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akheelsyed.bsky.social
akheel sͩyͬed
@akheelsyed.bsky.social
91 followers 89 following 37 posts
Consultant Endocrinologist and Professor
Salford Royal, Manchester Academic Health Science Centre, University of Manchester
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akheelsyed.bsky.social
akheel sͩyͬed @akheelsyed.bsky.social · Dec 6
www.telegraph.co.uk/health-fitne...
The real reason men get belly fat (and how to get rid of it)
Research suggests it’s more dangerous to be an overweight man than woman. Here’s why – and what you can do about it
www.telegraph.co.uk
Reposted by akheel sͩyͬed
mancunianmedic.bsky.social
My piece for BMJ this week. I have lived with this issue for my whole career and i don't think it will be sorted by the time i retire or either I or my parents need care
www.bmj.com/content/394/...
www.bmj.com
September 9, 2026 at 10:37 AM
akheelsyed.bsky.social
Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study - The Lancet www.thelancet.com/journals/lan...
Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study
This case shows that porcine kidney xenotransplantation can provide prolonged renal support and be discontinued without clinically significant allosensitisation or zoonotic infection. Early cellular r...
www.thelancet.com
September 4, 2026 at 11:21 AM
Reposted by akheel sͩyͬed
tonygoldstone.bsky.social
Our new paper: potential benefit of semaglutide to ⬇️ weight gain & ⬇️ hyperphagia in adults with PWS. Well tolerated. Caveat: small open label cohort, most T2DM @ImpPsych.bsky.social @imperialbrains.bsky.social
@imperialnhs.bsky.social @imperialmed.bsky.social @ipwso.bsky.social
tinyurl.com/56b874n6
Frontiers | Efficacy and safety of semaglutide for obesity and hyperphagia in adults with Prader-Willi syndrome
ContextPrader-Willi syndrome is a genetic neurodevelopmental disorder characterized by hyperphagia and early-onset obesity from hypothalamic dysfunction with...
tinyurl.com
September 3, 2026 at 9:25 AM
akheelsyed.bsky.social
What are the demographic factors affecting weight loss and recurrent weight gain after bariatric surgery over a 10-year follow-up period? Read more ➡️
pubmed.ncbi.nlm.nih.gov/42661133/

@ncaresearchnhs.bsky.social
Preoperative Factors Associated with Weight Loss and Recurrent Weight Gain after Bariatric Surgery: A Longitudinal Study in a UK Public Healthcare Setting - PubMed
Operation type, age, sex, preoperative body mass index, diabetes, operation type and smoking had significant associations with weight loss while age, hypertension, Index of Multiple Deprivation and initial postoperative weight loss had significant associations with recurrent weight gain.
pubmed.ncbi.nlm.nih.gov
August 28, 2026 at 11:06 AM
Reposted by akheel sͩyͬed
cmaj.ca
Hypertriglyceridemia-induced pancreatitis:
Diabetic ketoacidosis with severe hypertriglyceridemia-induced acute pancreatitis as the initial presentation of type 2 diabetes is a rare, severe metabolic emergency.
Learn more ➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.260244
Hypertriglyceridemia should be considered in all patients presenting with acute pancreatitis. Hypertriglyceridemia-induced pancreatitis DOI: 10.1503/cmaj.260244
August 25, 2026 at 8:30 PM
akheelsyed.bsky.social
DKA can occur in type 2 diabetes.
Hypertriglyceridemia should be considered in acute pancreatitis.
Incretin therapies can be considered with a history of pancreatitis.
Read more at Rathakrishnan et al.
www.cmaj.ca/content/198/...

@ncaresearchnhs.bsky.social
Undiagnosed type 2 diabetes presenting as diabetic ketoacidosis with hypertriglyceridemia-induced acute pancreatitis
www.cmaj.ca
August 25, 2026 at 2:17 AM
Reposted by akheel sͩyͬed
socendocrinology.bsky.social
Secure your discounted ticket for the Reproductive Endocrinology Meeting before Friday at 23:59!

Find out more: bit.ly/ReproEndo26
August 6, 2026 at 6:15 AM
akheelsyed.bsky.social
Come join a dynamic bariatric and upper GI surgery service in Greater Manchester 🙌
www.healthjobsuk.com/job/UK/Manch...
Job vacancy: Consultant Bariatric & Benign Upper GI Surgeon, Northern Care Alliance NHS Foundation Trust, Salford | trac.jobs
www.healthjobsuk.com
July 28, 2026 at 7:49 PM
akheelsyed.bsky.social
Excessive weight gain following treatment for hyperthyroidism is of concern to patients and clinicians. More needs to be done to understand its implications and the best strategies of management.
June 26, 2026 at 12:05 PM
Reposted by akheel sͩyͬed
cmaj.ca
Arginine vasopressin disorders:
Diabetes insipidus has been renamed to arginine vasopressin disorders for clarity and safety.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251716
Arginine vasopressin disorders cause failure to produce or respond to the antidiuretic hormone arginine vasopressin, previously called diabetes insipidus.
May 12, 2026 at 5:15 PM
Reposted by akheel sͩyͬed
socendocrinology.bsky.social
Preventing and Managing Adrenal Crisis – your experience matters. 📢

People living with, or affected by, adrenal insufficiency, including Addison’s, are the experts in their own rare condition. Your personal story is the most powerful tool for driving change.

Take part ➡️ loom.ly/YaPyAug
May 7, 2026 at 11:30 AM
akheelsyed.bsky.social
Incretin/GLP-1 users include many women of childbearing age. We discuss if this can have consequences for pregnancy outcomes.

