Scott Soderling
@scottsoderling.bsky.social
Neuroscientist-cell biologist, proteomics developer, deep learning collaborator, tackling brain disorders. PI @Duke. Chair of Cell Biology and Biochem. Founder, Triangle Protein Design.
http://soderlinglab.cellbio.duke.edu
http://soderlinglab.cellbio.duke.edu
Reposted by Scott Soderling
getting close to recreating Jane Richardson's style 😎
August 15, 2026 at 1:24 AM
getting close to recreating Jane Richardson's style 😎
Reposted by Scott Soderling
**Four** positions in AI/ML for biology at @dukemedschool.bsky.social, including in Neurobiology. @scottsoderling.bsky.social and David Page are leading a tremendous initiative in Discovery AI. Wonderful colleagues, wonderful place.
AI/ML for Biology - 4 tenure-track assistant professor positions - Durham, North Carolina job with Duke University - Biochemistry & Cell Biology | 12862109
Discovery AI Initiative and Departments of Biochemistry and Cell Biology, Integrative Immunobiology, Neurobiology, and Pharmacology & Cancer Biology
www.nature.com
July 28, 2026 at 12:22 AM
**Four** positions in AI/ML for biology at @dukemedschool.bsky.social, including in Neurobiology. @scottsoderling.bsky.social and David Page are leading a tremendous initiative in Discovery AI. Wonderful colleagues, wonderful place.
Funny quote of the day. “No major life decisions within 30 days of:
A meditation retreat
A psychedelic experience
Your first encounter with the latest Claude model”
😂
A meditation retreat
A psychedelic experience
Your first encounter with the latest Claude model”
😂
June 11, 2026 at 3:00 PM
Funny quote of the day. “No major life decisions within 30 days of:
A meditation retreat
A psychedelic experience
Your first encounter with the latest Claude model”
😂
A meditation retreat
A psychedelic experience
Your first encounter with the latest Claude model”
😂
Reposted by Scott Soderling
Deeply honored to be named a 2026 Beckman Young Investigator #BYI!🧬
This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution.
This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution.
Congratulations to our 2026 Beckman Young Investigator Awardees! Twelve Researchers Selected to Receive $7.2M in Total Science Funding for Cutting-edge Research www.beckman-foundation.org/latest-news/... #BYI #beckmanresearch #newlyawarded
June 9, 2026 at 8:19 PM
Deeply honored to be named a 2026 Beckman Young Investigator #BYI!🧬
This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution.
This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution.
Reposted by Scott Soderling
Researchers have identified MESH1, an enzyme that helps explain why many people with cancer lose muscle during treatment.
https://medschool.duke.edu/news/hidden-enzyme-may-explain-muscle-loss-tied-cancer-treatment-and-aging
#AcademicSky #MedSky
https://medschool.duke.edu/news/hidden-enzyme-may-explain-muscle-loss-tied-cancer-treatment-and-aging
#AcademicSky #MedSky
Hidden enzyme may explain muscle loss tied to cancer treatment and aging
Team from Duke University School of Medicine and Duke NUS identify an enzyme that helps explain why muscles weaken in some cancer patients.
medschool.duke.edu
April 27, 2026 at 3:22 PM
Researchers have identified MESH1, an enzyme that helps explain why many people with cancer lose muscle during treatment.
https://medschool.duke.edu/news/hidden-enzyme-may-explain-muscle-loss-tied-cancer-treatment-and-aging
#AcademicSky #MedSky
https://medschool.duke.edu/news/hidden-enzyme-may-explain-muscle-loss-tied-cancer-treatment-and-aging
#AcademicSky #MedSky
Reposted by Scott Soderling
It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants…reviewers, program officials and funders can be more empathetic in the face of unprecedented chaos in the US scientific enterprise.
April 10, 2026 at 1:36 AM
It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants…reviewers, program officials and funders can be more empathetic in the face of unprecedented chaos in the US scientific enterprise.
