Todd Douglas
@apoptoddic.bsky.social
• scientific associate studying why & how cells die
• princess margaret cancer centre
• he/him
https://orcid.org/0000-0002-6053-9345
• princess margaret cancer centre
• he/him
https://orcid.org/0000-0002-6053-9345
Pinned
Todd Douglas
@apoptoddic.bsky.social
· Apr 30
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
www.nature.com
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
I've been thinking about this comic all week.
August 30, 2026 at 5:51 PM
I've been thinking about this comic all week.
Reposted by Todd Douglas
Ribosomes have a strange protein modification in a universally-conserved protein uS11. This modification, isoaspartate, is also conserved in nearly all forms of life. We originally found this modification using cryo-EM, but had no idea how it was formed. 1/
elifesciences.org/articles/60482
elifesciences.org/articles/60482
Structure of the bacterial ribosome at 2 Å resolution
High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and ref...
elifesciences.org
August 27, 2026 at 2:26 PM
Ribosomes have a strange protein modification in a universally-conserved protein uS11. This modification, isoaspartate, is also conserved in nearly all forms of life. We originally found this modification using cryo-EM, but had no idea how it was formed. 1/
elifesciences.org/articles/60482
elifesciences.org/articles/60482
Reposted by Todd Douglas
WE'RE HIRING! Thanks to some recent successes with NIH funding, we're seeking two new postdoctoral scholars to join our team. See below for details.
Please share widely and feel free to reach out with any questions!
Please share widely and feel free to reach out with any questions!
August 22, 2026 at 6:31 PM
WE'RE HIRING! Thanks to some recent successes with NIH funding, we're seeking two new postdoctoral scholars to join our team. See below for details.
Please share widely and feel free to reach out with any questions!
Please share widely and feel free to reach out with any questions!
Reposted by Todd Douglas
830 wildfires burning across Canada right now. And you know what’s going to make it worse in the future? More oil pipelines. This is why our voice and our vote matters.
July 15, 2026 at 3:23 PM
830 wildfires burning across Canada right now. And you know what’s going to make it worse in the future? More oil pipelines. This is why our voice and our vote matters.
Reposted by Todd Douglas
Thanks to Boyi Gan's group (@mdanderson.bsky.social) for this nice summary and contextualization of our (@craigmcrews.bsky.social) recent paper! Still lots more to understand...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation - Cell Death & Differentiation
Cell Death & Differentiation - Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation
www.nature.com
July 11, 2026 at 12:34 PM
Thanks to Boyi Gan's group (@mdanderson.bsky.social) for this nice summary and contextualization of our (@craigmcrews.bsky.social) recent paper! Still lots more to understand...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thanks to Boyi Gan's group (@mdanderson.bsky.social) for this nice summary and contextualization of our (@craigmcrews.bsky.social) recent paper! Still lots more to understand...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation - Cell Death & Differentiation
Cell Death & Differentiation - Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation
www.nature.com
July 11, 2026 at 12:34 PM
Thanks to Boyi Gan's group (@mdanderson.bsky.social) for this nice summary and contextualization of our (@craigmcrews.bsky.social) recent paper! Still lots more to understand...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Todd Douglas
Add your name to tell Prime Minister Carney to protect our future over Big Oil profits: www.ourcommons.ca/petitions/en...
Yesterday's pipeline announcement is yet another reminder that Prime Minister Carney cares more about lining the pockets of his corporate friends than upholding the Constitutional rights of Indigenous peoples and protecting the public from the escalating climate emergency. (1/6)
July 3, 2026 at 9:19 PM
Add your name to tell Prime Minister Carney to protect our future over Big Oil profits: www.ourcommons.ca/petitions/en...
Reposted by Todd Douglas
Today’s announcement shows what this federal government will protect above all else: the profits of Big Oil.
Read my full statement on the oil pipeline proposal from the Prime Minister and Premier Smith:
www.ndp.ca/news/ndp-rea...
Read my full statement on the oil pipeline proposal from the Prime Minister and Premier Smith:
www.ndp.ca/news/ndp-rea...
NDP Reaction to West Coast Pipeline Announcement
NDP Leader Avi Lewis shared the following statement in response to the oil pipeline proposal from Alberta Premier Danielle Smith:
www.ndp.ca
July 3, 2026 at 2:02 AM
Today’s announcement shows what this federal government will protect above all else: the profits of Big Oil.
Read my full statement on the oil pipeline proposal from the Prime Minister and Premier Smith:
www.ndp.ca/news/ndp-rea...
Read my full statement on the oil pipeline proposal from the Prime Minister and Premier Smith:
www.ndp.ca/news/ndp-rea...
Reposted by Todd Douglas
Elon Musk's incitement of pogroms in Belfast reveals he'll use his immense wealth and influence to foment untold fascist violence in the future. Only a global movement can break his power.
