Ryan Senne (he/him)
@ryguy.io
Computational Neuroscience Ph.D. Student @ Boston University. Labs of Dr. Brian DePasquale, Ben Scott, & Steve Ramirez. #JuliaLang stan.
Check out my latest work from the Ramirez lab with co-author @rsuthard.bsky.social! It’s got astrocytes—what more do you need!?
🚨 new work from the lab!
"Hippocampal astrocytic sequences emerge during learning and memory recall" by @ryguy.io & @rsuthard.bsky.social
thank you to the entire team for your camaraderie and for muscling through science together 🧠 -- we welcome all feedback!
nature.com/articles/s41...
"Hippocampal astrocytic sequences emerge during learning and memory recall" by @ryguy.io & @rsuthard.bsky.social
thank you to the entire team for your camaraderie and for muscling through science together 🧠 -- we welcome all feedback!
nature.com/articles/s41...
Hippocampal astrocytic sequences emerge during learning and memory recall
Nature Neuroscience - Senne, Suthard and colleagues show that dorsal hippocampal astrocytes display time-compressed calcium-event sequences after foot shock and upon context re-exposure, and that...
nature.com
September 16, 2026 at 3:09 PM
Check out my latest work from the Ramirez lab with co-author @rsuthard.bsky.social! It’s got astrocytes—what more do you need!?
Reposted by Ryan Senne (he/him)
Nature research paper: Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours
go.nature.com/3UiC3bT
go.nature.com/3UiC3bT
Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours - Nature
Amygdala astrocyte primary cilia are disrupted during stress, and their restoration leads to improvements in stress-related behaviour in mice.
go.nature.com
August 8, 2026 at 2:48 PM
Nature research paper: Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours
go.nature.com/3UiC3bT
go.nature.com/3UiC3bT
Reposted by Ryan Senne (he/him)
📣 NEW! I’ve just released the BIGGEST and perhaps most creative project I’ve ever worked on!
“Searching for Birds” searchingforbirds.visualcinnamon.com 🐤
A project, an article, an exploration that dives into the data that connects humans with birds, by looking at how we search for birds.
“Searching for Birds” searchingforbirds.visualcinnamon.com 🐤
A project, an article, an exploration that dives into the data that connects humans with birds, by looking at how we search for birds.
February 12, 2026 at 10:02 AM
📣 NEW! I’ve just released the BIGGEST and perhaps most creative project I’ve ever worked on!
“Searching for Birds” searchingforbirds.visualcinnamon.com 🐤
A project, an article, an exploration that dives into the data that connects humans with birds, by looking at how we search for birds.
“Searching for Birds” searchingforbirds.visualcinnamon.com 🐤
A project, an article, an exploration that dives into the data that connects humans with birds, by looking at how we search for birds.
Reposted by Ryan Senne (he/him)
Harrison gives the state-space modeling tutorial at CNN
August 3, 2026 at 8:32 PM
Harrison gives the state-space modeling tutorial at CNN
Reposted by Ryan Senne (he/him)
I co-sign this great summary from @dereklowe.bsky.social .
The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
July 24, 2026 at 5:10 AM
I co-sign this great summary from @dereklowe.bsky.social .
The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
Reposted by Ryan Senne (he/him)
Why I’m a fan of the Oxford comma.
July 14, 2026 at 3:33 PM
Why I’m a fan of the Oxford comma.
Reposted by Ryan Senne (he/him)
Hippocampal engrams configure prefrontal context representations to guide flexible decisions
Impressive combo of methods to manipulate and record this process:
www.biorxiv.org/content/10.6...
Impressive combo of methods to manipulate and record this process:
www.biorxiv.org/content/10.6...
Hippocampal engrams configure prefrontal context representations to guide flexible decisions
Flexible behavior requires using past experiences to configure cortical computations to suit current task demands. A central question in neuroscience is how memory representations control such reconfi...
www.biorxiv.org
July 13, 2026 at 12:46 PM
Hippocampal engrams configure prefrontal context representations to guide flexible decisions
Impressive combo of methods to manipulate and record this process:
www.biorxiv.org/content/10.6...