My lab was lucky to be able to help test Proteina-Complexa binders experimentally. We were blown away by the results. Congrats to our colleagues at NVIDIA!
📢 We’re launching Proteina-Complexa — and after the Jensen keynote mention, we definitely had to post this thread now ;)
Atomistic binder design with generative pretraining + test-time compute, plus large-scale wet-lab validation.
Project page: research.nvidia.com/labs/genair/...
🧵 1/n
Atomistic binder design with generative pretraining + test-time compute, plus large-scale wet-lab validation.
Project page: research.nvidia.com/labs/genair/...
🧵 1/n
March 18, 2026 at 12:53 AM
My lab was lucky to be able to help test Proteina-Complexa binders experimentally. We were blown away by the results. Congrats to our colleagues at NVIDIA!
Reposted by Scott Soderling
Find out more: flip.protein.properties
FLIP2: Expanding Protein Fitness Landscape Benchmarks
FLIP2: A comprehensive benchmark for protein fitness prediction with 7 datasets, 16 splits, and real-world engineering scenarios
flip.protein.properties
February 26, 2026 at 9:58 PM
Find out more: flip.protein.properties
Reposted by Scott Soderling
You can use the model right now to freely generate families for single sequence inputs (i.e., diversification conditioned by intrinsic representations of evolution), or to engineer proteins based on family promts (diversification by conditioning on particular evoluationary trajectories).
December 22, 2025 at 2:57 PM
You can use the model right now to freely generate families for single sequence inputs (i.e., diversification conditioned by intrinsic representations of evolution), or to engineer proteins based on family promts (diversification by conditioning on particular evoluationary trajectories).
Reposted by Scott Soderling
@rohitsingh8080.bsky.social USHER: Guiding Foundation Model Representations through Distribution Shifts
Aditya Pratapa, Purushothama Rao Tata, Rohit Singh
bioRxiv 2025.11.20.689462; doi: doi.org/10.1101/2025...
Aditya Pratapa, Purushothama Rao Tata, Rohit Singh
bioRxiv 2025.11.20.689462; doi: doi.org/10.1101/2025...
USHER: Guiding Foundation Model Representations through Distribution Shifts
Foundation models pre-trained on certain biological data modalities exhibit systematic representational biases when encountering out-of-distribution (OOD) data from new assays. The embedding drift lar...
doi.org
December 15, 2025 at 8:54 PM
@rohitsingh8080.bsky.social USHER: Guiding Foundation Model Representations through Distribution Shifts
Aditya Pratapa, Purushothama Rao Tata, Rohit Singh
bioRxiv 2025.11.20.689462; doi: doi.org/10.1101/2025...
Aditya Pratapa, Purushothama Rao Tata, Rohit Singh
bioRxiv 2025.11.20.689462; doi: doi.org/10.1101/2025...
Reposted by Scott Soderling
The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!
A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature Communications
The existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to...
www.nature.com
December 3, 2025 at 4:43 PM
The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!
There is nothing sweeter than the first paper from your former postdoc’s own lab. Huge congratulations to Yudong and his lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature Communications
The existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to...
www.nature.com
December 4, 2025 at 1:57 AM
There is nothing sweeter than the first paper from your former postdoc’s own lab. Huge congratulations to Yudong and his lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sounds very exciting
Congratulations to @swcanner.bsky.social for the successful defense of his thesis, “The Protein Sugar Interactome”! Leveraging deep learning and AI, he created tools and uncovered putative structural interactions underlying intercellular communication. He will receive his diploma in December.
November 3, 2025 at 3:43 PM
Sounds very exciting
Reposted by Scott Soderling
The published version of our study on the early-life transition from isolation USVs to adult-like USVs in juvenile mice is out in Animal Behaviour!
authors.elsevier.com/a/1m1YDmjMA4GP
bsky.app/profile/kati...
authors.elsevier.com/a/1m1YDmjMA4GP
bsky.app/profile/kati...
