Prof. Gennadi Glinsky, MD, Ph.D.
@gglinsky.bsky.social
Posts are my own immediate personal reflections on current events or views expressed by others.
Retired.
Professor,
Translational and Functional Genomics.
Retired.
Professor,
Translational and Functional Genomics.
Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies
Plasma p-tau217 concentrations, considered together with APOE genotype, might help
stratify risk and estimate the timing of future cognitive impairment in asymptomatic
individuals who are at increased...
www.thelancet.com
September 12, 2026 at 5:24 AM
Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Transposable Elements Seed Transcription Factor Binding Sites to Sequence-Specific Double-Stranded DNA Binding TF Networks Contributing to Governance of Primate Brain Evolution
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Transposable Elements Seed Transcription Factor Binding Sites to Sequence-Specific Double-Stranded DNA Binding TF Networks Contributing to Governance of Primate Brain Evolution - Journal of Molecular ...
Transposable elements (TEs) have played a pivotal role in shaping the regulatory architecture of mammalian genomes. This contribution reports multiple lines of evidence suggesting that TE have made a ...
link.springer.com
September 12, 2026 at 5:16 AM
Transposable Elements Seed Transcription Factor Binding Sites to Sequence-Specific Double-Stranded DNA Binding TF Networks Contributing to Governance of Primate Brain Evolution
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary...
Timelines of population-level effects of viruses on humans varied from the evolutionary scale of million years to contemporary spread of viral infections. Correspondingly, these events are exemplified...
link.springer.com
September 9, 2026 at 5:54 AM
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Robust inference and correlates from genetic associations with personality.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Robust inference and correlates from genetic associations with personality - Nature
The genetic architecture of personality is robustly generalizable, minimally confounded and widely relevant to human experience.
www.nature.com
September 2, 2026 at 7:52 PM
Robust inference and correlates from genetic associations with personality.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transposable Elements Seed Transcription Factor Binding Sites to Sequence-Specific Double-Stranded DNA Binding TF Networks Contributing to Governance of Primate Brain Evolution.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Transposable Elements Seed Transcription Factor Binding Sites to Sequence-Specific Double-Stranded DNA Binding TF Networks Contributing to Governance of Primate Brain Evolution - Journal of Molecular ...
Transposable elements (TEs) have played a pivotal role in shaping the regulatory architecture of mammalian genomes. This contribution reports multiple lines of evidence suggesting that TE have made a ...
link.springer.com
September 1, 2026 at 5:24 AM
Transposable Elements Seed Transcription Factor Binding Sites to Sequence-Specific Double-Stranded DNA Binding TF Networks Contributing to Governance of Primate Brain Evolution.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration - Nature Aging
Yadav et al. develop a framework that quantifies tissue structural aging without training on chronological age, using a large dataset of human histology images. They reveal distinct yet coordinated or...
www.nature.com
September 1, 2026 at 5:21 AM
Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Prof. Gennadi Glinsky, MD, Ph.D.
Examples of default operations of assemblies of hetero- & homodimers of Yamanaka factors, neurogenesis constituents, and proteins of postsynaptic density of excitatory and inhibitory synaptogenesis are reported with detailed analytical focus on human Claustrum.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes
Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...
www.frontiersin.org
August 31, 2026 at 6:52 AM
Examples of default operations of assemblies of hetero- & homodimers of Yamanaka factors, neurogenesis constituents, and proteins of postsynaptic density of excitatory and inhibitory synaptogenesis are reported with detailed analytical focus on human Claustrum.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Reposted by Prof. Gennadi Glinsky, MD, Ph.D.
War crimes. Crimes against humanity. Genocide. Crime against peace.
Which one was not committed by Putin's regime?
Which one was not committed by Putin's regime?
August 31, 2026 at 10:10 PM
War crimes. Crimes against humanity. Genocide. Crime against peace.
Which one was not committed by Putin's regime?
Which one was not committed by Putin's regime?
It feels sometime like my whole world is dying one by one... very sad.
Wendell Berry, Writer Who Extolled America’s Agrarian Past, Dies at 92.
A Kentucky farmer, he railed against agribusiness and championed small family farms and the environment, winning widespread acclaim.
Wendell Berry, Writer Who Extolled America’s Agrarian Past, Dies at 92.
A Kentucky farmer, he railed against agribusiness and championed small family farms and the environment, winning widespread acclaim.
Thank you for so many strong essays, poems, ideas, stands, principles, examples, Wendell Berry. Thank you for loving the land, the country, the language. Thank you for living your principles. Quoted you in my talk yesterday, pulled these from my quotes collections.
