Axel Pahl
@apahl.bsky.social
Med. Chemist turned Data Scientist at Fraunhofer ITMP, Hamburg. Cell Painting. Linux enthusiast. Programming in Python & Rust (, Nim, Go, I just can't decide), general geek. Judo black belt.
Reposted by Axel Pahl
Antibiotikaresistenzen zählen zu den größten Herausforderungen unserer Zeit. Das Projekt #ANTARES setzt auf #KI, um neue Wirkstoffe schneller zu finden. Mit 1,18 Mio. € BMFTR-Förderung forschen @helmholtzhzi.bsky.social, Enamine Germany und wir an neuen Therapieoptionen gegen resistente Erreger.
September 3, 2026 at 11:26 AM
Antibiotikaresistenzen zählen zu den größten Herausforderungen unserer Zeit. Das Projekt #ANTARES setzt auf #KI, um neue Wirkstoffe schneller zu finden. Mit 1,18 Mio. € BMFTR-Förderung forschen @helmholtzhzi.bsky.social, Enamine Germany und wir an neuen Therapieoptionen gegen resistente Erreger.
Reposted by Axel Pahl
![Comic. [Person with bun gesturing at informational sign as she talks to person with ponytail, another person, person with shoulder-length hair, and a person with a white hat] PERSON WITH BUN: In some places, the bay is more than 182.8 meters deep. [thought bubble above another person’s head] PERSON: *”More than”?* Why would they use that for such a precise... Aha! 100 fathoms! [caption] My hobby: reverse-engineering original units](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreietzkk2q6orvtivslzksr7ex2gytqoqon5zjz6ourowsspulp6asi)
May 21, 2026 at 6:11 PM
Reposted by Axel Pahl
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
www.science.org
February 13, 2026 at 2:19 AM
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Axel Pahl
🔬Ein mobiles Gaschromatographie-Sensorsystem soll künftig helfen, Lebensmittelbetrug vor Ort zu erkennen. Drei Fraunhofer-Institute entwickeln das leicht bedienbare Gerät, das auch Analytik-Laien eine schnelle Bewertung ermöglicht. Mehr dazu: 🖇️ s.fhg.de/qxnv #Qualitätscheck #compliance
January 16, 2026 at 11:06 AM
🔬Ein mobiles Gaschromatographie-Sensorsystem soll künftig helfen, Lebensmittelbetrug vor Ort zu erkennen. Drei Fraunhofer-Institute entwickeln das leicht bedienbare Gerät, das auch Analytik-Laien eine schnelle Bewertung ermöglicht. Mehr dazu: 🖇️ s.fhg.de/qxnv #Qualitätscheck #compliance
Reposted by Axel Pahl
paper alert🚨
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry
www.nature.com/articles/s41...
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry
www.nature.com/articles/s41...
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Nature Chemistry
In targeted protein degradation, a degrader molecule brings a neosubstrate protein proximal to a hijacked E3 ligase for its ubiquitination. Here, pseudo-natural products derived from (−)-myrtanol—iDeg...
www.nature.com
January 8, 2026 at 10:46 AM
paper alert🚨
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry
www.nature.com/articles/s41...
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry
www.nature.com/articles/s41...
Reposted by Axel Pahl
Mols2grid 2.2.0 is out with full Marimo support 🎅 Huge thanks to @n283t.bsky.social for the contribution! See this for an example linking mols2grid selections with marimo's UI table: github.com/cbouy/mols2g...
N283T: x.com/tbsng_ktkm0923
N283T: x.com/tbsng_ktkm0923
December 21, 2025 at 10:27 AM
Mols2grid 2.2.0 is out with full Marimo support 🎅 Huge thanks to @n283t.bsky.social for the contribution! See this for an example linking mols2grid selections with marimo's UI table: github.com/cbouy/mols2g...
N283T: x.com/tbsng_ktkm0923
N283T: x.com/tbsng_ktkm0923
Reposted by Axel Pahl
![Comic. [Two people one one side of a pile of seven apples, next to person with long hair next to five apples.] PERSON: Okay, with my seven apples added to your five, we have… let’s se… twelve apples! PERSON 2 [with hands raised]: Incredible! Perfect agreement with the theory! [caption] Experimental Mathematicians](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreifgv5skm72kzcxgexs4hbpex45met5vxhb6kf2aqshmktmo37nl5a)
Reposted by Axel Pahl
This week's #RDKit blog post shows how to create simple protein--ligand interaction diagrams.
I think there's potential to take this a bit further...
greglandrum.github.io/rdkit-blog/p...
I think there's potential to take this a bit further...
greglandrum.github.io/rdkit-blog/p...
Drawing simple protein–ligand interaction diagrams with the RDKit – RDKit blog
Quick, but useful
greglandrum.github.io
September 26, 2025 at 3:58 PM
This week's #RDKit blog post shows how to create simple protein--ligand interaction diagrams.
