Daniel E. Weeks
@statgendan.bsky.social
Statistical geneticist. Professor of Human Genetics and Biostatistics at the University of Pittsburgh. Assiduously meticulous.
Reposted by Daniel E. Weeks
Thoughts and prayers for research data managers everywhere. You are not alone. We will get through this together techcommunity.microsoft.com/blog/excelbl...
Excel now supports multiple values in a single cell | Microsoft Community Hub
Lists, arrays in cells, and nested arrays introduce new ways to store and organize related information, helping you keep data together without sacrificing...
techcommunity.microsoft.com
September 25, 2026 at 8:47 AM
Thoughts and prayers for research data managers everywhere. You are not alone. We will get through this together techcommunity.microsoft.com/blog/excelbl...
Reposted by Daniel E. Weeks
Science peeps: Looks like SciENcv updated the digital certificate used to sign Biosketch and Current & Pending documents without notification. The old certificate expires Saturday, September 26, 2026.
SciENcv docs before that date may fail validation in eRA Commons delaying or blocking submission.
SciENcv docs before that date may fail validation in eRA Commons delaying or blocking submission.
September 25, 2026 at 7:18 PM
Science peeps: Looks like SciENcv updated the digital certificate used to sign Biosketch and Current & Pending documents without notification. The old certificate expires Saturday, September 26, 2026.
SciENcv docs before that date may fail validation in eRA Commons delaying or blocking submission.
SciENcv docs before that date may fail validation in eRA Commons delaying or blocking submission.
Reposted by Daniel E. Weeks
It is the case. The Biosketch has a certification so that happens when you generate the document. They updated the current certification to expire Sept 26. So you need new one
September 25, 2026 at 10:33 PM
It is the case. The Biosketch has a certification so that happens when you generate the document. They updated the current certification to expire Sept 26. So you need new one
Reposted by Daniel E. Weeks
FYI to everyone submitting this October NIH cycle
You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted.
Great timing!
You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted.
Great timing!
September 25, 2026 at 7:55 PM
FYI to everyone submitting this October NIH cycle
You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted.
Great timing!
You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted.
Great timing!
Reposted by Daniel E. Weeks
SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham.
I spent the last month diving deep into a massive academic scam spanning continents, for @nature.com
I spent the last month diving deep into a massive academic scam spanning continents, for @nature.com
Exclusive: Sham scientific societies are misleading star researchers
A Nature investigation reveals a network of organizations that have been building their ranks through deceptive practices.
www.nature.com
September 25, 2026 at 8:21 PM
SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham.
I spent the last month diving deep into a massive academic scam spanning continents, for @nature.com
I spent the last month diving deep into a massive academic scam spanning continents, for @nature.com
Reposted by Daniel E. Weeks
September 24, 2026 at 9:57 AM
Reposted by Daniel E. Weeks
IBG at CU Boulder is hiring 2-3 tenure-track faculty (junior or senior) in statistical genetics, twin/family designs, and computational work. A chance to help shape IBG for decades. Starts fall 2027.
More info: colorado.edu/ibg/. Apply by Oct 15. Please repost!
More info: colorado.edu/ibg/. Apply by Oct 15. Please repost!
Home
colorado.edu
September 23, 2026 at 9:27 PM
IBG at CU Boulder is hiring 2-3 tenure-track faculty (junior or senior) in statistical genetics, twin/family designs, and computational work. A chance to help shape IBG for decades. Starts fall 2027.
More info: colorado.edu/ibg/. Apply by Oct 15. Please repost!
More info: colorado.edu/ibg/. Apply by Oct 15. Please repost!
