If you are intrigued by principles of gene regulation not only at the cellular level but also at the subcellular level... my lab at the CRUK Cambridge Institute is recruiting highly motivated PhD students with Jan 2027 start! 4-year fully funded, UK + intl welcome (1/5)

Incredible review by @ivywtl.bsky.social and team eDyNAmiC about how extrachromosomal DNA fuels several hallmarks of cancer. Read on!

Excited to share recent work from the Mischel and Chang labs in which we show functional heterogeneity arising from extrachromosomal (ecDNA) copy number heterogeneity. Preprint below! 1/13

I'm thrilled to start my first bluesky post by highlighting the review paper Hyerim and I have been working really hard together - published just yesterday on Nature Reviews Drug Discovery. In this review, we outlined the latest ecDNA biology and corresponding therapeutic vulnerabilities [1/2] -

Exciting work about oncogenic PVT1 fusions arising from extrachromosomal DNA!!! from the Mischel and Chang labs and more :)

so much fun working on this project with Venkat, King, Ivy, and team! Read on to learn about the retention elements critical for the tethering of extrachromosomal DNA to mitotic chromosomes in cancer cells.

Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...

Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy. https://scim.ag/4m5x2f3

Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.

Beautiful study by Vishnu who found elevated levels of oxidative damage in patients with ME/CFS, an understudied disease that lacks definitive diagnostic tests and effective treatments despite its enormous prevalence and incredible severity. Read more here www.pnas.org/doi/10.1073/...

What a masterful #AACR25 Plenary talk by Paul Mischel @stanfordmedicine.bsky.social, #CancerGrandChallenges team eDyNAmiC lead) on the role of extrachromosomal DNAs (#ecDNAs) in cancer. As a funder, it’s incredible to see what we've enabled — in front of 21,000 cancer research leaders!

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs https://www.biorxiv.org/content/10.1101/2025.04.01.646515v1

Exclusive: An ambitious California Democrat wants the state to create its own National Institutes of Health and vaccine program, saying California can’t rely on the Trump administration to support research and science.

3 points of progress vs pancreatic cancer!
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...

🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...

High-resolution of cancer. Unprecedented. A brief review of what we've just learned from 17 new papers in the latest edition of Ground Truths.
It's free, open-access.
erictopol.substack.com/p/cancer-sci...

This week in Nature - four papers probe the relationship between ecDNA & cancer
* an atlas of ecDNA in cancer
* ecDNA inheritance in cancer during cell division
* a potential way to leverage ecDNA for treatment
* ecDNA role in tumour evolution & therapy resistance

www.nature.com/nature/volum...