Impressive combo of methods to manipulate and record this process:
www.biorxiv.org/content/10.6...
Reposted by Ryan Senne (he/him)
Polls show that only 8% of Americans have a positive view of Adolf Hitler. But in this Palo Alto ketamine bar, that number feels much higher
July 11, 2026 at 5:06 PM
Polls show that only 8% of Americans have a positive view of Adolf Hitler. But in this Palo Alto ketamine bar, that number feels much higher
Reposted by Ryan Senne (he/him)
Today I learned that some of my nested quantile visualizations implemented for R and Python in github.com/betanalpha/m... have been implemented for Julia in the FlexiChains library, pysm.dev/FlexiChains..... Neat!
GitHub - betanalpha/mcmc_visualization_tools: Markov Chain Monte Carlo Visualization Tools
Markov Chain Monte Carlo Visualization Tools. Contribute to betanalpha/mcmc_visualization_tools development by creating an account on GitHub.
github.com
July 9, 2026 at 3:57 AM
Today I learned that some of my nested quantile visualizations implemented for R and Python in github.com/betanalpha/m... have been implemented for Julia in the FlexiChains library, pysm.dev/FlexiChains..... Neat!
Reposted by Ryan Senne (he/him)
I’m so outrageously mad having realized a bunch of inane reviewer comments are probably AI. I’m also too busy and would rather be compen$ated for my reviews, but 1) who are we as academics if we don’t value reading and thinking about the literature and 2) dont waste my/student’s time with slop!!
July 6, 2026 at 10:29 PM
I’m so outrageously mad having realized a bunch of inane reviewer comments are probably AI. I’m also too busy and would rather be compen$ated for my reviews, but 1) who are we as academics if we don’t value reading and thinking about the literature and 2) dont waste my/student’s time with slop!!
Reposted by Ryan Senne (he/him)
Really don't like how every person with a social security account now gets unsolicited political messages from the SSA.
July 2, 2026 at 9:29 PM
Really don't like how every person with a social security account now gets unsolicited political messages from the SSA.
Reposted by Ryan Senne (he/him)
@aloctavodia.bsky.social has been porting Bayesian Workflow book avehtari.github.io/Bayesian-Wor... case studies to Python using CmdStanPy, numpyro, ArviZ, Bambi, and kulprit
arviz-devs.github.io/bayesian-wor...
He is working on porting the rest of the case studies, too
arviz-devs.github.io/bayesian-wor...
He is working on porting the rest of the case studies, too
Bayesian Workflow book: Case studies in Python – Bayesian Workflow case studies in Python
arviz-devs.github.io
June 26, 2026 at 9:06 AM
@aloctavodia.bsky.social has been porting Bayesian Workflow book avehtari.github.io/Bayesian-Wor... case studies to Python using CmdStanPy, numpyro, ArviZ, Bambi, and kulprit
arviz-devs.github.io/bayesian-wor...
He is working on porting the rest of the case studies, too
arviz-devs.github.io/bayesian-wor...
He is working on porting the rest of the case studies, too
Reposted by Ryan Senne (he/him)
Love having data to show the students
More evidence, from a large-scale study in China, that using AI hurts learning if it undermines mental effort. When homework time drops due to AI use, so do test scores.
Across studies, there is a clear theme: AI tutoring in support of classes is good, using AI to "help" with homework is bad.
Across studies, there is a clear theme: AI tutoring in support of classes is good, using AI to "help" with homework is bad.
June 19, 2026 at 3:48 PM
Love having data to show the students
Reposted by Ryan Senne (he/him)
More evidence, from a large-scale study in China, that using AI hurts learning if it undermines mental effort. When homework time drops due to AI use, so do test scores.
Across studies, there is a clear theme: AI tutoring in support of classes is good, using AI to "help" with homework is bad.
Across studies, there is a clear theme: AI tutoring in support of classes is good, using AI to "help" with homework is bad.