Reposted by Daniel E. Weeks
David J. Hunter, MB, BS, FMedSci, and Michael Inouye, PhD, review the ways common genetic variants, polygenic risk scores, and pharmacogenomic genotyping may be useful in the prevention of common diseases and the treatment of common diseases after diagnosis. Full review: https://nej.md/4Amwv0F
September 23, 2026 at 10:00 PM
David J. Hunter, MB, BS, FMedSci, and Michael Inouye, PhD, review the ways common genetic variants, polygenic risk scores, and pharmacogenomic genotyping may be useful in the prevention of common diseases and the treatment of common diseases after diagnosis. Full review: https://nej.md/4Amwv0F
Reposted by Daniel E. Weeks
More details below, tl;dr:
We did GWAS on a trait with known single-locus Mendelian inheritance. Depending on the linear reference (top 3 panels), you can get tons of off-target associations. A graph pangenome reference completely resolves this issue (bottom 2 panels) recovering just the single peak
We did GWAS on a trait with known single-locus Mendelian inheritance. Depending on the linear reference (top 3 panels), you can get tons of off-target associations. A graph pangenome reference completely resolves this issue (bottom 2 panels) recovering just the single peak
May 19, 2026 at 5:30 PM
More details below, tl;dr:
We did GWAS on a trait with known single-locus Mendelian inheritance. Depending on the linear reference (top 3 panels), you can get tons of off-target associations. A graph pangenome reference completely resolves this issue (bottom 2 panels) recovering just the single peak
We did GWAS on a trait with known single-locus Mendelian inheritance. Depending on the linear reference (top 3 panels), you can get tons of off-target associations. A graph pangenome reference completely resolves this issue (bottom 2 panels) recovering just the single peak
Reposted by Daniel E. Weeks
In case you ever wondered about the differences between magrittr pipe and base pipe 🤔
This table is taken from a great stackoverflow answer by @GeorgKindermann
https://stackoverflow.com/questions/67633022/what-are-the-differences-between-rs-native-pipe-and-the-magrittr-pipe
#rstats #dataviz #phd
This table is taken from a great stackoverflow answer by @GeorgKindermann
https://stackoverflow.com/questions/67633022/what-are-the-differences-between-rs-native-pipe-and-the-magrittr-pipe
#rstats #dataviz #phd
September 18, 2026 at 5:59 PM
In case you ever wondered about the differences between magrittr pipe and base pipe 🤔
This table is taken from a great stackoverflow answer by @GeorgKindermann
https://stackoverflow.com/questions/67633022/what-are-the-differences-between-rs-native-pipe-and-the-magrittr-pipe
#rstats #dataviz #phd
This table is taken from a great stackoverflow answer by @GeorgKindermann
https://stackoverflow.com/questions/67633022/what-are-the-differences-between-rs-native-pipe-and-the-magrittr-pipe
#rstats #dataviz #phd
Reposted by Daniel E. Weeks
Fst is a key genetic differentiation metric, but it emphasizes common variants over rare.
In IEEE ICASSP out now lab member Margarita Geleta introduces Fq, which can be tuned across the allele freq spectrum.
Fst & Shannon differentiation fall out of it as special cases.
arxiv.org/abs/2511.03063
In IEEE ICASSP out now lab member Margarita Geleta introduces Fq, which can be tuned across the allele freq spectrum.
Fst & Shannon differentiation fall out of it as special cases.
arxiv.org/abs/2511.03063
September 17, 2026 at 10:21 PM
Fst is a key genetic differentiation metric, but it emphasizes common variants over rare.
In IEEE ICASSP out now lab member Margarita Geleta introduces Fq, which can be tuned across the allele freq spectrum.
Fst & Shannon differentiation fall out of it as special cases.
arxiv.org/abs/2511.03063
In IEEE ICASSP out now lab member Margarita Geleta introduces Fq, which can be tuned across the allele freq spectrum.
Fst & Shannon differentiation fall out of it as special cases.
arxiv.org/abs/2511.03063
Reposted by Daniel E. Weeks
What can we learn about a single rare variant?
Published today in Science: the 23andMe Research Institute and Dana-Farber studied the EGFR T790M in 10.1M 23andMe research participants. The variant has OR = 25.2 for lung cancer, rising to 61.7 in never-smokers(!). 🧵
Published today in Science: the 23andMe Research Institute and Dana-Farber studied the EGFR T790M in 10.1M 23andMe research participants. The variant has OR = 25.2 for lung cancer, rising to 61.7 in never-smokers(!). 🧵
September 17, 2026 at 11:09 PM
What can we learn about a single rare variant?
Published today in Science: the 23andMe Research Institute and Dana-Farber studied the EGFR T790M in 10.1M 23andMe research participants. The variant has OR = 25.2 for lung cancer, rising to 61.7 in never-smokers(!). 🧵
Published today in Science: the 23andMe Research Institute and Dana-Farber studied the EGFR T790M in 10.1M 23andMe research participants. The variant has OR = 25.2 for lung cancer, rising to 61.7 in never-smokers(!). 🧵
Reposted by Daniel E. Weeks
Spoilers: all 10 ended up being desk rejected.
