COIOS Catalysts
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New research on the drivers of future health and mortality risk, summarised daily with its figures. Free twice-weekly digest at coios.me
Reposted by COIOS Catalysts
Diabetes, Obesity, and CardioMetabolic CARE®, is advancing diabetes and obesity care. Explore the first issue FREE. 🎉 https://bit.ly/40VcFci
See what everyone is reading in #DOCM most-read section ➡️
✨doi.org/10.2337/doci25-0008
✨doi.org/10.2337/doc25-0026
✨doi.org/10.2337/doci25-0010
See what everyone is reading in #DOCM most-read section ➡️
✨doi.org/10.2337/doci25-0008
✨doi.org/10.2337/doc25-0026
✨doi.org/10.2337/doci25-0010
March 30, 2026 at 1:15 PM
Diabetes, Obesity, and CardioMetabolic CARE®, is advancing diabetes and obesity care. Explore the first issue FREE. 🎉 https://bit.ly/40VcFci
See what everyone is reading in #DOCM most-read section ➡️
✨doi.org/10.2337/doci25-0008
✨doi.org/10.2337/doc25-0026
✨doi.org/10.2337/doci25-0010
See what everyone is reading in #DOCM most-read section ➡️
✨doi.org/10.2337/doci25-0008
✨doi.org/10.2337/doc25-0026
✨doi.org/10.2337/doci25-0010
Suicide mortality in the Americas: the regional age-standardised rate rose 1.05% a year from 2015 to 2021, driven by males, and only 10 of 33 countries were falling fast enough to cut it by a third by 2030.
Suicide mortality in the Americas rose from 2015 to 2021 despite a one-third cut target
The regional age-standardised suicide mortality rate rose by 1·05% a year on average between 2015 and 2021, and only 10 of 33 countries fell fast enough to meet a one-third cut by 2030.
www.coios.me
October 27, 2026 at 2:40 AM
Suicide mortality in the Americas: the regional age-standardised rate rose 1.05% a year from 2015 to 2021, driven by males, and only 10 of 33 countries were falling fast enough to cut it by a third by 2030.
Typhoons and deaths in Japan, 2010-2019: wind exposure was linked to 2,426 excess deaths among adults aged 70 and over, against 301 recorded direct deaths.
Typhoon exposure and excess deaths in Japan, 2010–2019, by age and local vulnerability
Typhoon winds were linked to 2,426 excess deaths among Japanese adults aged 70 and over, against 301 recorded direct deaths.
www.coios.me
October 27, 2026 at 2:00 AM
Typhoons and deaths in Japan, 2010-2019: wind exposure was linked to 2,426 excess deaths among adults aged 70 and over, against 301 recorded direct deaths.
Semaglutide and tirzepatide for obesity: of 9,189 adults without diabetes who started either drug, 18.6% had 336 days or more of coverage in the first year. Few who stopped restarted or switched to another agent.
Semaglutide and tirzepatide prescriptions in adults with obesity often end within a year
Of 9,189 adults with obesity but no diabetes starting semaglutide or tirzepatide, 18.6% had coverage for 336 days or more.
www.coios.me
October 27, 2026 at 1:20 AM
Semaglutide and tirzepatide for obesity: of 9,189 adults without diabetes who started either drug, 18.6% had 336 days or more of coverage in the first year. Few who stopped restarted or switched to another agent.
Epigenetic clocks in ageing trials: across 26 human intervention studies, changes in DNA-methylation clocks matched changes in clinical outcomes inconsistently, and none validated a clock as a surrogate endpoint.
Epigenetic clock changes correspond inconsistently to clinical changes in ageing studies
In human geroscience intervention studies, epigenetic-clock changes matched clinical-outcome changes inconsistently, and no study validated a clock as a surrogate.
www.coios.me
October 27, 2026 at 1:00 AM
Epigenetic clocks in ageing trials: across 26 human intervention studies, changes in DNA-methylation clocks matched changes in clinical outcomes inconsistently, and none validated a clock as a surrogate endpoint.
Polygenic risk scores and prostate cancer screening: in a UK-calibrated microsimulation, every PRS-guided strategy cost more and was less effective than an alternative. No screening had the lowest lifetime costs.
