Chris Burns
ampliaceo.bsky.social
Chris Burns
@ampliaceo.bsky.social
CEO of Amplia Therapeutics, a Melbourne, Australia, based biotech developing a pipeline of small molecule FAK inhibitors for cancer and fibrotic diseases. Our lead asset is narmafotinib currently in a Phase 2a trial in pancreatic cancer (NCT05355298).
Reposted by Chris Burns
STAT's new trust-in-science reporter @nicholasflorko.bsky.social chats with @alexhogan.bsky.social about why he thinks people have lost trust in science.
September 21, 2026 at 9:08 PM
Enjoyed speaking with Brad Sorenson from Zacks at the OTC Markets Investor Conference!

stocktwits.com/ZacksSCR/mes...
Zacks Small Cap Research (@ZacksSCR) | Stocktwits
$INNMF Amplia Therapeutics CEO Dr. Christopher Burns joined Zacks SCR at the OTC Markets Life Sciences Virtual Investor Forum for a CEO Chat. Read the transcript: https://scr.zacks.com/news/news-detai...
stocktwits.com
September 22, 2026 at 11:04 PM
Congratulations to the team at Kinoxis!
Main Sequence backs dementia and pain biotech Kinoxis www.innovationaus.com/main-sequenc...
www.innovationaus.com
September 22, 2026 at 10:58 PM
Amplia Signs Collaboration Agreement With Lilly, Evaluating Narmafotinib Plus Lilly’s Kras G12C Inhibitor, Olomorasib, in Non-small Cell Lung Cancer
#pancreaticcancer #FAK #olomorasib #narmafotinib
www.globenewswire.com/news-release...
Amplia Signs Collaboration Agreement With Lilly, Evaluating Narmafotinib Plus Lilly’s Kras G12C Inhibitor, Olomorasib, in Non-small Cell Lung Cancer
HIGHLIGHTS Amplia has executed a Clinical Trial Collaboration & Supply Agreement (CTCSA) with Eli Lilly & Company, to evaluate the Company’s...
www.globenewswire.com
August 4, 2026 at 9:20 PM
Scientific Paper Detailing Preclinical Studies of Narmafotinib in Pancreatic Cancer Now Online
#pancreaticcancer #FAK
www.globenewswire.com/news-release...
www.globenewswire.com
August 2, 2026 at 5:53 AM
Earlier this month, I presented Amplia's latest progress at the Monsoon Twilight Investor Briefing, including new ACCENT trial data and our plans for narmafotinib’s next stage of clinical development. Thanks to Monsoon and FB Rice for the opportunity.

Watch the recording here: bit.ly/45bC9Et
Twilight Investor Briefing: New AU Cancer Therapies | 8 July 2026
Watch the presentations from three ASX-listed biotechs at the forefront of promising new cancer therapies, each advancing treatments for diseases with significant unmet medical need. Inquiries: [email protected] The session includes company updates, pipeline progress and outlook discussions from: ✅ 03:00 Racura Oncology (ASX: RAC) Racura is a Phase 3 clinical-stage company advancing RC220 across three active oncology programs. RC220 has been discovered to silence MYC — a target implicated in 70% of all cancers and long considered undruggable — via DNA G4 binding. Active programs include a Phase 3 AML trial, the HARNESS-1 Phase 1 trial in EGFR-mutant NSCLC combining RC220 with Tagrisso®, and the CPACS-1 cardioprotection trial with patients already dosed in Hong Kong and Australia. First patient dosed in both Phase 3 AML and HARNESS-1 are targeted in 2026, with HARNESS-1 carrying explicit potential for FDA Accelerated Approval. Website: https://www.racuraoncology.com/ ✅ 25:44 Amplia Therapeutics (ASX: ATX | OTCQB: INNMF) Amplia is a clinical-stage Australian biotech developing best-in-class FAK inhibitors for fibrotic cancers. Its lead drug narmafotinib has delivered 5 confirmed complete responses in advanced pancreatic cancer — a 7.8% complete response rate confirmed by independent central review, compared to 0.2% for chemotherapy alone, and never before seen in this indication. The ACCENT trial achieved a 36% objective response rate and median overall survival of 11.1 months. A registration-enabling Phase 2b study is now underway, designed in alignment with FDA feedback, with a new ovarian cancer trial (PRROSE) and kRAS inhibitor partnering discussions further expanding the pipeline. Website: https://www.ampliatx.com ✅ 47:45 Prescient Therapeutics (ASX: PTX) Prescient is developing the world's only GGTase-1 inhibitor in clinical development — a first-in-class targeted therapy advancing through Phase 2a in Cutaneous T-Cell Lymphoma (CTCL), a blood cancer with no satisfactory treatment options. Phase 1b results in CTCL delivered a 43% response rate, 100% clinical benefit rate, 12.4-month duration of response, and zero serious treatment-related adverse events. The Phase 2a trial has enrolled 18 patients across 12 active sites in Australia, the US and Italy, scaling toward 16 sites globally. GGTase-1 biology is implicated in approximately 22% of all cancers, with the CTCL market forecast at ~US$1.2bn annually by 2034. Website: https://www.ptxtherapeutics.com
bit.ly
July 20, 2026 at 7:02 AM
Looking forward to hosting our shareholder webinar this Tuesday 14 July at 11am AEST / 9am AWST. I'll be walking through Amplia's drug development pathway and clinical strategy and taking your questions live. #FAK #Amplia

