Nazlı Akıllı
@nazliakilli.bsky.social
Former PhD student in @giacomo_cavalli lab-MSc at LMU Munich, @mpibiochem.bsky.social
Pinned
Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3
Abstract. Polycomb repressive complex 1 (PRC1) forms nuclear condensates that organize target chromatin domains. SUMOylation modulates PRC1 clustering, but
doi.org
Thrilled to share my PhD paper showing how SUMO regulates PRC1 clustering and 3D genome organisation independently of H3K27me3! Grateful to @djost-physbiol.bsky.social group and the Fabian Erdel group for this great collaboration. doi.org/10.1093/nar/...
Happy to be part of this work led by Thierry Cheutin. doi.org/10.1038/s414...
PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis - Cell Discovery
Cell Discovery - PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis
doi.org
September 23, 2026 at 4:51 PM
Happy to be part of this work led by Thierry Cheutin. doi.org/10.1038/s414...
Thrilled to share my PhD paper showing how SUMO regulates PRC1 clustering and 3D genome organisation independently of H3K27me3! Grateful to @djost-physbiol.bsky.social group and the Fabian Erdel group for this great collaboration. doi.org/10.1093/nar/...
Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3
Abstract. Polycomb repressive complex 1 (PRC1) forms nuclear condensates that organize target chromatin domains. SUMOylation modulates PRC1 clustering, but
doi.org
September 23, 2026 at 4:41 PM
Thrilled to share my PhD paper showing how SUMO regulates PRC1 clustering and 3D genome organisation independently of H3K27me3! Grateful to @djost-physbiol.bsky.social group and the Fabian Erdel group for this great collaboration. doi.org/10.1093/nar/...
Reposted by Nazlı Akıllı
This great work by the Cavalli lab is finally out in @narjournal.bsky.social ! Congrats to all the team 🥂 and in particular Paul-Swann in our group who did the modeling part 👏. doi.org/10.1093/nar/...
September 10, 2026 at 9:15 AM
This great work by the Cavalli lab is finally out in @narjournal.bsky.social ! Congrats to all the team 🥂 and in particular Paul-Swann in our group who did the modeling part 👏. doi.org/10.1093/nar/...
Reposted by Nazlı Akıllı
Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3 https://www.biorxiv.org/content/10.64898/2026.02.05.704038v1
February 7, 2026 at 6:33 AM
Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3 https://www.biorxiv.org/content/10.64898/2026.02.05.704038v1