Enes Ugur
@enesugur.bsky.social
Reposted by Enes Ugur
Same single cell, two modalities—both at depth. We digest protein first, run Smart-seq3xpress + C18 (Evotip) separation: peptides captured, cDNA in flowthrough. In HeLa & stem cells, proteome tracks cell state; RNA variance flags transitioning cells.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
In the same cell, the proteome defines cellular state and the transcriptome marks transitions
Bulk transcriptome and proteome correlate only modestly, but this has not been investigated in the same cell or across cell-state changes. Here we introduce a scalable technology that quantifies thous...
www.biorxiv.org
August 27, 2026 at 10:02 AM
Same single cell, two modalities—both at depth. We digest protein first, run Smart-seq3xpress + C18 (Evotip) separation: peptides captured, cDNA in flowthrough. In HeLa & stem cells, proteome tracks cell state; RNA variance flags transitioning cells.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...