June 19, 2026 at 3:12 PM
More evidence, from a large-scale study in China, that using AI hurts learning if it undermines mental effort. When homework time drops due to AI use, so do test scores.
Across studies, there is a clear theme: AI tutoring in support of classes is good, using AI to "help" with homework is bad.
Across studies, there is a clear theme: AI tutoring in support of classes is good, using AI to "help" with homework is bad.
Reposted by Ryan Senne (he/him)
How can AI change theoretical neuroscience? Technologies separate us from the mechanics of computation. Are we liberated to focus on the big picture or abandoning the substrate of thought? Born from an ongoing experiment in my lab about balancing these technologies for research and training
Agentic coding makes it possible to specify a neuroscience model in hours instead of months, writes @briandepasquale.bsky.social. The field risks becoming prolific but shallow—generating models faster than we can generate insights. #neuroskyence
www.thetransmitter.org/the-big-pict...
www.thetransmitter.org/the-big-pict...
How AI coding is reshaping theoretical neuroscience
Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Neuroscientists weigh in on that tectonic change.
www.thetransmitter.org
June 17, 2026 at 12:28 PM
How can AI change theoretical neuroscience? Technologies separate us from the mechanics of computation. Are we liberated to focus on the big picture or abandoning the substrate of thought? Born from an ongoing experiment in my lab about balancing these technologies for research and training
Reposted by Ryan Senne (he/him)
Interesting Transmitter article by Brian DePasquale on what will be the effect of the increasingly widespread use of LLMs to code up research ideas in neuroscience. Includes a somewhat sceptical commentary from me. 😉
Agentic coding makes it possible to specify a neuroscience model in hours instead of months, writes @briandepasquale.bsky.social. The field risks becoming prolific but shallow—generating models faster than we can generate insights. #neuroskyence
www.thetransmitter.org/the-big-pict...
www.thetransmitter.org/the-big-pict...
How AI coding is reshaping theoretical neuroscience
Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Neuroscientists weigh in on that tectonic change.
www.thetransmitter.org
June 16, 2026 at 4:12 PM
Interesting Transmitter article by Brian DePasquale on what will be the effect of the increasingly widespread use of LLMs to code up research ideas in neuroscience. Includes a somewhat sceptical commentary from me. 😉
Check out the new work from the DePaq lab!
🚨 New preprint from the lab! 🚨 We introduce BiXformer, a bidirectional cross-attention transformer for disentangling inter-regional neural dynamics. Recordings from multiple regions superimpose feedforward & feedback signals 🔁, offset in time, making it difficult to tease these signals apart. 🧠 🔁
BiXformer: A Bidirectional Cross Attention Transformer for Disentangling Inter-Regional Neural Dynamics https://www.biorxiv.org/content/10.64898/2026.06.05.730511v1
June 11, 2026 at 7:36 PM
Check out the new work from the DePaq lab!
Reposted by Ryan Senne (he/him)
Frequentists mogged by priormaxxing
June 1, 2026 at 9:17 PM
Frequentists mogged by priormaxxing
Reposted by Ryan Senne (he/him)
Statistics aka Likelihoodmaxxing
June 1, 2026 at 8:27 PM
Statistics aka Likelihoodmaxxing
Reposted by Ryan Senne (he/him)
In Jan 2029 a trifecta should pass a large bill package that overturns somewhere between 20 and 50 Roberts Court decisions of the last three decades.
We can roll back what they did to legalize political bribery, enable fraud, empower white collar criminals, destroy the govt, etc.
We can roll back what they did to legalize political bribery, enable fraud, empower white collar criminals, destroy the govt, etc.
We need Congress to be able to pass resolutions that state that a particular decision, while not being overturned, used an interpretation that does not represent the will of Congress, so it shall not be considered as precedent.
May 30, 2026 at 3:22 PM
In Jan 2029 a trifecta should pass a large bill package that overturns somewhere between 20 and 50 Roberts Court decisions of the last three decades.
We can roll back what they did to legalize political bribery, enable fraud, empower white collar criminals, destroy the govt, etc.