@ncaresearchnhs.bsky.social

pubmed.ncbi.nlm.nih.gov/42017293/
The Risk of GLP-1 Receptor Agonist (GLP-1 RA) Exposure in Early Pregnancy. A Call to Action: Quantifying the Impact on Pregnancy Outcomes in the United Kingdom - PubMed
The Risk of GLP-1 Receptor Agonist (GLP-1 RA) Exposure in Early Pregnancy. A Call to Action: Quantifying the Impact on Pregnancy Outcomes in the United Kingdom
pubmed.ncbi.nlm.nih.gov
April 22, 2026 at 11:24 AM
akheelsyed.bsky.social
Acromegaly | New England Journal of Medicine www.nejm.org/doi/full/10....

@safwaanadam.bsky.social and Syed.
We propose a role for incretin therapies in the management of coexisting conditions such as obesity, obstructive sleep apnea, and diabetes..
@ncaresearchnhs.bsky.social
@manchester.ac.uk
Acromegaly | NEJM
To the Editor: In their review article, Giustina and Colao (November 13 issue)1 discuss acromegaly and its craniofacial manifestations. Dentists and oral and maxillofacial surgeons are often among ...
www.nejm.org
February 19, 2026 at 8:13 AM
Reposted by akheel sͩyͬed
socendocrinology.bsky.social
In The #Endocrinologist, @safwaanadam.bsky.social and @akheelsyed.bsky.social, describe the various biological effects of obesity in worsening the health of the heart muscle and blood vessels, and how weight loss treatments have benefits for cardiovascular health too. 🫀

Read more👉 shorturl.at/KML5v
January 30, 2026 at 9:00 AM
akheelsyed.bsky.social
Thyroid overactivity worsens patients' quality of life (QoL). After treatment, QoL is not completely restored for many patients. We discuss reasons, and new approaches to address long-term effects on QoL.
@ncaresearchnhs.bsky.social
@endoconnect.bsky.social

www.researchgate.net/publication/...
Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Request PDF
Request PDF | Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Hyperthyroidism adversely affects quality of life (QoL), encompassing physical, mental ...
www.researchgate.net
January 11, 2026 at 6:18 PM
akheelsyed.bsky.social
What's the diagnosis? Be warned: Not everything is as it seems!
Ali, @adhithyasankar.bsky.social, et al. @ncaresearchnhs.bsky.social

www.ccjm.org/content/93/1...
A young woman with Kallmann syndrome and acute neurologic symptoms
Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.
www.ccjm.org
January 10, 2026 at 7:12 PM
akheelsyed.bsky.social
Women under 45 are at increased risk of vitamin D and calcium deficiencies after bariatric surgery.
@ncaresearchnhs.bsky.social

rdcu.be/eYuiy
Client Challenge
rdcu.be
January 10, 2026 at 6:12 PM
akheelsyed.bsky.social
Weight gain after treatment of hyperthyroidism is associated with a large adverse effect on quality of life.
Angelos Kyriacou et al.
@ncaresearchnhs.bsky.social
pubmed.ncbi.nlm.nih.gov/41448910/
Weight Gain after Treatment of Hyperthyroidism is Associated with Impairment of Quality of Life - PubMed
<span><b><i>Background:</i></b> There is evidence of quality of life (QoL) impairment and weight gain in treated hyperthyroidism. It is not known whether treatment-related weight gain is associated with QoL impairment in this patient group of this cohort. Our primary aim was to examine whether percentage</span> …
pubmed.ncbi.nlm.nih.gov
December 26, 2025 at 11:42 AM
akheelsyed.bsky.social
Recognising obesity as a primary driver of CVD reinforces the need for early, proactive intervention.
@safwaanadam.bsky.social
@socendocrinology.bsky.social
@ncaresearchnhs.bsky.social
www.endocrinology.org/endocrinolog...
OBESITY AND CARDIOVASCULAR DISEASE: CORE RELATIONSHIPS AND MANAGEMENT OPTIONS | Society for Endocrinology
The Society for Endocrinology aims to promote the advancement of public education in endocrinology
www.endocrinology.org
December 11, 2025 at 6:12 PM
Reposted by akheel sͩyͬed
cmaj.ca
Thymic hyperplasia:
Thymic hyperplasia, common in children and adolescents, is unusual in adults owing to age-related involution.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250929
Thymic hyperplasia in an adult with Graves disease
A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...
www.cmaj.ca
November 24, 2025 at 6:30 PM
akheelsyed.bsky.social
Jack Roddy, Shaishav Dhage and Akheel Syed.
@ncaresearchnhs.bsky.social
Treat the Graves' hyperthyroidism and the thymic hyperplasia resolves.

www.cmaj.ca/content/197/...
Thymic hyperplasia in an adult with Graves disease
A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...
www.cmaj.ca
November 24, 2025 at 12:05 PM
akheelsyed.bsky.social
Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis - Surgery for Obesity and Related Diseases www.soard.org/article/S155...
Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis
Long-term outcomes of Roux-en-Y gastric bypass (RYGB) in adolescents are limited. This systematic review and meta-analysis evaluates the safety and efficacy of RYGB in adolescents with obesity. A comp...
www.soard.org
November 2, 2025 at 10:35 PM
Reposted by akheel sͩyͬed
adhithyasankar.bsky.social
Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone

jamanetwork.com/journals/jam...
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
October 17, 2025 at 9:00 AM
akheelsyed.bsky.social
Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
October 15, 2025 at 8:58 PM
Reposted by akheel sͩyͬed
erictopol.bsky.social
More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose
nature.com/articles/s41...
Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis - International Journal of Obesity
International Journal of Obesity - Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis
nature.com
September 28, 2025 at 2:45 PM