Pablo Laborda
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pablolaborda.bsky.social
Pablo Laborda
@pablolaborda.bsky.social
Postdoctoral researcher at DTU | Ecology and evolution of antibiotic resistance and infection microbiology of Pseudomonas aeruginosa
Following our recent @natcomms.nature.com paper, we've now shared the story behind the study in a @springernature.com Behind the Paper post: how an initially puzzling observation led us to a broader view of bacterial metabolism during infection 🦠

communities.springernature.com/posts/when-a...
September 1, 2026 at 12:07 PM
Our latest work is out in @natcomms.nature.com!

Clinical adaptation of #PseudomonasAeruginosa can drive pyruvate secretion, where it scavenges ROS, dampens immune activation and promotes persistence, highlighting bacterial metabolism as an active player in infection🦠

www.nature.com/articles/s41...
Immune protection and persistence in Pseudomonas aeruginosa infections by pyruvate cross-feeding - Nature Communications
The study shows that metabolic mutations in Pseudomonas aeruginosa lead to pyruvate secretion, which reduces oxidative stress, dampens immune responses, promoting bacterial survival and persistence in...
www.nature.com
July 9, 2026 at 8:15 AM
Following up on our recent @natcomms.nature.com paper, we have now shared the story behind the study in a @springernature.com Behind the Paper post 🦠

With an amazing illustration by Elena Contel Maza (@helen.mushu.science in instagram) 🎨

communities.springernature.com/posts/when-a...
June 11, 2026 at 5:55 AM
The final version of our latest paper is now published in @natcomms.nature.com!
This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠
www.nature.com/articles/s41...
June 9, 2026 at 8:38 AM
Reposted by Pablo Laborda
Unnecessary bureaucracy is a global crisis impeding productivity, advancement of human and planetary wellbeing, science and sustainability. This self-inflicted problem urgently needs solution through global efforts at all levels. doi.org/10.1111/1751...
June 1, 2026 at 6:51 AM
Reposted by Pablo Laborda
The best results come from diverse minds working together. I´m very happy to share a collaborative work between 3 biologists, 2 mathematicians, a physicist, a chemist, and a physician:

www.biorxiv.org/cgi/content/...

@the100footpole.bsky.social @omeuxeito.bsky.social @pablolaborda.bsky.social
www.biorxiv.org
May 14, 2026 at 3:02 PM
Our latest comment is now out!

We discuss how the infection environment can shape #AntimicrobialResistance phenotypes, an important but often overlooked factor for predicting antimicrobial efficacy against bacterial pathogens 🦠🧫

#MicroSky
@rug-lrs.bsky.social
April 6, 2026 at 10:53 AM
Reposted by Pablo Laborda
How does treatment induced antibiotic resistance happen in real-world infections? We analysed 25k Pseudomonas isolates from 180 patients in a clinical trial to find out! TLDR: The ecological and evolutionary paths are surprisingly diverse & complex even in patients receiving identical treatment…
🚨 New pre-print! 🚨 In the largest study of its kind to-date, we investigate the ecological and evolutionary mechanisms driving within-patient evolution of antimicrobial resistance (AMR). Read here:
www.biorxiv.org/content/10.6... , and follow along with this thread, discussing our findings (1/21)
www.biorxiv.org
February 20, 2026 at 4:31 PM
Reposted by Pablo Laborda
🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover.
🔗 www.biorxiv.org/content/10.6...
www.biorxiv.org
February 16, 2026 at 4:39 PM
Reposted by Pablo Laborda
New paper out in PNAS!!! 🎉

Do more plasmid copies mean faster evolution?

🧵 Dive into the story

www.pnas.org/doi/10.1073/...
Plasmid mutation rates scale with copy number | PNAS
Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...
www.pnas.org
January 27, 2026 at 12:02 PM
New preprint!👇
Pyruvate secreted by P. aeruginosa acts as a signaling molecule during infection, reducing oxidative stress, dampening immune activation and promoting persistence
Bacterial metabolism isn’t just a background process but an active player in infection🦠🧫
www.biorxiv.org/content/10.6...
Immune protection and disease tolerance in Pseudomonas aeruginosa infections by pyruvate cross-feeding
Chronic infections by Pseudomonas aeruginosa in people with cystic fibrosis are characterized by persistent inflammation and oxidative stress, yet the mechanisms enabling bacterial persistence are not...
www.biorxiv.org
December 5, 2025 at 10:38 AM
Reposted by Pablo Laborda
The @imili-micro.bsky.social project is such a beautiful and necessary initiative!

I am really glad we could contribute.

Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text

- @cbitoulouse.bsky.social
November 20, 2025 at 1:26 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-10:

@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social

the ESKAPE Rogues

grupos.eez.csic.es/imili/wp-con...
November 19, 2025 at 9:46 AM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-11:

@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social

the ESKAPE Rogues

grupos.eez.csic.es/imili/wp-con...
November 19, 2025 at 8:49 AM
Reposted by Pablo Laborda
The NoticiaSEM: an excellent monthly newsletter for Spanish-speaking microbiologists, now celebrating its 200th edition. It also publishes Portraits from the IMiLI. On the occasion of its 200th "birthday", it published an IMiLI "MicroChat" on......birthdays.

www.semicrobiologia.org/revista-noti...
November 17, 2025 at 10:55 AM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-5
@pablolaborda.bsky.social

How we can fight AMR

imili.org/new_gallerie...

@sbigot.bsky.social
November 11, 2025 at 12:23 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-6
@pablolaborda.bsky.social, @crisherencias.bsky.social

How we can fight AMR

imili.org/pdf/Antimicr...
November 11, 2025 at 12:27 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7
@pablolaborda.bsky.social
@crisherencias.bsky.social

How we can fight AMR

imili.org/pdf/Antimicr...
November 11, 2025 at 12:30 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-8
@pablolaborda.bsky.social
@crisherencias.bsky.social

How it works

imili.org/pdf/Antimicr...
November 11, 2025 at 12:46 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-9
@pablolaborda.bsky.social
@crisherencias.bsky.social

How it works

imili.org/pdf/Antimicr...
November 11, 2025 at 12:50 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-4
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...
November 7, 2025 at 4:20 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-3
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...
November 7, 2025 at 4:18 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-2
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...
November 7, 2025 at 4:16 PM
Reposted by Pablo Laborda
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-1
@pablolaborda.bsky.social
imili.org/pdf/Antimicr...
November 7, 2025 at 4:10 PM
New preprint out! 📣🚨

We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠

#Microsky
Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection https://www.biorxiv.org/content/10.1101/2025.10.24.684370v1
October 25, 2025 at 12:29 PM