Irene Beusch
@pauletteoctopus.bsky.social
junior group leader at University of Würzburg || RNA biologist with a 🖤 for splicing || science & 🎨, #firstgen www.beuschlab.org
Reposted by Irene Beusch
We’re looking for postdocs to explore RNA dynamics in biologically relevant conditions in an international and genuinely curious research team. If you’re interested in RNA changing its shape to perform its function (even inside a living cell), we'd love to hear from you. Details: petzoldlab.com
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petzoldlab.com
October 1, 2026 at 2:11 PM
We’re looking for postdocs to explore RNA dynamics in biologically relevant conditions in an international and genuinely curious research team. If you’re interested in RNA changing its shape to perform its function (even inside a living cell), we'd love to hear from you. Details: petzoldlab.com
Reposted by Irene Beusch
I am currently advertising 2 PhD positions in my lab as part of IMB‘s PhD program, one dry, one wet, centered on dissecting the role of disordered protein regions in cell regulation. Check out project descriptions here:
www.imb.de/students-pos...
www.imb.de/students-pos...
Projects Offered
IMB Mainz
www.imb.de
September 23, 2026 at 8:26 PM
I am currently advertising 2 PhD positions in my lab as part of IMB‘s PhD program, one dry, one wet, centered on dissecting the role of disordered protein regions in cell regulation. Check out project descriptions here:
www.imb.de/students-pos...
www.imb.de/students-pos...
Reposted by Irene Beusch
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
October 20, 2025 at 11:26 AM
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
Reposted by Irene Beusch
🚨 The #HIRI & the Faculty of Medicine of the @uni-wuerzburg.de invite applications for 2️⃣ JUNIOR PROFESSORSHIPS in:
🔵 RNA-BASED INFECTION RESEARCH
🔵 MICROBIAL RNA BIOLOGY
🔵 RNA-BASED MEDICINE
Apply by September 21:
www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/5)
🔵 RNA-BASED INFECTION RESEARCH
🔵 MICROBIAL RNA BIOLOGY
🔵 RNA-BASED MEDICINE
Apply by September 21:
www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/5)
W1 Groups
The Faculty of Medicine of the Julius-Maximilians-University of Würzburgand theHelmholtz Institute for RNA-based Infection Research (HIRI, Würzburg)jointly open a call for
www.helmholtz-hiri.de
August 24, 2026 at 4:16 PM
🚨 The #HIRI & the Faculty of Medicine of the @uni-wuerzburg.de invite applications for 2️⃣ JUNIOR PROFESSORSHIPS in:
🔵 RNA-BASED INFECTION RESEARCH
🔵 MICROBIAL RNA BIOLOGY
🔵 RNA-BASED MEDICINE
Apply by September 21:
www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/5)
🔵 RNA-BASED INFECTION RESEARCH
🔵 MICROBIAL RNA BIOLOGY
🔵 RNA-BASED MEDICINE
Apply by September 21:
www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/5)
Reposted by Irene Beusch
🧬 @rnamed.bsky.social is hiring! Apply for one of six fully funded #PhD positions in RNA biology and RNA therapeutics, and work with leading RNA experts in an international, interdisciplinary environment.
📅 Application deadline: September 17, 2026
More info: www.helmholtz-hiri.de/en/jobs-tale...
📅 Application deadline: September 17, 2026
More info: www.helmholtz-hiri.de/en/jobs-tale...
RNAmed - Future Leaders in RNA-based Medicine
RNAmed takes a holistic approach to endow doctoral students with the necessary knowledge and skills in the fast-growing area of RNA-based medicine.
www.helmholtz-hiri.de
August 17, 2026 at 12:48 PM
🧬 @rnamed.bsky.social is hiring! Apply for one of six fully funded #PhD positions in RNA biology and RNA therapeutics, and work with leading RNA experts in an international, interdisciplinary environment.
📅 Application deadline: September 17, 2026
More info: www.helmholtz-hiri.de/en/jobs-tale...