Polygenic risk-guided prostate cancer screening was not cost-effective in a UK model
In a UK-calibrated microsimulation, prostate cancer screening guided by polygenic risk scores cost more and was less effective than alternatives.
www.coios.me
October 27, 2026 at 12:40 AM
Polygenic risk scores and prostate cancer screening: in a UK-calibrated microsimulation, every PRS-guided strategy cost more and was less effective than an alternative. No screening had the lowest lifetime costs.
GLP-1/GIP drugs in the US: use rose from 8.2% to 12.0% of adults between March 2024 and October 2025, about 32 million people. One user in three obtained them through non-traditional routes such as online prescribers or compounding pharmacies.
GLP-1/GIP use in US adults rose to 12% by 2025, a third via non-traditional access
GLP-1/GIP use rose from 8.2% to 12.0% of US adults in 18 months, led by weight-loss use.
www.coios.me
October 27, 2026 at 12:20 AM
GLP-1/GIP drugs in the US: use rose from 8.2% to 12.0% of adults between March 2024 and October 2025, about 32 million people. One user in three obtained them through non-traditional routes such as online prescribers or compounding pharmacies.
Reposted by COIOS Catalysts
If RFK Jr. successfully ends the practice of immunizing all newborns against HepB, chronic infections, like cirrhosis, liver cancer, and liver failure will increase 83% in Americans.
Source DOI: 10.7326/ANNALS-26-02135
Source DOI: 10.7326/ANNALS-26-02135
October 20, 2026 at 7:57 PM
If RFK Jr. successfully ends the practice of immunizing all newborns against HepB, chronic infections, like cirrhosis, liver cancer, and liver failure will increase 83% in Americans.
Source DOI: 10.7326/ANNALS-26-02135
Source DOI: 10.7326/ANNALS-26-02135
AI and stroke detection: against seven neurologists' consensus, a video-and-audio system detected deficits in 295 suspected stroke patients with 78.5% sensitivity, versus 59.4% for EMS personnel, at similar specificity.
Video-and-audio AI system detected stroke deficits more sensitively than EMS raters (APOLLAI)
Against a consensus of seven neurologists, an AI system reading video and audio of 295 suspected stroke patients detected neurological deficits with 78.5% sensitivity, versus 59.4% for emergency medical services (EMS) personnel, with similar specificity.
www.coios.me
October 25, 2026 at 4:10 PM
AI and stroke detection: against seven neurologists' consensus, a video-and-audio system detected deficits in 295 suspected stroke patients with 78.5% sensitivity, versus 59.4% for EMS personnel, at similar specificity.
Antibiotics in COVID-19 hospital care, 64 countries, 2020-2023: of 451,291 patients, 341,125 received antibiotics, mostly empirical WHO 'Watch' drugs, while suspected co-infection was reported in 47,050 of 592,898.
Antibiotic use in patients hospitalised for COVID-19 across 64 countries, 2020 to 2023
Of 451,291 patients hospitalised for COVID-19 in 64 countries, 341,125 received antibiotics, mostly empirical WHO 'Watch' drugs.
www.coios.me
October 25, 2026 at 3:30 PM
Antibiotics in COVID-19 hospital care, 64 countries, 2020-2023: of 451,291 patients, 341,125 received antibiotics, mostly empirical WHO 'Watch' drugs, while suspected co-infection was reported in 47,050 of 592,898.
Switching completely from cigarettes to e-cigarettes: all ten pooled toxicant exposure biomarkers were lower, including the nitrosamine NNN by 92% and NNAL by 61%. Reductions among dual users were smaller.
Switching from cigarettes to e-cigarettes and human biomarkers of toxicant exposure
Complete switching from cigarettes to e-cigarettes was linked to lower levels of all ten pooled toxicant exposure biomarkers.
www.coios.me
October 25, 2026 at 2:50 PM
Switching completely from cigarettes to e-cigarettes: all ten pooled toxicant exposure biomarkers were lower, including the nitrosamine NNN by 92% and NNAL by 61%. Reductions among dual users were smaller.
Cardiovascular disease in Europe by sex: in 2023 women had 55% of cases and 50% of deaths but less ischaemic heart disease (21% vs 38%), and gaps between countries were wider in women.
Cardiovascular disease burden in Europe is similar by sex but differs in composition
In 2023 women had 55% of cardiovascular cases and 50% of deaths, but less ischaemic heart disease.
www.coios.me
October 25, 2026 at 2:10 PM
Cardiovascular disease in Europe by sex: in 2023 women had 55% of cases and 50% of deaths but less ischaemic heart disease (21% vs 38%), and gaps between countries were wider in women.
