Supported by NINDS/NIH award UG3NS140088 via the NIH HEAL Initiative. Views our own.

A privilege to build this with an amazing team @alexanderbherman.bsky.social (co-PI) as well as Tay Netoff Michael Park Andrew Grande @drdamienfair.bsky.social and Ziad Nahas — psychiatry, engineering, neurosurgery, and neuroimaging on one problem.

this is very insightful and begs the question about the role of moderating factors for the salience tuning. Since alcohol may decrease the SNR of salience of many things, could we move forward with Bonferroni Beer

If partial afferents remain, could central targets (e.g., thalamus) be modulated through them?

Interested in how others conceptualize this. #pain
journals.lww.com/neurosurgpra...

electrodes can stay forever though like anything they can slowly degrade over time! We have some patients with electrodes in their brain for more than 20 years!

And it isn't just about invasive stimulation. It is a tool that we have amongst many and has its uses. But at the same time it sets the stage for validating noninvasive stimulation approaches. We can do invasive stimulation for those who truly need it. #depression

What is really interesting is that these networks are embedded in the same networks that play a role in executive function and working memory as well as emotional regulation. @alexanderbherman.bsky.social

We have always known that there is the possibility of top-down modulation of pain circuits potentiating the endogenous analgesia network. The question has been how do we even think about trying to target. PFM seems to be a giant leap forward with @drdamienfair.bsky.social @ndosenbach.bsky.social

These patients and many others suffer from central neuropathic pain that often is due to #stroke or #multiplesclerosis or treatment of #trigeminalneuralgia resulting in #anesthesiadolorosa. These are some of the worst pain syndromes on earth!