Yoann Santin
@ysantin.bsky.social
Ph.D. in Microbiology, post-doc at @UCLouvain_be in the @LalouxLab @EMBO fellow #Bdellovibrio, former in @CascalesLab #T6SS
Pinned
Yoann Santin
@ysantin.bsky.social
· Jun 24
Absolutely thrilled to share that I’ve been awarded an #ATIP-Avenir2026 Starting Grant to launch my own research team in Toulouse, starting January 1st, 2027 🎉
We’ll be diving into how one bacterium vampirizes another through a specialized cell-cell interface 🧛♂️
Stay tuned! more exciting news soon !
We’ll be diving into how one bacterium vampirizes another through a specialized cell-cell interface 🧛♂️
Stay tuned! more exciting news soon !
Reposted by Yoann Santin
New paper in Current Biology @currentbiology.bsky.social 🦠 Why do bacteria ditch their T6SS weapon? E. coli keeps it vs susceptible rivals, but loses it when facing immune ones. Great work by @bobytaillefer.bsky.social & Jonas Desjardins!
www.cell.com/current-biol...
www.cell.com/current-biol...
Experimental evolution reveals genetic routes for adaptive loss of the antibacterial type VI secretion system
Taillefer et al. show that a bacterial type VI secretion system is lost or attenuated
during experimental evolution when it provides no competitive advantage but is maintained
in the presence of susce...
www.cell.com
September 11, 2026 at 4:05 AM
New paper in Current Biology @currentbiology.bsky.social 🦠 Why do bacteria ditch their T6SS weapon? E. coli keeps it vs susceptible rivals, but loses it when facing immune ones. Great work by @bobytaillefer.bsky.social & Jonas Desjardins!
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Yoann Santin
Happy to share our latest review on the "Structure and function of the #T9SS for protein secretion and cellular motility" to be published in the incoming volume 80 of Annual Review in Microbiology.
Kudos to Yaelle Aouizerate and @thicoz.bsky.social !
www.annualreviews.org/content/jour...
Kudos to Yaelle Aouizerate and @thicoz.bsky.social !
www.annualreviews.org/content/jour...
August 7, 2026 at 3:38 AM
Happy to share our latest review on the "Structure and function of the #T9SS for protein secretion and cellular motility" to be published in the incoming volume 80 of Annual Review in Microbiology.
Kudos to Yaelle Aouizerate and @thicoz.bsky.social !
www.annualreviews.org/content/jour...
Kudos to Yaelle Aouizerate and @thicoz.bsky.social !
www.annualreviews.org/content/jour...
Reposted by Yoann Santin
Come join us at ETH!
My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...
Professor of Molecular Cell Biology and Biochemistry - Zurich, Switzerland job with ETH Zurich | 12861386
The Department of Biology at ETH Zurich invites applications for the above-mentioned tenured professorship at the Institute of Biochemistry
www.nature.com
August 6, 2026 at 12:19 PM
Come join us at ETH!
Reposted by Yoann Santin
New online! Predation in microbial communities: gradients of nutritive killing
Predation in microbial communities: gradients of nutritive killing
Nature Reviews Microbiology, Published online: 08 May 2026; doi:10.1038/s41579-026-01299-7In this Review, Vasse and Velicer explore the phylogenetic and functional diversity of predators of microorganisms, conceptualizing the forms of microbial predation along gradients, including gradients of evolutionary adaptedness for predation and privatization of prey-derived nutrients.
dlvr.it
May 8, 2026 at 4:08 PM
New online! Predation in microbial communities: gradients of nutritive killing
Reposted by Yoann Santin
THE new lab to follow ! Amazing science with an amazing person, seems like a unique opportunity 🤩
🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️
Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Research Technician (Osterman Group – Metabolism-driven immunity)
EMBL Hamburg / CSSB The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organization, with more than 110 independent research groups across Heidelberg, Hamburg, Grenobl...
