Patricia Yuste-Checa
@pyustecheca.bsky.social
Molecular biologist interested in proteostasis and neurodegeneration | Postdoc at Max Planck Institute Biochemistry
🦠What if viruses could act as "vehicles" for toxic brain proteins in neurodegenerative diseases?
Our new preprint shows that lentiviral particles efficiently package and transmit seeding-competent tau in a cellular model, providing insights into how viral infections may drive neurodegeneration.
Our new preprint shows that lentiviral particles efficiently package and transmit seeding-competent tau in a cellular model, providing insights into how viral infections may drive neurodegeneration.
Virus-mediated tau aggregate seeding in a cellular model
Formation of neuronal tau protein aggregates is a defining feature of tauopathies, including Alzheimer’s disease and frontotemporal dementia. Tau pathology propagates across brain regions by a cell-to...
www.biorxiv.org
June 30, 2026 at 1:51 PM
🦠What if viruses could act as "vehicles" for toxic brain proteins in neurodegenerative diseases?
Our new preprint shows that lentiviral particles efficiently package and transmit seeding-competent tau in a cellular model, providing insights into how viral infections may drive neurodegeneration.
Our new preprint shows that lentiviral particles efficiently package and transmit seeding-competent tau in a cellular model, providing insights into how viral infections may drive neurodegeneration.
Reposted by Patricia Yuste-Checa
Structural & functional analysis revealed that the extracellular #chaperone #clusterin functions through two tails in preventing protein aggregation.
❕Paper: www.nature.com/articles/s41...
❕Press Release: www.biochem.mpg.de/structure-of...
#Alzheimers @natsmb.nature.com @pyustecheca.bsky.social
❕Paper: www.nature.com/articles/s41...
❕Press Release: www.biochem.mpg.de/structure-of...
#Alzheimers @natsmb.nature.com @pyustecheca.bsky.social
September 5, 2025 at 2:59 PM
Structural & functional analysis revealed that the extracellular #chaperone #clusterin functions through two tails in preventing protein aggregation.
❕Paper: www.nature.com/articles/s41...
❕Press Release: www.biochem.mpg.de/structure-of...
#Alzheimers @natsmb.nature.com @pyustecheca.bsky.social
❕Paper: www.nature.com/articles/s41...
❕Press Release: www.biochem.mpg.de/structure-of...
#Alzheimers @natsmb.nature.com @pyustecheca.bsky.social
Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ!
#proteostasis #apolipoprotein
rdcu.be/ezRLv
#proteostasis #apolipoprotein
rdcu.be/ezRLv
Structural analyses define the molecular basis of clusterin chaperone function
Nature Structural & Molecular Biology - The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions...
rdcu.be
August 8, 2025 at 2:58 PM
Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ!
#proteostasis #apolipoprotein
rdcu.be/ezRLv
#proteostasis #apolipoprotein
rdcu.be/ezRLv
Reposted by Patricia Yuste-Checa
New online: Structural analyses define the molecular basis of clusterin chaperone function
Structural analyses define the molecular basis of clusterin chaperone function
Nature Structural & Molecular Biology, Published online: 08 August 2025; doi:10.1038/s41594-025-01631-4The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions as an extracellular molecular chaperone and apolipoprotein, as well as for receptor binding and cellular uptake.
go.nature.com
August 8, 2025 at 9:44 AM
New online: Structural analyses define the molecular basis of clusterin chaperone function
Reposted by Patricia Yuste-Checa
Exicted to share our latest review in @narjournal.bsky.social on how the ribosome coordinates mRNA decay with a focus on structural advances in the field.
#ribosome #mRNAdecay #translation
#ribosome #mRNAdecay #translation
The ribosome as a platform to coordinate mRNA decay
Abstract. Messenger RNA (mRNA) homeostasis is a critical aspect of cellular function, involving the dynamic interplay between transcription and decay proce
academic.oup.com
February 10, 2025 at 10:11 AM
Exicted to share our latest review in @narjournal.bsky.social on how the ribosome coordinates mRNA decay with a focus on structural advances in the field.
#ribosome #mRNAdecay #translation
#ribosome #mRNAdecay #translation