@kingsdentistry.bsky.social
@kingscollegelondon.bsky.social

This work has been published at the Journal of Anatomy.

Congratulations to all authors!

#Craniofacial
#Embryogenesis
#Cartilage
#Pterygoid

(5/5)

Through the use of mutants, they showed that the secondary cartilage has a role in guiding the tensor veli palatini and facilitating suckling. This provides new insight into how coordinated tissue interactions underpin the function of the mammalian feeding apparatus. 

(4/5)

They show that the pterygoid plate is formed from two distinct developmental processes (membranous and endochondral ossification) and that it is composed entirely of neural crest.

This study broadens our understanding of the embryonic development of a significant part of mammal evolution.

(3/5)

In this paper Luke Barlow, Emi Nomura and Abigail Tucker examined the embryonic development of the medial pterygoid plate, a structure that supports the soft palate and helps stiffen it. This is key in producing a posterior seal in the oral cavity to allow suckling behaviours in mammals.

(2/5)

The paper was highlighted in this issue of the journal and the authors were interviewed by the journal for a “The people behind the papers”.

Read here: journals.biologists.com/dev/article/...

This work could provide framework for understanding the mechanisms underlying microtia, a birth defect affecting pinna morphology and often associated with hearing loss in individuals with congenital disorders.

Congratulations to all authors!

(4/4)

This interaction is mediated through FGFs secreted by the muscle, which signal to the developing cartilage, where they upregulate BMP4 expression. BMP4, in turn, induces the expression of Sox9, a master transcription factor for cartilage differentiation.

(3/4)

In this paper that the authors show the role of the auricular muscle in regulating pinna development. The muscle (mesoderm-derived) instructs differentiation of the cartilage (derived from neural crest).

(2/4)

Using this approach, the authors predict and experimentally validate a novel driver of placode development, the transcription factor FOXK2.

Congratulations to all authors!

(4/4)

Integrating this new data with previously published scRNA-seq from the lab, the paper explores dynamics of chromatin accessibility across emerging cell types and infers a gene regulatory network controlling the specification of cranial placodes.

(3/4)

This work led by Eva Hamrud presents a single cell ATAC-seq atlas of the developing chick ectoderm across stages that coincides with the emergence of major cell lineages from the neural plate border.

(2/4)

This paper, published at the Journal of Anatomy, is the third publication this year for PhD Student Ticha, which is a tremendous achievement!

@kingscollegelondon.bsky.social @kingsdentistry.bsky.social

#TMJ
#TemporomandibularJoint
#Fibrocartilage

(3/3)

In the paper authors show that the fibrocartilage of the murine glenoid fossa and condyle of the TMJ are shown to form at distinct times with distinct molecular identities. Changes in the condyle during disease lead to remodelling of the fossa to maintain joint alignment.

(2/3)