embl.wd103.myworkdayjobs.com
July 16, 2026 at 1:12 PM
THE new lab to follow ! Amazing science with an amazing person, seems like a unique opportunity 🤩
Reposted by Yoann Santin
Reposted by Yoann Santin
Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA
led by @olivia--smith.bsky.social
Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs
led by @olivia--smith.bsky.social
Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs
July 15, 2026 at 9:00 AM
Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA
led by @olivia--smith.bsky.social
Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs
led by @olivia--smith.bsky.social
Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs
Reposted by Yoann Santin
🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️
Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Research Technician (Osterman Group – Metabolism-driven immunity)
EMBL Hamburg / CSSB The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organization, with more than 110 independent research groups across Heidelberg, Hamburg, Grenobl...
embl.wd103.myworkdayjobs.com
July 13, 2026 at 5:16 AM
🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️
Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Yoann Santin
Fresh out of the lab! Our new preprint is now up on BioRxiv, exploring how the beneficial bacterium Pseudomonas putida controls its T6SS nanoweapon. It turns out the Gac/Rsm pathway acts as a strict molecular brake on the system. 👇 (1/4)
Read the full preprint here: doi.org/10.64898/202...
Read the full preprint here: doi.org/10.64898/202...
July 11, 2026 at 1:17 PM
Fresh out of the lab! Our new preprint is now up on BioRxiv, exploring how the beneficial bacterium Pseudomonas putida controls its T6SS nanoweapon. It turns out the Gac/Rsm pathway acts as a strict molecular brake on the system. 👇 (1/4)
Read the full preprint here: doi.org/10.64898/202...
Read the full preprint here: doi.org/10.64898/202...
Reposted by Yoann Santin
New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion.
@coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
@coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...
www.biorxiv.org
July 9, 2026 at 10:24 PM
Reposted by Yoann Santin
So excited to share our new preprint! 🎉🤩 Check it out to discover how we investigated the role and spatiotemporal dynamics of an essential Tad nanomachine during the lifecycle of our favorite bacterial predator, B.bacteriovorus 🦠 Many thanks to everyone who made this work possible!
New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion.
@coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
@coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...
www.biorxiv.org
July 9, 2026 at 4:02 PM
So excited to share our new preprint! 🎉🤩 Check it out to discover how we investigated the role and spatiotemporal dynamics of an essential Tad nanomachine during the lifecycle of our favorite bacterial predator, B.bacteriovorus 🦠 Many thanks to everyone who made this work possible!
Reposted by Yoann Santin
📢 Looking for institutional support for an ERC or SNSF Starting Grant?
The University of Geneva is inviting applications from outstanding junior researchers in host–pathogen interactions, bacteriology, virology, parasitology and mycology.
🔗 www.unige.ch/medecine/mim...
The University of Geneva is inviting applications from outstanding junior researchers in host–pathogen interactions, bacteriology, virology, parasitology and mycology.
🔗 www.unige.ch/medecine/mim...
July 9, 2026 at 7:46 AM
📢 Looking for institutional support for an ERC or SNSF Starting Grant?
The University of Geneva is inviting applications from outstanding junior researchers in host–pathogen interactions, bacteriology, virology, parasitology and mycology.
🔗 www.unige.ch/medecine/mim...
The University of Geneva is inviting applications from outstanding junior researchers in host–pathogen interactions, bacteriology, virology, parasitology and mycology.
🔗 www.unige.ch/medecine/mim...
Our new preprint is out ! #Predatory bacteria & #TAD nanomachine !! Huge work from @coralietesseur.bsky.social 🤩
New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion.
@coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
@coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...
www.biorxiv.org
July 9, 2026 at 2:20 PM
Our new preprint is out ! #Predatory bacteria & #TAD nanomachine !! Huge work from @coralietesseur.bsky.social 🤩
Reposted by Yoann Santin
🔬 Rencontre avec @navarropaula.bsky.social, pour qui les secrets du vivant se cachent à l’échelle atomique. Pour explorer cet univers minuscule, la biologiste s’appuie sur la #cryo-microscopie #électronique.