New piece from @polphilpod.bsky.social and me. Threading highlights below. 1/
newrepublic.com/article/2119...
New piece from @polphilpod.bsky.social and me. Threading highlights below. 1/
newrepublic.com/article/2119...
Elon Musk’s Race War Just Took Darker Turn—Time for a Global Response
The violent fascist riots in Belfast reveal the future that the trillionaire really wants. We need an international movement to constrain him.
newrepublic.com
June 17, 2026 at 11:15 AM
Elon Musk's incitement of pogroms in Belfast reveals he'll use his immense wealth and influence to foment untold fascist violence in the future. Only a global movement can break his power.
New piece from @polphilpod.bsky.social and me. Threading highlights below. 1/
newrepublic.com/article/2119...
New piece from @polphilpod.bsky.social and me. Threading highlights below. 1/
newrepublic.com/article/2119...
Reposted by Todd Douglas
I NEED YOUR ATTENTION.
When violent and controlling people start to feel their power slip, they become more violent and controlling.
I believe this is what’s happening in the Administration, now.
This is a CRITICAL INFLECTION POINT: we MUST come together and push back *hard* NOW.
🧵 a thread
When violent and controlling people start to feel their power slip, they become more violent and controlling.
I believe this is what’s happening in the Administration, now.
This is a CRITICAL INFLECTION POINT: we MUST come together and push back *hard* NOW.
🧵 a thread
June 6, 2026 at 2:36 AM
I NEED YOUR ATTENTION.
When violent and controlling people start to feel their power slip, they become more violent and controlling.
I believe this is what’s happening in the Administration, now.
This is a CRITICAL INFLECTION POINT: we MUST come together and push back *hard* NOW.
🧵 a thread
When violent and controlling people start to feel their power slip, they become more violent and controlling.
I believe this is what’s happening in the Administration, now.
This is a CRITICAL INFLECTION POINT: we MUST come together and push back *hard* NOW.
🧵 a thread
Reposted by Todd Douglas
Scientists: Your voice is needed.
New federal regulations could reshape research funding, publishing, and collaboration. Comments close July 13.
https://www.ascb.org/science-policy/proposed-regulations-would-fundamentally-change-american-science/
New federal regulations could reshape research funding, publishing, and collaboration. Comments close July 13.
https://www.ascb.org/science-policy/proposed-regulations-would-fundamentally-change-american-science/
June 4, 2026 at 2:25 PM
Scientists: Your voice is needed.
New federal regulations could reshape research funding, publishing, and collaboration. Comments close July 13.
https://www.ascb.org/science-policy/proposed-regulations-would-fundamentally-change-american-science/
New federal regulations could reshape research funding, publishing, and collaboration. Comments close July 13.
https://www.ascb.org/science-policy/proposed-regulations-would-fundamentally-change-american-science/
Reposted by Todd Douglas
Listen, the @standupforscience.net national team is working all hours of the day to stop Vought, RFK Jr., and Trump et al., from destroying our scientific ecosystem.
We are fueled by small donors--plz chip in if you are able.
If you're a big donor PLZ SUPPORT US!
www.standupforscience.net/donate
We are fueled by small donors--plz chip in if you are able.
If you're a big donor PLZ SUPPORT US!
www.standupforscience.net/donate
Fuel the fight! — STAND UP FOR SCIENCE
www.standupforscience.net
June 3, 2026 at 11:25 PM
Listen, the @standupforscience.net national team is working all hours of the day to stop Vought, RFK Jr., and Trump et al., from destroying our scientific ecosystem.
We are fueled by small donors--plz chip in if you are able.
If you're a big donor PLZ SUPPORT US!
www.standupforscience.net/donate
We are fueled by small donors--plz chip in if you are able.
If you're a big donor PLZ SUPPORT US!
www.standupforscience.net/donate
Reposted by Todd Douglas
☕Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and interferes with the cytoprotective roles of PABPC1 and MKRN1.
bit.ly/49kgpZN
bit.ly/49kgpZN
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
bit.ly
May 25, 2026 at 1:59 PM
☕Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and interferes with the cytoprotective roles of PABPC1 and MKRN1.
bit.ly/49kgpZN
bit.ly/49kgpZN
Police don't make communities safe.
Canadians deserve to be safe in their communities.
That’s why we’re hiring 1,000 new RCMP personnel — and giving law enforcement the tools and support they need to keep our streets safe.
That’s why we’re hiring 1,000 new RCMP personnel — and giving law enforcement the tools and support they need to keep our streets safe.
May 24, 2026 at 9:57 PM
Police don't make communities safe.
Reposted by Todd Douglas
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
www.nature.com
April 30, 2026 at 10:16 AM
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
www.nature.com
April 30, 2026 at 10:16 AM
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
www.nature.com/articles/s41...