📅 Application deadline: September 17, 2026
More info: www.helmholtz-hiri.de/en/jobs-tale...
Reposted by Irene Beusch
One week left to apply for PhD and Postdoc positions at the @uni-wuerzburg.de site of our @nucleate-cluster.bsky.social Cluster of Excellence!
Join our group or the lab of one of our outstanding colleagues to help shape the future of nucleic acid science.
Apply here: nucleate-cluster.de/careers/
Join our group or the lab of one of our outstanding colleagues to help shape the future of nucleic acid science.
Apply here: nucleate-cluster.de/careers/
August 7, 2026 at 10:24 AM
One week left to apply for PhD and Postdoc positions at the @uni-wuerzburg.de site of our @nucleate-cluster.bsky.social Cluster of Excellence!
Join our group or the lab of one of our outstanding colleagues to help shape the future of nucleic acid science.
Apply here: nucleate-cluster.de/careers/
Join our group or the lab of one of our outstanding colleagues to help shape the future of nucleic acid science.
Apply here: nucleate-cluster.de/careers/
Reposted by Irene Beusch
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource go.nature.com/4mc1SmQ
rdcu.be/fxFp9
rdcu.be/fxFp9
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
go.nature.com
August 6, 2026 at 4:03 AM
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource go.nature.com/4mc1SmQ
rdcu.be/fxFp9
rdcu.be/fxFp9
Reposted by Irene Beusch
⏯️Webinar replay:
Everything you wanted to know about pre-mRNA splicing but were afraid to ask
🎤 Speaker: Aaron Hoskins, @uwmadisonrna.bsky.social
Watch for an overview of pre-mRNA splicing and the cellular machine responsible — the spliceosome: www.youtube.com/watch?v=Hf2w....
#RNAResearch
Everything you wanted to know about pre-mRNA splicing but were afraid to ask
🎤 Speaker: Aaron Hoskins, @uwmadisonrna.bsky.social
Watch for an overview of pre-mRNA splicing and the cellular machine responsible — the spliceosome: www.youtube.com/watch?v=Hf2w....
#RNAResearch
Everything you wanted to know about pre-mRNA splicing but were afraid to ask
YouTube video by American Society for Biochemistry and Molecular Biology (ASBMB)
www.youtube.com
August 1, 2026 at 4:25 AM
⏯️Webinar replay:
Everything you wanted to know about pre-mRNA splicing but were afraid to ask
🎤 Speaker: Aaron Hoskins, @uwmadisonrna.bsky.social
Watch for an overview of pre-mRNA splicing and the cellular machine responsible — the spliceosome: www.youtube.com/watch?v=Hf2w....
#RNAResearch
Everything you wanted to know about pre-mRNA splicing but were afraid to ask
🎤 Speaker: Aaron Hoskins, @uwmadisonrna.bsky.social
Watch for an overview of pre-mRNA splicing and the cellular machine responsible — the spliceosome: www.youtube.com/watch?v=Hf2w....
#RNAResearch
Reposted by Irene Beusch
ICYMI: New Online! Exchange dynamics and kinetic control of gene regulation complexes
Exchange dynamics and kinetic control of gene regulation complexes
Nature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-00991-zRecent evidence reveals how gene expression complexes form transient assemblies that continually exchange their subunits under kinetic control. This Perspective proposes that these dynamics form the basis of RNA processing and gene regulation.
dlvr.it
August 2, 2026 at 5:28 PM
ICYMI: New Online! Exchange dynamics and kinetic control of gene regulation complexes
Reposted by Irene Beusch
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
May 13, 2026 at 8:19 AM
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Come join us in Würzburg!
Exciting opportunity: We are recruiting 3 Independent Group Leaders for our Munich-Würzburg Cluster of Excellence #NUCLEATE on Nucleic Acid Sciences and Technologies 🧬. www.nature.com/naturecareers/job/12861192/independent-group-leader-at-nucleate-excellence-cluster/
@nucleate-cluster.bsky.social
@nucleate-cluster.bsky.social
Independent Group Leader at NUCLEATE Excellence Cluster - Munich or Würzburg job with NUCLEATE Cluster | 12861192
Independent Group Leader in Nucleic Acid Sciences and Technologies within the NUCLEATE Cluster at LMU Munich, TU Munich or JMU Würzburg.
www.nature.com
July 9, 2026 at 6:14 AM
Come join us in Würzburg!