Lire la suite 👉 www.unil.ch/news/fr/1783...
Lire la suite 👉 www.unil.ch/news/fr/1783...
Lausanne, Terre promise de la cryo-microscopie électronique
Pour Paula Navarro, les secrets du vivant se cachent à l’échelle atomique. Pour explorer cet univers minuscule, la biologiste s’appuie sur la cryo-microscopie électronique. Et s’il y a un endroit où p...
www.unil.ch
July 7, 2026 at 1:51 PM
🔬 Rencontre avec @navarropaula.bsky.social, pour qui les secrets du vivant se cachent à l’échelle atomique. Pour explorer cet univers minuscule, la biologiste s’appuie sur la #cryo-microscopie #électronique.
Lire la suite 👉 www.unil.ch/news/fr/1783...
Lire la suite 👉 www.unil.ch/news/fr/1783...
Reposted by Yoann Santin
#microsky
New preprint from the lab!
Widespread immune systems protect bacteria against conjugative plasmids
www.biorxiv.org/content/10.6...
Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab.
🧵⬇️
New preprint from the lab!
Widespread immune systems protect bacteria against conjugative plasmids
www.biorxiv.org/content/10.6...
Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab.
🧵⬇️
Widespread immune systems protect bacteria against conjugative plasmids
Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...
www.biorxiv.org
July 7, 2026 at 7:58 AM
#microsky
New preprint from the lab!
Widespread immune systems protect bacteria against conjugative plasmids
www.biorxiv.org/content/10.6...
Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab.
🧵⬇️
New preprint from the lab!
Widespread immune systems protect bacteria against conjugative plasmids
www.biorxiv.org/content/10.6...
Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab.
🧵⬇️
Reposted by Yoann Santin
Excited to see our story published in @natmicrobiol.nature.com today! It’s been a long journey. We answered a major outstanding question: why does E. coli encode two aPBPs, yet only one plays a critical role in ensuring reliable PG fortification during cell division?
🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo
bit.ly/3SCbOg1
👇
bit.ly/3SCbOg1
👇
The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology
A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.
doi.org
July 3, 2026 at 10:14 AM
Excited to see our story published in @natmicrobiol.nature.com today! It’s been a long journey. We answered a major outstanding question: why does E. coli encode two aPBPs, yet only one plays a critical role in ensuring reliable PG fortification during cell division?
Reposted by Yoann Santin
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications.
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
Open Positions
-
tiny.cc
March 29, 2026 at 11:22 AM
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications.
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
Reposted by Yoann Santin
More than a century after the discovery of catalase, the enzyme responsible for the degradation of hydrogen peroxide, we are proud to report the discovery of a new antioxidant enzyme capable of degrading urate hydroperoxide and to demonstrate its physiological importance in vivo.
#microsky
#microsky
👇👇👇 NEW PREPRINT ONLINE 👇👇👇
www.biorxiv.org/content/10.6...
#NewPreprint
#Microbiology #Inflammation #GutMicrobiome
www.biorxiv.org/content/10.6...
#NewPreprint
#Microbiology #Inflammation #GutMicrobiome
June 3, 2026 at 7:59 AM
More than a century after the discovery of catalase, the enzyme responsible for the degradation of hydrogen peroxide, we are proud to report the discovery of a new antioxidant enzyme capable of degrading urate hydroperoxide and to demonstrate its physiological importance in vivo.
#microsky
#microsky
Reposted by Yoann Santin
Substrate-induced assembly and functional mechanism of the membrane protein insertase SecYEG-YidC
@kedrov-lab.bsky.social, Roland Beckmann and coworkers
link.springer.com/article/10.1...
@kedrov-lab.bsky.social, Roland Beckmann and coworkers
link.springer.com/article/10.1...
