Roux Lab, Geneva
@rouxlab.bsky.social
A mix of physics and biology, understanding shapes in biology, from molecules to tissues.
http://www.orelrouxlab.org
http://www.orelrouxlab.org
Reposted by Roux Lab, Geneva
We are also very excited to present the first 'in curvo' nematics of each actin layer in the same Hydra ! 🤩
Amazing work by NeMo's dad @kandreadis.bsky.social and the fantastic imaging by @oriolmb.bsky.social from the @rouxlab.bsky.social, to illustrate the possible use of NeMo.
Amazing work by NeMo's dad @kandreadis.bsky.social and the fantastic imaging by @oriolmb.bsky.social from the @rouxlab.bsky.social, to illustrate the possible use of NeMo.
September 23, 2026 at 7:46 AM
We are also very excited to present the first 'in curvo' nematics of each actin layer in the same Hydra ! 🤩
Amazing work by NeMo's dad @kandreadis.bsky.social and the fantastic imaging by @oriolmb.bsky.social from the @rouxlab.bsky.social, to illustrate the possible use of NeMo.
Amazing work by NeMo's dad @kandreadis.bsky.social and the fantastic imaging by @oriolmb.bsky.social from the @rouxlab.bsky.social, to illustrate the possible use of NeMo.
Reposted by Roux Lab, Geneva
NeMo is finally out! 🐟
We present our new method to peel cellular layers and extract their nematics.
If you're wondering what a fish has to do with curved nematics, check out the thread and the publication 👀👇🏼
arxiv.org/html/2609.12...
We present our new method to peel cellular layers and extract their nematics.
If you're wondering what a fish has to do with curved nematics, check out the thread and the publication 👀👇🏼
arxiv.org/html/2609.12...
September 23, 2026 at 7:45 AM
NeMo is finally out! 🐟
We present our new method to peel cellular layers and extract their nematics.
If you're wondering what a fish has to do with curved nematics, check out the thread and the publication 👀👇🏼
arxiv.org/html/2609.12...
We present our new method to peel cellular layers and extract their nematics.
If you're wondering what a fish has to do with curved nematics, check out the thread and the publication 👀👇🏼
arxiv.org/html/2609.12...
Fantastic collaboration with the Kaksonen lab, amazing work from Anne-Laure Boinet with some truly surprising result! Congrats to all contributors!
Endocytic clathrin coats are surprisingly dynamic: triskelia turn over in seconds. How is the turnover regulated and what is it for? Read Anne-Laure Boinet's preprint with @rouxlab.bsky.social www.biorxiv.org/content/10.6...
August 11, 2026 at 5:04 PM
Fantastic collaboration with the Kaksonen lab, amazing work from Anne-Laure Boinet with some truly surprising result! Congrats to all contributors!
@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social
rdcu.be/fihKk
rdcu.be/fihKk
May 12, 2026 at 12:09 PM
@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social
rdcu.be/fihKk
rdcu.be/fihKk
Congrats to Nicolas, Mathieu ad Claire for this important achievement. This will help the community tremendously!
Congrats to all authors: @dedenonmathieu.bsky.social, @rouxlab.bsky.social and especially Nicolas Rembert for pushing this project from his internship through his PhD!
April 23, 2026 at 6:54 AM
Congrats to Nicolas, Mathieu ad Claire for this important achievement. This will help the community tremendously!
Reposted by Roux Lab, Geneva
New method paper out today on FLIM analysis with Flipper-TR.
We discuss fitting strategies, common pitfalls, and quantitative interpretation for measurements.
First corresponding/last authorship for me!
Free link:
authors.elsevier.com/a/1me2hHRzCb...
Thanks to @rouxlab.bsky.social and Tithi Mandal!
We discuss fitting strategies, common pitfalls, and quantitative interpretation for measurements.
First corresponding/last authorship for me!
Free link:
authors.elsevier.com/a/1me2hHRzCb...
Thanks to @rouxlab.bsky.social and Tithi Mandal!
Please wait whilst we redirect you
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
authors.elsevier.com
February 18, 2026 at 9:56 PM
New method paper out today on FLIM analysis with Flipper-TR.
We discuss fitting strategies, common pitfalls, and quantitative interpretation for measurements.
First corresponding/last authorship for me!
Free link:
authors.elsevier.com/a/1me2hHRzCb...
Thanks to @rouxlab.bsky.social and Tithi Mandal!
We discuss fitting strategies, common pitfalls, and quantitative interpretation for measurements.
First corresponding/last authorship for me!
Free link:
authors.elsevier.com/a/1me2hHRzCb...
Thanks to @rouxlab.bsky.social and Tithi Mandal!
Reposted by Roux Lab, Geneva
This monday we had our monthly Sciences Club.
Here Cesar Bernat is showing his work on CHMP1A in mammalian cells in the @rouxlab.bsky.social !
#postdoclife
Here Cesar Bernat is showing his work on CHMP1A in mammalian cells in the @rouxlab.bsky.social !
#postdoclife
February 19, 2026 at 8:31 AM
This monday we had our monthly Sciences Club.
