Atlas of Variant Effects Alliance
@varianteffect.bsky.social
Advancing the promise of the Human Genome Project by interpreting the landscape of human genetic variation.
https://www.varianteffect.org
https://www.linkedin.com/company/atlas-of-variant-effects-alliance
#AtlasOfVariantEffects
https://www.varianteffect.org
https://www.linkedin.com/company/atlas-of-variant-effects-alliance
#AtlasOfVariantEffects
We're delighted that Nobel Laureate David Baker, Director of the Institute for Protein Design at the University of Washington, will deliver a keynote address at the Mutational Scanning Symposium, next June. Event registration opens soon. Learn more: tinyurl.com/3x8d5rev
Image: Christopher P. Michel
Image: Christopher P. Michel
September 17, 2026 at 4:48 PM
We're delighted that Nobel Laureate David Baker, Director of the Institute for Protein Design at the University of Washington, will deliver a keynote address at the Mutational Scanning Symposium, next June. Event registration opens soon. Learn more: tinyurl.com/3x8d5rev
Image: Christopher P. Michel
Image: Christopher P. Michel
Our YouTube channel is a great resource that incudes:
✅ Deep mutational scanning principles
✅ Functional evidence workshops
✅ Mutational Scanning Symposia
✅ Early career seminars
✅ Virology Interest Group talks
and more.
Search by presenter, topic or series: tinyurl.com/2e4rbcm3
✅ Deep mutational scanning principles
✅ Functional evidence workshops
✅ Mutational Scanning Symposia
✅ Early career seminars
✅ Virology Interest Group talks
and more.
Search by presenter, topic or series: tinyurl.com/2e4rbcm3
September 16, 2026 at 2:39 PM
Our YouTube channel is a great resource that incudes:
✅ Deep mutational scanning principles
✅ Functional evidence workshops
✅ Mutational Scanning Symposia
✅ Early career seminars
✅ Virology Interest Group talks
and more.
Search by presenter, topic or series: tinyurl.com/2e4rbcm3
✅ Deep mutational scanning principles
✅ Functional evidence workshops
✅ Mutational Scanning Symposia
✅ Early career seminars
✅ Virology Interest Group talks
and more.
Search by presenter, topic or series: tinyurl.com/2e4rbcm3
Get the latest research from our Virology Interest Group on our YouTube channel: youtu.be/XNu2ejij_vo?...
This month's talk was given by Caroline Langley (Bonilla Lab, Rockefeller University) on how strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.
This month's talk was given by Caroline Langley (Bonilla Lab, Rockefeller University) on how strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.
“Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins”
YouTube video by Variant Effects
youtu.be
September 10, 2026 at 12:50 PM
Get the latest research from our Virology Interest Group on our YouTube channel: youtu.be/XNu2ejij_vo?...
This month's talk was given by Caroline Langley (Bonilla Lab, Rockefeller University) on how strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.
This month's talk was given by Caroline Langley (Bonilla Lab, Rockefeller University) on how strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.
If you missed last week's Variant Effects Seminar, you can now find the presentations on the VESS playlist on our YouTube channel. Catch up with the excellent talks from Sergio Garcia Busto and Kortni Kindree whenever it works for you.
See the VESS playlist: youtu.be/24n8i78STPQ?...
See the VESS playlist: youtu.be/24n8i78STPQ?...
September 9, 2026 at 2:55 PM
If you missed last week's Variant Effects Seminar, you can now find the presentations on the VESS playlist on our YouTube channel. Catch up with the excellent talks from Sergio Garcia Busto and Kortni Kindree whenever it works for you.
See the VESS playlist: youtu.be/24n8i78STPQ?...
See the VESS playlist: youtu.be/24n8i78STPQ?...
If you're interpreting functional assays for clinical use, check out this resource from members of our ClinGen/AVE Functional Data Working Group.
Get more information and download the presentation: www.varianteffect.org/clinical-app...
Read the preprint: www.medrxiv.org/content/10.6...
Get more information and download the presentation: www.varianteffect.org/clinical-app...
Read the preprint: www.medrxiv.org/content/10.6...
August 27, 2026 at 8:01 AM
If you're interpreting functional assays for clinical use, check out this resource from members of our ClinGen/AVE Functional Data Working Group.
Get more information and download the presentation: www.varianteffect.org/clinical-app...