I think there's potential to take this a bit further...
greglandrum.github.io/rdkit-blog/p...
I think there's potential to take this a bit further...
greglandrum.github.io/rdkit-blog/p...
Reposted by Axel Pahl
“We only have a few minutes left so please keep your questions brief.”
“Thank you for your talk, before I ask my convoluted question and get to the point, please allow me to tell you my name, title, position, rank and academic biography…”
“Thank you for your talk, before I ask my convoluted question and get to the point, please allow me to tell you my name, title, position, rank and academic biography…”
September 17, 2025 at 8:11 AM
“We only have a few minutes left so please keep your questions brief.”
“Thank you for your talk, before I ask my convoluted question and get to the point, please allow me to tell you my name, title, position, rank and academic biography…”
“Thank you for your talk, before I ask my convoluted question and get to the point, please allow me to tell you my name, title, position, rank and academic biography…”
Reposted by Axel Pahl
Reposted by Axel Pahl
I will soon be posting a postdoc position in protein biochemistry/biophyics! Interested candidates are welcome to reach out at [email protected]. Experience in protein expression, purification, and assay development is a must. Structural biology would be great! Please RT :)
May 24, 2025 at 8:25 AM
I will soon be posting a postdoc position in protein biochemistry/biophyics! Interested candidates are welcome to reach out at [email protected]. Experience in protein expression, purification, and assay development is a must. Structural biology would be great! Please RT :)
Reposted by Axel Pahl
Rxn-INSIGHT also has some functions for molecules, but many more for reactions. Functional groups and rings are handled separately here:
github.com/mrodobbe/Rxn...
github.com/mrodobbe/Rxn...
March 8, 2025 at 1:58 PM
Rxn-INSIGHT also has some functions for molecules, but many more for reactions. Functional groups and rings are handled separately here:
github.com/mrodobbe/Rxn...
github.com/mrodobbe/Rxn...
Reposted by Axel Pahl
Reposted by Axel Pahl
I will be playing in the O2 Arena!
Well, I won't be playing, I'll be talking... and no, it's not the one in London but the one in Amsterdam...
But if you're around, it would be cool to meet you there. 😊
www.dtls.nl/data-represe...
Well, I won't be playing, I'll be talking... and no, it's not the one in London but the one in Amsterdam...
But if you're around, it would be cool to meet you there. 😊
www.dtls.nl/data-represe...
February 15, 2025 at 11:45 AM
I will be playing in the O2 Arena!
Well, I won't be playing, I'll be talking... and no, it's not the one in London but the one in Amsterdam...
But if you're around, it would be cool to meet you there. 😊
www.dtls.nl/data-represe...
Well, I won't be playing, I'll be talking... and no, it's not the one in London but the one in Amsterdam...
But if you're around, it would be cool to meet you there. 😊
www.dtls.nl/data-represe...
Reposted by Axel Pahl
If you work in drug discovery and you read one thing this weekend, make it this exceptional J Med Chem editorial. Hits on almost every blessed thing I’ve tweetorialized over the last several years.
Quantitation and Error Measurements in Dose–Response Curves
Quantitation and Error Measurements in Dose–Response Curves
Quantitation and Error Measurements in Dose–Response Curves
pubs.acs.org
January 31, 2025 at 6:30 PM
If you work in drug discovery and you read one thing this weekend, make it this exceptional J Med Chem editorial. Hits on almost every blessed thing I’ve tweetorialized over the last several years.
Quantitation and Error Measurements in Dose–Response Curves
Quantitation and Error Measurements in Dose–Response Curves
Reposted by Axel Pahl
Microsoft researchers introduce MatterGen, a model that can discover new materials tailored to specific needs—like efficient solar cells or CO2 recycling—advancing progress beyond trial-and-error experiments. www.microsoft.com/en-us/resear...
January 16, 2025 at 12:18 PM
Sunday morning, Hamburg Fischmarkt.
December 22, 2024 at 7:06 AM
Sunday morning, Hamburg Fischmarkt.
Reposted by Axel Pahl
Multiresistente Keime: Die Waffen gegen gefährliche Bakterien werden zunehmend stumpf, immer häufiger können lebensbedrohliche Infektionen nicht mehr therapiert werden. Ersatz gibt es bisher kaum. Im neuen Fraunhofer-Magazin stellen wir neue Chancen aus der angewandten Forschung vor: s.fhg.de/P3pj
December 9, 2024 at 11:32 AM
Multiresistente Keime: Die Waffen gegen gefährliche Bakterien werden zunehmend stumpf, immer häufiger können lebensbedrohliche Infektionen nicht mehr therapiert werden. Ersatz gibt es bisher kaum. Im neuen Fraunhofer-Magazin stellen wir neue Chancen aus der angewandten Forschung vor: s.fhg.de/P3pj
Reposted by Axel Pahl
Want to make beautiful scientific figures? Easy!