Long-acting HIV injections in Spain: of 3,280 virologically suppressed adults on cabotegravir plus rilpivirine, 70.4% received every injection within ±7 days of target and 0.7% had suboptimal adherence.
Injection-schedule adherence to long-acting cabotegravir plus rilpivirine in Spain (RELATIVITY)
Among 3280 virologically suppressed adults in Spain, 70.4% received every evaluable injection within ±7 days; 0.7% had suboptimal adherence.
www.coios.me
October 25, 2026 at 1:30 PM
Long-acting HIV injections in Spain: of 3,280 virologically suppressed adults on cabotegravir plus rilpivirine, 70.4% received every injection within ±7 days of target and 0.7% had suboptimal adherence.
Education and dementia: a compulsory schooling reform showed that extra education lowered dementia incidence and weakened the link between genetic risk and dementia.
Education and dementia: a schooling reform cut incidence and weakened genetic risk
A compulsory schooling reform showed that extra education lowered dementia incidence and weakened the link between genetic risk and dementia.
www.coios.me
October 25, 2026 at 12:50 PM
Education and dementia: a compulsory schooling reform showed that extra education lowered dementia incidence and weakened the link between genetic risk and dementia.
Semaglutide starting dose in the US: 14.5% of adults starting injections began on a high dose, and high-dose starts carried a 25% higher risk of early discontinuation (HR 1.25, 95% CI 1.17-1.34).
Semaglutide: 14.5% of US initiators start at high dose, with earlier discontinuation
Among US adults starting injectable semaglutide, high-dose initiation was associated with a 25% higher early discontinuation risk and lower 1-year persistence.
www.coios.me
October 23, 2026 at 11:50 PM
Semaglutide starting dose in the US: 14.5% of adults starting injections began on a high dose, and high-dose starts carried a 25% higher risk of early discontinuation (HR 1.25, 95% CI 1.17-1.34).
Anti-obesity drugs in routine care: median exposure to tirzepatide and semaglutide fell far short of the 72 weeks used in trials, and after at least 72 weeks on tirzepatide nearly half missed 10% weight loss.
Anti-obesity drugs in routine care: short exposure, smaller weight loss than in trials
In routine care, nearly half of tirzepatide users did not reach 10% weight loss after at least 72 weeks.
www.coios.me
October 23, 2026 at 11:10 PM
Anti-obesity drugs in routine care: median exposure to tirzepatide and semaglutide fell far short of the 72 weeks used in trials, and after at least 72 weeks on tirzepatide nearly half missed 10% weight loss.
Temperature and cardiovascular deaths in Europe: under high emissions, temperature-attributable cardiovascular mortality is projected to rise from 31.4 to 62.4 per 100,000 by late century, with heat-attributable rates up 472%.
Temperature-attributable cardiovascular deaths in Europe may double by late century
Under high emissions, temperature-attributable cardiovascular deaths in Europe rise from 31.4 to 62.4 per 100,000, with heat-attributable rates up 472%.
www.coios.me
October 23, 2026 at 10:40 PM
Temperature and cardiovascular deaths in Europe: under high emissions, temperature-attributable cardiovascular mortality is projected to rise from 31.4 to 62.4 per 100,000 by late century, with heat-attributable rates up 472%.
HPV catch-up vaccination in 132 low- and middle-income countries: a one-time campaign for females aged 9-30 was modelled to prevent 6.93 million cervical cancer cases and 3.56 million deaths.
HPV catch-up vaccination to age 30 modelled in 132 low- and middle-income countries
A one-time catch-up campaign for females aged 9-30 was projected to prevent 6.93 million cervical cancer cases and 3.56 million deaths.
www.coios.me
October 23, 2026 at 10:00 PM
HPV catch-up vaccination in 132 low- and middle-income countries: a one-time campaign for females aged 9-30 was modelled to prevent 6.93 million cervical cancer cases and 3.56 million deaths.
Alzheimer pathology at autopsy in Sao Paulo: of 2,711 decedents, 19.6% had both amyloid and tau at biomarker-detectable levels, rising from 0% at ages 23-50 to 45.9% at 91-111.