Here Cesar Bernat is showing his work on CHMP1A in mammalian cells in the @rouxlab.bsky.social !
#postdoclife
Here Cesar Bernat is showing his work on CHMP1A in mammalian cells in the @rouxlab.bsky.social !
#postdoclife
Reposted by Roux Lab, Geneva
I am super happy and honored to see some of my movies making it into the NYT. I hope everybody enjoys watching them go as much as I do!
Scientists have seen Asgard archaea crawling for the first time. When it comes to the origin of eukaryotes, this is like seeing a feathered dinosaur in the wild. (Video courtesy of Philipp Ralder)
February 19, 2026 at 8:44 AM
I am super happy and honored to see some of my movies making it into the NYT. I hope everybody enjoys watching them go as much as I do!
So grateful to @epimechfc.bsky.social for citing our work! It’s a classic from the lab, forever thanks to @colomlab.bsky.social
📄 The first study from @rouxlab.bsky.social in cells showed that planarizable Flipper probes report lipid composition, packing and phase state in GUVs, and respond to tension via changes in lipid order, both in model membranes and cells. @colomlab.bsky.social
🔗 bsky.app/profile/epim...
🔗 bsky.app/profile/epim...
February 8, 2026 at 6:45 PM
So grateful to @epimechfc.bsky.social for citing our work! It’s a classic from the lab, forever thanks to @colomlab.bsky.social
thanks for showing this movie! The gradients of tension reorient while migrating cells change directions.
📄 Tension gradients during migration. Using Flipper-TR FLIM, we showed that membrane tension gradients exist in all adherent cells and are actively maintained by actin and adhesion, not passively equilibrating. @rouxlab.bsky.social and Aumeier lab
🔗 bsky.app/profile/epim...
🔗 bsky.app/profile/epim...
February 8, 2026 at 10:08 AM
thanks for showing this movie! The gradients of tension reorient while migrating cells change directions.
All what you want to know about flipper probes without daring asking
Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social
Mandal, T., Roux, A., & García-Arcos, J. M. (2025). Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM. bioRxiv. #EpithelialMechanics
buff.ly/NAytZaR
buff.ly/NAytZaR
February 6, 2026 at 4:43 PM
All what you want to know about flipper probes without daring asking
Reposted by Roux Lab, Geneva
Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social
Mandal, T., Roux, A., & García-Arcos, J. M. (2025). Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM. bioRxiv. #EpithelialMechanics
buff.ly/NAytZaR
buff.ly/NAytZaR
February 6, 2026 at 1:27 PM
Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social
You should also read Juanma’s paper, which visualizes membrane tension gradients in migrating and non-migrating cells! rdcu.be/e2u20
It also shows that flipper truly reports tension, but that response varies with lipid composition.
It also shows that flipper truly reports tension, but that response varies with lipid composition.
February 5, 2026 at 1:14 PM
You should also read Juanma’s paper, which visualizes membrane tension gradients in migrating and non-migrating cells! rdcu.be/e2u20
It also shows that flipper truly reports tension, but that response varies with lipid composition.
It also shows that flipper truly reports tension, but that response varies with lipid composition.
Reposted by Roux Lab, Geneva
Roffay, C., Molinard, G., ..., & Roux, A. (2021). Passive coupling of membrane tension and cell volume during active response of cells to osmosis. Proceedings of the National Academy of Sciences of the United States of America, 118(47), e2103228118. #EpithelialMechanics
buff.ly/r1Hj7F6
buff.ly/r1Hj7F6
February 3, 2026 at 8:01 AM
Roffay, C., Molinard, G., ..., & Roux, A. (2021). Passive coupling of membrane tension and cell volume during active response of cells to osmosis. Proceedings of the National Academy of Sciences of the United States of America, 118(47), e2103228118. #EpithelialMechanics
buff.ly/r1Hj7F6
buff.ly/r1Hj7F6
Guillaume Pernollet shows that epithelial cells adjust their shape to locally flatten, forming scutoids for any geometry, changing our view of cell packing. Thanks to all! @clairedessalles.bsky.social @juanmagararc.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 20, 2026 at 10:51 AM
Guillaume Pernollet shows that epithelial cells adjust their shape to locally flatten, forming scutoids for any geometry, changing our view of cell packing. Thanks to all! @clairedessalles.bsky.social @juanmagararc.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@marineluciano.bsky.social recreates intestinal Villi geometry by growing epithelial cells on wavy rolling substrates. Unexpected intrication of curvature effects is observed. Thanks to all! @caterinatomba.bsky.social @sgabriele.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 20, 2026 at 10:24 AM
@marineluciano.bsky.social recreates intestinal Villi geometry by growing epithelial cells on wavy rolling substrates. Unexpected intrication of curvature effects is observed. Thanks to all! @caterinatomba.bsky.social @sgabriele.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Roux Lab, Geneva
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
www.nature.com
January 19, 2026 at 4:39 PM
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Reposted by Roux Lab, Geneva
A great start to 2026! It was a pleasure to present my work on membrane asymmetry in the @rouxlab.bsky.social at the Geneva Chemistry and Biochemistry Days. It was also an honor to receive the Best Oral Presentation in Life Science!