The NIH released a library of 2000+ free scientific illustrations called *BioArt*.
Check it out! bioart.niaid.nih.gov
#AcademicSky #PsychSciSky 🧠🟦 🧪
The NIH released a library of 2000+ free scientific illustrations called *BioArt*.
Check it out! bioart.niaid.nih.gov
#AcademicSky #PsychSciSky 🧠🟦 🧪
October 30, 2024 at 9:45 AM
Want to make beautiful scientific figures? Easy!
The NIH released a library of 2000+ free scientific illustrations called *BioArt*.
Check it out! bioart.niaid.nih.gov
#AcademicSky #PsychSciSky 🧠🟦 🧪
The NIH released a library of 2000+ free scientific illustrations called *BioArt*.
Check it out! bioart.niaid.nih.gov
#AcademicSky #PsychSciSky 🧠🟦 🧪
After almost 10 years on consecutive temporary contracts, it was time for me to leave the MPI in Dortmund. Thank you to everyone for the really good time.
November 3, 2024 at 12:52 PM
After almost 10 years on consecutive temporary contracts, it was time for me to leave the MPI in Dortmund. Thank you to everyone for the really good time.
Reposted by Axel Pahl
Fantastic resource for bio icons: NIH Bioart Source
Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov
Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov
October 29, 2024 at 7:19 AM
Fantastic resource for bio icons: NIH Bioart Source
Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov
Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov
Reposted by Axel Pahl
Reposted by Axel Pahl
Register! Broad Institute
Machine Learning for Drug Discovery
broad.io/mldd
Oct 31/Nov 1
In-person, or free virtual attendance!
Speakers:
Jennifer Listgarten
James Collins
Jakob Uszkoreit
Jian Tang Mila
Antonia Mey
Jakub Tomczak
Henry van den Bedem
Nicolas Stransky
Machine Learning for Drug Discovery
broad.io/mldd
Oct 31/Nov 1
In-person, or free virtual attendance!
Speakers:
Jennifer Listgarten
James Collins
Jakob Uszkoreit
Jian Tang Mila
Antonia Mey
Jakub Tomczak
Henry van den Bedem
Nicolas Stransky
Machine Learning in Drug Discovery Symposium
The 2024 Machine Learning in Drug Discovery Symposium will feature a half-day workshop on October 31, 2024 and a full day of talks on November 1, 2024. Learn more about the symposium and workshop on t...
broad.io
September 3, 2024 at 5:18 PM
Register! Broad Institute
Machine Learning for Drug Discovery
broad.io/mldd
Oct 31/Nov 1
In-person, or free virtual attendance!
Speakers:
Jennifer Listgarten
James Collins
Jakob Uszkoreit
Jian Tang Mila
Antonia Mey
Jakub Tomczak
Henry van den Bedem
Nicolas Stransky
Machine Learning for Drug Discovery
broad.io/mldd
Oct 31/Nov 1
In-person, or free virtual attendance!
Speakers:
Jennifer Listgarten
James Collins
Jakob Uszkoreit
Jian Tang Mila
Antonia Mey
Jakub Tomczak
Henry van den Bedem
Nicolas Stransky
Reposted by Axel Pahl
Hey friends! Just letting you know about the full hybrid conference "AI in Chemistry". In-person registration (Cambridge, UK) closes tonight, and virtual registration will be open a while longer. It's a *great* conference ⚗ www.rscbmcs.org/events/aiche...
7th AI in Chemistry - RSC BMCS
We organise international conferences that ensure the cross fertilisation of ideas amongst experts in our field
www.rscbmcs.org
September 2, 2024 at 8:29 AM
Hey friends! Just letting you know about the full hybrid conference "AI in Chemistry". In-person registration (Cambridge, UK) closes tonight, and virtual registration will be open a while longer. It's a *great* conference ⚗ www.rscbmcs.org/events/aiche...
Reposted by Axel Pahl
Join us and Herbert Waldmann, Dorothea Fiedler, Christian Hackenberger, Stephan Sieber, Tamir Gonen, Ralf Jungmann, Andrea Rentmeister, Ronald Micura, John Yates, Kerstin Goepfrich and Michael Jewett at the @GDChBiochem.bsky.social Conference (30.9.-02.10.24).
veranstaltungen.gdch.de/microsite/in...
veranstaltungen.gdch.de/microsite/in...
August 1, 2024 at 8:14 AM
Join us and Herbert Waldmann, Dorothea Fiedler, Christian Hackenberger, Stephan Sieber, Tamir Gonen, Ralf Jungmann, Andrea Rentmeister, Ronald Micura, John Yates, Kerstin Goepfrich and Michael Jewett at the @GDChBiochem.bsky.social Conference (30.9.-02.10.24).
veranstaltungen.gdch.de/microsite/in...
veranstaltungen.gdch.de/microsite/in...