Reposted by Irene Beusch
Exciting opportunity: We are recruiting 3 Independent Group Leaders for our Munich-Würzburg Cluster of Excellence #NUCLEATE on Nucleic Acid Sciences and Technologies 🧬. www.nature.com/naturecareers/job/12861192/independent-group-leader-at-nucleate-excellence-cluster/
@nucleate-cluster.bsky.social
@nucleate-cluster.bsky.social
Independent Group Leader at NUCLEATE Excellence Cluster - Munich or Würzburg job with NUCLEATE Cluster | 12861192
Independent Group Leader in Nucleic Acid Sciences and Technologies within the NUCLEATE Cluster at LMU Munich, TU Munich or JMU Würzburg.
www.nature.com
July 8, 2026 at 6:26 AM
Exciting opportunity: We are recruiting 3 Independent Group Leaders for our Munich-Würzburg Cluster of Excellence #NUCLEATE on Nucleic Acid Sciences and Technologies 🧬. www.nature.com/naturecareers/job/12861192/independent-group-leader-at-nucleate-excellence-cluster/
@nucleate-cluster.bsky.social
@nucleate-cluster.bsky.social
Reposted by Irene Beusch
How can a splicing factor bind to thousands of exons but regulate only a few of them? In our new preprint, we show that SRSF6 resolves this paradox through two distinct binding modes. @lab-nmr.bsky.social & @julianvonehr.bsky.social. Check it out:
www.researchsquare.com/article/rs-9...
www.researchsquare.com/article/rs-9...
June 17, 2026 at 1:59 PM
How can a splicing factor bind to thousands of exons but regulate only a few of them? In our new preprint, we show that SRSF6 resolves this paradox through two distinct binding modes. @lab-nmr.bsky.social & @julianvonehr.bsky.social. Check it out:
www.researchsquare.com/article/rs-9...
www.researchsquare.com/article/rs-9...
Reposted by Irene Beusch
One week left to apply. Help us find new antimicrobials and understand the inner workings of bacteria – as a technical assistant in the Machine Biophotonics and Nanoscale Bacteriology labs at the Rudolf-Virchow-Zentrum, University of Würzburg – See details below (in German). Please spread the word.
Stellenangebote - Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
Aktuelle Stellenanzeigen des Rudolf-Virchow-Zentrums / Current positions of the Rudolf Virchow Center
www.uni-wuerzburg.de
May 31, 2026 at 4:45 AM
One week left to apply. Help us find new antimicrobials and understand the inner workings of bacteria – as a technical assistant in the Machine Biophotonics and Nanoscale Bacteriology labs at the Rudolf-Virchow-Zentrum, University of Würzburg – See details below (in German). Please spread the word.
It‘s not always the best solution to do your CRISPR(i) screen at a low MOI (or the dogmatic 0.3-0.5 range 😉) - superinfection can give you a higher quality output!
Super cool to finally see some of @chnebster.bsky.social postdoc work out and published!
Super cool to finally see some of @chnebster.bsky.social postdoc work out and published!
A project from my postdoc in the McManus lab @mcmanuslab.bsky.social at UCSF @ucsfdc.bsky.social is out today 🎉
For years, pooled CRISPR screens have operated under a central assumption: one perturbation per cell.
We challenged that assumption. 🤯
www.nature.com/articles/s41592-026-03095-w
For years, pooled CRISPR screens have operated under a central assumption: one perturbation per cell.
We challenged that assumption. 🤯
www.nature.com/articles/s41592-026-03095-w
Multiplexed perturbation enables scalable pooled screens - Nature Methods
This paper shows that high MOI sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers, challenging conventional reliance on low-MOI infections.
www.nature.com
May 26, 2026 at 8:34 AM
It‘s not always the best solution to do your CRISPR(i) screen at a low MOI (or the dogmatic 0.3-0.5 range 😉) - superinfection can give you a higher quality output!