Read the preprint: www.medrxiv.org/content/10.6...
Get more information and download the presentation: www.varianteffect.org/clinical-app...
Read the preprint: www.medrxiv.org/content/10.6...
Join us next week for the Variant Effects Seminar!
Our September speakers are Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto)
Learn more about our speakers, their work and how to join the seminar: www.varianteffect.org/seminar-seri...
Our September speakers are Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto)
Learn more about our speakers, their work and how to join the seminar: www.varianteffect.org/seminar-seri...
August 26, 2026 at 7:39 AM
Join us next week for the Variant Effects Seminar!
Our September speakers are Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto)
Learn more about our speakers, their work and how to join the seminar: www.varianteffect.org/seminar-seri...
Our September speakers are Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto)
Learn more about our speakers, their work and how to join the seminar: www.varianteffect.org/seminar-seri...
Have you listened to the Variants and Us (VUS) podcast yet? Now into its second season, the podcast focuses on the basic and translational science necessary to map the effect of variants in disease and rare disease.
Listen to all episodes here: www.varianteffect.org/podcast/
Listen to all episodes here: www.varianteffect.org/podcast/
August 24, 2026 at 10:22 AM
Have you listened to the Variants and Us (VUS) podcast yet? Now into its second season, the podcast focuses on the basic and translational science necessary to map the effect of variants in disease and rare disease.
Listen to all episodes here: www.varianteffect.org/podcast/
Listen to all episodes here: www.varianteffect.org/podcast/
Our next Variant Effects Seminar is on September 1. Join Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto) and explore their research.
Learn more about our speakers' work and how to join the seminar: www.varianteffect.org/seminar-seri...
Learn more about our speakers' work and how to join the seminar: www.varianteffect.org/seminar-seri...
August 17, 2026 at 1:55 PM
Our next Variant Effects Seminar is on September 1. Join Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto) and explore their research.
Learn more about our speakers' work and how to join the seminar: www.varianteffect.org/seminar-seri...
Learn more about our speakers' work and how to join the seminar: www.varianteffect.org/seminar-seri...
Missed the August Variant Effects Seminar? The good news is that its now available on our YouTube channel. So, you can watch @sarahgurev.bsky.social's presentation on prediction of viral mutation effects whenever it works for you.
Watch now: tinyurl.com/4amhv94k
#AtlasOfVariantEffects
Watch now: tinyurl.com/4amhv94k
#AtlasOfVariantEffects
Toward reliable viral mutation effect prediction for pandemic preparedness - Sarah Gurev
Sarah Gurev (Marks Lab, Harvard, MIT) 'Toward reliable viral mutation effect prediction for pandemic preparedness', presented at the August 4, 2026 Variant Effects Seminar Series (VESS) – an early career scientist-led seminar series sponsored by the Atlas of Variant Effects Alliance (https://www.varianteffect.org/seminar-series/)
tinyurl.com
August 14, 2026 at 6:29 AM
Missed the August Variant Effects Seminar? The good news is that its now available on our YouTube channel. So, you can watch @sarahgurev.bsky.social's presentation on prediction of viral mutation effects whenever it works for you.
Watch now: tinyurl.com/4amhv94k
#AtlasOfVariantEffects
Watch now: tinyurl.com/4amhv94k
#AtlasOfVariantEffects
You can now watch the latest research presentation from AVE's Virology Interest Group: tinyurl.com/5n7t932k
This month's talk was given by @williambakhache.bsky.social on the subject of genotype-by-inhibitor interactions to dissect enterovirus replication.
#AtlasOfVariantEffects
This month's talk was given by @williambakhache.bsky.social on the subject of genotype-by-inhibitor interactions to dissect enterovirus replication.
#AtlasOfVariantEffects
“Genotype-by-inhibitor interactions to dissect enterovirus replication” - William Bakhache
William Bakhache (IBMC Institute of Molecular and Cell Biology | Mechanisms of Positive-Strand RNA Virus Laboratory (M+RVL)) “Genotype-by-inhibitor interactions to dissect enterovirus replication” - presentation to the Atlas of Variant Effects (AVE) Virology Interest Group August 07 2026
tinyurl.com
August 13, 2026 at 2:50 PM
You can now watch the latest research presentation from AVE's Virology Interest Group: tinyurl.com/5n7t932k
This month's talk was given by @williambakhache.bsky.social on the subject of genotype-by-inhibitor interactions to dissect enterovirus replication.