We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
Reposted by Todd Douglas
The international boycott of ChatGPT has absolutely exploded.
2.5M people have already joined, and this is just the beginning.
Go to quitgpt.org.
Cancel your subscription, delete your account.
And tell at least one person why.
My op-ed: www.theguardian.com/commentisfre...
2.5M people have already joined, and this is just the beginning.
Go to quitgpt.org.
Cancel your subscription, delete your account.
And tell at least one person why.
My op-ed: www.theguardian.com/commentisfre...
March 4, 2026 at 9:03 AM
The international boycott of ChatGPT has absolutely exploded.
2.5M people have already joined, and this is just the beginning.
Go to quitgpt.org.
Cancel your subscription, delete your account.
And tell at least one person why.
My op-ed: www.theguardian.com/commentisfre...
2.5M people have already joined, and this is just the beginning.
Go to quitgpt.org.
Cancel your subscription, delete your account.
And tell at least one person why.
My op-ed: www.theguardian.com/commentisfre...
Reposted by Todd Douglas
This project started with confusion 🤔 www.nature.com/articles/s41...
Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects.
Neither LUBAC nor OTULIN had been linked to metabolic regulation.
So where do these metabolic manifestations come from?
Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects.
Neither LUBAC nor OTULIN had been linked to metabolic regulation.
So where do these metabolic manifestations come from?
February 24, 2026 at 8:52 AM
This project started with confusion 🤔 www.nature.com/articles/s41...
Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects.
Neither LUBAC nor OTULIN had been linked to metabolic regulation.
So where do these metabolic manifestations come from?
Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects.
Neither LUBAC nor OTULIN had been linked to metabolic regulation.
So where do these metabolic manifestations come from?
these are my politics if you even care
man I’m sorry to be all corny here but when I see a “the city is beautiful! There’s more to it than homeless people!” I gotta say you know who’s also beautiful? People who have no place to live & are trying to get by in a system that has turned its back on them & if you don’t see that that’s on you
February 9, 2026 at 1:31 AM
these are my politics if you even care
Reposted by Todd Douglas
So moved by the people of Minnesota who—drawing on LA, Portland, Chicago, DC etc—are writing a shining new chapter in the history of nonviolent resistance.
The rest of us need to be taking notes—and helping them!
www.standwithminnesota.com
The rest of us need to be taking notes—and helping them!
www.standwithminnesota.com
Stand With Minnesota
A directory of places to give to as Minnesota defends itself from ICE occupation
www.standwithminnesota.com
January 17, 2026 at 1:33 PM
So moved by the people of Minnesota who—drawing on LA, Portland, Chicago, DC etc—are writing a shining new chapter in the history of nonviolent resistance.
The rest of us need to be taking notes—and helping them!
www.standwithminnesota.com
The rest of us need to be taking notes—and helping them!
www.standwithminnesota.com
Reposted by Todd Douglas
2025 sucked.
In 2026, we are taking back our science!
We are excited to launch our Substack: The Science Fight Club.
Read our first post, written by @cdelawalla.bsky.social, a review of 2025, a preview of 2026, and a big call to action.
open.substack.com/pub/sciencef...
In 2026, we are taking back our science!
We are excited to launch our Substack: The Science Fight Club.
Read our first post, written by @cdelawalla.bsky.social, a review of 2025, a preview of 2026, and a big call to action.
open.substack.com/pub/sciencef...
January 1, 2026 at 2:00 PM
2025 sucked.
In 2026, we are taking back our science!
We are excited to launch our Substack: The Science Fight Club.
Read our first post, written by @cdelawalla.bsky.social, a review of 2025, a preview of 2026, and a big call to action.
open.substack.com/pub/sciencef...
In 2026, we are taking back our science!
We are excited to launch our Substack: The Science Fight Club.
Read our first post, written by @cdelawalla.bsky.social, a review of 2025, a preview of 2026, and a big call to action.
open.substack.com/pub/sciencef...
Reposted by Todd Douglas
In thinking about what you can do this year, keep this in mind: showing up at protests has real impact - -
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
How effective is protesting? According to historians and political scientists: very
From emancipation to women’s suffrage, civil rights and BLM, mass movement has shaped the arc of US history
www.theguardian.com
December 25, 2025 at 3:24 PM
In thinking about what you can do this year, keep this in mind: showing up at protests has real impact - -
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
checking in on news after 2 weeks without social media
November 21, 2025 at 5:35 PM
checking in on news after 2 weeks without social media
Reposted by Todd Douglas
November 8, 2025 at 4:05 PM
is this what hope feels like??????????
BREAKING: Zohran Mamdani wins the New York City mayoral race, NBC News projects. nbcnews.to/4nIzNUC
November 5, 2025 at 2:48 AM
is this what hope feels like??????????