We can roll back what they did to legalize political bribery, enable fraud, empower white collar criminals, destroy the govt, etc.
Reposted by Ryan Senne (he/him)
Russell Vought’s OMB published a rule today attacking peer review, which came along with a Murdoch NY Post article favorable to the rule- and attacking peer review.
Which all makes the timing of yesterday’s Murdoch WSJ article attacking peer review seem much more suspicious!
Which all makes the timing of yesterday’s Murdoch WSJ article attacking peer review seem much more suspicious!
#MurdochJournal attacks peer review as, uh, woke "group think." If the academy is so left-wing, it's amazing how easy it for the Journal, Times, and Post to find right-wing profs to write op-eds.
A Way to Challenge the Groupthink of Scholarly Journals www.wsj.com/opinion/a-wa...
A Way to Challenge the Groupthink of Scholarly Journals www.wsj.com/opinion/a-wa...
Opinion | A Way to Challenge the Groupthink of Scholarly Journals
Peer review has become a closed system that protects shoddy and politically motivated research.
www.wsj.com
May 30, 2026 at 12:00 AM
Russell Vought’s OMB published a rule today attacking peer review, which came along with a Murdoch NY Post article favorable to the rule- and attacking peer review.
Which all makes the timing of yesterday’s Murdoch WSJ article attacking peer review seem much more suspicious!
Which all makes the timing of yesterday’s Murdoch WSJ article attacking peer review seem much more suspicious!
Move over, GLM-HMM—there’s a new hidden Markov model in town.
In our new preprint, we introduce the DDM-HMM: a model that jointly infers latent decision states from reaction times and choices.
Using 24-hour behavioral data from rats, we found that evidence accumulation changes with time of day!
In our new preprint, we introduce the DDM-HMM: a model that jointly infers latent decision states from reaction times and choices.
Using 24-hour behavioral data from rats, we found that evidence accumulation changes with time of day!
Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making https://www.biorxiv.org/content/10.64898/2026.05.25.727672v1
May 30, 2026 at 2:46 PM
Move over, GLM-HMM—there’s a new hidden Markov model in town.
In our new preprint, we introduce the DDM-HMM: a model that jointly infers latent decision states from reaction times and choices.
Using 24-hour behavioral data from rats, we found that evidence accumulation changes with time of day!
In our new preprint, we introduce the DDM-HMM: a model that jointly infers latent decision states from reaction times and choices.
Using 24-hour behavioral data from rats, we found that evidence accumulation changes with time of day!
Reposted by Ryan Senne (he/him)
And finally it was published! Massive thanks to my coauthors, the editor and reviewers, and the institutions that supported our research. journals.plos.org/plosone/arti...
May 29, 2026 at 6:41 PM
And finally it was published! Massive thanks to my coauthors, the editor and reviewers, and the institutions that supported our research. journals.plos.org/plosone/arti...
Reposted by Ryan Senne (he/him)
Congratulations to #FlatironCCN director @eerosim.bsky.social on his election to the National Academy of Sciences! https://bit.ly/42AEUhl #science #neuroscience
CCN Director Eero Simoncelli Elected to National Academy of Sciences
Eero Simoncelli, director of the Flatiron Institute’s Center for Computational Neuroscience (CCN), has been elected to the National Academy of Sciences.
bit.ly
April 30, 2026 at 2:55 PM
Congratulations to #FlatironCCN director @eerosim.bsky.social on his election to the National Academy of Sciences! https://bit.ly/42AEUhl #science #neuroscience
Reposted by Ryan Senne (he/him)
Super excited to (finally!) show our work on identifying cell types! Now in press www.nature.com/articles/s41.... We show how to identify cell types from ephys recordings *without* optotagging. This opens the study of not just individual cell types, but the interacting neural circuit during behavior
April 27, 2026 at 9:26 PM
Super excited to (finally!) show our work on identifying cell types! Now in press www.nature.com/articles/s41.... We show how to identify cell types from ephys recordings *without* optotagging. This opens the study of not just individual cell types, but the interacting neural circuit during behavior