#AtlasOfVariantEffects
This month's talk was given by @williambakhache.bsky.social on the subject of genotype-by-inhibitor interactions to dissect enterovirus replication.
#AtlasOfVariantEffects
@eag91.bsky.social was recently the 100th speaker of our Variant Effects Seminar Series. The work he presented has just been published as a preprint.
Learn more: tinyurl.com/mrxf5zxv
@solersanchisx.bsky.social, @cwjpugh.bsky.social,
@federicobilleci.bsky.social, @jonnyfrazer.bsky.social
Learn more: tinyurl.com/mrxf5zxv
@solersanchisx.bsky.social, @cwjpugh.bsky.social,
@federicobilleci.bsky.social, @jonnyfrazer.bsky.social
Blending physics-based models improves protein folding stability prediction | Ezequiel Galpern posted on the topic | LinkedIn
🎉 New preprint: “Blending physics-based and inverse folding models to disentangle variant effects on stability and function”
➡️ Read it on https://lnkd.in/dCDw-3nb
Together with Xavier Soler Sanchis...
lnkd.in
August 10, 2026 at 12:43 PM
@eag91.bsky.social was recently the 100th speaker of our Variant Effects Seminar Series. The work he presented has just been published as a preprint.
Learn more: tinyurl.com/mrxf5zxv
@solersanchisx.bsky.social, @cwjpugh.bsky.social,
@federicobilleci.bsky.social, @jonnyfrazer.bsky.social
Learn more: tinyurl.com/mrxf5zxv
@solersanchisx.bsky.social, @cwjpugh.bsky.social,
@federicobilleci.bsky.social, @jonnyfrazer.bsky.social
Reposted by Atlas of Variant Effects Alliance
🧪 One small step towards a complete atlas of human sequence variant effects, a giant leap for figuring out which variants in the Autoimmune Regulator (AIRE) protein are pathogenic, and some baby steps towards understanding the AIRE protein @varianteffect.bsky.social
🧬Online now!
📄Systematic and proactive evaluation of AIRE missense variant effects
🧑🤝🧑 @axakova.bsky.social @fritzroth.bsky.social & co
www.cell.com/ajhg/fulltex...
📄Systematic and proactive evaluation of AIRE missense variant effects
🧑🤝🧑 @axakova.bsky.social @fritzroth.bsky.social & co
www.cell.com/ajhg/fulltex...
Systematic and proactive evaluation of AIRE missense variant effects
We measure the impact of every possible amino acid change in the autoimmune regulator
protein AIRE via fluorescent reporter assay, providing a variant effect map and proactive
evidence that enables mo...
www.cell.com
August 6, 2026 at 5:19 PM
🧪 One small step towards a complete atlas of human sequence variant effects, a giant leap for figuring out which variants in the Autoimmune Regulator (AIRE) protein are pathogenic, and some baby steps towards understanding the AIRE protein @varianteffect.bsky.social
Starting now!
Don't forget, we'll be live later for our Variant Effects Seminar. Today's talk is with @sarahgurev.bsky.social.
Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...
Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...
August 4, 2026 at 3:54 PM
Starting now!
Don't forget, we'll be live later for our Variant Effects Seminar. Today's talk is with @sarahgurev.bsky.social.
Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...
Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...
August 4, 2026 at 7:45 AM
Don't forget, we'll be live later for our Variant Effects Seminar. Today's talk is with @sarahgurev.bsky.social.
Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...
Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...
Our Variant Effects Seminar Series returns next Tuesday, August 4!
Join @sarahgurev.bsky.social for her presentation, 'Towards reliable viral mutation effect prediction for pandemic preparedness'.
Discover Sarah's work and get the event joining info:
www.varianteffect.org/seminar-seri...
Join @sarahgurev.bsky.social for her presentation, 'Towards reliable viral mutation effect prediction for pandemic preparedness'.
Discover Sarah's work and get the event joining info:
www.varianteffect.org/seminar-seri...
July 29, 2026 at 10:09 AM
Our Variant Effects Seminar Series returns next Tuesday, August 4!
Join @sarahgurev.bsky.social for her presentation, 'Towards reliable viral mutation effect prediction for pandemic preparedness'.
Discover Sarah's work and get the event joining info:
www.varianteffect.org/seminar-seri...
