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🤖 Feed for papers about HLA/MHC neoantigens, immunopeptidomes and HDX-MS from PubMed and bioRxiv. Run by @ab604.uk inspired by @phypapers.bsky.social and https://bsky.app/profile/r-bloggers.bsky.social. Code: https://github.com/ab604/prot-paper-bot

Oncogenic fusions induce an extensive cancer-restricted cryptic proteome in Ewing sarcoma

https://www.biorxiv.org/content/10.64898/2026.09.16.751792v1
September 17, 2026 at 8:24 PM
Immunopeptidomics-guided cancer vaccine design: Advances, challenges, and emerging opportunities https://pubmed.ncbi.nlm.nih.gov/42743775/
September 16, 2026 at 10:03 AM
Therapeutic cancer vaccines: development, challenges, and future perspectives https://pubmed.ncbi.nlm.nih.gov/42736453/
September 15, 2026 at 8:18 PM
Impact of the functional ERAP2 rs2248374 polymorphism on the HLA class I immunopeptidome in primary human epidermal keratinocytes https://pubmed.ncbi.nlm.nih.gov/42735508/
September 15, 2026 at 10:11 AM
HDX-MS-Guided computational modeling for rapid and accurate antibody-antigen interface mapping https://pubmed.ncbi.nlm.nih.gov/42725674/
September 12, 2026 at 9:27 AM

A peptidomimetic inhibitor blocks Vibrio cholerae adhesin FrhA.

https://www.biorxiv.org/content/10.64898/2026.09.07.749730v1
September 11, 2026 at 9:50 AM
Discovery of CD4+ T cell-recognized B. pertussis antigens that reduce airway colonization https://pubmed.ncbi.nlm.nih.gov/42708360/
September 8, 2026 at 7:58 PM
Understanding HLA risk in immune-mediated inflammatory diseases requires antigen discovery https://pubmed.ncbi.nlm.nih.gov/42705941/
September 8, 2026 at 9:50 AM
ExchangeXplorer: an R/Shiny application for processing and visualization of LC-HDX-MS data in metabolomics, lipidomics, and exposomics https://pubmed.ncbi.nlm.nih.gov/42702477/
September 7, 2026 at 10:28 AM
Immunopeptidomics in gliomas: Decoding antigen presentation for precision immunotherapy https://pubmed.ncbi.nlm.nih.gov/42697339/
September 5, 2026 at 7:07 PM
Mass Spectrometry-Based Profiling of Personalized Immunopeptidomes in Thai Renal Cell Carcinoma https://pubmed.ncbi.nlm.nih.gov/42695889/
September 5, 2026 at 9:10 AM
HLA-II peptide-binding diversity shapes humoral immune responses and susceptibility to infections https://pubmed.ncbi.nlm.nih.gov/42686785/
September 3, 2026 at 9:57 AM

Cryo-EM Structure of a Triazole alpha-Conotoxin GI Mimetic Bound to the Muscle-Type Nicotinic Acetylcholine Receptor

https://www.biorxiv.org/content/10.64898/2026.08.31.748223v1
September 2, 2026 at 7:52 PM
Normal-immunopeptidome denominator: a safety atlas for immunotherapies targeting non-canonical and aberrantly expressed tumor antigens https://pubmed.ncbi.nlm.nih.gov/42680204/
September 2, 2026 at 9:45 AM

Mapping Light-Induced Conformational Dynamics of Pigeon Cryptochrome 4 by HDX-MS: Structural Transitions from Spin Pair Formation to Activated Conformational States

https://www.biorxiv.org/content/10.64898/2026.08.27.747556v1
September 1, 2026 at 8:00 PM
Systematic Workflow Optimization for Ultra-sensitive Targeted Immunopeptidomics https://pubmed.ncbi.nlm.nih.gov/42551630/
August 30, 2026 at 10:32 AM

LemonCatcher Acidic Pull-Down Enables Selective In-Cell Hydrogen-Deuterium Exchange Mass Spectrometry

https://www.biorxiv.org/content/10.64898/2026.08.26.747387v1
August 29, 2026 at 7:49 PM

Fusion-derived phospho-neoepitopes define a prioritized candidate neoantigen repertoire in MASLD-HCC

https://www.biorxiv.org/content/10.64898/2026.08.26.747243v1
August 29, 2026 at 11:44 AM
Phosphorylation shapes antigen presentation and immune recognition: mechanistic insights and translational perspectives https://pubmed.ncbi.nlm.nih.gov/42657027/
August 28, 2026 at 5:30 PM
Skewed MHC Class I Peptide Presentation in Psoriatic Arthritis https://pubmed.ncbi.nlm.nih.gov/42653321/
August 27, 2026 at 4:35 PM
Micropeptides encoded by lncRNAs associated with cancer progression reveal novel immunogenic epitopes https://pubmed.ncbi.nlm.nih.gov/42635236/
August 24, 2026 at 5:51 PM
Association analysis between HLA evolutionary divergence and CMV serological status in a cohort of 526 adult subjects https://pubmed.ncbi.nlm.nih.gov/42624171/
August 21, 2026 at 5:52 AM
Probing protein-lipid interactions by hydrogen/deuterium exchange-mass spectrometry: advances, challenges and future directions https://pubmed.ncbi.nlm.nih.gov/42609751/
August 19, 2026 at 5:54 AM
HDX-MS Detects Steric Protection and Trimeric Compaction of TNFalpha after It Binds Receptors or Antibodies https://pubmed.ncbi.nlm.nih.gov/42597968/
August 14, 2026 at 6:15 PM

Benchmarking Spectral Library Prediction Platforms for Neuropeptidomics Applications

https://www.biorxiv.org/content/10.64898/2026.08.07.743122v1
August 14, 2026 at 6:48 AM