DeBerardinis Lab at UT Southwestern Medical Center
@rjdlab.bsky.social
I still like small data but I'm not opposed to big data. We study #metabolism, #genetics, #pediatric inborn errors & cancer. Views are my own.
This beam, signed by hundreds of supporters, will be part of the Children’s Health & UT Southwestern Pediatric Campus in Dallas, now under construction. It’s exciting to see all the support! There’s almost no room left to sign.
September 24, 2026 at 11:08 AM
This beam, signed by hundreds of supporters, will be part of the Children’s Health & UT Southwestern Pediatric Campus in Dallas, now under construction. It’s exciting to see all the support! There’s almost no room left to sign.
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
What does the newborn heart need to complete its metabolic transition? Check out our paper on mitoSAM import in the postnatal mouse heart. Great work by @anarum.bsky.social and collaborators @rjdlab.bsky.social, @trevortippetts.bsky.social. @ki.se , @kawresearch.bsky.social
doi.org/10.1126/scia...
doi.org/10.1126/scia...
Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart
The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear....
www.science.org
August 27, 2026 at 11:19 AM
What does the newborn heart need to complete its metabolic transition? Check out our paper on mitoSAM import in the postnatal mouse heart. Great work by @anarum.bsky.social and collaborators @rjdlab.bsky.social, @trevortippetts.bsky.social. @ki.se , @kawresearch.bsky.social
doi.org/10.1126/scia...
doi.org/10.1126/scia...
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers
@seanjmorrison.bsky.social @rjdlab.bsky.social @haozhulab.bsky.social @hrshin.bsky.social @peterlylab.bsky.social @henrydebelly.bsky.social
@seanjmorrison.bsky.social @rjdlab.bsky.social @haozhulab.bsky.social @hrshin.bsky.social @peterlylab.bsky.social @henrydebelly.bsky.social
August 19, 2026 at 7:31 PM
Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers
@seanjmorrison.bsky.social @rjdlab.bsky.social @haozhulab.bsky.social @hrshin.bsky.social @peterlylab.bsky.social @henrydebelly.bsky.social
@seanjmorrison.bsky.social @rjdlab.bsky.social @haozhulab.bsky.social @hrshin.bsky.social @peterlylab.bsky.social @henrydebelly.bsky.social
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
TODAY in @dallasnews.com: Read more about McBrayer Lab's #relentlessdiscovery in @science.org, with a cameo from CRI Genetic & Metabolic Disease Program Director @rjdlab.bsky.social 🧪
A new study from Dallas scientists suggests a mutated gene leads to severe neurological impairment, and points towards a potential treatment strategy.
Dallas scientists uncover mutated gene's role in rare brain disorder
A new study from Dallas scientists suggests a mutated gene leads to severe neurological impairment, and points towards a potential treatment strategy.
bit.ly
July 30, 2026 at 7:33 PM
TODAY in @dallasnews.com: Read more about McBrayer Lab's #relentlessdiscovery in @science.org, with a cameo from CRI Genetic & Metabolic Disease Program Director @rjdlab.bsky.social 🧪
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
🚨 Deadline extension: Register until July 10 for the #FrankfurtCancerConference 2026!
✨ Highlights: 9 scientific sessions, 32 excellent speakers, short talks, posters, lots of time to connect!
👇 Check out our program and register here: www.frankfurtcancerconference.org
✨ Highlights: 9 scientific sessions, 32 excellent speakers, short talks, posters, lots of time to connect!
👇 Check out our program and register here: www.frankfurtcancerconference.org
June 25, 2026 at 7:55 PM
🚨 Deadline extension: Register until July 10 for the #FrankfurtCancerConference 2026!
✨ Highlights: 9 scientific sessions, 32 excellent speakers, short talks, posters, lots of time to connect!
👇 Check out our program and register here: www.frankfurtcancerconference.org
✨ Highlights: 9 scientific sessions, 32 excellent speakers, short talks, posters, lots of time to connect!
👇 Check out our program and register here: www.frankfurtcancerconference.org
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
👏👏 On a roll with #MotivationMonday & another successful dissertation defense! Congrats to @haozhulab.bsky.social & @rjdlab.bsky.social lab grad student Roger Liang. Dr. Liang is headed back to medical school to finish up his M.D. Onward! #relentlessdiscovery 🧪
June 15, 2026 at 6:55 PM
👏👏 On a roll with #MotivationMonday & another successful dissertation defense! Congrats to @haozhulab.bsky.social & @rjdlab.bsky.social lab grad student Roger Liang. Dr. Liang is headed back to medical school to finish up his M.D. Onward! #relentlessdiscovery 🧪
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
www.nature.com
May 21, 2026 at 12:14 AM
Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
Advancing our understanding of how metabolism shapes neuronal development: doi.org/10.1172/JCI1...