November 3, 2025 at 1:49 PM
The published version of our study on the early-life transition from isolation USVs to adult-like USVs in juvenile mice is out in Animal Behaviour!
authors.elsevier.com/a/1m1YDmjMA4GP
bsky.app/profile/kati...
authors.elsevier.com/a/1m1YDmjMA4GP
bsky.app/profile/kati...
Deadline for applications- November 1st!
Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be.
academicjobsonline.org/ajo/jobs/30509
academicjobsonline.org/ajo/jobs/30509
Duke University, Cell Biology/Duke University Medical Center
Job #AJO30509, 24903 Tenure - Track Assistant Professor Position - AI/ML for Biology, Cell Biology/Duke University Medical Center, Duke University, Durham, North Carolina, US
academicjobsonline.org
October 27, 2025 at 6:07 PM
Deadline for applications- November 1st!
Reposted by Scott Soderling
We are hiring!
Please repost!!:
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology - Durham, North Carolina (US) job with Duke University School of Medicine | 12844591
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology
www.nature.com
October 25, 2025 at 9:58 PM
We are hiring!
Please repost!!:
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology - Durham, North Carolina (US) job with Duke University School of Medicine | 12844591
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology
www.nature.com
October 25, 2025 at 3:11 PM
Please repost!!:
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!!
www.nature.com/naturecareer...
Reposted by Scott Soderling
I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...
October 10, 2025 at 10:28 PM
I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...
Cool new work- DynamicsPLM adds prot conformational dynamics to LMs: fuses seq with per-residue structure-token distributions from an ensemble (no averaging) → state-aware embeddings. Gains: +4% HumanPPI, +11% on multi-state proteins. Firing this up in the lab soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
October 8, 2025 at 1:17 AM
Cool new work- DynamicsPLM adds prot conformational dynamics to LMs: fuses seq with per-residue structure-token distributions from an ensemble (no averaging) → state-aware embeddings. Gains: +4% HumanPPI, +11% on multi-state proteins. Firing this up in the lab soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Scott Soderling
Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be.
academicjobsonline.org/ajo/jobs/30509
academicjobsonline.org/ajo/jobs/30509
Duke University, Cell Biology/Duke University Medical Center
Job #AJO30509, 24903 Tenure - Track Assistant Professor Position - AI/ML for Biology, Cell Biology/Duke University Medical Center, Duke University, Durham, North Carolina, US
academicjobsonline.org
September 7, 2025 at 5:24 PM
Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be.
academicjobsonline.org/ajo/jobs/30509
academicjobsonline.org/ajo/jobs/30509
Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509
#hiring #AIforBio #CompBio
#hiring #AIforBio #CompBio
September 7, 2025 at 7:47 PM
Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509
#hiring #AIforBio #CompBio
#hiring #AIforBio #CompBio
Reposted by Scott Soderling
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
September 2, 2025 at 4:46 PM
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
Reposted by Scott Soderling
Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...)
Additional thread below
Additional thread below
September 2, 2025 at 5:34 PM
Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!
Reposted by Scott Soderling
Duke researchers have uncovered a promising path to potentially treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA).
🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders
#AcademicSky #MedSky
🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders
#AcademicSky #MedSky
Fundamental Cell Molecule Could Help Fight Rare Brain Disorders | Duke Department of Molecular Genetics and Microbiology
Duke researchers may have found a path to treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA). People with NBIA have extra iron accumulation ...
mgm.duke.edu
August 20, 2025 at 4:07 PM
Duke researchers have uncovered a promising path to potentially treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA).
🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders
#AcademicSky #MedSky
🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders
#AcademicSky #MedSky
Another milestone for the amazing Munjal lab!
So happy for Kira! She also received NOA for her F32.
Congratulations to the @socdevbio.bsky.social 2025 West Coast Regional Meeting postdoc poster winners (left to right): 1st place- Celja Uebel (Villeneuve lab), 2nd place- Kira Heikes (Munjal lab), honorable mention- Hailey Edward's (Yelon lab)!
August 18, 2025 at 7:34 PM
Another milestone for the amazing Munjal lab!