Join @sarahgurev.bsky.social for her presentation, 'Towards reliable viral mutation effect prediction for pandemic preparedness'.
Discover Sarah's work and get the event joining info:
www.varianteffect.org/seminar-seri...
Some of our Virology Interest Group have authored a review of the recent technological & conceptual advances in the deep mutational scanning methods being applied to virology. Also covered are the insights these advances are yielding & suggestions for future studies.
Read now: tinyurl.com/84dcy96z
Read now: tinyurl.com/84dcy96z
Scanning the horizon: deep mutational scanning approaches in virology | Journal of Virology
The development of deep mutational scanning (DMS) approaches has led to a fundamental
shift in our ability to connect viral genotype and phenotype (1) and accelerated our understanding of viral evolut...
tinyurl.com
July 28, 2026 at 8:35 AM
Some of our Virology Interest Group have authored a review of the recent technological & conceptual advances in the deep mutational scanning methods being applied to virology. Also covered are the insights these advances are yielding & suggestions for future studies.
Read now: tinyurl.com/84dcy96z
Read now: tinyurl.com/84dcy96z
As our Variant Effect Seminar Series (VESS) returns, we caught up with two of our earliest speakers, Mafalda Dias & Jonathan Frazer. Now group leaders at the Centre for Genomic Regulation (CRG) in Barcelona, we explore the role of VESS in their journey.
Read their interview: tinyurl.com/m4ncw2nf
Read their interview: tinyurl.com/m4ncw2nf
July 28, 2026 at 8:30 AM
As our Variant Effect Seminar Series (VESS) returns, we caught up with two of our earliest speakers, Mafalda Dias & Jonathan Frazer. Now group leaders at the Centre for Genomic Regulation (CRG) in Barcelona, we explore the role of VESS in their journey.
Read their interview: tinyurl.com/m4ncw2nf
Read their interview: tinyurl.com/m4ncw2nf
Mark your calendars for the next instalment of our Variant Effects Seminar Series. 🗓️ On August 4, Sarah Gurev will be our sole speaker, with her extended presentation, 'Toward reliable viral mutation effect prediction for pandemic preparedness'.
More info: tinyurl.com/4ms3mmzy
More info: tinyurl.com/4ms3mmzy
July 23, 2026 at 7:53 AM
Mark your calendars for the next instalment of our Variant Effects Seminar Series. 🗓️ On August 4, Sarah Gurev will be our sole speaker, with her extended presentation, 'Toward reliable viral mutation effect prediction for pandemic preparedness'.
More info: tinyurl.com/4ms3mmzy
More info: tinyurl.com/4ms3mmzy
You can still register for, 'Unmasking the Genome: Integrating WGS, AI and Functional Genomics', from 1-4 September at the University of Exeter, UK.
The workshop is for all researchers working at the leading edge of genomic science. 🧬
Get the programme and register now: tinyurl.com/4vbrp63p
The workshop is for all researchers working at the leading edge of genomic science. 🧬
Get the programme and register now: tinyurl.com/4vbrp63p
Unmasking the Genome: Integrating WGS, AI and Functional Genomics - UK Human Functional Genomics Initiative
Unmasking the Genome is a four-day advanced workshop designed for researchers working at the leading edge of genomic science. This programme brings together expertise from Google DeepMind, leaders in ...
tinyurl.com
July 20, 2026 at 9:07 AM
You can still register for, 'Unmasking the Genome: Integrating WGS, AI and Functional Genomics', from 1-4 September at the University of Exeter, UK.
The workshop is for all researchers working at the leading edge of genomic science. 🧬
Get the programme and register now: tinyurl.com/4vbrp63p
The workshop is for all researchers working at the leading edge of genomic science. 🧬
Get the programme and register now: tinyurl.com/4vbrp63p
The new publication by members of the Atlas of Variant Effects Clinical Variant Interpretation working group provides guidance for combining data from multiple MAVEs to strengthen the functional evidence for clinical variant classification.
Read now: tinyurl.com/yn6bkhhn
Read now: tinyurl.com/yn6bkhhn
Combining multiplexed functional data to improve variant classification - Genome Medicine
Background With the surge in the number of variants of uncertain significance (VUS) reported in ClinVar in recent years, there is an imperative to resolve VUS at scale. Multiplexed assays of variant e...
link.springer.com
July 16, 2026 at 3:49 PM
The new publication by members of the Atlas of Variant Effects Clinical Variant Interpretation working group provides guidance for combining data from multiple MAVEs to strengthen the functional evidence for clinical variant classification.