Super cool to finally see some of @chnebster.bsky.social postdoc work out and published!
Super cool to finally see some of @chnebster.bsky.social postdoc work out and published!
Reposted by Irene Beusch
What should Europe do when demand for #ERC funding keeps rising?
Restrict access or invest in excellence?
Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness
Consider to share & sign - see below 🧪
Restrict access or invest in excellence?
Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness
Consider to share & sign - see below 🧪
#erc | Johanna Joyce
What should Europe do when demand for its most successful frontier research programme keeps rising?
Restrict access, or invest in the excellence it has created?
A new open letter, spearheaded by Sara...
www.linkedin.com
April 22, 2026 at 9:24 AM
What should Europe do when demand for #ERC funding keeps rising?
Restrict access or invest in excellence?
Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness
Consider to share & sign - see below 🧪
Restrict access or invest in excellence?
Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness
Consider to share & sign - see below 🧪
Reposted by Irene Beusch
Our genes come in bits & pieces!🧬Learn how splicing "cuts & pastes" RNA to create different proteins from a single gene, for its discovery the 1993 Nobel Prize in Physiology or Medicine was awarded.
www.youtube.com/watch?v=-x7H...
@snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social
www.youtube.com/watch?v=-x7H...
@snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social
RNA Explained: Split Genes – RNA Splicing & Protein Diversity
YouTube video by NCCR RNA & Disease
www.youtube.com
April 23, 2026 at 3:29 PM
Our genes come in bits & pieces!🧬Learn how splicing "cuts & pastes" RNA to create different proteins from a single gene, for its discovery the 1993 Nobel Prize in Physiology or Medicine was awarded.
www.youtube.com/watch?v=-x7H...
@snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social
www.youtube.com/watch?v=-x7H...
@snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social
19F NMR is such a powerful tool! Lovely NMR work ❤️
Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 μs) than those in the proximal pore (~300 μs). Congrats Elise! 🎉🎉 www.sciencedirect.com/science/arti...
19F NMR Strategy for Probing Site-specific RNA Dynamics in Large RNA-protein Complexes: Application to the Hfq RNA Chaperone
Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited to probing motions on the microsecond to millisecond timescales that underlie RNA rec…
www.sciencedirect.com
April 22, 2026 at 6:41 PM
19F NMR is such a powerful tool! Lovely NMR work ❤️
Reposted by Irene Beusch
Yale MB&B's Karla Neugebauer and Guillermina Kubaczka have been featured in a new @natmethods.nature.com piece 🌍🔬
The article spotlights researchers bridging the molecular and planetary scales to address global health challenges.
@karlaneugebauer.bsky.social
www.nature.com/articles/s41...
The article spotlights researchers bridging the molecular and planetary scales to address global health challenges.
@karlaneugebauer.bsky.social
www.nature.com/articles/s41...
Cell biology’s fantastic voyage to Planet Earth - Nature Methods
A nascent group of researchers sees planetary health as an urgent reason to bridge the molecular and planetary scales. This is shaping their strategies, methods, collaborations and outlook about their...
www.nature.com
March 31, 2026 at 8:08 PM
Yale MB&B's Karla Neugebauer and Guillermina Kubaczka have been featured in a new @natmethods.nature.com piece 🌍🔬
The article spotlights researchers bridging the molecular and planetary scales to address global health challenges.
@karlaneugebauer.bsky.social
www.nature.com/articles/s41...
The article spotlights researchers bridging the molecular and planetary scales to address global health challenges.
@karlaneugebauer.bsky.social
www.nature.com/articles/s41...
looking forward to reading this! Love to see an RRM-by-RRM dissection as similar principles are employed by so many multi-RBD proteins.