- 1 paper withdrawn
- 1 author was too busy for a call
- 1 author no-showed
- Authors of 3 papers couldn't answer basic qs
- Authors of 3 papers could, but not technical qs
- 1 author answered all qs, but paper had a major flaw
- 1 paper withdrawn
- 1 author was too busy for a call
- 1 author no-showed
- Authors of 3 papers couldn't answer basic qs
- Authors of 3 papers could, but not technical qs
- 1 author answered all qs, but paper had a major flaw
September 16, 2026 at 8:33 PM
Spoilers: all 10 ended up being desk rejected.
- 1 paper withdrawn
- 1 author was too busy for a call
- 1 author no-showed
- Authors of 3 papers couldn't answer basic qs
- Authors of 3 papers could, but not technical qs
- 1 author answered all qs, but paper had a major flaw
- 1 paper withdrawn
- 1 author was too busy for a call
- 1 author no-showed
- Authors of 3 papers couldn't answer basic qs
- Authors of 3 papers could, but not technical qs
- 1 author answered all qs, but paper had a major flaw
Reposted by Daniel E. Weeks
Okay before I do write my screed about cluster analysis, please send me your favorite *positive* examples that illustrate the utility of the method!
Did you know that there’s only a single letter separating an “idionomic clinical workflow” from an “idiotnomic clinical workflow”?
I haven’t managed to write my screed about cluster analysis yet, here’s another blog post in the meantime:
www.the100.ci/2024/10/28/i...
I haven’t managed to write my screed about cluster analysis yet, here’s another blog post in the meantime:
www.the100.ci/2024/10/28/i...
Idiographic Approaches in Psychology: Hold your horses
There have been persistent calls spurring psychologists to do more “idiographic” research, starting even before Peter Molenaar’s “Manifesto on Psychology as Idiographic Science”, which is already 20 y...
www.the100.ci
September 14, 2026 at 10:57 AM
Okay before I do write my screed about cluster analysis, please send me your favorite *positive* examples that illustrate the utility of the method!
Reposted by Daniel E. Weeks
The academic process is 10% having ideas and 90% discovering why they won't work
September 10, 2026 at 6:48 AM
The academic process is 10% having ideas and 90% discovering why they won't work
Reposted by Daniel E. Weeks
Workshop done 😀 since I anyway put together a list of resources, I'm going to share it in this thread. So here we go, my top recommendations for how to improve computational reproducibility of your work
I am giving a workshop on "good (enough) practices for computational reproducibility" tomorrow. Can't wait to share how much fun it is to use Git
Elaine Benes' Excited Celebration
ALT: Elaine Benes' Excited Celebration
static.klipy.com
September 8, 2026 at 5:18 PM
Workshop done 😀 since I anyway put together a list of resources, I'm going to share it in this thread. So here we go, my top recommendations for how to improve computational reproducibility of your work
Reposted by Daniel E. Weeks
Can dietary interventions change how fast genomes accumulate mutations with age?
We studied how caloric restriction (CR)—one of the most robust lifespan-extending interventions—affects somatic mutations across the genome in different tissues and cell types in mice.
We studied how caloric restriction (CR)—one of the most robust lifespan-extending interventions—affects somatic mutations across the genome in different tissues and cell types in mice.
September 9, 2026 at 3:15 PM
Can dietary interventions change how fast genomes accumulate mutations with age?
We studied how caloric restriction (CR)—one of the most robust lifespan-extending interventions—affects somatic mutations across the genome in different tissues and cell types in mice.
We studied how caloric restriction (CR)—one of the most robust lifespan-extending interventions—affects somatic mutations across the genome in different tissues and cell types in mice.
Reposted by Daniel E. Weeks
Siblings differ in proportions of genetic ancestry. Wang, Berumen, et al. exploit this (and others) to show within-family genetic ancestry effects on height, T2D, and metabolic traits, but no effects on educational attainment. (EA ancestry associations are environmentally caused or confounded.)
Within-family effect of ancestry on complex traits in a Mexican population - Nature
This study uses a within-family design to identify significant ancestry differences in complex traits such as height and type 2 diabetes in a genetically diverse population from Mexico City.
www.nature.com
September 9, 2026 at 9:31 PM
Siblings differ in proportions of genetic ancestry. Wang, Berumen, et al. exploit this (and others) to show within-family genetic ancestry effects on height, T2D, and metabolic traits, but no effects on educational attainment. (EA ancestry associations are environmentally caused or confounded.)
