Alexandre Hervé
@alexhv.bsky.social
PhD student at Institut Pasteur / MDM Lab: mining ancestral immune modules across domains of life to uncover novel immune proteins in eukaryotes.
Reposted by Alexandre Hervé
Out @cp-cellhostmicrobe.bsky.social, natural products meet bacterial immunity!
We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages.
Led by @hshomar.bsky.social & @mariegllm.bsky.social
www.sciencedirect.com/science/arti...
We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages.
Led by @hshomar.bsky.social & @mariegllm.bsky.social
www.sciencedirect.com/science/arti...
A family of lanthipeptides with anti-phage function
Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some nat…
www.sciencedirect.com
July 21, 2026 at 10:24 AM
Out @cp-cellhostmicrobe.bsky.social, natural products meet bacterial immunity!
We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages.
Led by @hshomar.bsky.social & @mariegllm.bsky.social
www.sciencedirect.com/science/arti...
We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages.
Led by @hshomar.bsky.social & @mariegllm.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Alexandre Hervé
Congratulations to Aude Bernheim (@audeber.bsky.social), elected EMBO Member 2026 🎉
Her work on bacterial immunity is reshaping how we understand immune systems across all life forms — from bacteria to humans.
@embo.org
Her work on bacterial immunity is reshaping how we understand immune systems across all life forms — from bacteria to humans.
@embo.org
June 30, 2026 at 11:48 AM
Congratulations to Aude Bernheim (@audeber.bsky.social), elected EMBO Member 2026 🎉
Her work on bacterial immunity is reshaping how we understand immune systems across all life forms — from bacteria to humans.
@embo.org
Her work on bacterial immunity is reshaping how we understand immune systems across all life forms — from bacteria to humans.
@embo.org
Reposted by Alexandre Hervé
Key human defenses against pathogens were forged billions of years ago in microbial battles with viruses. https://scim.ag/4uv29Ww
Ancient wars between microbes gave us key immune defenses
A better understanding of battles between bacteria and viruses could inspire new medicines
scim.ag
May 25, 2026 at 1:33 PM
Key human defenses against pathogens were forged billions of years ago in microbial battles with viruses. https://scim.ag/4uv29Ww
Reposted by Alexandre Hervé
Bacteria have been fighting off viruses using a huge arsenal of molecular weaponry that scientists did not know about — until now. Researchers have identified proteins that could lead to virus-fighting drugs and technologies.
go.nature.com/4dqQnXI
go.nature.com/4dqQnXI
‘Treasure trove’ of antiviral proteins could inspire powerful molecular tools
Two research teams mined genomic data from bacteria to create databases containing thousands of antiviral defence proteins that could inspire powerful biotechnologies.
go.nature.com
April 2, 2026 at 6:47 PM
Bacteria have been fighting off viruses using a huge arsenal of molecular weaponry that scientists did not know about — until now. Researchers have identified proteins that could lead to virus-fighting drugs and technologies.
go.nature.com/4dqQnXI
go.nature.com/4dqQnXI
Reposted by Alexandre Hervé
How diverse is bacterial immunity ?
We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...
Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...
Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
www.science.org
April 2, 2026 at 6:44 PM
How diverse is bacterial immunity ?
We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...
Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...
Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
Reposted by Alexandre Hervé
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery https://www.biorxiv.org/content/10.1101/2025.04.02.646746v1
April 2, 2025 at 4:16 PM
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery https://www.biorxiv.org/content/10.1101/2025.04.02.646746v1
Reposted by Alexandre Hervé
What is the diversity of antiphage systems out there ?
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
January 9, 2025 at 1:18 PM
What is the diversity of antiphage systems out there ?
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...