Amyloid and tau stage in 2711 Sao Paulo autopsies, by age and cognitive status
In 2711 Sao Paulo autopsies, 19.6% had both amyloid and tau at biomarker-detectable levels, rising steeply with age.
www.coios.me
October 23, 2026 at 9:20 PM
Alzheimer pathology at autopsy in Sao Paulo: of 2,711 decedents, 19.6% had both amyloid and tau at biomarker-detectable levels, rising from 0% at ages 23-50 to 45.9% at 91-111.
Heat and mortality in Spain, 2015-2024: heat-attributable mortality rose 15% per 1 °C of mean heatwave daily maximum temperature, while heat-attributable deaths fell 3.9-5.8% a year after adjusting for temperature.
Heat-attributable mortality in Spain rose 15% per 1 °C of mean heatwave daily Tmax
Event-level heat metrics explained much of the variability in heatwave mortality, while heat-attributable deaths fell 3.9-5.8% a year after adjusting for temperature.
www.coios.me
October 23, 2026 at 8:40 PM
Heat and mortality in Spain, 2015-2024: heat-attributable mortality rose 15% per 1 °C of mean heatwave daily maximum temperature, while heat-attributable deaths fell 3.9-5.8% a year after adjusting for temperature.
Obesity treatment access in the US: a microsimulation of 107.6 million adults projects 5.3 million more deaths over ten years under current access limits than with incretin-based therapies.
US obesity treatment access modelled as 5.3 million preventable deaths over a decade
Modelling projects 5.3 million preventable deaths and $10.5-13.3 trillion foregone benefits over a decade of restricted obesity treatment access.
www.coios.me
October 19, 2026 at 3:00 PM
Obesity treatment access in the US: a microsimulation of 107.6 million adults projects 5.3 million more deaths over ten years under current access limits than with incretin-based therapies.
Bloodstream infections in Calgary, 2006-2022: S. aureus resistant to four antibiotics fell 16% a year as fluoroquinolone prescribing fell, while community-onset E. coli ST1193 rose 17.7% a year.
Bacteraemia resistance and strain trends in Calgary alongside antibiotic prescribing
Population-based Calgary cohort covering five bacteraemia pathogens, 2006 to 2022: fluoroquinolone resistance fell in Gram-positive species, while Escherichia coli ST1193 and CTX-M-27-producing ST131 rose.
www.coios.me
October 19, 2026 at 2:20 PM
Bloodstream infections in Calgary, 2006-2022: S. aureus resistant to four antibiotics fell 16% a year as fluoroquinolone prescribing fell, while community-onset E. coli ST1193 rose 17.7% a year.
Depression after a cancer diagnosis in South Korea: among 755,079 adults with no prior depression, those later diagnosed with it had a suicide hazard 4.76 times higher, strongest under 60 and in women.
Depression recorded after cancer diagnosis and suicide risk in 755,079 South Korean adults
Cancer patients with no prior depression who were later diagnosed with it had a suicide hazard 4.76 times that of those without.
www.coios.me
October 19, 2026 at 1:50 PM
Depression after a cancer diagnosis in South Korea: among 755,079 adults with no prior depression, those later diagnosed with it had a suicide hazard 4.76 times higher, strongest under 60 and in women.
GLP-1 drugs in Alzheimer's disease and MCI: pooled across seven randomised trials (4,132 people), they improved neither cognition nor disease progression. Discontinuation was 16.4% against 7.9% on placebo or usual care.
GLP-1 receptor agonists do not improve cognition or function in Alzheimer's disease or MCI
GLP-1 receptor agonists improved neither cognition nor disease progression in pooled trials, with more adverse events and discontinuation.
www.coios.me
October 19, 2026 at 1:10 PM
GLP-1 drugs in Alzheimer's disease and MCI: pooled across seven randomised trials (4,132 people), they improved neither cognition nor disease progression. Discontinuation was 16.4% against 7.9% on placebo or usual care.
Temperature and mortality across 3,116 Dutch districts, 2010-2019: cold was associated with 11,988 excess deaths a year, heat with 346.
Temperature-related mortality across 3,116 Dutch districts is dominated by cold, not heat
Cold was associated with 11,988 excess deaths a year in the Netherlands, heat with 346.
www.coios.me
October 18, 2026 at 2:10 PM
Temperature and mortality across 3,116 Dutch districts, 2010-2019: cold was associated with 11,988 excess deaths a year, heat with 346.