Register: ampliatx.com/webinars/exk...
July 13, 2026 at 3:24 AM
Amplia Announces Publication of New FAK Inhibitor Patent Application www.globenewswire.com/news-release...
Amplia Announces Publication of New FAK Inhibitor Patent Application
HIGHLIGHTS New patent application published covering chemically novel FAK inhibitors discovered by AmpliaApplication expands Amplia’s intellectual...
www.globenewswire.com
July 9, 2026 at 9:45 PM
Very nice paper showing synergistic benefit of FAK inhibition with G12C KRAS inhibitors from @mdanderson.bsky.social

Adaptive feedback signaling via the FAK/SRC pathway promotes KRAS G12C inhibitor resistance - Journal of Thoracic Oncology www.jto.org/article/S155...
Adaptive feedback signaling via the FAK/SRC pathway promotes KRAS G12C inhibitor resistance
Allele-specific KRAS inhibitors such as the KRASG12C inhibitors sotorasib and adagrasib have demonstrated clinical activity as monotherapy but adaptive signaling in response to KRAS pathway inhibition...
www.jto.org
June 30, 2026 at 3:09 AM
Great piece on Amplia's strategy after the recent ASCO conference available from Bulls'n'Bears.
www.bullsnbears.com.au/post/amplia-...
Amplia Therapeutics eyes major role in new cancer drug frontier
While many cancer companies spend billions trying to make stronger chemotherapies, Melbourne-based Amplia Therapeutics (ASX: ATX) is taking a different path, developing a “shield-breaking” treatment t...
www.bullsnbears.com.au
June 15, 2026 at 4:46 AM
UCSD researchers show potential of FAK inhibitors in ovarian cancer.
FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages: Cell Reports www.cell.com/cell-reports...
FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages
FAK tyrosine kinase drives ovarian cancer tumor progression in part via effects on the tumor microenvironment. Chen et al. show that ovarian tumor FAK inhibition triggers release of omega-3 fatty acid...
www.cell.com
May 1, 2026 at 6:49 AM
I'll be attending next month's AACR Special Conference on Ras Oncogenesis and Therapeutics in Los Angeles to present a poster describing Amplia's preclinical studies of various kRAS inhibitors with our best-in-class FAK inhibitor narmafotinib.
#AACRras26 #FAK #pancreaticcancer
February 19, 2026 at 10:49 PM
Amplia Therapeutics (ASX:ATX; OTCQB:INNMF) has announced the successful completion its first large-scale manufacturing campaign of narmafotinib, producing approximately 13 kg of active pharmaceutical ingredient (API). Read the ASX release: bit.ly/4bayyuN
#pancreaticcancer #FAK
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January 23, 2026 at 7:58 AM
Amplia has reported a further confirmed PR in the ACCENT trial evaluating FAK inhibitor narmafotinib in combination with chemotherapy in metastatic pancreatic cancer. View presentation: ampliatx.com/announcement...

$ATX $INNMF #Amplia #pancreaticcancer #clinicaltrial #FAK
December 11, 2025 at 11:00 PM
Amplia CEO Dr Chris Burns will present at the Life Sciences Virtual Investor Forum this week, sharing recent achievements and next steps in the development of narmafotinib: 3pm Thur 11 December (US ET) / 7am Fri 12 December (AEDT)
🔗 To register: bit.ly/4ptfJHt
#Amplia #pancreaticcancer #FAK
Amplia Therapeutics Ltd. (OTCQB: INNMF | ASX: ATX)
Amplia Therapeutics Ltd. (OTCQB: INNMF | ASX: ATX)
bit.ly
December 10, 2025 at 6:18 AM
Triple negative breast cancer remains tough to treat. A new study finds FAK interacts with PD-L1, boosting immune evasion when inhibited. Combining FAK inhibitors with PD-L1 blockade could unlock better therapies.
www.mdpi.com/3547364
#FAK #TNBC #Immunotherapy
www.mdpi.com
November 15, 2025 at 6:33 AM
Adelaide scientists have identified the cell surface receptor F2R as a promising biomarker and treatment target for ovarian cancer. This breakthrough could improve diagnosis and therapy for women with this deadly disease, especially those with drug-resistant cancers. www.mdpi.com/3481014
www.mdpi.com
October 27, 2025 at 9:57 PM
New research finds that targeting mechanoresponsive myeloid cells through FAK inhibition reduces fibrosis and scarring by restoring anti-inflammatory cell populations—offering fresh hope for systemic therapies against organ fibrosis. #FAK #Fibrosis #Immunology rdcu.be/eMOrH
Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis
Nature Biomedical Engineering - Myeloid-specific mechanotransduction ablation downregulates pro-fibrotic fibroblast transcriptional profiles to reduce scar formation in human cells
rdcu.be
October 26, 2025 at 9:38 PM
#Amplia is expanding its U.S. presence to boost investor awareness & engagement. As its Phase 1b/2a AMPLICITY trial continues in the U.S. and Australia, Amplia has launched a U.S. capital markets campaign and is pursuing an OTCQB uplisting. bit.ly/3IRUrmV $ATX #clinicaltrials #pancreaticcancer
ASX:ATX - Amplia Therapeutics to Significantly Expand U.S. Presence
Read and interact with this announcement: Amplia Therapeutics to Significantly Expand U.S. Presence on Amplia's investor hub
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October 17, 2025 at 1:44 AM
New Data | Amplia’s ongoing ACCENT clinical trial in advanced pancreatic cancer has recorded an additional confirmed partial response and one unconfirmed partial response. Read the ASX release: bit.ly/3IQavFG
$ATX $INNMF #Amplia #clinicaltrial #pancreaticcancer #innovation #pharma
October 8, 2025 at 11:23 PM