Wendell Berry, Writer Who Extolled America’s Agrarian Past, Dies at 92
A Kentucky farmer, he railed against agribusiness and championed small family farms and the environment, winning widespread acclaim.
www.nytimes.com
September 1, 2026 at 2:43 AM
It feels sometime like my whole world is dying one by one... very sad.
Wendell Berry, Writer Who Extolled America’s Agrarian Past, Dies at 92.
A Kentucky farmer, he railed against agribusiness and championed small family farms and the environment, winning widespread acclaim.
Wendell Berry, Writer Who Extolled America’s Agrarian Past, Dies at 92.
A Kentucky farmer, he railed against agribusiness and championed small family farms and the environment, winning widespread acclaim.
War crimes. Crimes against humanity. Genocide. Crime against peace.
Which one was not committed by Putin's regime?
Which one was not committed by Putin's regime?
August 31, 2026 at 10:10 PM
War crimes. Crimes against humanity. Genocide. Crime against peace.
Which one was not committed by Putin's regime?
Which one was not committed by Putin's regime?
Examples of default operations of assemblies of hetero- & homodimers of Yamanaka factors, neurogenesis constituents, and proteins of postsynaptic density of excitatory and inhibitory synaptogenesis are reported with detailed analytical focus on human Claustrum.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes
Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...
www.frontiersin.org
August 31, 2026 at 6:52 AM
Examples of default operations of assemblies of hetero- & homodimers of Yamanaka factors, neurogenesis constituents, and proteins of postsynaptic density of excitatory and inhibitory synaptogenesis are reported with detailed analytical focus on human Claustrum.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Safety and lipoprotein(a)-lowering effects of Kylo-11, a non-canonical, long-duration small interfering RNA targeting lipoprotein(a): a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Safety and lipoprotein(a)-lowering effects of Kylo-11, a non-canonical, long-duration small interfering RNA targeting lipoprotein(a): a first-in-human, randomised, double-blind, placebo-controlled, ph...
A single dose of Kylo-11 was well tolerated, and at doses of 225 mg or higher, durably
reduced serum lipoprotein(a) concentrations up to 48 weeks.
www.thelancet.com
August 30, 2026 at 8:11 AM
Safety and lipoprotein(a)-lowering effects of Kylo-11, a non-canonical, long-duration small interfering RNA targeting lipoprotein(a): a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
The foundational observations reported in this contribution should facilitate experimental and theoretical explorations of TE-seeded genomic codes for initiators of PPI chain reactions creating pools of dimer-attractors to guide and accelerate the EMC assemblies.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes
Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...
www.frontiersin.org
August 30, 2026 at 8:05 AM
The foundational observations reported in this contribution should facilitate experimental and theoretical explorations of TE-seeded genomic codes for initiators of PPI chain reactions creating pools of dimer-attractors to guide and accelerate the EMC assemblies.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Prevalence of Silent Atherosclerosis across Adult Life | New England Journal of Medicine www.nejm.org/doi/full/10....
Prevalence of Silent Atherosclerosis across Adult Life | NEJM
Atherosclerosis may begin in early adulthood and remain clinically silent for decades
before cardiovascular disease manifests. Although silent atherosclerosis is associated
with cardiovascular even...
www.nejm.org
August 29, 2026 at 6:13 PM
Prevalence of Silent Atherosclerosis across Adult Life | New England Journal of Medicine www.nejm.org/doi/full/10....
When infection surges, downshifting the category thresholds by CDC hardly the correct public health safety approach.
August 29, 2026 at 7:44 AM
When infection surges, downshifting the category thresholds by CDC hardly the correct public health safety approach.
Genome-wide, chromosome-naïve compartmentalization of major developmental networks tailored by modular placement of human embryo-regulatory Long Terminal Repeats.
www.academia.edu/3064-9765/2/...
www.academia.edu/3064-9765/2/...
Genome-wide, chromosome-naïve compartmentalization of major developmental networks tailored by modular placement of human embryo-regulatory Long Terminal Repeats
At inception, eukaryotes solved the conflict of the physical dimensions of meter-sized linear chromatin fibers placed into micron-sized nuclei by employing two mechanisms: (i) fragmenting genomic DNA ...
www.academia.edu
August 29, 2026 at 4:58 AM
Genome-wide, chromosome-naïve compartmentalization of major developmental networks tailored by modular placement of human embryo-regulatory Long Terminal Repeats.
www.academia.edu/3064-9765/2/...
www.academia.edu/3064-9765/2/...
Reposted by Prof. Gennadi Glinsky, MD, Ph.D.
If you have issues with acid reflux , GERD, IBS , try out new Q and A feature and let me know your thoughts.