@rjdlab.bsky.social & team generated neural progenitor cells from patients, finding that L2HG epigenetically activates MYC to impair neuronal differentiation—and the effect is reversible
@rjdlab.bsky.social & team generated neural progenitor cells from patients, finding that L2HG epigenetically activates MYC to impair neuronal differentiation—and the effect is reversible
May 13, 2026 at 12:02 PM
Advancing our understanding of how metabolism shapes neuronal development: doi.org/10.1172/JCI1...
@rjdlab.bsky.social & team generated neural progenitor cells from patients, finding that L2HG epigenetically activates MYC to impair neuronal differentiation—and the effect is reversible
@rjdlab.bsky.social & team generated neural progenitor cells from patients, finding that L2HG epigenetically activates MYC to impair neuronal differentiation—and the effect is reversible
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
We already thought @haozhulab.bsky.social hung the (liver-shaped) moon🌙 & now his #relentlessdiscovery is promulgated. Check out Chp 6, "When Our Bodies Autocorrect," p140 to read how somatic mutations could give us "hope." Great topic, @roxannekhamsi.bsky.social! 🧪 Watch out #booktok 🤓
May 5, 2026 at 8:24 PM
We already thought @haozhulab.bsky.social hung the (liver-shaped) moon🌙 & now his #relentlessdiscovery is promulgated. Check out Chp 6, "When Our Bodies Autocorrect," p140 to read how somatic mutations could give us "hope." Great topic, @roxannekhamsi.bsky.social! 🧪 Watch out #booktok 🤓
I am so grateful for this honor - grateful to my mentors, lab, and family. Thank you @seanjmorrison.bsky.social for your support. And how great to be elected with some very good friends and two awesome UTSW colleagues, Elizabeth Chen and Joel Elmquist. Feeling very fortunate today.
April 29, 2026 at 1:10 AM
I am so grateful for this honor - grateful to my mentors, lab, and family. Thank you @seanjmorrison.bsky.social for your support. And how great to be elected with some very good friends and two awesome UTSW colleagues, Elizabeth Chen and Joel Elmquist. Feeling very fortunate today.
This kind of stable, sustained support can transform a career: @hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI
The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...
bit.ly
April 17, 2026 at 7:26 PM
This kind of stable, sustained support can transform a career: @hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
New paper from Dr. Wen Gu on the impact of L-2-hydroxyglutarate deficiency on neural stem cell function and neuronal differentiation. Interesting connection between an IEM and chronic oncogene activation. Thanks to Dr. Bushra Afroze and her patients for participating.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression
www.jci.org
March 19, 2026 at 5:41 PM
New paper from Dr. Wen Gu on the impact of L-2-hydroxyglutarate deficiency on neural stem cell function and neuronal differentiation. Interesting connection between an IEM and chronic oncogene activation. Thanks to Dr. Bushra Afroze and her patients for participating.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Incredible chance to learn about genetics, from the fundamentals to the latest science. I attended this course when I was a PhD student in the 90s and have lectured in it for the last dozen or so.
And science aside, there's nowhere better to be in late July than Bar Harbor, ME. See you there.
And science aside, there's nowhere better to be in late July than Bar Harbor, ME. See you there.
March 3, 2026 at 11:35 PM
Incredible chance to learn about genetics, from the fundamentals to the latest science. I attended this course when I was a PhD student in the 90s and have lectured in it for the last dozen or so.
And science aside, there's nowhere better to be in late July than Bar Harbor, ME. See you there.
And science aside, there's nowhere better to be in late July than Bar Harbor, ME. See you there.
#RareDiseaseDay2026: “think of zebras (rare diseases) when you hear hoofbeats.” On Feb 28, we wear stripes to recognize patients with rare diseases and support rare disease research in CRI and the McDermott Center at UT Southwestern. Thanks to the Rare Disease CoE for all you do for these patients.
February 28, 2026 at 11:47 AM
#RareDiseaseDay2026: “think of zebras (rare diseases) when you hear hoofbeats.” On Feb 28, we wear stripes to recognize patients with rare diseases and support rare disease research in CRI and the McDermott Center at UT Southwestern. Thanks to the Rare Disease CoE for all you do for these patients.