Reposted by Daniel E. Weeks
Increasingly powerful methods are enabling increasing complex models of ancient human history to be inferred from population genomic data. In a recent review, I highlight two blind spots in these inferences: limitations of the methods and choices of models to fit.
arxiv.org/abs/2608.27591
arxiv.org/abs/2608.27591
Two blind spots in the demographic inference of human origins from genomic data
Ancient DNA and new inference methods have transformed the study of human origins, but consensus has not followed. Evidence increasingly indicates that hominin populations were pervasively structured ...
arxiv.org
September 9, 2026 at 9:09 PM
Increasingly powerful methods are enabling increasing complex models of ancient human history to be inferred from population genomic data. In a recent review, I highlight two blind spots in these inferences: limitations of the methods and choices of models to fit.
arxiv.org/abs/2608.27591
arxiv.org/abs/2608.27591
Reposted by Daniel E. Weeks
Check out this new preprint led by Daniel Malawsky in my group who has developed a very cool new method to infer genetic nurture effects unconfounded by parental assortment (RAVEL) www.biorxiv.org/content/10.6....
September 8, 2026 at 8:19 PM
Check out this new preprint led by Daniel Malawsky in my group who has developed a very cool new method to infer genetic nurture effects unconfounded by parental assortment (RAVEL) www.biorxiv.org/content/10.6....
Reposted by Daniel E. Weeks
Five years of writing about the last song on albums, and today a peer-reviewed article based on the data is free to read: The cover feature in this month's Significance, the RSS magazine. 2,284 albums, 1953 to 2026 and one question: "Are closing tracks actually different?"
September 7, 2026 at 10:38 AM
Five years of writing about the last song on albums, and today a peer-reviewed article based on the data is free to read: The cover feature in this month's Significance, the RSS magazine. 2,284 albums, 1953 to 2026 and one question: "Are closing tracks actually different?"
Reposted by Daniel E. Weeks
📣 New preprint out from the lab! “Enhanced power and transferability for genetics-driven metabolomic biomarker discovery in admixed American cohorts” tackles the important problem that many omics studies still have limited representation of admixed populations www.medrxiv.org/content/10.6...
September 8, 2026 at 8:23 AM
📣 New preprint out from the lab! “Enhanced power and transferability for genetics-driven metabolomic biomarker discovery in admixed American cohorts” tackles the important problem that many omics studies still have limited representation of admixed populations www.medrxiv.org/content/10.6...
Reposted by Daniel E. Weeks
I just published a brief account of Jim Watson’s life, aimed at students. It leans heavily on the insights of @nccomfort.bsky.social, whose biography of Watson will be out next year. Free link here: rdcu.be/M91CnnE3N4wa
September 7, 2026 at 8:33 AM
I just published a brief account of Jim Watson’s life, aimed at students. It leans heavily on the insights of @nccomfort.bsky.social, whose biography of Watson will be out next year. Free link here: rdcu.be/M91CnnE3N4wa
Reposted by Daniel E. Weeks
This is very interesting - a blog by a mathematician who was working on a proof of Fermat's Last Theorem on finding out that Anthropic has done it in 11 days. It is interesting because it does not concede the field, but says what it does / doesn't do
xenaproject.wordpress.com/2026/09/04/f...
xenaproject.wordpress.com/2026/09/04/f...
FLT: Anthropic has beaten me to it
I guess technically it was revealed to the world by a coffee shop in Islington on Insta, but an hour later it was officially announced by Anthropic: one of their internal models, using the prove2.m…
xenaproject.wordpress.com
September 7, 2026 at 8:29 AM
This is very interesting - a blog by a mathematician who was working on a proof of Fermat's Last Theorem on finding out that Anthropic has done it in 11 days. It is interesting because it does not concede the field, but says what it does / doesn't do
xenaproject.wordpress.com/2026/09/04/f...
xenaproject.wordpress.com/2026/09/04/f...
Reposted by Daniel E. Weeks
Scientific datasets are riddled with copy-paste errors
www.sciencedetective.org/scientific-d...
18 datasets out of 600 are reported as having serious issues. This is bad enough, but not as bad as the title may suggest.
The approach is simple, but powerful and interesting. 1/
www.sciencedetective.org/scientific-d...
18 datasets out of 600 are reported as having serious issues. This is bad enough, but not as bad as the title may suggest.
The approach is simple, but powerful and interesting. 1/
September 7, 2026 at 11:44 AM
Scientific datasets are riddled with copy-paste errors
www.sciencedetective.org/scientific-d...
18 datasets out of 600 are reported as having serious issues. This is bad enough, but not as bad as the title may suggest.
The approach is simple, but powerful and interesting. 1/
www.sciencedetective.org/scientific-d...
18 datasets out of 600 are reported as having serious issues. This is bad enough, but not as bad as the title may suggest.
The approach is simple, but powerful and interesting. 1/