Ask it questions about recipes. What foods might help or hurt. Try it out !
foodguides.com/pages/ask-fo...
Ask it questions about recipes. What foods might help or hurt. Try it out !
foodguides.com/pages/ask-fo...
Ask The Foodguides AI
foodguides.com
April 2, 2025 at 2:07 AM
If you have issues with acid reflux , GERD, IBS , try out new Q and A feature and let me know your thoughts.
Ask it questions about recipes. What foods might help or hurt. Try it out !
foodguides.com/pages/ask-fo...
Ask it questions about recipes. What foods might help or hurt. Try it out !
foodguides.com/pages/ask-fo...
Reposted by Prof. Gennadi Glinsky, MD, Ph.D.
Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes
Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...
www.frontiersin.org
August 27, 2026 at 5:39 AM
Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
C.I.A. Chief Delivered Bleak Assessment of Russia’s War in Secretive Moscow Visit.
C.I.A. analysts have questioned whether President Vladimir V. Putin’s advisers have given him honest assessments of the conflict.
www.nytimes.com/2026/08/27/u...
C.I.A. analysts have questioned whether President Vladimir V. Putin’s advisers have given him honest assessments of the conflict.
www.nytimes.com/2026/08/27/u...
C.I.A. Chief Delivered Bleak Assessment of Russia’s War in Secretive Moscow Visit
C.I.A. analysts have questioned whether President Vladimir V. Putin’s advisers have given him honest assessments of the conflict.
www.nytimes.com
August 27, 2026 at 7:29 PM
C.I.A. Chief Delivered Bleak Assessment of Russia’s War in Secretive Moscow Visit.
C.I.A. analysts have questioned whether President Vladimir V. Putin’s advisers have given him honest assessments of the conflict.
www.nytimes.com/2026/08/27/u...
C.I.A. analysts have questioned whether President Vladimir V. Putin’s advisers have given him honest assessments of the conflict.
www.nytimes.com/2026/08/27/u...
China abruptly delays mission to probe Moon’s hidden water.
Chang’e-7, which will investigate the origin of and abundance of lunar ice, set back until 2027.
www.science.org/content/arti...
Chang’e-7, which will investigate the origin of and abundance of lunar ice, set back until 2027.
www.science.org/content/arti...
China abruptly delays mission to probe Moon’s hidden water
Chang’e-7, which will investigate the origin of and abundance of lunar ice, set back until 2027
www.science.org
August 27, 2026 at 6:29 PM
China abruptly delays mission to probe Moon’s hidden water.
Chang’e-7, which will investigate the origin of and abundance of lunar ice, set back until 2027.
www.science.org/content/arti...
Chang’e-7, which will investigate the origin of and abundance of lunar ice, set back until 2027.
www.science.org/content/arti...
Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes
Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...
www.frontiersin.org
August 27, 2026 at 5:39 AM
Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
HAP initiators appear to operate within nucleosome-depleted islands of transposable elements (TE) – derived sequences within heterochromatin. PPI assembly lines of EMCs operate in 2 concurrent modes: TF-TF PPI cascade and PPI HUB protein cascade.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes
Mechanisms governing initiation steps of the assembly of endogenous multi-protein complexes (EMC) remain incompletely understood. Here, multiple lines of obs...
www.frontiersin.org
August 27, 2026 at 4:32 AM
HAP initiators appear to operate within nucleosome-depleted islands of transposable elements (TE) – derived sequences within heterochromatin. PPI assembly lines of EMCs operate in 2 concurrent modes: TF-TF PPI cascade and PPI HUB protein cascade.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
C.I.A. Director Makes Secret Visit to Moscow
John Ratcliffe flew to Moscow in a military cargo plane from Riga, Latvia. It is not clear whom he met or what the purpose of his trip was.
www.nytimes.com/2026/08/25/u...
John Ratcliffe flew to Moscow in a military cargo plane from Riga, Latvia. It is not clear whom he met or what the purpose of his trip was.
www.nytimes.com/2026/08/25/u...
C.I.A. Director Makes Secret Visit to Moscow
John Ratcliffe flew to Moscow in a military cargo plane from Riga, Latvia. It is not clear whom he met or what the purpose of his trip was.
www.nytimes.com
August 26, 2026 at 1:53 AM
C.I.A. Director Makes Secret Visit to Moscow
John Ratcliffe flew to Moscow in a military cargo plane from Riga, Latvia. It is not clear whom he met or what the purpose of his trip was.
www.nytimes.com/2026/08/25/u...
John Ratcliffe flew to Moscow in a military cargo plane from Riga, Latvia. It is not clear whom he met or what the purpose of his trip was.
www.nytimes.com/2026/08/25/u...