translation on squares of discovery
Nature Reviews Immunology, Published online: 19 August 2026; doi:10.1038/s41577-026-01347-6Why do so many promising immunotherapies fail to reach their potential? Adrian Hayday argues that transformative clinical advances depend on protecting specialized ‘squares of discovery’ in which deep understanding and unexpected insights emerge, while building stronger pathways to biotechnology, pharmaceutical development and patient care.
dlvr.it
August 19, 2026 at 5:38 PM
Building clinical translation on squares of discovery
ICYMI: Why adaptive immunity?
Why adaptive immunity?
Nature Reviews Immunology, Published online: 18 August 2026; doi:10.1038/s41577-026-01350-xAdaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen recognition evolved and whether its original advantage extended beyond host defence.
dlvr.it
August 19, 2026 at 2:40 PM
ICYMI: Why adaptive immunity?
Reposted by Nature Reviews Immunology
Hope you enjoy this short piece, which came out yesterday. Some thoughts I’ve been musing on for a while about why adaptive immunity evolved. Read it for free at rdcu.be/fAO5P
August 19, 2026 at 11:24 AM
Hope you enjoy this short piece, which came out yesterday. Some thoughts I’ve been musing on for a while about why adaptive immunity evolved. Read it for free at rdcu.be/fAO5P
Why adaptive immunity?
Why adaptive immunity?
Nature Reviews Immunology, Published online: 18 August 2026; doi:10.1038/s41577-026-01350-xAdaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen recognition evolved and whether its original advantage extended beyond host defence.
dlvr.it
August 18, 2026 at 2:39 PM
Why adaptive immunity?
ICYMI: Immune surveillance and immune evasion of senescent cells
Immune surveillance and immune evasion of senescent cells
Nature Reviews Immunology, Published online: 11 August 2026; doi:10.1038/s41577-026-01335-wThis Review outlines the context-dependent mechanisms that determine the immune surveillance or immune evasion of senescent cells and how targeting these immune-mediated pathways may prevent or treat senescence-related tissue dysfunction.
dlvr.it
August 12, 2026 at 12:59 PM
ICYMI: Immune surveillance and immune evasion of senescent cells
A new Review by @paugarbau.bsky.social, Manuel Serrano & @corina-amor.bsky.social discusses the tissue-specific processes that influence immune surveillance of senescent cells and how their accumulation can be prevented by immune-based therapeutic approaches.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 12, 2026 at 11:20 AM
A new Review by @paugarbau.bsky.social, Manuel Serrano & @corina-amor.bsky.social discusses the tissue-specific processes that influence immune surveillance of senescent cells and how their accumulation can be prevented by immune-based therapeutic approaches.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune surveillance and immune evasion of senescent cells
Immune surveillance and immune evasion of senescent cells
Nature Reviews Immunology, Published online: 11 August 2026; doi:10.1038/s41577-026-01335-wThis Review outlines the context-dependent mechanisms that determine the immune surveillance or immune evasion of senescent cells and how targeting these immune-mediated pathways may prevent or treat senescence-related tissue dysfunction.
dlvr.it
August 11, 2026 at 12:58 PM
Immune surveillance and immune evasion of senescent cells