Read now: tinyurl.com/yn6bkhhn
Read now: tinyurl.com/yn6bkhhn
The latest episode of the Variants and Us (VUS) podcast explores how MAVEs are made with two scientists (@kmatreyek.bsky.social and @gregfindlay.bsky.social) that have transformed the generation of phenotypic data for thousands of variants simultaneously.
Listen now: tinyurl.com/3kv774ee
Listen now: tinyurl.com/3kv774ee
Inside the toolbox: how MAVEs are made
Variants and Us (VUS) Podcast · Episode
tinyurl.com
July 15, 2026 at 10:31 AM
The latest episode of the Variants and Us (VUS) podcast explores how MAVEs are made with two scientists (@kmatreyek.bsky.social and @gregfindlay.bsky.social) that have transformed the generation of phenotypic data for thousands of variants simultaneously.
Listen now: tinyurl.com/3kv774ee
Listen now: tinyurl.com/3kv774ee
Our Variant Effects Seminar Series (VESS) is taking a break this month, but will be back on August 4 with an extended presentation from @sarahgurev.bsky.social, 'Towards reliable viral mutation effect prediction for pandemic preparedness'.
Discover VESS and all speakers: tinyurl.com/4atzepeb
Discover VESS and all speakers: tinyurl.com/4atzepeb
July 13, 2026 at 11:46 AM
Our Variant Effects Seminar Series (VESS) is taking a break this month, but will be back on August 4 with an extended presentation from @sarahgurev.bsky.social, 'Towards reliable viral mutation effect prediction for pandemic preparedness'.
Discover VESS and all speakers: tinyurl.com/4atzepeb
Discover VESS and all speakers: tinyurl.com/4atzepeb
Our Variant Effects Seminar Series (VESS) is organized and led by a committee of early career scientists. We asked Priyanka Bajaj and @ohannab.bsky.social about their experiences on the VESS committee, as they depart for new adventures in variant science.
Read now: tinyurl.com/lifeaftervess
Read now: tinyurl.com/lifeaftervess
July 7, 2026 at 8:46 AM
Our Variant Effects Seminar Series (VESS) is organized and led by a committee of early career scientists. We asked Priyanka Bajaj and @ohannab.bsky.social about their experiences on the VESS committee, as they depart for new adventures in variant science.
Read now: tinyurl.com/lifeaftervess
Read now: tinyurl.com/lifeaftervess
Missed Abbye McEwan's excellent introduction to MAVE technology? It's now available on YouTube: www.youtube.com/watch?v=FeUp...
Learn more about how to use MAVE data to inform clinical variant classification, and discover how these datasets may help resolve variants of uncertain significance.
Learn more about how to use MAVE data to inform clinical variant classification, and discover how these datasets may help resolve variants of uncertain significance.
VSN presents Beyond the VUS Using MAVE Data to Inform Clinical Variant Classification
YouTube video by Variant Scientists Network
www.youtube.com
July 1, 2026 at 11:24 AM
Missed Abbye McEwan's excellent introduction to MAVE technology? It's now available on YouTube: www.youtube.com/watch?v=FeUp...
Learn more about how to use MAVE data to inform clinical variant classification, and discover how these datasets may help resolve variants of uncertain significance.
Learn more about how to use MAVE data to inform clinical variant classification, and discover how these datasets may help resolve variants of uncertain significance.
Did you know you can find all the Variant Effects Seminars on the AVE YouTube channel? Established in 2021, the seminar series reached its 100 speaker milestone last month. So, there are plenty of great talks to choose from.
Find your next watch: tinyurl.com/AVE-VESS
#AtlasOfVariantEffects
Find your next watch: tinyurl.com/AVE-VESS
#AtlasOfVariantEffects
June 29, 2026 at 10:26 AM
Did you know you can find all the Variant Effects Seminars on the AVE YouTube channel? Established in 2021, the seminar series reached its 100 speaker milestone last month. So, there are plenty of great talks to choose from.
Find your next watch: tinyurl.com/AVE-VESS
#AtlasOfVariantEffects
Find your next watch: tinyurl.com/AVE-VESS
#AtlasOfVariantEffects