NAR breakthrough alert 🎉 Joint work with @mfeldbruegge.bsky.social on Rrm4. We dissect its modular RRM binding code & how domain combinations shape RNA interactions. Like finding needles in a haystack, comparative iCLIP sorts functional vs accessory sites. Work by Nina & @srimeenakshi.bsky.social
Breakthrough article 😊
Joint effort of teams Zarnack & König & Feldbrügge clarifies how multiple RNA-binding domains cooperate to identify functional important binding sites in vivo
doi.org/10.1093/nar/...
@zarnack-group.bsky.social
@könig-lab.bsky.social
@mibinet.bsky.social
#EMBOrnaLocalization
Joint effort of teams Zarnack & König & Feldbrügge clarifies how multiple RNA-binding domains cooperate to identify functional important binding sites in vivo
doi.org/10.1093/nar/...
@zarnack-group.bsky.social
@könig-lab.bsky.social
@mibinet.bsky.social
#EMBOrnaLocalization
April 8, 2026 at 6:12 AM
looking forward to reading this! Love to see an RRM-by-RRM dissection as similar principles are employed by so many multi-RBD proteins.
Reposted by Irene Beusch
❗️5 days left to apply for a PhD position in our group👇
Passionate about transcription?
🚀 We’re recruiting a PhD student in Transcriptional Regulation at @ucph.bsky.social Start Summer 2026
Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab @cgen2025.bsky.social
Meet us: gregersenlab.com
Apply by Apr 10, 2026👇
tinyurl.com/PhD-CGEN
🚀 We’re recruiting a PhD student in Transcriptional Regulation at @ucph.bsky.social Start Summer 2026
Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab @cgen2025.bsky.social
Meet us: gregersenlab.com
Apply by Apr 10, 2026👇
tinyurl.com/PhD-CGEN
April 5, 2026 at 3:12 PM
❗️5 days left to apply for a PhD position in our group👇
Very neat and cool!
Lots of papers out today!
From Doug Black and Hong Zhou's labs: structural mechanism of RBM5 regulated splicing via U2 interactions
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing
Shiheng Liu et al..
www.biorxiv.org/content/10.6...
From Doug Black and Hong Zhou's labs: structural mechanism of RBM5 regulated splicing via U2 interactions
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing
Shiheng Liu et al..
www.biorxiv.org/content/10.6...
www.biorxiv.org
April 7, 2026 at 8:33 AM
Very neat and cool!
Reposted by Irene Beusch
Lots of papers out today!
From Doug Black and Hong Zhou's labs: structural mechanism of RBM5 regulated splicing via U2 interactions
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing
Shiheng Liu et al..
www.biorxiv.org/content/10.6...
From Doug Black and Hong Zhou's labs: structural mechanism of RBM5 regulated splicing via U2 interactions
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing
Shiheng Liu et al..
www.biorxiv.org/content/10.6...
www.biorxiv.org
April 6, 2026 at 9:51 PM
Lots of papers out today!
From Doug Black and Hong Zhou's labs: structural mechanism of RBM5 regulated splicing via U2 interactions
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing
Shiheng Liu et al..
www.biorxiv.org/content/10.6...
From Doug Black and Hong Zhou's labs: structural mechanism of RBM5 regulated splicing via U2 interactions
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing
Shiheng Liu et al..
www.biorxiv.org/content/10.6...
Reposted by Irene Beusch
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
March 26, 2026 at 9:03 PM
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
Reposted by Irene Beusch
Happy to share our latest work on the previously uncharacterized splicing factor Cwc15! Importantly, all of the people who did this work are/were undergrads!
S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for 5' Splice Site Cleavage
www.biorxiv.org/content/10.6...
S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for 5' Splice Site Cleavage
www.biorxiv.org/content/10.6...
www.biorxiv.org
March 23, 2026 at 7:43 PM
Happy to share our latest work on the previously uncharacterized splicing factor Cwc15! Importantly, all of the people who did this work are/were undergrads!
S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for 5' Splice Site Cleavage
www.biorxiv.org/content/10.6...
S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for 5' Splice Site Cleavage
www.biorxiv.org/content/10.6...