January 17, 2026 at 4:25 PM
A great start to 2026! It was a pleasure to present my work on membrane asymmetry in the @rouxlab.bsky.social at the Geneva Chemistry and Biochemistry Days. It was also an honor to receive the Best Oral Presentation in Life Science!
A fantastic opportunity to work in Geneva if you are in the field of origins of life!
📢 Open faculty position – Origins of Life
We have an opening in our section at the University of Geneva! 🧬🚀
SPREAD THE WORD
Apply here: jobs.unige.ch/www/wd_porta...
We have an opening in our section at the University of Geneva! 🧬🚀
SPREAD THE WORD
Apply here: jobs.unige.ch/www/wd_porta...
a woman says " would you like to join us " with her eyes closed
ALT: a woman says " would you like to join us " with her eyes closed
media.tenor.com
January 16, 2026 at 5:52 PM
A fantastic opportunity to work in Geneva if you are in the field of origins of life!
Reposted by Roux Lab, Geneva
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 2, 2025 at 9:02 PM
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
Reposted by Roux Lab, Geneva
Un très grand plaisir d'avoir pu enfin (après 5 ans) voir @elisabethbik.bsky.social en face à face à l'UNIL.
Elle y donne en plus un séminaire aujourd'hui.
Elle y donne en plus un séminaire aujourd'hui.
December 1, 2025 at 9:57 AM
Un très grand plaisir d'avoir pu enfin (après 5 ans) voir @elisabethbik.bsky.social en face à face à l'UNIL.
Elle y donne en plus un séminaire aujourd'hui.
Elle y donne en plus un séminaire aujourd'hui.
Reposted by Roux Lab, Geneva
All credits to the dreamteam that made this possible! what a pleasure and honor working with these people! 🥰
@diorgeps.bsky.social @mhakala.bsky.social @juanmagararc.bsky.social @joshuatran.bsky.social @mudgal17.bsky.social @Carlos Marcuello @Andrea Merino
@diorgeps.bsky.social @mhakala.bsky.social @juanmagararc.bsky.social @joshuatran.bsky.social @mudgal17.bsky.social @Carlos Marcuello @Andrea Merino
December 1, 2025 at 9:27 AM
All credits to the dreamteam that made this possible! what a pleasure and honor working with these people! 🥰
@diorgeps.bsky.social @mhakala.bsky.social @juanmagararc.bsky.social @joshuatran.bsky.social @mudgal17.bsky.social @Carlos Marcuello @Andrea Merino
@diorgeps.bsky.social @mhakala.bsky.social @juanmagararc.bsky.social @joshuatran.bsky.social @mudgal17.bsky.social @Carlos Marcuello @Andrea Merino
Reposted by Roux Lab, Geneva
The crucial test: We fused Heimdall Hofund to a fission-defective yeast ESCRT-III protein (Did2). This chimera restored Mup1 trafficking to vacuoles back to wt! A short amphipathic helix, present in Asgard and retained as fragments in eukaryotes, acts as a minimal membrane fission trigger!
December 1, 2025 at 9:24 AM
The crucial test: We fused Heimdall Hofund to a fission-defective yeast ESCRT-III protein (Did2). This chimera restored Mup1 trafficking to vacuoles back to wt! A short amphipathic helix, present in Asgard and retained as fragments in eukaryotes, acts as a minimal membrane fission trigger!
Reposted by Roux Lab, Geneva
Eukaryotic ESCRT-IIIA paralogs, known to form heteropolymers, retain Hofund elements at their N-termini.
In yeast, mutating these elements blocks ESCRT-III-dependent Mup1 transport to vacuoles.
So these elements matter in eukaryotes too.
In yeast, mutating these elements blocks ESCRT-III-dependent Mup1 transport to vacuoles.
So these elements matter in eukaryotes too.
December 1, 2025 at 9:21 AM
Eukaryotic ESCRT-IIIA paralogs, known to form heteropolymers, retain Hofund elements at their N-termini.
In yeast, mutating these elements blocks ESCRT-III-dependent Mup1 transport to vacuoles.
So these elements matter in eukaryotes too.
In yeast, mutating these elements blocks ESCRT-III-dependent Mup1 transport to vacuoles.
So these elements matter in eukaryotes too.
Reposted by Roux Lab, Geneva
Is this Asgard-specific, or conserved with their eukaryotic paralogs?
Hard to tell, since the exact molecular mechanism of fission by eukaryotic ESCRT-III remains blurry, probably due to its complexity.
Let’s figure it out!
Hard to tell, since the exact molecular mechanism of fission by eukaryotic ESCRT-III remains blurry, probably due to its complexity.
Let’s figure it out!
December 1, 2025 at 9:20 AM
Is this Asgard-specific, or conserved with their eukaryotic paralogs?
Hard to tell, since the exact molecular mechanism of fission by eukaryotic ESCRT-III remains blurry, probably due to its complexity.
Let’s figure it out!
Hard to tell, since the exact molecular mechanism of fission by eukaryotic ESCRT-III remains blurry, probably due to its complexity.
Let’s figure it out!