My first co-authored paper appeared 30 years ago today.
pubmed.ncbi.nlm.nih.gov/8626737/
pubmed.ncbi.nlm.nih.gov/8626737/
Human enteric defensins. Gene structure and developmental expression - PubMed
Paneth cells, secretory epithelial cells of the small intestinal crypts, are proposed to contribute to local host defense. Both mouse and human Paneth cells express a collection of antimicrobial proteins, including members of a family of antimicrobial peptides named defensins. In this study, data fr …
pubmed.ncbi.nlm.nih.gov
February 23, 2026 at 12:05 PM
My first co-authored paper appeared 30 years ago today.
pubmed.ncbi.nlm.nih.gov/8626737/
pubmed.ncbi.nlm.nih.gov/8626737/
Great time in Boston, as always! Thanks for the invitation!
Live from our Cancer Research Institute seminar: @rjdlab.bsky.social. His lab studies how oncogenic control of #metabolism impacts tumor growth and progression. Using isotope tracers, he assesses tumor metabolism in vivo and measures mitochondrial function in purine metabolism.
#CancerResearch
#CancerResearch
February 19, 2026 at 8:09 PM
Great time in Boston, as always! Thanks for the invitation!
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
That’s a wrap on the past 12 months, with even more #relentlessdiscovery to come in 2026. cri.utsw.edu/discoveries/
@seanjmorrison.bsky.social
@rjdlab.bsky.social
@haozhulab.bsky.social
🧪 #stemcells #regeneration #CancerResearch #metabolism #NYE2025 #NYE2026
@seanjmorrison.bsky.social
@rjdlab.bsky.social
@haozhulab.bsky.social
🧪 #stemcells #regeneration #CancerResearch #metabolism #NYE2025 #NYE2026
December 31, 2025 at 9:23 PM
That’s a wrap on the past 12 months, with even more #relentlessdiscovery to come in 2026. cri.utsw.edu/discoveries/
@seanjmorrison.bsky.social
@rjdlab.bsky.social
@haozhulab.bsky.social
🧪 #stemcells #regeneration #CancerResearch #metabolism #NYE2025 #NYE2026
@seanjmorrison.bsky.social
@rjdlab.bsky.social
@haozhulab.bsky.social
🧪 #stemcells #regeneration #CancerResearch #metabolism #NYE2025 #NYE2026
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
ONLINE NOW in @pnas.org: Agathocleous Lab, collaborators discover why humans, some animals may need intermittent vitamin C deficiency: to survive parasite infections. 🧪 Read more ⬇️ cri.utsw.edu/loss-of-vita... #relentlessdiscovery
Loss of vitamin C synthesis protects animals from schistosomiasis - Children's Medical Center Research Institute (CRI) | Dallas Texas
Agathocleous Lab, collaborators discover vitamin C deficiency can benefit animals by depriving vitamin from parasitic worms DALLAS – Dec. 23, 2025 – Scientists at Children’s Medical Center Research In...
cri.utsw.edu
December 23, 2025 at 10:52 PM
ONLINE NOW in @pnas.org: Agathocleous Lab, collaborators discover why humans, some animals may need intermittent vitamin C deficiency: to survive parasite infections. 🧪 Read more ⬇️ cri.utsw.edu/loss-of-vita... #relentlessdiscovery
Just a nice lab happy hour before the holidays
December 18, 2025 at 1:25 AM
Just a nice lab happy hour before the holidays
An excellent opportunity for summer undergraduate research - the Cech Fellows Program! Applications due in 10 days:
www.hhmi.org/programs/cec...
www.hhmi.org/programs/cec...
Summer Undergraduate Research Experience (REU) | Cech Fellows | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
www.hhmi.org
December 12, 2025 at 9:47 PM
An excellent opportunity for summer undergraduate research - the Cech Fellows Program! Applications due in 10 days:
www.hhmi.org/programs/cec...
www.hhmi.org/programs/cec...
A true legend.
www.bcm.edu/about-us/lea...
www.bcm.edu/about-us/lea...
In Memoriam: Bert W. O'Malley, M.D.
In Memoriam: Bert W. O'Malley, M.D....
www.bcm.edu
November 11, 2025 at 7:00 PM
A true legend.
www.bcm.edu/about-us/lea...
www.bcm.edu/about-us/lea...
Reposted by DeBerardinis Lab at UT Southwestern Medical Center
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
November 10, 2025 at 5:40 PM
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
Here's the beautiful paper from @chembiohub.bsky.social reporting NUDT5's role in purine synthesis. I cannot emphasize enough how gracious and open these authors were when we all realized we were working on the same mechanism.
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
www.science.org
November 6, 2025 at 8:33 PM
Here's the beautiful paper from @chembiohub.bsky.social reporting NUDT5's role in purine synthesis. I cannot emphasize enough how gracious and open these authors were when we all realized we were working on the same mechanism.
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 7:01 PM
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...