Substrate-induced assembly and functional mechanism of the membrane protein insertase SecYEG-YidC - The EMBO Journal
The Sec translocon and the YidC/Oxa1-type insertases universally mediate biogenesis of α-helical membrane proteins, but the molecular basis of their cooperation has remained disputed. Recent discovery...
link.springer.com
June 29, 2026 at 9:39 AM
Substrate-induced assembly and functional mechanism of the membrane protein insertase SecYEG-YidC
@kedrov-lab.bsky.social, Roland Beckmann and coworkers
link.springer.com/article/10.1...
@kedrov-lab.bsky.social, Roland Beckmann and coworkers
link.springer.com/article/10.1...
Because good news apparently likes company, I’m very happy to share that I have been recruited as a #CNRS researcher! 🎉😀
Huge thanks to everyone who supported me along the way!
A new chapter starts now 🥳🤩
Huge thanks to everyone who supported me along the way!
A new chapter starts now 🥳🤩
Happy Dance
ALT: Happy Dance
static.klipy.com
June 29, 2026 at 2:00 PM
Because good news apparently likes company, I’m very happy to share that I have been recruited as a #CNRS researcher! 🎉😀
Huge thanks to everyone who supported me along the way!
A new chapter starts now 🥳🤩
Huge thanks to everyone who supported me along the way!
A new chapter starts now 🥳🤩
Reposted by Yoann Santin
I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets.
More info globdb.org 🦠🖥️🧬
More info globdb.org 🦠🖥️🧬
home | GlobDB
globdb.org
June 26, 2026 at 6:48 AM
I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets.
More info globdb.org 🦠🖥️🧬
More info globdb.org 🦠🖥️🧬
Reposted by Yoann Santin
@zjmaggiexu.bsky.social's story on suctorian trap structure adaptation is now online in @currentbiology.bsky.social , with new evolutionary analyses and modeling! This fall, Maggie will keep exploring predatory protists as a PD in @nbellono.bsky.social group; keep an eye out for her she's amazing!
June 24, 2026 at 4:32 PM
@zjmaggiexu.bsky.social's story on suctorian trap structure adaptation is now online in @currentbiology.bsky.social , with new evolutionary analyses and modeling! This fall, Maggie will keep exploring predatory protists as a PD in @nbellono.bsky.social group; keep an eye out for her she's amazing!
Reposted by Yoann Santin
Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!
A novel reverse lipase toxin substrate of the Staphylococcus aureus type VII secretion system https://www.biorxiv.org/content/10.64898/2026.06.22.733114v1
June 24, 2026 at 5:08 AM
Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!
Absolutely thrilled to share that I’ve been awarded an #ATIP-Avenir2026 Starting Grant to launch my own research team in Toulouse, starting January 1st, 2027 🎉
We’ll be diving into how one bacterium vampirizes another through a specialized cell-cell interface 🧛♂️
Stay tuned! more exciting news soon !
We’ll be diving into how one bacterium vampirizes another through a specialized cell-cell interface 🧛♂️
Stay tuned! more exciting news soon !
June 24, 2026 at 11:31 AM
Absolutely thrilled to share that I’ve been awarded an #ATIP-Avenir2026 Starting Grant to launch my own research team in Toulouse, starting January 1st, 2027 🎉
We’ll be diving into how one bacterium vampirizes another through a specialized cell-cell interface 🧛♂️
Stay tuned! more exciting news soon !
We’ll be diving into how one bacterium vampirizes another through a specialized cell-cell interface 🧛♂️
Stay tuned! more exciting news soon !
Reposted by Yoann Santin
Open postdoc position in the Imaging and Modeling Unit at Institut Pasteur, in collaboration with Mickaël Cohen of IBPC (Paris, France). High-throughput imaging and deep learning to analyze mitochondrial morphology and understand genetic bases of cellular respiration. Please spread the word.
June 18, 2026 at 7:45 AM
Open postdoc position in the Imaging and Modeling Unit at Institut Pasteur, in collaboration with Mickaël Cohen of IBPC (Paris, France). High-throughput imaging and deep learning to analyze mitochondrial morphology and understand genetic bases of cellular respiration. Please spread the word.