Stefan Oberlin
@chnebster.bsky.social
Reposted by Stefan Oberlin
New paper! A team led by @dbuendia.bsky.social and group leader Arturo Marí-Ordóñez at the GMI of the @oeaw.bsky.social investigated how plants silence potentially parasitic transposons when these “jumping genes” take over most of the genome.
August 6, 2026 at 6:29 AM
New paper! A team led by @dbuendia.bsky.social and group leader Arturo Marí-Ordóñez at the GMI of the @oeaw.bsky.social investigated how plants silence potentially parasitic transposons when these “jumping genes” take over most of the genome.
Reposted by Stefan Oberlin
High multiplicity of infection sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multiplexed perturbation enables scalable pooled screens - Nature Methods
This paper shows that high MOI sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers, challenging conventional reliance on low-MOI infections.
www.nature.com
June 2, 2026 at 6:24 PM
High multiplicity of infection sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A project from my postdoc in the McManus lab @mcmanuslab.bsky.social at UCSF @ucsfdc.bsky.social is out today 🎉
For years, pooled CRISPR screens have operated under a central assumption: one perturbation per cell.
We challenged that assumption. 🤯
www.nature.com/articles/s41592-026-03095-w
For years, pooled CRISPR screens have operated under a central assumption: one perturbation per cell.
We challenged that assumption. 🤯
www.nature.com/articles/s41592-026-03095-w
Multiplexed perturbation enables scalable pooled screens - Nature Methods
This paper shows that high MOI sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers, challenging conventional reliance on low-MOI infections.
www.nature.com
May 25, 2026 at 7:39 PM
A project from my postdoc in the McManus lab @mcmanuslab.bsky.social at UCSF @ucsfdc.bsky.social is out today 🎉
For years, pooled CRISPR screens have operated under a central assumption: one perturbation per cell.
We challenged that assumption. 🤯
www.nature.com/articles/s41592-026-03095-w
For years, pooled CRISPR screens have operated under a central assumption: one perturbation per cell.
We challenged that assumption. 🤯
www.nature.com/articles/s41592-026-03095-w